LOCUS       NM_205472               2375 bp    mRNA    linear   VRT 28-APR-2025
DEFINITION  Gallus gallus POU class 2 homeobox 1 (POU2F1), mRNA.
ACCESSION   NM_205472
VERSION     NM_205472.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Kisliouk,T., Cramer,T. and Meiri,N.
  TITLE     Methyl CpG level at distal part of heat-shock protein promoter
            HSP70 exhibits epigenetic memory for heat stress by modulating
            recruitment of POU2F1-associated nucleosome-remodeling deacetylase
            (NuRD) complex
  JOURNAL   J Neurochem 141 (3), 358-372 (2017)
   PUBMED   28278364
  REMARK    GeneRIF: These results suggest that methylation level of a distal
            part of the HSP70 promoter and POU2F1 recruitment may reflect
            heat-stress-related epigenetic memory
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Lopez-Bayghen,E., Cruz-Solis,I., Corona,M., Lopez-Colome,A.M. and
            Ortega,A.
  TITLE     Glutamate-induced octamer DNA binding and transcriptional control
            in cultured radial glia cells
  JOURNAL   J Neurochem 98 (3), 851-859 (2006)
   PUBMED   16787415
  REMARK    GeneRIF: A glutamate-dependent increase in Oct-1 DNA binding and
            transcriptional activity is detected in retinal Muller glial cells,
            but not in cerebellar Bergmann glial cells.
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Takechi,S., Adachi,M. and Nakayama,T.
  TITLE     Cloning and characterization of the chick Oct binding factor OBF-1
  JOURNAL   Biochim Biophys Acta 1577 (3), 466-470 (2002)
   PUBMED   12359338
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Petryniak,B., Staudt,L.M., Postema,C.E., McCormack,W.T. and
            Thompson,C.B.
  TITLE     Characterization of chicken octamer-binding proteins demonstrates
            that POU domain-containing homeobox transcription factors have been
            highly conserved during vertebrate evolution
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1099-1103 (1990)
   PUBMED   1967834
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M29972.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29972.1, SRR12888496.81386.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="1"
                     /map="1"
     gene            1..2375
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="POU class 2 homeobox 1"
                     /db_xref="CGNC:49816"
                     /db_xref="GeneID:396463"
     exon            1..64
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2226
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="octamer-binding protein (Oct-1); NF-A1; OTF-1;
                     octamer-binding protein 1; octamer-binding transcription
                     factor 1"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 1"
                     /protein_id="NP_990803.1"
                     /db_xref="CGNC:49816"
                     /db_xref="GeneID:396463"
                     /translation="

MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGPISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQLLAAAVQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQHLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLASQPATPTRTIAATPIQPLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSTLSSPSALNSPGQGIEGVNRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVNPVLPLTSPAVTSLSVTGTTETTSNNTATVISTAPPASSAVTSPSLSPSPSASASISEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPGLMASSQFAAGGALLSLNPGTLGGALSPALMSNSTLATIQALASSGSLPITSLDASGNLVFANAGGTPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGASGPVASLHATSTSAESIQNSLLTVASASGATSTTTTASKAQ"

     misc_feature    7..123
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P15143.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    205..291
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P15143.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    763..837
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P15143.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    826..1050
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1063..1140
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P15143.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1132..1302
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1342..2172
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="POU domain, class 2, transcription factor 1
                     C-terminal; Region: POU2F1_C; pfam19536"
                     /db_xref="CDD:437368"
     misc_feature    1471..1665
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P15143.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            65..165
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..219
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..339
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..519
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..637
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..732
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..906
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1048
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1194
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1374
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1480
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1826
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1915
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2375
                     /gene="POU2F1"
                     /gene_synonym="chOCT-1; Oct-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tcaagaatgaacaatccgtcagaaaccagtaaaccatcaatggagagtggagatgggaacacaggcacgcaaacaaatggcctggactttcaaaagcagcctgtgcctgttggaggaccaatctctacagcccaggcccaggcctttcttgggcaccttcatcaggttcagctcgctggaacaagtttacaggctgctgctcagtccttaaatgtacagtctaaatctaatgaagaatctggggactctcagcagccaagccagccttcccagcagccttcagtgcaggcggccataccccagacccagctcatgctggccggaggacagatcactgggctcacgttgacgccagcccagcaacagttattgctacaacaggcgcaggcacagttgctggcagctgcagtgcagcattcagccagtcagcagcacagcgctgctggtgccaccatctcggcctctgctgcaacgccgatgacgcagatccctctatctcagccaatacagattgcacagcacttgcagcagcttcagcagcagaatctcaacctgcaacagtttgtgttggtgcatccaacaaccaacttgcagccagcacagttcatcatctcacaaacaccgcaggggcagcagggtctcctgcaagcgcagaatctcttaacgcaactacctcagcaaagccaagccaacctcctgcagtctcagccaagcatcacccttgcctcgcagccagcaaccccaacacgcacaatagcagcgacccccattcagccacttccacagagccagtcaacaccaaagcgaatagacactcccagcttggaggagcccagtgaccttgaggagcttgagcagtttgccaagactttcaaacaaagacggatcaaacttggattcactcagggtgatgttgggctcgctatgggcaaactctatggaaatgacttcagccaaactaccatctctcgctttgaagccttgaacctcagctttaagaacatgtgcaagttaaagccacttctggaaaagtggctcaatgatgcagaaaacctctcatctgattcaactctctccagcccaagtgccctgaattctccagggcaaggaatcgaaggcgtgaaccgtaggaggaagaaacgcaccagcatagagaccaacatacgtgtggccttagagaagagtttcctggagaaccaaaagcctacctcggaggagatcaccatgatagctgaccagctaaacatggagaaggaggtgatccgcgtttggttctgtaaccggcgccagaaggagaaaaggatcaacccacccagcagtggtggaaccagcagctcgcccatcaaagcaattttcccttccccaacctcactggtggcaaccacgccaagccttgtgactagcagtgcagctactaccctgactgtcaatcctgtgctccctctgaccagccctgctgtaactagtttgtcagtcacaggcacaacagaaaccacctccaacaacacagcaacagtgatttcaacggcacctccagcttcttcagcagtgacatcaccctccctgagtccttccccttctgcctcagcctccatttcagaggcatccagtgccagcgagaccagcacaacacagacaacctccactcccttgtcctcccctcttgggaccagccaggtgatggtaacagcatcagggttgcaaacagcagcagcagccgcattacaaggagctgcacagttgcctgcaaatgcaagtcttgctgccatggctgctgcagcaggactaaacccaggcttgatggcatcctcacagtttgcagctggaggtgccttactcagtctcaatccagggacattaggtggtgctctcagcccagccctgatgagcaacagtacactggcaactattcaagctcttgcatctagtggctctcttccaataacatcactggatgcatctggaaacttggtgtttgccaatgctggaggtactcctaacatcgtaactgcccctctgttcctgaaccctcagaacctttctctgctcaccagcaacccggttagcttggtctctgcagctgcagcctccgcaggggcctctggaccagtcgccagccttcatgccacctccacctcagccgagtccatccagaactctctcctcacggtggcctctgcgagcggggccacgtccaccaccactactgcctccaaggcacagtgagctgggctgagctgtgctgccagcagcctttttcactgtgcagtgggattggctgccagtggggtttatgaactgaaaaatgtgatggtcatcctctcgccgtgttgctggggacaagggagagaaggagaaatattaaaaaaaaaaaa

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