LOCUS       NM_001031539            6405 bp    mRNA    linear   VRT 04-FEB-2024
DEFINITION  Gallus gallus ELOVL fatty acid elongase 6 (ELOVL6), mRNA.
ACCESSION   NM_001031539 XM_426328
VERSION     NM_001031539.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 6405)
  AUTHORS   Zhang,D.D., Wang,D.D., Wang,Z., Wang,Y.B., Li,G.X., Sun,G.R.,
            Tian,Y.D., Han,R.L., Li,Z.J., Jiang,R.R., Liu,X.J., Kang,X.T. and
            Li,H.
  TITLE     Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting
            ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver
  JOURNAL   Int J Mol Sci 21 (5), 1624 (2020)
   PUBMED   32120850
  REMARK    GeneRIF: Estrogen Abolishes the Repression Role of gga-miR-221-5p
            Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken
            Liver.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6405)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   3  (bases 1 to 6405)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6405)
  AUTHORS   Caldwell,R.B., Kierzek,A.M., Arakawa,H., Bezzubov,Y., Zaim,J.,
            Fiedler,P., Kutter,S., Blagodatski,A., Kostovska,D., Koter,M.,
            Plachy,J., Carninci,P., Hayashizaki,Y. and Buerstedde,J.M.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000074.1.
            
            On Nov 5, 2021 this sequence version replaced NM_001031539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ720366.1, SRR13267649.176987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA103992323
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAENSK010000074.1  10474663-10474899
            238-369             JAENSK010000074.1  10518516-10518647
            370-521             JAENSK010000074.1  10535715-10535866
            522-6405            JAENSK010000074.1  10538630-10544513
FEATURES             Location/Qualifiers
     source          1..6405
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="4"
                     /map="4"
     gene            1..6405
                     /gene="ELOVL6"
                     /note="ELOVL fatty acid elongase 6"
                     /db_xref="CGNC:53457"
                     /db_xref="GeneID:428772"
     exon            1..237
                     /gene="ELOVL6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    35..37
                     /gene="ELOVL6"
                     /note="upstream in-frame stop codon"
     CDS             149..946
                     /gene="ELOVL6"
                     /EC_number="2.3.1.199"
                     /note="elongation of very long chain fatty acids protein
                     6; elongation of very long chain fatty acids family member
                     protein 6; 3-keto acyl-CoA synthase ELOVL6; ELOVL family
                     member 6, elongation of long chain fatty acids (FEN1/Elo2,
                     SUR4/Elo3-like, yeast); ELOVL FA elongase 6; very long
                     chain 3-oxoacyl-CoA synthase 6; very long chain
                     3-ketoacyl-CoA synthase 6"
                     /codon_start=1
                     /product="very long chain fatty acid elongase 6"
                     /protein_id="NP_001026710.1"
                     /db_xref="CGNC:53457"
                     /db_xref="GeneID:428772"
                     /translation="

MNMSVLTLQEYEFEKQFNEHEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLSLAVFSIFGAVRTAPYMLYILMTKGLKQSVCDQSFYIGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLVGCVINYLVFSWMQHGQCHSHVQNIIWSSLMYLSYFVLFCHFFFEAYIGKTTKARKVD"

     misc_feature    152..154
                     /gene="ELOVL6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03206; propagated from
                     UniProtKB/Swiss-Prot (Q5ZJR8.1); glycosylation site"
     misc_feature    221..931
