LOCUS       NM_201196               1639 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio shox homeobox 2 (shox2), mRNA.
ACCESSION   NM_201196
VERSION     NM_201196.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Laureano,A.S., Flaherty,K., Hinman,A.M., Jadali,A., Nakamura,T.,
            Higashijima,S.I., Sabaawy,H.E. and Kwan,K.Y.
  TITLE     shox2 is required for vestibular statoacoustic neuron development
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36594417
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Mukaigasa,K., Sakuma,C. and Yaginuma,H.
  TITLE     The developmental hourglass model is applicable to the spinal cord
            based on single-cell transcriptomes and non-conserved
            cis-regulatory elements
  JOURNAL   Dev Growth Differ 63 (7), 372-391 (2021)
   PUBMED   34473348
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Hoffmann,S., Roeth,R., Diebold,S., Gogel,J., Hassel,D., Just,S. and
            Rappold,G.A.
  TITLE     Identification and Tissue-Specific Characterization of Novel
            SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members
            Among Other Genes
  JOURNAL   Front Genet 12, 688808 (2021)
   PUBMED   34122528
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
  REMARK    GeneRIF: Network-driven discovery yields new insight into
            Shox2-dependent cardiac rhythm control.
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Koopman,C.D., De Angelis,J., Iyer,S.P., Verkerk,A.O., Da Silva,J.,
            Berecki,G., Jeanes,A., Baillie,G.J., Paterson,S., Uribe,V.,
            Ehrlich,O.V., Robinson,S.D., Garric,L., Petrou,S., Simons,C.,
            Vetter,I., Hogan,B.M., de Boer,T.P., Bakkers,J. and Smith,K.A.
  TITLE     The zebrafish grime mutant uncovers an evolutionarily conserved
            role for Tmem161b in the control of cardiac rhythm
  JOURNAL   Proc Natl Acad Sci U S A 118 (9) (2021)
   PUBMED   33597309
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Marquart,G.D., Tabor,K.M., Brown,M., Strykowski,J.L.,
            Varshney,G.K., LaFave,M.C., Mueller,T., Burgess,S.M.,
            Higashijima,S. and Burgess,H.A.
  TITLE     A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines
            for Functional Neuroanatomy Studies
  JOURNAL   Front Neural Circuits 9, 78 (2015)
   PUBMED   26635538
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1639)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1639)
  AUTHORS   Sawada,R., Kamei,H., Hakuno,F., Takahashi,S. and Shimizu,T.
  TITLE     In vivo loss of function study reveals the short stature
            homeobox-containing (shox) gene plays indispensable roles in early
            embryonic growth and bone formation in zebrafish
  JOURNAL   Dev Dyn 244 (2), 146-156 (2015)
   PUBMED   25483930
REFERENCE   9  (bases 1 to 1639)
  AUTHORS   Hoffmann,S., Berger,I.M., Glaser,A., Bacon,C., Li,L., Gretz,N.,
            Steinbeisser,H., Rottbauer,W., Just,S. and Rappold,G.
  TITLE     Islet1 is a direct transcriptional target of the homeodomain
            transcription factor Shox2 and rescues the Shox2-mediated
            bradycardia
  JOURNAL   Basic Res Cardiol 108 (2), 339 (2013)
   PUBMED   23455426
REFERENCE   10 (bases 1 to 1639)
  AUTHORS   Blaschke,R.J., Hahurij,N.D., Kuijper,S., Just,S., Wisse,L.J.,
            Deissler,K., Maxelon,T., Anastassiadis,K., Spitzer,J., Hardt,S.E.,
            Scholer,H., Feitsma,H., Rottbauer,W., Blum,M., Meijlink,F.,
            Rappold,G. and Gittenberger-de Groot,A.C.
