LOCUS       NM_204595               2324 bp    mRNA    linear   VRT 08-APR-2024
DEFINITION  Gallus gallus homeobox A7 (HOXA7), mRNA.
ACCESSION   NM_204595 XM_444651
VERSION     NM_204595.3
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Starkova,J., Zamostna,B., Mejstrikova,E., Krejci,R., Drabkin,H.A.
            and Trka,J.
  TITLE     HOX gene expression in phenotypic and genotypic subgroups and low
            HOXA gene expression as an adverse prognostic factor in pediatric
            ALL
  JOURNAL   Pediatr Blood Cancer 55 (6), 1072-1082 (2010)
   PUBMED   20672366
  REMARK    GeneRIF: Low expression of HOXA7 RNA is associated with
            hyperdiploid leukemia.
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Chung,N., Jee,B.K., Chae,S.W., Jeon,Y.W., Lee,K.H. and Rha,H.K.
  TITLE     HOX gene analysis of endothelial cell differentiation in human bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Mol Biol Rep 36 (2), 227-235 (2009)
   PUBMED   17972163
  REMARK    GeneRIF: HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed
            during angiogenesis, sugessting these proteins might be involved in
            the angiogenesis of hMSCs.
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Gaunt,S.J., Cockley,A. and Drage,D.
  TITLE     Additional enhancer copies, with intact cdx binding sites,
            anteriorize Hoxa-7/lacZ expression in mouse embryos: evidence in
            keeping with an instructional cdx gradient
  JOURNAL   Int J Dev Biol 48 (7), 613-622 (2004)
   PUBMED   15470633
  REMARK    GeneRIF: during development, Hox expression boundaries become set
            along instructional cdx gradients, formed by cdx decay in cells
            moving away from the primitive streak region
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Gaunt,S.J.
  TITLE     Gradients and forward spreading of vertebrate Hox gene expression
            detected by using a Hox/lacZ transgene
  JOURNAL   Dev Dyn 221 (1), 26-36 (2001)
   PUBMED   11357191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000037.1.
            
            On Sep 23, 2021 this sequence version replaced NM_204595.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267647.18001.1,
                                           ERR2365562.110797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992323
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               JAENSK010000037.1  1567693-1568184     c
            493-2324            JAENSK010000037.1  1564748-1566579     c
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="2"
                     /map="2"
     gene            1..2324
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="homeobox A7"
                     /db_xref="CGNC:8400"
                     /db_xref="GeneID:395290"
     exon            1..492
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    81..83
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="upstream in-frame stop codon"
     CDS             117..776
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="homeodomain transcription factor HoxA-7; homeo box
                     A7"
                     /codon_start=1
                     /product="homeobox protein Hox-A7"
                     /protein_id="NP_989926.1"
                     /db_xref="CGNC:8400"
                     /db_xref="GeneID:395290"
                     /translation="

MSSSYYVNALFSKYTAGASLFQNAEPTSCSFASNSQRSGYGPGAGAFASSMPGLYNVNSTIYQSPFSSGYSLGSDAYNLHCSSFDQNIPVLCNDLTKPSCEKAEESNLHNQAEANFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKEESSSTPAPNEPTSAAASVEKVEEDEEEED"

     misc_feature    468..485
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90VZ9.1);
                     Region: Antp-type hexapeptide"
     misc_feature    504..674
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    672..773
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90VZ9.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            493..2324
                     /gene="HOXA7"
                     /gene_synonym="HOXA-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtccaaaagaaaatggggtttggtgtaaatctgggggtgtaatgttatcatatatcacgctacctcgtaaaaccgacactgaagcctgccggacaacaaatcacaggtcaaaattatgagctcttcgtattatgtgaatgcgctttttagcaaatatacggcgggggcttctcttttccaaaatgcggagcctacttcttgctcctttgcaagcaactcccagagaagcggctatggaccaggcgcgggtgccttcgcctcctccatgcccggcttgtacaatgtgaacagtaccatatatcaaagcccgttctcttccggatacagcctgggctctgatgcctacaacctgcattgttcctcttttgatcagaacattcccgtcctctgcaatgacctaaccaaacccagctgtgagaaagcggaggaaagcaacctgcacaaccaggctgaggctaatttccggatatacccctggatgaggtcttcaggtcccgataggaagcgagggcgccagacctacacccgctaccagaccctggagctggagaaggaattccacttcaatcgctatctgactcggcggcggcggatagagatcgcccatgccctctgcctgacggagcggcagatcaagatctggttccagaaccggcggatgaagtggaagaaggagcacaaggaggagagttccagcactccggctcccaacgagcccacgtcagcagcagcgtctgtggagaaagtggaagaagatgaggaagaggaggactagggagtcccagtcgaggaagcaatctcttagaataacgtatgcacgtgacagctgtaaaagctccctttaaagagagaaagaaagaaaaaaaaaagagagagagagacactcactgtttttattaaaaaaaaaaaaaatagtaatcagttccctttagttctgcctcgcaagcgggcgtttgcaaacatgaaaacgtctcttgggttggacttccagccctctctcccctctcccgtcctccccaaacctgccccgtggtagcgtatcctgagggcatcctacaatcatttgagttttcgttcgcccgctctcgggtgggtttctcctggggacgtttcggtgggaggactgctgcttgcacataaagtacaccgtgaccttccgaagtaactacctgactcaatagtcccaatcgcgttgtaaggggaaaagtgcattaggctcgcattaagaaaaaaaaaaactacctaattttgaagaagtagctctgcacttttctttttttctttttcctttatcttttaattattgttagcaaagtaccgtaactaacagctacactaacaaaaggtaacacagcaagcgaaggggggggggggaagatgtgccacaaaccactacaatccacagcaatgagtcgtactacctatttttcagactacctatatatcttgctccgcctacctatcttcgaaagtatgctgtattttagtagtcagaagaagataacgtactaatgtgaattgcaaaatgcttttagacacgtaagcgcagtcgttcgaaaagcacgcatccgtagctttggtatagaatttggtaccgtaaaggctgaatatatttaaaatgaaaataatatatttattccaaagcaattattaatgaaaaccatatgctgcaatatatctctgtccgcgaacctttactctccggagtgagggagcggacgcacacgccaatattgtataaagcggtttaatatctaccgtgggcttctaccttaggctgcctccgctcaaggccgtttccttatcctgggttgatcttactcaatatagctgaaagtgttcttggcaaagcgaatttaaacgaccatgtaaccgcctttcaaatatctgttcgtcctgacgatcccaacgtgttaatacgtaataccgtgaattttcctaagatagcagatattgtatatttgaacgattttttttttttctctttgtcatttatatttgtctcggagctcatttgtaagaccacgtcataaattgggaagtatgtaattaattgggaaactttgtcgcatgacgtatcgttcagatctctgtataaatccgtctcgaaggtttggctaaagtttattcaaacaactgtatgttacgatgtgtttcgatgtgttcgttgtgaacatttggatatgccgtgtaagtattggaagtggagaaaaaaaagaaaatgtctgtgaactctctttggaagtgatcccgtgttcaagtatcccccacgataaatgtgttctatgtcacacggaaaataaagatgcttgttgacaattaa

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