LOCUS       NM_001025512            1292 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio GS homeobox 2 (gsx2), mRNA.
ACCESSION   NM_001025512 NM_001130724 XM_684476
VERSION     NM_001025512.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Coltogirone RA, Sherfinski EI, Dobler ZA, Peterson SN, Andlinger
            AR, Fadel LC, Patrick RL and Bergeron SA.
  TITLE     Gsx2, but not Gsx1, is necessary for early forebrain patterning and
            long-term survival in zebrafish
  JOURNAL   Dev Dyn 252 (3), 377-399 (2023)
   PUBMED   36184733
  REMARK    GeneRIF: Gsx2, but not Gsx1, is necessary for early forebrain
            patterning and long-term survival in zebrafish.
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Hageter J, Waalkes M, Starkey J, Copeland H, Price H, Bays L,
            Showman C, Laverty S, Bergeron SA and Horstick EJ.
  TITLE     Environmental and Molecular Modulation of Motor Individuality in
            Larval Zebrafish
  JOURNAL   Front Behav Neurosci 15, 777778 (2021)
   PUBMED   34938167
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Scott K, O'Rourke R, Winkler CC, Kearns CA and Appel B.
  TITLE     Temporal single-cell transcriptomes of zebrafish spinal cord pMN
            progenitors reveal distinct neuronal and glial progenitor
            populations
  JOURNAL   Dev Biol 479, 37-50 (2021)
   PUBMED   34303700
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Mukaigasa K, Sakuma C and Yaginuma H.
  TITLE     The developmental hourglass model is applicable to the spinal cord
            based on single-cell transcriptomes and non-conserved
            cis-regulatory elements
  JOURNAL   Dev Growth Differ 63 (7), 372-391 (2021)
   PUBMED   34473348
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Itoh T, Takeuchi M, Sakagami M, Asakawa K, Sumiyama K, Kawakami K,
            Shimizu T and Hibi M.
  TITLE     Gsx2 is required for specification of neurons in the inferior
            olivary nuclei from Ptf1a-expressing neural progenitors in
            zebrafish
  JOURNAL   Development 147 (19) (2020)
   PUBMED   32928905
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Dirian L, Galant S, Coolen M, Chen W, Bedu S, Houart C, Bally-Cuif
            L and Foucher I.
  TITLE     Spatial regionalization and heterochrony in the formation of adult
            pallial neural stem cells
  JOURNAL   Dev Cell 30 (2), 123-136 (2014)
   PUBMED   25017692
REFERENCE   7  (bases 1 to 1292)
  AUTHORS   Satou C, Kimura Y, Hirata H, Suster ML, Kawakami K and Higashijima
            S.
  TITLE     Transgenic tools to characterize neuronal properties of discrete
            populations of zebrafish neurons
  JOURNAL   Development 140 (18), 3927-3931 (2013)
   PUBMED   23946442
REFERENCE   8  (bases 1 to 1292)
  AUTHORS   Wolf A and Ryu S.
  TITLE     Specification of posterior hypothalamic neurons requires
            coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2
  JOURNAL   Development 140 (8), 1762-1773 (2013)
   PUBMED   23533176
REFERENCE   9  (bases 1 to 1292)
  AUTHORS   Ariza-Cosano A, Visel A, Pennacchio LA, Fraser HB, Gomez-Skarmeta
            JL, Irimia M and Bessa J.
  TITLE     Differences in enhancer activity in mouse and zebrafish reporter
            assays are often associated with changes in gene expression
  JOURNAL   BMC Genomics 13, 713 (2012)
   PUBMED   23253453
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1292)
  AUTHORS   Siegel N, Hoegg S, Salzburger W, Braasch I and Meyer A.
  TITLE     Comparative genomics of ParaHox clusters of teleost fishes: gene
            cluster breakup and the retention of gene sets following whole
            genome duplications
  JOURNAL   BMC Genomics 8, 312 (2007)
   PUBMED   17822543
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC115063.1.
            
            On or before Jan 10, 2013 this sequence version replaced
            NM_001130724.1, NM_001025512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115063.1, BC164330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA4476735
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     gene            1..1292
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /note="GS homeobox 2"
                     /db_xref="GeneID:561076"
                     /db_xref="ZFIN:ZDB-GENE-041001-114"
     exon            1..485
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    62..64
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /note="upstream in-frame stop codon"
     CDS             98..826
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /codon_start=1
                     /product="GS homeobox 2"
                     /protein_id="NP_001020683.1"
                     /db_xref="GeneID:561076"
                     /db_xref="ZFIN:ZDB-GENE-041001-114"
                     /translation="

MSRSFYVDSLIIKDPARPTLSEHTAQDFLIPIGMHSPGVMSVTAPICPSRKTGTFCVCPLCVSSHIHSPRGGIPLLKGQGFTAGDAAFCQRMAHQQSPALAHPGHGHAPVCTPTSFSVTDPRRYHCLSLGASDNSHIQNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLSEKQVKIWFQNRRVKHKKEGKGTQRSAHAGCKCSGSHSHYPRSEDEESLSPVSATEEKETSPI"

     misc_feature    518..688
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            486..1273
                     /gene="gsx2"
                     /gene_synonym="gsh2; si:dkey-97c6.1; zgc:136270"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agttttgagaccactgggcactgcgcaagttcttggagcatcgccatcagtgcggtatcactgacaccatcagcatctcgctcagacaggagcaatcatgtcgaggtctttctacgtagactctttgattatcaaggatcccgcgcgcccaactctaagcgagcacacggcgcaggactttctcatccccattggcatgcactctcccggcgtgatgagcgtcactgcgcccatctgcccgtcccggaagaccggcactttttgcgtttgtccgctgtgcgtatcctcacacatccactctccccgcggcggaattccactgctcaagggacaaggcttcactgccggtgacgcggcgttctgccagaggatggcacaccaacagagccccgcgttagcgcaccctggacacggacacgcgcctgtctgcacgcccacaagcttcagcgtcactgaccctcggaggtatcactgcctgtctctaggtgcatctgacaacagccacatacagaacggcaaacggatgcgcacagccttcaccagcactcaactgctcgagttggagcgcgaattctcatctaacatgtacctctcacgcttacgcaggatcgaaatagccacatacctgaatctgtcagagaaacaagtgaaaatatggtttcaaaaccgacgcgttaagcacaagaaagaaggcaaaggtacgcaaaggagcgcgcacgcaggatgcaaatgctcgggcagccactcgcattatccgcgctcagaagacgaagaatccctgtcacctgtatcagccacagaggagaaggagacttcacctatttaggggcgtcacaaacattacagactacaattttgtaccatacgtggcacttttaaacggatcggatgaaactactgagtttatgggacgttgtcttctttccataacccaaagtgtgtggaggtttagtctgtattcccacaaactactgttttaccctgacactcaagttatatgtgtgttttatcaatgtttcactgtgacagaatactttttttacaggttgttttaagtgaattctggtaattcattgtcttccctgttctttaaagaataaactttggactcatgaagaagatgaaatatttcctgtttgatattgtaaatatgcagactgttaatcctagactactgagaagctgtgattttttttcatctgaattttatgtgcatattaatgaaaatgtgtatatttgtatttatttaaataaaaatacatctgtgactttaacaaaaaaaaaaaaaaaaa

//