LOCUS       NM_001442092            1374 bp    mRNA    linear   VRT 24-JUL-2025
DEFINITION  Danio rerio claudin 8.3 (cldn8.3), transcript variant 1, mRNA.
ACCESSION   NM_001442092
VERSION     NM_001442092.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Baltzegar,D.A., Reading,B.J., Brune,E.S. and Borski,R.J.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000015.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588735.3544728.1,
                                           SRR32588720.1797968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN18715719 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JBMGRA010000015.1  45267563-45267634
            73-152              JBMGRA010000015.1  45270628-45270707
            153-223             JBMGRA010000015.1  45271463-45271533
            224-289             JBMGRA010000015.1  45295471-45295536
            290-1374            JBMGRA010000015.1  45300325-45301409
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1374
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /note="claudin 8.3"
                     /db_xref="GeneID:100001934"
                     /db_xref="ZFIN:ZDB-GENE-070821-2"
     exon            1..72
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /inference="alignment:Splign:2.1.0"
     exon            73..152
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /inference="alignment:Splign:2.1.0"
     exon            153..223
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    164..166
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /note="upstream in-frame stop codon"
     misc_feature    218..220
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MRSLRPQDLDVKSLIGGIIFVQIRITDEIIK"
     exon            224..289
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1374
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1318
                     /gene="cldn8.3"
                     /gene_synonym="cldn17; cldn8c; zgc:173444"
                     /note="claudin 17"
                     /codon_start=1
                     /product="claudin-17"
                     /protein_id="NP_001429021.1"
                     /db_xref="GeneID:100001934"
                     /db_xref="ZFIN:ZDB-GENE-070821-2"
                     /translation="

MVQGPCDVIALCLSLIGLIGVATVTALPMWRVTAFIGENIIVMETRWEGLWMNCYRQANIRMQCKVYDSLLYLPPDLQAARGLTCCSLALCGFGIIVSLFGLRCMSCLSDQPRNKSIILMITGIIEILASFCIVIPVSWTAHTIIRDFYNPLLLDAQRRELGEALYIGWVTSAFLLASGVIFLCRRVDSNEQPFYARPPRNKQVLNHFQAFNSLRRQPLLQNNSFSTPQHSSAAFSFAVTPSSGQYSQHNVQPVVNGSLVYSPNMIPPQRVNYHGQNVMQSQILASNAQYPVSDPRDSFNTGSAFHPVQQNPLYVGYNYSRVQSGSSNSSTGLRI"

ORIGIN      

gttgttttgattggtttgtcgtgtgaaactcaagtcacacatggtttcccagcggctcgacccgtcagacagatgtttgaaatcgaaagaagacaaactttacactttacacgtttgtactttacagcaatgtgatttggatcaaaatgaagatgtttgaaactgaaagaagaccaattctcagtttgtactttacagccatgtgatttggatcaaaatgaggtctctgagacctcaggatttggacgttaaatcgctgatcggcgggattatctttgttcagatcaggatcacggatgagataataaaaatggttcagggtccgtgtgatgtcatcgccctctgcctgagcctcatcggtctgattggtgtcgccactgttacggctctcccgatgtggagagtcactgcattcataggagaaaacatcatcgtgatggagacccgctgggagggtttgtggatgaactgctacaggcaagccaacatccgaatgcagtgtaaagtgtacgactccctgctgtatcttcctcctgatctgcaggcggcccgcggattgacctgctgctctctggcgctgtgtggattcgggataatagtgtccctcttcggcctccgttgcatgtcttgtctgagtgatcaaccacgcaacaaaagcatcattttaatgatcactggcataattgaaatcttagcaagtttttgcatcgtcatccctgtctcctggacggcccatactattatcagagacttttacaatccgttactattggatgcccagcggagagaactgggagaggctctgtatatcggttgggtaactagcgcgtttcttttggcatctggagtcatctttctctgtcgtcgtgttgattcgaacgagcagccattttatgctcgtccaccacgtaataaacaagttctgaatcatttccaggcctttaactctctccgtcgtcagccgttgctccagaataatagtttttccactcctcagcattcatcagctgcattcagctttgctgtcacgccctctagtggtcaatattcacagcacaacgtgcagccggtggtcaatgggtctttagtatacagtccaaacatgattccacctcagagagtgaattatcatgggcagaatgtaatgcaaagtcagattttagccagtaacgcacagtaccccgtcagtgatcctcgggattcctttaacaccgggtctgcttttcatcctgtgcaacagaacccactctatgtcgggtataattactcccgggtacagtctggtagctccaacagtagcacaggactgcggatataagagtttctctgtgttttatcttttattttaaaataaagagtgctgaaaattccagt

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