LOCUS       NM_174861               1837 bp    mRNA    linear   VRT 23-MAR-2025
DEFINITION  Danio rerio gastrulation brain homeobox 1 (gbx1), mRNA.
ACCESSION   NM_174861
VERSION     NM_174861.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Zhao,S., Wang,C., Luo,H., Li,F., Wang,Q., Xu,J., Huang,Z., Liu,W.
            and Zhang,W.
  TITLE     A role for Retinoblastoma 1 in hindbrain morphogenesis by
            regulating GBX family
  JOURNAL   J Genet Genomics 51 (9), 900-910 (2024)
   PUBMED   38570112
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Silva,N. and Campinho,M.A.
  TITLE     In a zebrafish biomedical model of human Allan-Herndon-Dudley
            syndrome impaired MTH signaling leads to decreased neural cell
            diversity
  JOURNAL   Front Endocrinol (Lausanne) 14, 1157685 (2023)
   PUBMED   37214246
  REMARK    Erratum:[Front Endocrinol (Lausanne). 2023 May 31;14:1228183. doi:
            10.3389/fendo.2023.1228183. PMID: 37324251]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Brunt,L., Greicius,G., Rogers,S., Evans,B.D., Virshup,D.M.,
            Wedgwood,K.C.A. and Scholpp,S.
  TITLE     Vangl2 promotes the formation of long cytonemes to enable distant
            Wnt/beta-catenin signaling
  JOURNAL   Nat Commun 12 (1), 2058 (2021)
   PUBMED   33824332
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Tuazon,F.B., Wang,X., Andrade,J.L., Umulis,D. and Mullins,M.C.
  TITLE     Proteolytic Restriction of Chordin Range Underlies BMP Gradient
            Formation
  JOURNAL   Cell Rep 32 (7), 108039 (2020)
   PUBMED   32814043
REFERENCE   5  (bases 1 to 1837)
  AUTHORS   Kesavan,G., Machate,A., Hans,S. and Brand,M.
  TITLE     Cell-fate plasticity, adhesion and cell sorting complementarily
            establish a sharp midbrain-hindbrain boundary
  JOURNAL   Development 147 (11) (2020)
   PUBMED   32439756
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1837)
  AUTHORS   Kikuta,H., Kanai,M., Ito,Y. and Yamasu,K.
  TITLE     gbx2 Homeobox gene is required for the maintenance of the isthmic
            region in the zebrafish embryonic brain
  JOURNAL   Dev Dyn 228 (3), 433-450 (2003)
   PUBMED   14579382
REFERENCE   7  (bases 1 to 1837)
  AUTHORS   Rhinn,M., Lun,K., Amores,A., Yan,Y.L., Postlethwait,J.H. and
            Brand,M.
  TITLE     Cloning, expression and relationship of zebrafish gbx1 and gbx2
            genes to Fgf signaling
  JOURNAL   Mech Dev 120 (8), 919-936 (2003)
   PUBMED   12963112
  REMARK    GeneRIF: Here we report the isolation, mapping, chromosomal synteny
            and spatiotemporal expression of gbx1 and gbx2 in zebrafish. We
            focus in particular on the expression of these genes during
            development of the midbrain-hindbrain territory.
REFERENCE   8  (bases 1 to 1837)
  AUTHORS   Itoh,M., Kudoh,T., Dedekian,M., Kim,C.H. and Chitnis,A.B.
  TITLE     A role for iro1 and iro7 in the establishment of an anteroposterior
            compartment of the ectoderm adjacent to the midbrain-hindbrain
            boundary
  JOURNAL   Development 129 (10), 2317-2327 (2002)
   PUBMED   11973265
REFERENCE   9  (bases 1 to 1837)
  AUTHORS   Reim,G. and Brand,M.
  TITLE     Spiel-ohne-grenzen/pou2 mediates regional competence to respond to
            Fgf8 during zebrafish early neural development
  JOURNAL   Development 129 (4), 917-933 (2002)
   PUBMED   11861475
REFERENCE   10 (bases 1 to 1837)
  AUTHORS   Burgess,S., Reim,G., Chen,W., Hopkins,N. and Brand,M.
  TITLE     The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain
            protein Pou2 related to mammalian Oct4 and is essential for
            formation of the midbrain and hindbrain, and for pre-gastrula
            morphogenesis
  JOURNAL   Development 129 (4), 905-916 (2002)
   PUBMED   11861474
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF288763.1.
            
