LOCUS       NM_001130784            2680 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio homeobox and leucine zipper encoding b (homezb), mRNA.
ACCESSION   NM_001130784 XM_689495
VERSION     NM_001130784.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2680)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC163532.1.
            
            On Aug 6, 2008 this sequence version replaced XM_689495.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC163532.1, GW710532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2680
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..2680
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="homeobox and leucine zipper encoding b"
                     /db_xref="GeneID:566226"
                     /db_xref="ZFIN:ZDB-GENE-030131-9225"
     exon            1..770
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    456..458
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="upstream in-frame stop codon"
     CDS             465..2621
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="homeodomain leucine zipper gene b"
                     /codon_start=1
                     /product="homeobox and leucine zipper encoding b"
                     /protein_id="NP_001124256.1"
                     /db_xref="GeneID:566226"
                     /db_xref="ZFIN:ZDB-GENE-030131-9225"
                     /translation="

MEQCAAPQLESASSRSLPPDPAGKPGGDAVETAKDAYECRICGYKAQDVKCLSQHLHAAHPVTSLCSSAMSERPNVNVTRPHKTVLGPDTPSVNGDLGKRNKPITPEGSESASLQTPDDLNETSSSTEAREQEEKMDDSPSPEGTQSSSPELPQEKSPCSSGVQKRPTVTSGTSTHNQVNLVCLPLVSEGLKLIWVRSEQVHELDAVSELVEAFNSFPYPTSQEASALARKCALPPDQVKAWFMMQRVRYGISWADDDIQETRRKLWHIQKKATSDECVEIDDEEDCVAVDKTQAAQQAFIPPPVSNTHADQREHIPKPSQTVPHHITTDQSHLRFGQNNASQSNNGVQHSLPSNVVYKNGVGHAPQVPQVNPGFQSESRNAPTQNTGVQLIDTFGRPSYVMTNEQPSALSYPELPELSQSLHCLPGKKSKAQLMALRRSFVNKSWPSDGEVQRLQKMTGLSRREIRKWFADSRYQLRKNGRAWLNKLAKHNRSLQLMQKDIDDIPSVDFDDNDEVDDTEAGFEVDVDVADGEGSLNQSNETKDEVSDEGGDMDDGSTSTKPLSVDVSPSPSPSPSFRRGLVEPNVRLRKKTREQLEMLRQSFLCCQWPTSDDYEILQKKTGLTRTEIIQWYGDTRYHVKHNQMRWMTSQERERIIAAITQQQKRGGKYSRGRISFENLSSGLSVGDSALINGSSASGPATWNEFYNESAPIEHEGEL"

     misc_feature    495..>989
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    1077..1226
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    1746..1904
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1746..1748,1866..1868,1875..1880,1887..1889)
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    2229..2393
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(2232..2234,2352..2354,2361..2366,2373..2375)
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            771..2680
                     /gene="homezb"
                     /gene_synonym="fk11d03; wu:fk11d03"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gatgcgacagaccgaacctgtgacagctttctgggtaaactgtgcgacccgatggcgagtgcgagttgcagggaatgacgctttcacctgcattatttttctaacaactttaattcctgaaagaaagaaaaacaataaatcaatccgctgtgcactcgagctgtctgttttccactttttaatgcatttgtgtgaaacccacacgacaagctcttcggttagctcgcaggctagccagtctttgttctgtaacgtaacgttactcagaccagcagggtggccataaattaggaatcagccttcactttttgcatgtcgacttttgctacacttactttatccagatgaaactcgtccatttctgaaagacttgcatattgacttggcagtgggagaaatttagcctttagcctcagtgctcgcttgtatgaattgcgtcttggctcggtcgttcataggttgccatggagcaatgcgcagccccgcagctcgagagcgctagctcgcgatctttacctccagacccggcaggaaagcccggaggagatgccgtggagacggctaaggacgcttacgagtgcaggatttgtggttataaagctcaagatgttaaatgcctcagccagcacctgcacgccgcccacccggtcaccagcctgtgtagttcggcgatgagcgagagacctaacgttaacgttacccgaccgcacaagaccgtgttgggtccggacacaccgagcgttaacggtgacttggggaagagaaataagccaatcacccctgagggatcagaatctgcttcacttcagactcctgatgacttaaatgagacatcgtcctcaacagaggctagggaacaagaagagaagatggacgactctccttctcctgagggaacgcagagctcatcccctgaattacctcaggagaagtcaccctgctcctcaggagtccagaagaggccaacggtaacctccggcacatcgacccacaaccaggtcaacctggtctgtcttccattggtctctgaggggttaaagctgatctgggtgcgctctgagcaggttcatgaactggatgctgtgtcagaactcgtcgaagcgtttaattcatttccataccccacatcacaggaggcgagtgctctagcacgaaagtgtgcattaccgcctgaccaagtgaaagcatggttcatgatgcaacgggtacgttacggaatcagctgggctgatgatgacatccaggagacgagacgcaagctgtggcacattcagaaaaaagcaacaagtgacgagtgtgtggaaatcgatgatgaggaggattgtgtagcggttgataaaacgcaagctgcgcaacaggcttttattccaccacctgtgtcaaatacccatgcagatcagagagaacacatacctaaacccagccagactgttcctcatcacatcaccactgaccaatcccacttgcgtttcgggcagaataatgcttcccagtccaataatggtgttcagcactctctcccttctaatgttgtgtacaaaaatggtgtgggacacgcaccccaagttcctcaagttaaccctggctttcaaagtgaaagtagaaacgcaccaacacaaaatactggagtccagctgattgatacttttggacgtccatcatatgtgatgacgaatgagcaaccatctgcgttatcataccctgagctccctgagctgtcacagtcactacactgcttgcctgggaaaaaatccaaagcgcaactaatggccctgcgccgcagtttcgtaaataaatcctggcccagcgatggtgaggttcagcggctccagaaaatgactggactcagtcggcgtgaaatccgcaaatggttcgcggacagccgctatcagcttcggaagaatggcagagcttggctaaacaagctcgcgaagcacaatcgctcattgcaactgatgcaaaaggacattgatgatatacccagtgtggattttgatgataatgacgaagttgacgacactgaggctgggtttgaggttgatgtggatgtggccgacggtgaggggtcactcaaccaatcaaacgagaccaaggatgaagtaagtgatgaaggcggcgacatggatgacggcagcacttccacgaaaccgttatcagttgatgtttcaccctcaccttctccttccccatcattccgccgcgggctagtagaacccaacgtgcgactccgaaagaagacgagggaacagttggaaatgttgcggcagagtttcctttgctgccagtggcccacaagtgacgattacgagatcctgcagaagaagacaggcctgacgaggacagagatcatccagtggtacggagacacacgttaccacgttaaacacaatcagatgcgctggatgacctcacaggagagggagcgcatcatcgccgccataacgcaacagcagaaaagaggcgggaaatactcgcgaggaagaatctcctttgagaacttgagctccggcttgagtgtgggtgattctgcgttaattaacggcagcagcgcgagcggaccagcaacatggaacgaattttataatgaaagtgccccaattgagcatgagggtgaactttgacctaagaagtgaaatctgctttcgatggcatttgtagctgtgcagattggtggaaagcg

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