  TITLE     Targeted mutation reveals essential functions of the homeodomain
            transcription factor Shox2 in sinoatrial and pacemaking development
  JOURNAL   Circulation 115 (14), 1830-1838 (2007)
   PUBMED   17372176
  REMARK    GeneRIF: Shox2 deficiency interferes with pacemaking function in
            zebrafish embryos. Shox2 has a critical function in the recruitment
            of sinus venosus myocardium comprising the sinoatrial nodal region.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC056324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056324.1, CA477296.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505371,
                                           SAMEA3505384 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1639
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /note="shox homeobox 2"
                     /db_xref="GeneID:394171"
                     /db_xref="ZFIN:ZDB-GENE-040426-1457"
     exon            1..427
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    118..120
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /note="upstream in-frame stop codon"
     CDS             178..1077
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /note="short stature homeobox 2"
                     /codon_start=1
                     /product="short stature homeobox protein 2"
                     /protein_id="NP_957490.1"
                     /db_xref="GeneID:394171"
                     /db_xref="ZFIN:ZDB-GENE-040426-1457"
                     /translation="

MEELTAFVSKSFDQKVKEKKEVITYREVLETGSVRNRESLSADPNREEISSITRSGVRSSPVREADMLASERSRDSSSPKLTDGNTDMKERKEDCKPLEDETQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVPPFSFQVQAQLQLDSAVAHAHHHLHSHLAAHAPYMMFPAPPFGLPLATLAAESASAASVVAAAAAAKTTNKNSSIADLRLKAKKHAAALGL"

     misc_feature    502..672
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1009..1062
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     exon            428..636
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /inference="alignment:Splign:2.1.0"
     exon            637..694
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /inference="alignment:Splign:2.1.0"
     exon            695..783
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1597
                     /gene="shox2"
                     /gene_synonym="zgc:65884; zgc:77344"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcaacaagaggaattgtcaaagatctcatcatcacaccatcatctcgcatttaggccgatagaaagagagagagcgcgcgcgctgttcccgttcttatggtagtctgctaaggatctaaaaggaagattgtgtggggctttttttttcttcttcttcgttcttcttgggtgcagtgatggaagaacttacagcgtttgtctctaaatcttttgatcagaaagtgaaggagaagaaggaagtgatcacgtaccgggaggtgttggaaaccggttcggtgaggaaccgggagagtctgtcggcggatccaaaccgcgaggaaatcagcagcatcacgcggagcggagtgcgctcatcgccggtcagggaagcggacatgctcgcgtcagagagaagcagagactcgagcagtcctaaacttacagacggtaatacagatatgaaggaacgcaaagaggattgtaagccgctggaggatgagacacagactaaaatcaagcagagaaggagtcggactaactttacccttgagcagctcaatgagctggagagactgttcgatgaaacgcactatccggacgccttcatgagagaggagctgagccagagactcgggctgtcggaggccagggtgcaggtttggtttcagaaccgaagggctaaatgcagaaagcaggaaaatcagttgcataaaggggttctcatcggagcggcgagccagtttgaagcatgtcgcgtggctccatatgtcaacgtgggagctctgcgcatgccctttcagcaggatagtcattgcaacgtgccgcccttctcctttcaggtgcaggcgcagctgcagctggacagcgccgtggctcacgcgcatcatcacctgcactcgcacctggctgcgcatgcgccgtacatgatgtttcccgcgccgccgttcgggttgcccctggcgacgctcgcagcggaatccgcgtcggcggcgtcggtggtggcggcagccgccgccgcgaaaaccaccaacaaaaactccagcatcgcggatctgagactgaaggcgaaaaagcacgccgcggctctgggactgtgacgtcacattgcattgaacgacggcatatcgacgttaaccacagacaataaacgcaaattttcgtatgaaggacacgcaagaaggagaggctatttataaagacaaactgtgaaatggagaaacatttcgtggatcttcacaaggatggaaacaactgcaagatgcagaactatacgagaaaataaagctgaacttaaagcgaacagaactttttttttgtgcagaacacgagaggtttgaatccgaaaataatgatataaagcagctgggacagttgtgtgacaacgcggacatttctgctttaacacgttattagtaattaatgaaaataaagaggctggcctcgtttatttgaaacaaagtttctttgtggatatttgtgaaatattacagaaataccttttgttgccaaatcatgaaaactccagtgttaaaaaccccccatttccgtcctcacggatgacacacactttacatgctctctggtttatgaaactaaataaatgagcattaaatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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