LOCUS       NM_131101               1800 bp    mRNA    linear   VRT 28-APR-2025
DEFINITION  Danio rerio homeobox B5a (hoxb5a), mRNA.
ACCESSION   NM_131101
VERSION     NM_131101.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Maeno,A., Koita,R., Nakazawa,H., Fujii,R., Yamada,K., Oikawa,S.,
            Tani,T., Ishizaka,M., Satoh,K., Ishizu,A., Sugawara,T., Adachi,U.,
            Kikuchi,M., Iwanami,N., Matsuda,M. and Kawamura,A.
  TITLE     The Hox code responsible for the patterning of the anterior
            vertebrae in zebrafish
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38940461
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Sundaramoorthi,H., Fallatah,W., Mary,J. and Jagadeeswaran,P.
  TITLE     Discovery of seven hox genes in zebrafish thrombopoiesis
  JOURNAL   Blood Cells Mol Dis 104, 102796 (2024)
   PUBMED   37717409
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Wang,H., He,J., Han,X., Wu,X., Ye,X., Lv,W. and Zu,Y.
  TITLE     hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated
            Heart Malformation in Bosley-Salih-Alorainy Syndrome
  JOURNAL   Biology (Basel) 12 (7), 899 (2023)
   PUBMED   37508332
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Weiss,J.M., Hunter,M.V., Cruz,N.M., Baggiolini,A., Tagore,M.,
            Ma,Y., Misale,S., Marasco,M., Simon-Vermot,T., Campbell,N.R.,
            Newell,F., Wilmott,J.S., Johansson,P.A., Thompson,J.F., Long,G.V.,
            Pearson,J.V., Mann,G.J., Scolyer,R.A., Waddell,N., Montal,E.D.,
            Huang,T.H., Jonsson,P., Donoghue,M.T.A., Harris,C.C., Taylor,B.S.,
            Xu,T., Chaligne,R., Shliaha,P.V., Hendrickson,R., Jungbluth,A.A.,
            Lezcano,C., Koche,R., Studer,L., Ariyan,C.E., Solit,D.B.,
            Wolchok,J.D., Merghoub,T., Rosen,N., Hayward,N.K. and White,R.M.
  TITLE     Anatomic position determines oncogenic specificity in melanoma
  JOURNAL   Nature 604 (7905), 354-361 (2022)
   PUBMED   35355015
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Albert,L., Nagpal,J., Steinchen,W., Zhang,L., Werel,L.,
            Djokovic,N., Ruzic,D., Hoffarth,M., Xu,J., Kaspareit,J.,
            Abendroth,F., Royant,A., Bange,G., Nikolic,K., Ryu,S., Dou,Y.,
            Essen,L.O. and Vazquez,O.
  TITLE     Bistable Photoswitch Allows in Vivo Control of Hematopoiesis
  JOURNAL   ACS Cent Sci 8 (1), 57-66 (2022)
   PUBMED   35106373
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Snell,E.A., Scemama,J.L. and Stellwag,E.J.
  TITLE     Genomic organization of the Hoxa4-Hoxa10 region from Morone
            saxatilis: implications for Hox gene evolution among vertebrates
  JOURNAL   J Exp Zool 285 (1), 41-49 (1999)
   PUBMED   10327649
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Prince,V.E., Price,A.L. and Ho,R.K.
  TITLE     Hox gene expression reveals regionalization along the
            anteroposterior axis of the zebrafish notochord
  JOURNAL   Dev Genes Evol 208 (9), 517-522 (1998)
   PUBMED   9799433
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Prince,V.E., Joly,L., Ekker,M. and Ho,R.K.
  TITLE     Zebrafish hox genes: genomic organization and modified colinear
            expression patterns in the trunk
  JOURNAL   Development 125 (3), 407-420 (1998)
   PUBMED   9425136
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Fritz,A., Rozowski,M., Walker,C. and Westerfield,M.
  TITLE     Identification of selected gamma-ray induced deficiencies in
            zebrafish using multiplex polymerase chain reaction
  JOURNAL   Genetics 144 (4), 1735-1745 (1996)
   PUBMED   8978059
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Patil,J.G. and Khoo,H.W.
  TITLE     Nuclear internalization of foreign DNA by zebrafish spermatozoa and
            its enhancement by electroporation
  JOURNAL   J Exp Zool 274 (2), 121-129 (1996)
   PUBMED   8742692
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC071493.1.
            
