LOCUS       NM_131323               1393 bp    mRNA    linear   VRT 27-APR-2025
DEFINITION  Danio rerio distal-less homeobox 6a (dlx6a), mRNA.
ACCESSION   NM_131323 XM_694106
VERSION     NM_131323.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Yu,E.P.Y., Saxena,V., Perin,S. and Ekker,M.
  TITLE     Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and
            Meckel's Cartilage Morphology
  JOURNAL   Biomolecules 13 (9), 1347 (2023)
   PUBMED   37759750
  REMARK    GeneRIF: Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt
            Signaling and Meckel's Cartilage Morphology.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Truong,B.T., Shull,L.C., Lencer,E., Bend,E.G., Field,M., Blue,E.E.,
            Bamshad,M.J., Skinner,C., Everman,D., Schwartz,C.E.,
            Flanagan-Steet,H. and Artinger,K.B.
  TITLE     PRDM1 DNA-binding zinc finger domain is required for normal limb
            development and is disrupted in split hand/foot malformation
  JOURNAL   Dis Model Mech 16 (4) (2023)
   PUBMED   37083955
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Coltogirone,R.A., Sherfinski,E.I., Dobler,Z.A., Peterson,S.N.,
            Andlinger,A.R., Fadel,L.C., Patrick,R.L. and Bergeron,S.A.
  TITLE     Gsx2, but not Gsx1, is necessary for early forebrain patterning and
            long-term survival in zebrafish
  JOURNAL   Dev Dyn 252 (3), 377-399 (2023)
   PUBMED   36184733
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Okeke,C., Paulding,D., Riedel,A., Paudel,S., Phelan,C., Teng,C.S.
            and Barske,L.
  TITLE     Control of cranial ectomesenchyme fate by Nr2f nuclear receptors
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36367707
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Fisher,S., Jagadeeswaran,P. and Halpern,M.E.
  TITLE     Radiographic analysis of zebrafish skeletal defects
  JOURNAL   Dev Biol 264 (1), 64-76 (2003)
   PUBMED   14623232
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Levkowitz,G., Zeller,J., Sirotkin,H.I., French,D., Schilbach,S.,
            Hashimoto,H., Hibi,M., Talbot,W.S. and Rosenthal,A.
  TITLE     Zinc finger protein too few controls the development of
            monoaminergic neurons
  JOURNAL   Nat Neurosci 6 (1), 28-33 (2003)
   PUBMED   12469125
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Zerucha,T., Stuhmer,T., Hatch,G., Park,B.K., Long,Q., Yu,G.,
            Gambarotta,A., Schultz,J.R., Rubenstein,J.L. and Ekker,M.
  TITLE     A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is
            the site of cross-regulatory interactions between Dlx genes in the
            embryonic forebrain
  JOURNAL   J Neurosci 20 (2), 709-721 (2000)
   PUBMED   10632600
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Amores,A., Force,A., Yan,Y.L., Joly,L., Amemiya,C., Fritz,A.,
            Ho,R.K., Langeland,J., Prince,V., Wang,Y.L., Westerfield,M.,
            Ekker,M. and Postlethwait,J.H.
  TITLE     Zebrafish hox clusters and vertebrate genome evolution
  JOURNAL   Science 282 (5394), 1711-1714 (1998)
   PUBMED   9831563
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U67844.1.
            
            On Jul 6, 2005 this sequence version replaced XM_694106.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67844.1, BC114264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="19"
                     /map="19"
     gene            1..1393
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /note="distal-less homeobox 6a"
                     /db_xref="GeneID:30586"
                     /db_xref="ZFIN:ZDB-GENE-980526-448"
     exon            1..499
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /note="upstream in-frame stop codon"
     CDS             190..933
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /note="DLX-6; distal-less homeobox protein 6a; distal-less
                     homeobox gene 6a"
                     /codon_start=1
                     /product="homeobox protein Dlx6a"
                     /protein_id="NP_571398.1"
                     /db_xref="GeneID:30586"
                     /db_xref="ZFIN:ZDB-GENE-980526-448"
                     /translation="

MMTMTTMADGLEAQDSSKSAFMEFGQQSHSQQSSPSMAASHYPLHCLHSGSHHHHQHDSSPYSGSNSYNRSLPYSYVSHPHHSPYLPSYHSNASGTQTRLDATEQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGGNPHETDTLPGSIALSPRSPAIPPIWDVSASSKGVNMSANSYMPGYSHWYSSPHQDAMQR"

     misc_feature    253..387
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q98877.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    565..735
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            500..693
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1393
                     /gene="dlx6a"
                     /gene_synonym="dlx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ttaaaatctctgcatttactcaagcccaccttccaccataccgcgtgagaattacaggacaaaaaaggataaattgtggaggtaataacgcaatatctcctaaccaaggagagaaagaaacgaacacagcgaaaggactcatttggacttctgagatagggggtaagtgctctcaaagcagaaaatttgatgatgaccatgactacgatggctgacggtctggaggctcaagactcgtcaaaatctgctttcatggagtttggacagcaatcgcactcacaacagagctccccgtcgatggccgccagccattatccgctccactgtctccattccggctcccatcatcatcatcagcacgacagctctccgtactccggctcgaactcatataacaggtcgctaccttactcttatgtgagccatccgcaccacagtccgtacctgccgtcctaccacagtaacgccagcggaacacagaccaggttagacgctacagaacagcagaaaacaacagtgattgaaaacggtgaaatacgtttcaacggaaaaggcaaaaagataagaaaaccaaggacgatttattccagtttgcagcttcaggcattaaatcaccgtttccagcagactcaatacctggcattaccggagcgcgcggagctggctgcctcactcgggctcacacagacgcaggtaaagatatggtttcaaaacaaaaggtccaagttcaagaagctgttgaaacaaggcggtaaccctcacgagacggacactttgcctggctctatcgccctgtccccgcgctctccagccattcctcctatctgggacgtctcagcctcctccaaaggagtaaacatgtctgctaacagctacatgcccggctattcacactggtactcgtcacctcatcaggacgccatgcagagataggcaactatagccttgttttaggccataggccttgatgttgacatgctgacttcgcccagttcacgtgcgctaggacgcacaatgtcatcggtttaacatccctaatagagacattgctagtctattaaggggacgttttttgaaggatgaagacatgcggcgtgtcaatggtcgacaatggaactatctgacagaagcatctgaaacgatgattaaaaaactgttctcacgtccgactgtaatcaaacacgcattgccgacatgaaattgggacaggaagcgaatcgttttgtcacatcacacgcgcacgcacgcgcatgagtcgcatttgaaaacgaactcaaacctccttcgtagatgttttctgatcatgcaaaagcaagcaatttgattgtaaatatgttgtccgattttagttgttaaaactttttatgttttgtcataaatggagtaaaccatg

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