            On Jun 3, 2003 this sequence version replaced NM_174861.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288763.1, BC162948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="24"
                     /map="24"
     gene            1..1837
                     /gene="gbx1"
                     /gene_synonym="cb619; fj77a06; wu:fj77a06"
                     /note="gastrulation brain homeobox 1"
                     /db_xref="GeneID:142985"
                     /db_xref="ZFIN:ZDB-GENE-020117-2"
     CDS             149..1099
                     /gene="gbx1"
                     /gene_synonym="cb619; fj77a06; wu:fj77a06"
                     /codon_start=1
                     /product="homeobox protein GBX-1"
                     /protein_id="NP_777286.1"
                     /db_xref="GeneID:142985"
                     /db_xref="ZFIN:ZDB-GENE-020117-2"
                     /translation="

MQRPSGTGTAFSIDSLIGTPQPRPGHLLYTGYPMFMPYRPLMIPQALSHSSLPSGIPPLAPLASFAGRLTNTFCAGLGQGMPSMVALTTTLPSFSDPPDSFYPPQEMPGPRLGADGTGMNRQESPHDELKGSELLNFTETFQAVAGETKLYSSDDEKLDLKAAEAACSDREDSSADSENESFSDGNTCASASQKGKLKGGSQDALPPGGSAGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVNNRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQIEPGSRP"

     misc_feature    791..961
                     /gene="gbx1"
                     /gene_synonym="cb619; fj77a06; wu:fj77a06"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

cccgcgcccgacaaaaaacgcaccaggtntcagtcagttggacggcgaggacccttcagcagcgccaggacaaccgtggaccacacatttgggtgatttgaaggccagtacagcacgggatttatacgaccagaccgctcagttcaccatgcagagaccgagcggtacgggcacggcgttttccattgattctttgattggcactccacagccacgaccgggccacctgctctacacgggctacccgatgtttatgccgtaccgaccgcttatgattccacaagccctgtctcattcgtcattaccgtcagggatcccacctttggcaccgctggcatctttcgcagggcgtctgaccaacactttttgcgcggggttaggacagggaatgccctccatggtggcgctcaccaccaccctgcctagtttctcggaccctccagatagtttctaccccccgcaggagatgccgggaccccggttaggcgcagacgggacggggatgaaccggcaagagagcccgcatgacgaactcaaaggctctgaactcctcaatttcacggaaacttttcaagcagtcgcaggcgaaaccaaactctacagttcagatgacgagaaactggacctgaaagcagcggaggccgcgtgcagtgaccgggaggacagctcggccgacagcgagaacgaaagcttctccgacgggaacacctgcgcctctgcgtcccagaaaggcaaactgaaaggcggctcacaggacgcgttaccgccgggcggctctgcgggaaagagccgcaggagacggacagctttcacgagcgagcagctgctggaactcgagaaggagtttcactgtaagaagtatctgtccctcaccgagcgctcgcagatcgcgcatgcgctcaaactcagcgaggtccaggtcaaaatctggttccagaaccgcagggccaaatggaaacgcatcaaagccggaaatgtcaacaacagatcaggcgagcccgtccggaaccccaaaatcgtggtgcccattccagtgcacgtcaacaggttcgcggtgcggagtcaacatcaacagatcgaaccgggcagcaggccatgaatgaactcctcaatataaatgactcctcaagtgaacatttacttgacctcgtttcactggtcaggggccacagatgcatgaagcacagctcaaaggagacaattaggatacttctttaggtaacaataaaatacacgaggcctactcaatgcttaacggattatctgtttatatttattcgattctaaatagcatatatatcaaagtttataatatttgaatgtatattaacatgtaacctgttaagcatttacacatggacgttatttgaaagtgttaccgacttttatatctgtacatttcgacattgctttcaggtttgttcaaatttctttatttttaatttattattttgtacattttgtaaatatgaaatgtgtccgcgcgacacacatgtgcactatacgagactgtaaagagactttttaaaagaataataagtatttataagttgctgtctagtgagtttttgcatgtgttttgccatttgttgtctgatttccccgtgttgttttaacgggccgttctcgttgtttcgaccttttttgcatgtgctcttaaagcatttctgtccctcacaggcggaatctctcccagttctttgtggaaaaaacggtgatggaaataaataagctgaagaacacaatggcagactgatatattccaatcgacctcacaataaatatggtgcaatatgtttgcataaaactgttcagggggaaaaaaaaaaaaaaaaaa

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