2024-05-21 23:05:08, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_022937 1447 bp mRNA linear ROD 14-JUL-2023 DEFINITION Rattus norvegicus double C2 domain alpha (Doc2a), mRNA. ACCESSION NM_022937 VERSION NM_022937.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1447) AUTHORS Yao J, Gaffaney JD, Kwon SE and Chapman ER. TITLE Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release JOURNAL Cell 147 (3), 666-677 (2011) PUBMED 22036572 REFERENCE 2 (bases 1 to 1447) AUTHORS Pang ZP, Bacaj T, Yang X, Zhou P, Xu W and Sudhof TC. TITLE Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism JOURNAL Neuron 70 (2), 244-251 (2011) PUBMED 21521611 REFERENCE 3 (bases 1 to 1447) AUTHORS Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A and Sasaki T. TITLE Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells JOURNAL J Immunol 180 (7), 4774-4784 (2008) PUBMED 18354201 REFERENCE 4 (bases 1 to 1447) AUTHORS Korteweg N, Denekamp FA, Verhage M and Burbach JP. TITLE Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development JOURNAL Eur J Neurosci 12 (1), 165-171 (2000) PUBMED 10651871 REFERENCE 5 (bases 1 to 1447) AUTHORS Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y and Takai Y. TITLE Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport JOURNAL J Biol Chem 273 (46), 30065-30068 (1998) PUBMED 9804756 REFERENCE 6 (bases 1 to 1447) AUTHORS Verhage M, de Vries KJ, Roshol H, Burbach JP, Gispen WH and Sudhof TC. TITLE DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion JOURNAL Neuron 18 (3), 453-461 (1997) PUBMED 9115738 REFERENCE 7 (bases 1 to 1447) AUTHORS Naito A, Orita S, Wanaka A, Sasaki T, Sakaguchi G, Maeda M, Igarashi H, Tohyama M and Takai Y. TITLE Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain JOURNAL Brain Res Mol Brain Res 44 (2), 198-204 (1997) PUBMED 9073161 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JACYVU010000044.1. On Nov 27, 2020 this sequence version replaced NM_022937.2. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00132291, SAMD00132293 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-330 JACYVU010000044.1 8387647-8387976 331-410 JACYVU010000044.1 8388332-8388411 411-485 JACYVU010000044.1 8388589-8388663 486-595 JACYVU010000044.1 8388774-8388883 596-722 JACYVU010000044.1 8390017-8390143 723-782 JACYVU010000044.1 8390223-8390282 783-946 JACYVU010000044.1 8390365-8390528 947-1028 JACYVU010000044.1 8390616-8390697 1029-1125 JACYVU010000044.1 8390787-8390883 1126-1447 JACYVU010000044.1 8390966-8391287 FEATURES Location/Qualifiers source 1..1447 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="1" /map="1q36" gene 1..1447 /gene="Doc2a" /note="double C2 domain alpha" /db_xref="GeneID:65031" /db_xref="RGD:620518" exon 1..330 /gene="Doc2a" /inference="alignment:Splign:2.1.0" CDS 60..1271 /gene="Doc2a" /note="doc2-alpha; double C2, alpha; double C2-like domains, alpha" /codon_start=1 /product="double C2-like domain-containing protein alpha" /protein_id="NP_075226.1" /db_xref="GeneID:65031" /db_xref="RGD:620518" /translation="
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRRGPGPEGGGGGRGFGEAPAHLAPLALAPPAALLGATTPDDGAEVDSYDSDDTTALGTLEFDLLYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTYSGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLPSPSSMSAALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEMELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEAQKHWRDCLHQPDTAVERWHTLTSELPPAAGALPLA"
misc_feature 60..335 /gene="Doc2a" /note="propagated from UniProtKB/Swiss-Prot (P70611.1); Region: Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250" misc_feature 336..707 /gene="Doc2a" /note="C2 domain first repeat present in Rabphilin and Double C2 domain; Region: C2A_Rabphilin_Doc2; cd04035" /db_xref="CDD:176000" misc_feature order(426..428,444..446,609..611,615..617,633..635) /gene="Doc2a" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176000" misc_feature 711..1268 /gene="Doc2a" /note="propagated from UniProtKB/Swiss-Prot (P70611.1); Region: Interaction with UNC13D. /evidence=ECO:0000250" misc_feature 828..1226 /gene="Doc2a" /note="C2 domain second repeat present in Rabphilin and Double C2 domain; Region: C2B_Rabphilin_Doc2; cd08384" /db_xref="CDD:176030" misc_feature order(912..914,930..932,1092..1094,1098..1100,1116..1118) /gene="Doc2a" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:176030" exon 331..410 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 411..485 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 486..595 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 596..722 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 723..782 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 783..946 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 947..1028 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 1029..1125 /gene="Doc2a" /inference="alignment:Splign:2.1.0" exon 1126..1447 /gene="Doc2a" /inference="alignment:Splign:2.1.0" ORIGIN
cctacagaccccagccggccactccagctctacacccgtctcccagccagaggtgctgcatgaggggccgcaggggcgatcgcatgaccatcaacatccaggagcacatggccatcaacgtgtgccctggacccatcaggcccatccgccagatctccgactacttccctcgcagggggccaggaccagagggtggcggcggcggcaggggcttcggggaagccccagctcatctggcccctctggctctggccccccctgcggctctccttggggccactacacccgacgatggagctgaggtagacagctacgactcggatgataccactgccctgggcacgctggaatttgaccttctctatgatcaggcttcctgcatgctgcactgtagaatcctcagggccaagggcctcaagcccatggatttcaacggcctggctgacccctatgtaaagctgcacctcctgccaggagcctgcaaggccaataagctaaaaaccaagacacagaggaacacactgaacccagtgtggaacgaggagctgacgtacagtggaatcacagatgacgacatcacccacaaggtgctcaggatctcggtctgtgatgaggacaagctgagtcacaatgaatttattggggagatccgagtgcccctccgccgcctcaagccttcacagaagaagcattttaacatctgccttgagcgtcaggtcccgcttccttcgccctcttcaatgtctgcggcgctgaggggcatatcctgttacctgaaggagctagagcaggcagagcagggacctgggctgttggaagagcgcgggcgcatcctgctgagcctcagctacagctctcggcggcatgggctgctggtgggcattgttcgctgtgctcacctggctgcaatggatgttaacggctactctgacccttatgtgaagacgtacttgagaccagacgtggataagaaatccaagcataagacgtgtgtaaagaagaagacgctgaacccggaatttaatgaggaattcttttatgagatggaactctccactctggctaccaagaccctggaagtcacagtctgggactacgacattggcaaatccaatgacttcataggtggtgtgtctctggggccaggagcccggggagaggcccagaaacactggagagactgtctacatcagccggacacagcagtggagcgctggcataccctgaccagcgagctgcccccagcagcaggggcgttgccgttggcctgaacagactgcagctgcccagcacaggccctctgcggccgggtccagtacccaaccttcgcacgagtgtgttgcacgtttacatgggtgggacgcccctgccccacactacctgtcttatttttgtgagtctctgtgaccgtgggtctatcttcttgtgagggatgtggagagctata
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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