2024-05-21 22:22:48, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001159304 1265 bp mRNA linear MAM 29-JUL-2016 DEFINITION Sus scrofa cyclin dependent kinase 1 (CDK1), mRNA. ACCESSION NM_001159304 XM_001924501 VERSION NM_001159304.2 KEYWORDS RefSeq. SOURCE Sus scrofa (pig) ORGANISM Sus scrofa Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. REFERENCE 1 (bases 1 to 1265) AUTHORS Fujii W, Nishimura T, Kano K, Sugiura K and Naito K. TITLE CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes JOURNAL Biol. Reprod. 85 (6), 1124-1132 (2011) PUBMED 21778139 REMARK GeneRIF: CDK7 and CCNH activate CDC2 by T161 phosphorylation and make up CDK-activating kinase, which is required for normal meiotic progression during porcine oocyte maturation. REFERENCE 2 (bases 1 to 1265) AUTHORS Zhang DX, Cui XS and Kim NH. TITLE Molecular characterization and polyadenylation-regulated expression of cyclin B1 and Cdc2 in porcine oocytes and early parthenotes JOURNAL Mol. Reprod. Dev. 77 (1), 38-50 (2010) PUBMED 19705412 REMARK GeneRIF: Results describe the expression of maternal cyclin B1 and Cdc2 during in vitro maturation of porcine oocytes. REFERENCE 3 (bases 1 to 1265) AUTHORS Nishimura T, Shimaoka T, Kano K and Naito K. TITLE Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes JOURNAL J. Reprod. Dev. 55 (5), 553-557 (2009) PUBMED 19550110 REMARK GeneRIF: insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs REFERENCE 4 (bases 1 to 1265) AUTHORS Zhang DX, Cui XS and Kim NH. TITLE Involvement of polyadenylation status on maternal gene expression during in vitro maturation of porcine oocytes JOURNAL Mol. Reprod. Dev. 76 (9), 881-889 (2009) PUBMED 19479986 REFERENCE 5 (bases 1 to 1265) AUTHORS Shimaoka T, Nishimura T, Kano K and Naito K. TITLE Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytes JOURNAL Cell Cycle 8 (15), 2375-2384 (2009) PUBMED 19633431 REMARK GeneRIF: These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B, but not pigMyt1, is involved in the meiotic arrest of porcine oocytes. REFERENCE 6 (bases 1 to 1265) AUTHORS Holzenspies JJ, Stoorvogel W, Colenbrander B, Roelen BA, Gutknecht DR and van Haeften T. TITLE CDC2/SPDY transiently associates with endoplasmic reticulum exit sites during oocyte maturation JOURNAL BMC Dev. Biol. 9, 8 (2009) PUBMED 19187565 REMARK GeneRIF: Data demonstrate the presence of a novel structure in the cortex of porcine oocytes that comprises ERES and transiently accumulates CDC2 prior to germinal vesicle breakdown. Publication Status: Online-Only REFERENCE 7 (bases 1 to 1265) AUTHORS Chen WY, Yang JG and Li PS. TITLE Effect of dexamethasone on the expression of p34(cdc2) and cyclin B1 in pig oocytes in vitro JOURNAL Mol. Reprod. Dev. 56 (1), 74-79 (2000) PUBMED 10737969 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP161545.1, CU468520.2 and GQ184633.1. On Dec 19, 2009 this sequence version replaced NM_001159304.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK238864.1, GQ184633.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3179989, SAMEA3179990 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-59 BP161545.1 1-59 60-60 CU468520.2 108089-108089 61-1250 GQ184633.1 24-1213 1251-1265 CU468520.2 122959-122973 FEATURES Location/Qualifiers source 1..1265 /organism="Sus scrofa" /mol_type="mRNA" /db_xref="taxon:9823" /chromosome="14" /map="14" gene 1..1265 /gene="CDK1" /gene_synonym="CDC2" /note="cyclin dependent kinase 1" /db_xref="GeneID:100155762" misc_feature 111..113 /gene="CDK1" /gene_synonym="CDC2" /note="upstream in-frame stop codon" CDS 120..1013 /gene="CDK1" /gene_synonym="CDC2" /note="cell division cycle 2, G1 to S and G2 to M" /codon_start=1 /product="cyclin-dependent kinase 1" /protein_id="NP_001152776.1" /db_xref="GeneID:100155762" /translation="
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALNHPYFNDLDNQVKRM"
misc_feature 126..980 /gene="CDK1" /gene_synonym="CDC2" /note="Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; Region: STKc_CDK1_euk; cd07861" /db_xref="CDD:270845" misc_feature order(147..158,171..173,210..212,216..218,267..269, 309..311,357..368,375..377,381..386,501..503,507..509, 513..518,522..524,555..557,564..566,600..602,606..617, 621..623,735..740) /gene="CDK1" /gene_synonym="CDC2" /note="active site" /db_xref="CDD:270845" misc_feature order(147..158,171..173,210..212,216..218,309..311, 357..368,375..377,384..386,513..518,522..524,555..557) /gene="CDK1" /gene_synonym="CDC2" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270845" misc_feature order(228..230,243..251,255..257,264..269,273..278, 285..290,330..332,468..470,477..488,570..578,582..587, 597..602,936..938,948..956) /gene="CDK1" /gene_synonym="CDC2" /note="CDK/cyclin interface [polypeptide binding]; other site" /db_xref="CDD:270845" misc_feature order(267..269,381..383,501..503,507..509,564..566, 600..602,606..617,621..623,735..740) /gene="CDK1" /gene_synonym="CDC2" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270845" misc_feature 552..623 /gene="CDK1" /gene_synonym="CDC2" /note="activation loop (A-loop); other site" /db_xref="CDD:270845" ORIGIN
acttagcttttcaaagctggctctgggagcttaaggagagcgacgctgacgtggtagcccctgccgccgctttcgtcgcgggataataagctgggatctaccacatccactgagtaactatggaagactataccaagatagagaaaattggagaaggtacctatggagttgtgtataagggtagacacaaaactacaggtcaagtggtagccatgaagaaaatcaggctagaaagtgaagaggaaggtgttcctagtactgccattcgagaaatatctctattaaaagaacttcgccatccaaatatagtcagtcttcaagatgtgcttatgcaagactccaggttatatctcatctttgaattcctttctatggatctcaagaaatacttggattctatccctcctggtcagttcatggattcttcacttgttaagagttatttgtaccaaatcctgcaagggattgtgttttgtcactctcgaagagttttacacagagacttaaaacctcaaaatctattgattgatgataaaggaacaattaaactggcagattttggtcttgccagagcttttgggatacctattagagtatatacacatgaggtagtaacactctggtatagatctccagaagtattgctggggtcagctcgctactcaactccagttgatatttggagtataggtaccatatttgccgaactagcaactaagaaaccacttttccacggggattcagaaatcgatcaactcttcagaattttcagagctttgggcactcccaataatgaagtgtggccagaagtggagtctttacaggactataagaatacatttcccaagtggaaaccaggaagcctagcatcccacgtcaaaaacttggatgaaaatggcttggatctgctctcgaaaatgttagtctatgatcctgccaagcgaatttctggcaaaatggcactgaatcatccatattttaatgatttggacaatcaagttaagagaatgtagctttcccacacgttgtatcaagaacagatagttgtatttttactgttaactctgcttttgtcttgtgtatttttcttttctatgttgtaaaacttaagcttacttcatcttctgatttcaaagtgtaacttaaaaatgtaaatattgttctatatgaatttaaatataattctgtatatgtttgtagattccactgtaacaacctatttgttactacaataaaactatataaatctattgttgatgtcaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]