                     /gene="ELOVL6"
                     /note="GNS1/SUR4 family; Region: ELO; pfam01151"
                     /db_xref="CDD:460083"
     misc_feature    248..301
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    356..418
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    479..541
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    557..616
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    623..685
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    737..799
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     misc_feature    842..904
                     /gene="ELOVL6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5ZJR8.1);
                     transmembrane region"
     exon            238..369
                     /gene="ELOVL6"
                     /inference="alignment:Splign:2.1.0"
     exon            370..521
                     /gene="ELOVL6"
                     /inference="alignment:Splign:2.1.0"
     exon            522..6405
                     /gene="ELOVL6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggaggagaggcgcggaggggagcggagctatgctaaacctggggtaccgctgaggcggggcagccaggccggaggcgggagctctccggctcccgaggcggcaggcggcatttcggcgcggggagcggctccgcagccaccgggccaatgaacatgtccgtgttgactttgcaggaatacgaattcgagaagcagttcaacgagcatgaggccatccagtggatgcaggagaactggaagaaatcttttctattttcagcactgtacgctgccttcatatttggtggtcggcacctaatgaataaacgagcaaaatttgaactgaggaaaccactagtgctctggtccctgagccttgctgtcttcagtatattcggtgctgttcgaactgctccttacatgctgtacattttgatgaccaaaggcctgaagcagtcagtgtgtgaccagagtttttacattggacctgtcagcaaattctgggcatatgcatttgtgctaagcaaagcacctgaactaggagatacaatattcattattcttaggaaacagaagctcatcttcttacactggtaccaccacattactgtgttactttattcttggtattcctacaaggacatggtggctggcggtggctggtttatgaccatgaactatggagtgcacgccgttatgtactcttactatgccttgcgggctgctggcttcagagtctcacgcaagtttgccatgttcatcaccttgtcgcagatcacccagatgttggtcggctgtgtaatcaactatctggtcttctcctggatgcagcatggccagtgccattcccacgtgcagaatatcatctggtcctctctcatgtacctcagctactttgtgctcttctgccattttttctttgaggcctatatcggcaaaaccacaaaagcaaggaaggttgactagtggtaagaatgagacagaagccatagctcagggtcatcaagaaaaacaaaactacaagaaaagaaaatggcacaaggaaacacatatatgtatggtgcagctaaaacttggcagcttagggaaagttagcttggtttaacccagtaagtttatgatcctatcatggtgaggactcactgaaatctactctaactcaaaggactgctgacaaaagactccttccttcttgtacctgcctgctccagaaaagaaaggagaaaaggagaaacagaaaaaaagtgagaagaaaagagaagaaaagcagaaaggaataatattgagaggaaaaaatatagtacattaaataaactgtgtttccctgggatggaaaaaaaatttattgtgaaaaaaagtttctaaattctttctaatagtttttcagcattaaagttgaacaagacattgacattaatggtaggattgtgaaattaaaatcttttctgtaaaaggtttataccttcagccagaatgaaatccaagaggatgtcacgtacacctatgcggaaagcggttgaactccattgtggtcatgaatggcagcaagaagagattgagtgctctgttctgtcctgtgccaagggagtagagctgggaggcaggcacctctctggagtgcaggaaggagcaggacttgtacaagagcctaacatgaaaacaagtgctgttgcaatacatatctcagcaagtgcattttccaagtgcgcttttcagctaaaggcaaggagtttctgcagcaggataagacatagagggttaaatcaactgatatttgctaaattaccaggggctaatagcagatgaatgttcaggaaggagagggaggcaactactgaaacgtgatttttaagaattatccattaatctcaaattaacccacagcaacacggaatggaatgaggggaaatgagaagccactcttgccagcgagcggcccctcttcccattgattcccaagccgtgcgtcaggtggacctgggaggcaaggcaaggggaagaggcgcaggaccaggcagcgctgggtggctctgtgcctctgcacgcacctgccaggctgggcgaagatgtgccaagagccctcccctggtcacatggagatactactgcaaaacatgcccggaataagattttcttggcatcggtataggaaatcagtctgagcggagtgattttgctgcaatggcttagctctaatgtccagagagaattgttcttcattaaacgtgtatctctctctctgcagagtctgtactgtaacatcagactgaccactaaagaagacgctcttcttctccacagtcggctacagaaataaggagaaacgtatttcactctgaaccttagagagctagttgataacagccatattctctcaaagacggatagattgcattatctgtgatattccagtccttacaaagccaaataaaatgtgtaaaagttcctagtatttcaaagacgcaagtatgtaaacttgatgttaaatgtgttaatgtagtactctaaattgtatcagttaggtagcttaactaaacaattagaagaactagatcaacaaaataggggctgctgttctgcgtagaatacacacacctataactacacccatatacacgttctgtgaattgtcagcaagaaaaaagcccagcggcagagaatcacatttcctggctaacgcaaaagattgtcattatctttcttgttttaatttgagattgtacagtgcaaagggtttggttttttttttaattacgatttttagctttaattgtgctgtcattcatgaaacagagctgctttagtatcctgttaagagatgacaagggcttttggtgtctcattatatacaaaagaaaaacaaataaagttacattccatgttatgtgaatggtcttacaaatcaaaaagcctccgtaggccgaaatcataattataacaagcagaaaagatgtttacatttgtgttatttaagttattgatgtgctgacgttattttatggtacacaacaaacagcaaaatgtgatatccagtaatgaagctatgatattcattaataggactactgtatacatggaaacaataggcaaaaccaattaaatgtgtaaaccatcttgttttacagcttgggagtagataactgtaatgctgagtaagcctttatcctcacgcttaattttgccctggctaagaaccaggttatgaagactgagtaacagggaaaacccaaatttcaagttccctaccccgcagatgggaagtgttggtagaagccccatcgtgccacgcaaggagctgcacgcaacccctggtagctggaagattgcaggtaaaggctaaaaagcccaagaagctttacaagtaggaagtgatactgcagctaggtgaagacctgtggcccaagttttacacagacagaaaacagagcgggttgctaacaagtgtgcaaacaacccactgtgttttgtacactgtgttccttaattgcatgaggggaaaaaaaaaaaaaagaaagaaaaaaaagcattgtgtgtgtgccagatggagatgctggcaatgccaacactgagttgagcagagcaggcattttacccgttccctgaaagtcctcacaggtgctgtttgctcccaacctgcctgcatccctgtgagcactcacgttagacctggaggtgtccccacacatcccaaggatcaggttcctcctctgctgcctggtcagtagctccagagcaagggctgacctacaggcctcctccagatgcagtataggtgtgccccacgtgtgcagggaaaagtgggggcgtccagtgggaggataggtttgcgggcgagtatgtgtatagggaagggacagcaagatcagacacgtaaggaacaaatgaggatacctctgccatcagaagttggaactgccatgtcacagaggcatttctacaggtcctatggccatagggcttctcctctgagatttttcactggaggcaagtgtggcaactaacattaaagaagttgaggataagaccaaagtcaacatacgctgtttttcttttttggttgttttgttttgtttttccctttaaaaagtgcatacttgatagttagacatcacttttaacccatacacctaaacagcaaggcagtcatccctaagctaatgacacctctaatattctagctgttccaacccaaacacagctaattgggtcctacttatttcccctgatttaagccttggggccacacttgcacactattctgtcactaccagaaccctttttttttggcaataacttttaagtaaagttgcagttctgccatattcacacataccttgggggactccagcttgcagagtgcgccaaacattatgggactgtgacagtgaccacaatgctgtcaggggattcactgctgaagtcaggcaagttacactgatgataaggtcagtctgccagggccgaggtctgtgcttgatgtctgacacatttatccagtgtactgaaataaaaacagtagggttgtgcaggtttacctgtaagcaaccgtgagcaggatttggtaggaaaacatcaagaagccggctaagagcaaagttccttcaagctatgcctgtgaggagaaggaaagccctcatgctgacaagccttctgtaagtcagtcacagatgatgtgcatctcagctcactggtaacatgtaagtggctgcttcccaaagacatctttcagcacaatttcaaaggaaactaataaaagcattatcttaccataagggtttaagcatgcgaaaggaatcagtcaaagaggtccagctgaacagcagggataaataaagcctgttttgtaggggagcacaaactgcaggcgaggtggcagcggagaccagtcggtgccttggtagggaggaagcttcgaggacagggctgaaccactgctggactgactcgtgcccagtggcctgcttgccatgagggtgggccgtgatggaaggaggctgcagccaaagacctgcggtctgctggtctgtgctttaacagccggcccactgctgggcacgtcgtttctttatcctagaaagaaaaacgtaggagaatggattaactgagagcaacgacacctaggggatcaatatcaggttttcaggtaacagccagtgaaaggcgccaattaccgtggccatgacacagcagcctttgtaagcatgtgccataacgtctccagtatttgcattctgtctctgtacttcagaaccagaaaaagagctattgatacacaagccgtaaatgcagaaccacttttaagtaacaaaagtggcactggttgaggaagaaagctcagcagagtgcggtttgtgccacataagctcagcacacggctgaatacctgcagaaaatgagattgctagtcaggtgcctggagatgtgcaccagctttgcttcagtcgattgcagtgtggttggttcagagggcagtgacacaaactgccaaggccctggcgttagtcctcagtcctatttcccagccccacctcaatgagccttctaaaagagaagaaatacagctcagcactctcagcgtgtttctactcttttatttcaatacattttcatggaatcccacagaatggcaggggttggaagggacctctagcgaccgttgagtccaacccccctgataaagcaggtaaaatatagcagaggatggttgcccatcccatttattttattaaaaaacaagctacaagatgagtccctgatcctgctattacaaatgctccattgtggtcagtgtacacgggcacagaaaccctttgcttacaggggcaaggacaggatcagtgccttgttaaagacttactctctagcagagcaacaaccacacacagactagaattaatttgatttcttaaacacatataaggtgagatctgcacaagagccctacaccgaagggagaccagggacctcccagtgcaccataaagctcaataaaatgctgcatggagtggggtcagagggtatttcccaatgggtatgaaatgatattcccctgaaatagtgaccttcctgagaagtctcacgtctgtccggccctggacagcttcagacagggctgactgctggaaaaacacagctctgattgacttatctgctttctctaaagagccactacatgctttaggctttgaggagccttaaagctcgagctagatttctattcagaaaaaagaaaaaaaaagaaaaaaaaaacaagggaaaataatacatgtacaatagctacgagagaatagtatgagaaatacctttattttaccattttcaaatggctatttcactacataaaaggaagtttttatttttattttttttttcttttggtatattgatattccaaataaaattttaacttttggttcaaaagaaaa

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