LOCUS       XM_005158556            3712 bp    mRNA    linear   VRT 12-MAY-2025
DEFINITION  PREDICTED: Danio rerio NRDE-2, necessary for RNA interference,
            domain containing (nrde2), mRNA.
ACCESSION   XM_005158556
VERSION     XM_005158556.6
DBLINK      BioProject: PRJNA1248012
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133192) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 12, 2025 this sequence version replaced XM_005158556.5.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_049306965.1-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/11/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3712
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /isolation_source="Zebrafish international resource
                     center"
                     /db_xref="taxon:7955"
                     /chromosome="17"
                     /sex="male"
                     /tissue_type="Fibroblasts and whole tissue"
                     /dev_stage="adult"
                     /ecotype="United States"
                     /geo_loc_name="USA"
                     /collection_date="2022-07-19"
                     /collected_by="National Human Genome Research Institute"
                     /genotype="Double heterozygous"
     gene            1..3712
                     /gene="nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 ESTs, 4045 long SRA reads, 1
                     Protein"
                     /db_xref="GeneID:794348"
                     /db_xref="ZFIN:ZDB-GENE-111117-3"
     misc_feature    1
                     /gene="nrde2"
                     /experiment="COORDINATES: cap analysis [ECO:0007248]"
                     /note="transcription start site"
     CDS             71..3538
                     /gene="nrde2"
                     /codon_start=1
                     /product="nuclear exosome regulator NRDE2"
                     /protein_id="XP_005158613.2"
                     /db_xref="GeneID:794348"
                     /db_xref="ZFIN:ZDB-GENE-111117-3"
                     /translation="

MALFPSFSGLSGSNSSAESKAPADLEWLSNQSFSTEDALKTHQRATDRARAETEEPAGTSEEKHKERGDNHGKSKKRKKEKKKKHKKKRSRDNSESSGSESDTIYPSDLLKKENTDREEAQVRVSETFMWLDDLQTPTDSPFCIDRRADRANWQYKSLYRGDIARYKRKGGSCLGLDLRTQAVTWIDGGPEKKRVDKKAERYFSSSTRQLLQTRGLLALPILSEGSATNSDPYIKLAVCAEEQGSSTQTPESWVNPLGIYDPGTTLWLEGKGQPEVKGEQQSTEAQESNSTLLSARVEEFNRNLRENPTDIKLWLDFVHFQDELAFGSGSFSSAGDCDAEMRKMSLRAVLEKKLSIMDRAVESNPSDVDLKLEKLRLCKELWEPAVLQKEWKKLVFIHPNSAPLWKKYLLFTQSHFSTFSVSKVNGVFGKCLSTLSAVQDGSMVSHPPLPGTQEDLLDIFLQQCHFLRQAGHTEKAVCLFQALLDFTFFKPDNVKNLATRQQVDFFEPFWDSGEPRIGERGARGWKAWMLQQEKGGWVIPPEPDDDEEEEQEDSEIKDKTWPKWKIWLDVEASREANQWLPWRPDKTKGQSEEDCEDPDRQVLFDDIGPSMIRVDRADLQAQLILAFLQFLGLPGALTKFFTASSSSFLLDDLTFLEEGPDPERPLTSYDLPVTGIRAVGHMTCLSGCRRQAGLCKAGEEFLHNVLHQTLRLVPAQDQAAITLCWLQYEKLKVLRCLRSGNKRQMKSQGKRSKRLAKRLLKEPENRGSLALWREYAHLEWLLGNLEEARKVFDTALSMGVSRGLNDHVLCKLCFLYAQLEVEQALSSETVSTFPKAVYILTKLAEGASYTPFSGQINPVVILKARKAYEQALLSILPEQNTDSNARASKKHNRTSSLIGCFGLFQYLTMGIDAAQAVYSQAIQKLIPSHFNSEAADGSRRRSTIFADCEAVAVQHVALLRHHTNTNVFPLSRLRLALTDALSLLPSSASLWHLYLQTENHYHSAGRTRRFFHSMAKKTDSVVPYLFAITAEQRLKQLLDSVQRSRLPGEALPTLPVNGLSNRIRCLFESATGAEHGAHCPLLWRMYLNFMVCDGNADRGSGIFYKALQEVPWVKGLYMDAVQLFPERVQEFLDLMTEKELRLRMPMEEVDILLEE"

     polyA_site      3712
                     /gene="nrde2"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

