LOCUS       NM_200050               2818 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio paired related homeobox 1b (prrx1b), mRNA.
ACCESSION   NM_200050
VERSION     NM_200050.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Okeke,C., Paulding,D., Riedel,A., Paudel,S., Phelan,C., Teng,C.S.
            and Barske,L.
  TITLE     Control of cranial ectomesenchyme fate by Nr2f nuclear receptors
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36367707
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   de Bakker,D.E.M., Bouwman,M., Dronkers,E., Simoes,F.C., Riley,P.R.,
            Goumans,M.J., Smits,A.M. and Bakkers,J.
  TITLE     Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte
            proliferation during zebrafish heart regeneration
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34486669
  REMARK    GeneRIF: Prrx1b restricts fibrosis and promotes Nrg1-dependent
            cardiomyocyte proliferation during zebrafish heart regeneration.
REFERENCE   3  (bases 1 to 2818)
  AUTHORS   Howard,A.G. 4th, Baker,P.A., Ibarra-Garcia-Padilla,R., Moore,J.A.,
            Rivas,L.J., Tallman,J.J., Singleton,E.W., Westheimer,J.L.,
            Corteguera,J.A. and Uribe,R.A.
  TITLE     An atlas of neural crest lineages along the posterior developing
            zebrafish at single-cell resolution
  JOURNAL   Elife 10, e60005 (2021)
   PUBMED   33591267
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2818)
  AUTHORS   Tessadori,F., de Bakker,D.E.M., Barske,L., Nelson,N., Algra,H.A.,
            Willekers,S., Nichols,J.T., Crump,J.G. and Bakkers,J.
  TITLE     Zebrafish prrx1a mutants have normal hearts
  JOURNAL   Nature 585 (7826), E14-E16 (2020)
   PUBMED   32968253
REFERENCE   5  (bases 1 to 2818)
  AUTHORS   Fazilaty,H., Rago,L., Kass Youssef,K., Ocana,O.H.,
            Garcia-Asencio,F., Arcas,A., Galceran,J. and Nieto,M.A.
  TITLE     A gene regulatory network to control EMT programs in development
            and disease
  JOURNAL   Nat Commun 10 (1), 5115 (2019)
   PUBMED   31712603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2818)
  AUTHORS   Chassaing,N., Sorrentino,S., Davis,E.E., Martin-Coignard,D.,
            Iacovelli,A., Paznekas,W., Webb,B.D., Faye-Petersen,O.,
            Encha-Razavi,F., Lequeux,L., Vigouroux,A., Yesilyurt,A.,
            Boyadjiev,S.A., Kayserili,H., Loget,P., Carles,D., Sergi,C.,
            Puvabanditsin,S., Chen,C.P., Etchevers,H.C., Katsanis,N.,
            Mercer,C.L., Calvas,P. and Jabs,E.W.
  TITLE     OTX2 mutations contribute to the otocephaly-dysgnathia complex
  JOURNAL   J Med Genet 49 (6), 373-379 (2012)
   PUBMED   22577225
REFERENCE   7  (bases 1 to 2818)
  AUTHORS   Hernandez-Vega,A. and Minguillon,C.
  TITLE     The Prx1 limb enhancers: targeted gene expression in developing
            zebrafish pectoral fins
  JOURNAL   Dev Dyn 240 (8), 1977-1988 (2011)
   PUBMED   21674688
REFERENCE   8  (bases 1 to 2818)
  AUTHORS   Rosel,T.D., Hung,L.H., Medenbach,J., Donde,K., Starke,S., Benes,V.,
            Ratsch,G. and Bindereif,A.
  TITLE     RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in
            alternative splicing regulation
  JOURNAL   EMBO J 30 (10), 1965-1976 (2011)
   PUBMED   21468032
REFERENCE   9  (bases 1 to 2818)
  AUTHORS   Jin,D., Ni,T.T., Hou,J., Rellinger,E. and Zhong,T.P.
  TITLE     Promoter analysis of ventricular myosin heavy chain (vmhc) in
            zebrafish embryos
  JOURNAL   Dev Dyn 238 (7), 1760-1767 (2009)
   PUBMED   19517572
  REMARK    GeneRIF: Prrx1b, a Prx-related homeobox protein, participates in
            the regulation of vmhc expression with other transcriptional
            factors.
REFERENCE   10 (bases 1 to 2818)
  AUTHORS   Marques,I.J., Leito,J.T., Spaink,H.P., Testerink,J., Jaspers,R.T.,
            Witte,F., van den Berg,S. and Bagowski,C.P.