            On Oct 16, 2004 this sequence version replaced NM_131101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071493.1, CN512717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     gene            1..1800
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="homeobox B5a"
                     /db_xref="GeneID:30317"
                     /db_xref="ZFIN:ZDB-GENE-980526-70"
     exon            1..667
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    85..87
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="upstream in-frame stop codon"
     CDS             88..915
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="homeobox protein Zf-21; homeobox gene B-5; homeo
                     box B5a"
                     /codon_start=1
                     /product="homeobox protein Hox-B5a"
                     /protein_id="NP_571176.2"
                     /db_xref="GeneID:30317"
                     /db_xref="ZFIN:ZDB-GENE-980526-70"
                     /translation="

MSSYFVNSFSGRYPNGPDYQLLNYGTSSSAMNASYRDSGTMHSGSYGYNYNGMDLSVNRSTSTGHFGAVGDNSRVFQSPAPETRFRQPSSCSLASPEPLPCSNSESLGPKGSSPPSDQSTTTAGNNLNSNTHFTEIDEASASSETEEASHRANNSAPRTQQKQETTATSTTSATSDGQAPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP"

     misc_feature    295..630
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="propagated from UniProtKB/Swiss-Prot (P09014.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    631..648
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="propagated from UniProtKB/Swiss-Prot (P09014.2);
                     Region: Antp-type hexapeptide"
     misc_feature    688..858
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            668..1778
                     /gene="hoxb5a"
                     /gene_synonym="hox-2.1; hox-B5; hoxb5; wu:fc38c09; z-18;
                     ZF-21; ZF21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gctataattcattaatacatcataaatcgtgaagcacagcgttataacgaccaagatctacaaatcaagccctctaaaacaacctaaatgagctcttactttgtaaactcgttctcagggcgctacccaaatggccctgactatcagttactaaattatggaactagcagcagcgctatgaacgcttcgtacagggactccggcaccatgcattcaggctcttacggctacaactacaatggaatggacctaagcgtcaatcgttcaaccagcactggccactttggggcggttggggacaactcccgggtcttccagtctccagctccggagacgcgattccggcagccatcaagctgctcgctcgcgtctccggagccgctgccttgttccaacagcgaaagccttggacccaaaggctcttcgcccccttccgaccaaagcaccaccactgcgggtaataatctcaacagcaacacacattttacagaaatcgacgaggccagtgcttcatcggagaccgaggaggcgtctcacagagcgaacaactctgcaccccggacacaacagaagcaagagaccacggcaacctccactacctcggcgacgtccgatggccaagctccccaaatattcccttggatgaggaaactacatattagccatgatatgactggaccagacggcaaaagggcccgaactgcatatacccgctatcagacgctagagctggaaaaagagttccatttcaatagatacctcacccgaagaaggaggatagagatagcccacgctctatgcctctcagagcgtcaaattaagatatggttccaaaaccggcggatgaaatggaaaaaggacaataaactgaagagcatgagtctggctaccgcaggtagcgctttccaaccatagttgtatcccaagacctgctacgtggtgtgcaaaaaattacgcggaaaatgagatgaaaaagagatctcaaaacattacctacagagtactgtacatcgcggcacctttcggcatgttatggatgttttaggcattttaaaattctactgtggtactgctataatgaaacgaaaattagtgttcatatgttgttcttttatggtgactttaattttggcaagtaaataaaactgaagggaaagaagctatcaatataacgcttgttgttcttgttacaaatattgtttatgtgtcaagtgctatgttaatgctttcttgagagttagcatgtgagctcttaaatgttataacttatttacctatacacgtgtataactaccttttgagtttacagcttagaaacgcatctgcccttgtatgaagtgaagctctagtttagaggtgactgcagtaaatttagcagaagcctatgtttcatggtcctctgtttaatcaatgtctaaataatcacaatcgatttgtcatgtgttcacaatcttctattattattattattttttttgaaaaaaaataataattaaatggtgtaaatagacctcgctagattcttgtactcgttcatacgtgtgtatagttgtattccaaatatataattgtatattactggatcatgtttatgttccaaaaaaggttgtatatattgaacatttttattgtgatcagttggctatttgtagtgggcagaataaacggcaatgtggaaaaaagtcatgtcaatctgcctgttagcattttgccaaaatgctttttgtatttgtttgtagtttaacttggagtaaaaaataaagttcctcatattcaaaaaaaaaaaaagaaaaaaaaaaa

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