atgctttcctgtcaggtcgcaggtagatgacgtcattatcccgcgtctgttttgatgtattagaagcagcatggctctgttcccgtccttctctggactgtcaggcagcaacagctctgcagaaagtaaagctccagcggatctggaatggctgagtaatcagagcttcagcactgaagatgctttgaagactcaccagcgagccacagacagagcccgagcagagacagaggaaccagcaggcacaagtgaggagaagcataaagagagaggagacaaccatggaaaatcgaagaagagaaagaaagaaaaaaagaaaaaacacaaaaagaagaggagcagagataactctgaaagtagtgggtccgaatcagacaccatatatcccagtgaccttctaaaaaaggagaacactgacagagaggaagctcaagttcgggtgagcgagacctttatgtggctggatgacctccagacccccactgactcccccttctgcatcgacaggagagctgaccgtgccaactggcaatacaaatccctttataggggagacatagccaggtataagagaaagggaggctcttgtctggggttggacttaagaacgcaagctgtgacctggattgatggaggaccagagaagaagcgagtggacaagaaagcagaacgctatttctcttcttccacccgtcagctgcttcaaacaaggggtctgctagctttgcctatactctctgaaggcagcgccaccaactctgatccctatataaaacttgcagtctgtgctgaagaacagggctcttctacccagacacctgaatcatgggtcaatccgctgggcatttatgatcctggaaccaccttgtggctggagggcaagggccagccggaggtcaagggagaacaacagagcactgaggcccaagagagcaacagcactcttctgagcgctcgagtggaggagtttaacaggaacctacgggagaatcctacagacatcaagctgtggctggactttgtacactttcaagatgagctggccttcggttctgggtctttctcttctgccggtgactgtgatgcagaaatgaggaagatgtctctacgtgctgtgctggagaagaagctctccatcatggacagagcagtggaaagtaacccttctgacgttgacctgaaattagagaaactccgtctgtgcaaggagttatgggagcctgccgtcctgcagaaagagtggaagaaactagtgttcattcatccaaatagcgcacctttatggaagaagtatctgctcttcacacagagccatttcagcaccttctcagtgtctaaggtcaatggagttttcggcaagtgtctgagcacgcttagtgcagtccaggatggcagcatggtgtctcaccctccacttccaggcacacaggaagacctcttggatatctttctgcagcagtgccatttcctgcgccaggcaggtcatacagagaaagctgtttgcctttttcaagccctactggacttcactttcttcaagccagacaatgtaaagaatctggccaccagacaacaggtggatttttttgagccgttttgggacagtggagagcccaggattggggagcggggggctcgcggatggaaggcttggatgcttcaacaggagaaaggaggatgggtgattccacctgagccagatgatgacgaagaggaagagcaggaggattctgagatcaaagacaaaacttggcccaagtggaagatctggttagatgtggaggcgtcccgagaggcaaaccaatggctgccatggagaccagataaaaccaagggccaatcagaagaggactgcgaggacccggacagacaggtcttatttgatgatattggcccatccatgattcgtgttgacagagcagatctccaggcgcagctaattctggcattcctgcagttcctcggtctccccggagctctaaccaagttctttacagcatcttcttctagctttctgctggacgatctcaccttccttgaagagggccctgatccggagcgaccactgacctcttatgacctcccagtgactgggatccgtgctgtgggtcacatgacatgtcttagtggatgcaggaggcaagcagggctatgtaaagctggagaggagtttcttcacaatgttttgcatcaaactctccgactagtccctgcacaggatcaagctgctattactctgtgctggctgcagtacgagaaactcaaggtgctgaggtgtttacgaagtggaaataaaagacaaatgaagtctcaggggaagcgcagtaaacgtcttgcaaaaaggctgctaaaggagccagagaacaggggcagtctggcactttggagagaatatgcccatctggagtggcttctaggaaatctggaagaggctcgaaaagtttttgacactgctttgagtatgggtgtttctaggggtcttaatgaccatgttctctgcaagctctgctttctttacgcccagctagaggtagaacaggctttaagcagtgaaacagtttctacattccccaaagctgtctacattctgactaaattagcagaaggtgcttcctacactcctttctctggccagatcaacccagtggtcatattgaaggccagaaaggcctatgagcaggccctgttgagtattttacccgaacagaacacagacagcaatgctagagcttcaaagaaacacaataggacgtccagtctaattggatgttttggactttttcagtacctaacaatggggatcgatgcagcacaagctgtgtacagtcaggccatccaaaaactcattcccagccatttcaattcagaagcagcagatggatctcggagaagatccacgatctttgcggactgtgaggctgttgctgtccagcatgtagcactgctgcgccatcacactaacactaatgtgttccccctatcccgactgagactggcacttacagatgcgctctccttactgccctccagtgcctcattatggcatctctacctgcaaacagagaaccactaccacagcgcaggccgaactcgcaggttctttcacagcatggcaaagaaaactgacagtgttgtgccgtatctcttcgccatcactgcagaacaacgtcttaaacagttgctggactctgtgcaaaggtctcgtcttcctggtgaagctcttcccaccctgccagtgaatggtcttagcaatcgtatccgttgtctgtttgaaagcgctacaggagcagagcatggagcccactgtcctctgctgtggagaatgtatctgaacttcatggtgtgtgatgggaatgcagacagaggcagtggaatcttttacaaggctttacaggaagtcccctgggtaaagggcttgtacatggatgcagtgcagctgtttcctgaacgtgtgcaggagtttttagacctcatgactgagaaggagttgcgtctgagaatgcccatggaggaggtggacatcctgctggaggagtagccatcaaacccttcccgtaatacaccagaatcaacaaccgctgttcattagccaacagaaacagaatctctctcaacaaacagtaaaaaaataattaattacagattttatttatttttatccatttctaaatgtatttttcgtaattttgagattaaataatgtttcatttaa

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