  TITLE     Transcriptome analysis of the response to chronic constant hypoxia
            in zebrafish hearts
  JOURNAL   J Comp Physiol B 178 (1), 77-92 (2008)
   PUBMED   17828398
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064671.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505373, SAMEA3505374
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     gene            1..2818
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /note="paired related homeobox 1b"
                     /db_xref="GeneID:337089"
                     /db_xref="ZFIN:ZDB-GENE-030131-9033"
     exon            1..608
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    323..325
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /note="upstream in-frame stop codon"
     CDS             362..1099
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /note="phox1"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 1b"
                     /protein_id="NP_956344.1"
                     /db_xref="GeneID:337089"
                     /db_xref="ZFIN:ZDB-GENE-030131-9033"
                     /translation="

MTSSYAHVMDRQATISSRLESPITANLENLQAKKNFSVSHLLDLEEAREMVGSQVDESVGETGRTMLESPGLTSGSDTTQQENEQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLASKNASLLKSYSGDVTAVEQPIVPRPAPRPNDYLSWGSAAPYSTMATYPPTCANTTSTQGMNMANSIANLRLKAKEYNLNQVPTVN"

     misc_feature    662..820
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1019..1072
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     exon            609..784
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /inference="alignment:Splign:2.1.0"
     exon            785..966
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2761
                     /gene="prrx1b"
                     /gene_synonym="fa97b09; wu:fa97b09; zgc:101095; zgc:64199"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acgctttacacacatgcatctgaaaggcatcagcatttctggatcggcgctcagtcaacaactccgtggagctcgaggagttttttttcttattgactacattgacaaaagagattacatggctctgagtaaacggaatcaacagacgtcgtggtcatcacagtcacgttaagttatacaaagttttagactaggttaactcaacctggatctgtaggagctgctttcctataggtaacgaccaagagacggaggccccgttttgaaggcaatgactatcttgagtttgccttaaatatatgcaaggaggaactgttttggttagtataatacacttgccaatttttatcgtatttgcgtcatgacttctagctatgcacatgtaatggacagacaagcaaccatatccagcagactggagagtcccattacagccaacctggaaaacctgcaagccaaaaagaacttctcggtgagccacctgttggatctagaggaggcaagagaaatggtcggttctcaggtggatgaaagtgttggcgaaacgggcaggactatgctggaatctccgggtttaacgagtggcagtgatacaacacaacaagagaatgagcagctgaactcagaagaaaagaagaagcggaaacagcggaggaatagaaccacgtttaacagcagccagctgcaggcgctggagcgagtgtttgagcggacacactacccagatgcctttgttagagaggacttggcacgtagggtcaatcttactgaggctagagttcaggtgtggttccaaaatagacgggcaaagtttcggcggaatgagcgggcgatgctggccagtaagaacgcttcacttcttaaatcctattcaggagacgtaacagcagtggaacagcctatcgtgccccgacccgcaccacgtccaaatgactacctatcctggggaagcgcagccccatacagcaccatggcaacctacccacccacttgtgccaacaccacttccacccagggaatgaatatggccaatagcattgctaatctgagactgaaggccaaagaatacaacctcaaccaggtgcctactgtcaactaagcctgaaaagagggacggaatgaggggacgtaaaaaaggaagacacactgagaagagaagatctcagaagagctggactggtttagcggtaacagtgatttttctggctttctgcagtgttaaagcagagtggatatgacttttggccccctccttaaacaatgaaattgcgttgttgtccctctcaattggcttttttcttcatcatagattaaggtacgtttttgagaaactcaatctcattttgtactgatatgaagattgtaaagacagcacatgttctgctttttggagatcaaatcaacgagaagggctccgctaaatcacaaagaagtggcagacgaagtgcctggatgctgtatgctgttctttccatgttctttttggctttattttgggtcatccggatggaaagtaaagaaactttcaaggaacacaatggaggactgttttgcgccattcaccactgaatggtttaaattacaccagaattttaatgtggagatttggcaacaaagtggcttaaaatgtctccacgtctgcctttggtaaaataaagacacatttgtggactataatcagtatatgagatgtttacaactgtcagtgctaacggaagcattagggccggattacatatttttaggtctgaatattacaccactctttaaggttaatacggttccccatggtgacatatgtatctgttcacagtacacaattatgtttcagttttgccacaggtgactttttttcatttattttattttcttcttatatttggaaactatatagtaataaaacatttttaagaaataactcttatgttattgtgattgacaatcctgcagctaaatagattgtgccattttagctaaatactcacatttgaggagctgttgcaggcaatagtattactagaatcaggaccttattataatatatccacatgtaacatttcctgatttatgttaaacaccagtgctaaaaaataagttgtgcaaattaatttagttctatcttataaatgttgatggttataaacattttttattattatttgttctgaaactatgtgagaatgaaactagatttttagatttattttatattaattaaacatttctgacctgttttacaggtaaattcttttaatagaaaacactatcaggaatgattttacagcatgttaaatgcaatggctgtttttttttagctaatcctggttgtgctataaataaactctatttcttccacttttaattaaaactaaattaaactggatttatataaatgttttgataaaagtttactatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatatattataatcaagtaaaaaaaaattataatgaacacctcatcagcatgttatgattagataatagatgtaatactctcttattgtgctgggagaacaatgtgatgaaaggaatatttgagaattaatttccactgtaacccaatcctttaaactcaatatttgttgactgtacatgcgaatgacatcgctttgcccaatttaaagcattttagtttcaagtccaacaaaatgtaaattaatttacaacagtaaatgtgtttggaacgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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