LOCUS       NM_001004559            1873 bp    mRNA    linear   VRT 25-JAN-2026
DEFINITION  Danio rerio claudin 2 (cldn2), mRNA.
ACCESSION   NM_001004559 XM_685901
VERSION     NM_001004559.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Zhao,Y., Mei,X., Liu,Q., Yang,D. and Wang,Z.
  TITLE     beta-Glucan pretreatment mitigates Edwardsiella piscicida-induced
            enteritis through restoring gut microbiota-associated tyrosine
            metabolism in zebrafish
  JOURNAL   Fish Shellfish Immunol 167, 110873 (2025)
   PUBMED   40945627
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Zhang,F., Tian,J., Li,J., Zhang,T. and Wang,X.
  TITLE     ILA mitigates HFD-induced metabolic dysfunction via lipid-immune
            crosstalk and gut microbiota modulation in zebrafish
  JOURNAL   Fish Shellfish Immunol 167, 110683 (2025)
   PUBMED   40865746
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Yang,Y., Du,H., Pan,Y., Gong,P., Yang,Y., Wu,F., Pan,D., Xie,W.,
            Fu,Z. and Ni,Y.
  TITLE     Bifidobacterium animalis subsp. lactis LKM512 Alleviates
            Inflammatory Bowel Disease in Larval Zebrafish by Reshaping
            Microbiota
  JOURNAL   Biol Pharm Bull 46 (12), 1706-1713 (2023)
   PUBMED   37778980
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   El Mai,M., Bird,M., Allouche,A., Targen,S., Serifoglu,N.,
            Lopes-Bastos,B., Guigonis,J.M., Kang,D., Pourcher,T., Yue,J.X. and
            Ferreira,M.G.
  TITLE     Gut-specific telomerase expression counteracts systemic aging in
            telomerase-deficient zebrafish
  JOURNAL   Nat Aging 3 (5), 567-584 (2023)
   PUBMED   37142828
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   van den Bos,R., Cromwijk,S., Tschigg,K., Althuizen,J., Zethof,J.,
            Whelan,R., Flik,G. and Schaaf,M.
  TITLE     Early Life Glucocorticoid Exposure Modulates Immune Function in
            Zebrafish (Danio rerio) Larvae
  JOURNAL   Front Immunol 11, 727 (2020)
   PUBMED   32411141
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1873)
  AUTHORS   McKee,R., Gerlach,G.F., Jou,J., Cheng,C.N. and Wingert,R.A.
  TITLE     Temporal and spatial expression of tight junction genes during
            zebrafish pronephros development
  JOURNAL   Gene Expr Patterns 16 (2), 104-113 (2014)
   PUBMED   25460834
REFERENCE   8  (bases 1 to 1873)
  AUTHORS   Baltzegar,D.A., Reading,B.J., Brune,E.S. and Borski,R.J.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   9  (bases 1 to 1873)
  AUTHORS   Kumai,Y., Bahubeshi,A., Steele,S. and Perry,S.F.
  TITLE     Strategies for maintaining Na balance in zebrafish (Danio rerio)
            during prolonged exposure to acidic water
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 160 (1), 52-62 (2011)
   PUBMED   21600298
REFERENCE   10 (bases 1 to 1873)
  AUTHORS   Clelland,E.S. and Kelly,S.P.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000021.1.
            
            On or before Aug 5, 2009 this sequence version replaced
            XM_685901.2, NM_001004559.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081634.1, CF998858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JBMGRA010000021.1  41305980-41306129
            151-1873            JBMGRA010000021.1  41310888-41312610
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..1873
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="claudin 2"
                     /db_xref="GeneID:562525"
                     /db_xref="ZFIN:ZDB-GENE-040912-26"
     exon            1..150
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    110..112
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="upstream in-frame stop codon"
     exon            151..1873
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1006
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /codon_start=1
                     /product="claudin-2"
                     /protein_id="NP_001004559.2"
                     /db_xref="GeneID:562525"
                     /db_xref="ZFIN:ZDB-GENE-040912-26"
                     /translation="

MAILALELMGFFFGLIGMLGTLVATLLPYWATSAHVGPNIVTAVVSMKGLWMECVYQSTGAFQCETYNTLLGLTVDLQAARAMMVMSSIFSVMACAVSTVGMQCTVCMDGSSVKTKVAGVGGSMFLLAGLLSLIPVAWKTHEVVQTFYMPNMPASLKFEIGDCLYVGLASSLLSMLGGGLLSASCCDDIDGNRGSRRHYPYPERNALRGPSHSMTYQPAALHSTTNPNITNKTQTLNSHTSSGTHSIQAQDSRKMTRQNTAAGYDVTGYV"

     misc_feature    206..694
                     /gene="cldn2"
                     /gene_synonym="zgc:92260"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
ORIGIN      

cagaggtgcttgtgtgttcatggacggggcagatcctcatatctacagatcaacagagatggcaggatcacaaacagaaggactgtgggaaaacacaggcacatatgagtgaattaagagctgctggcaacacctcactgctgaacatagcaatccagcaaaacttcatcaaacacttcctccagcacacaacatggcgattctagcactggagttgatgggtttcttttttggcctcatcggcatgcttgggaccctggtagccactcttctcccctactgggcaacatctgcacacgttggccccaatattgtgaccgcagttgtcagcatgaagggtctttggatggagtgcgtttaccagagcactggcgccttccaatgcgagacttacaacaccctcctgggactaaccgtcgacctgcaagcggcccgggccatgatggtcatgtcctccatcttctccgtcatggcctgcgccgtttccaccgttggcatgcagtgcaccgtctgcatggacggatcttcagtcaagaccaaagtagctggagttggcggctccatgttcctcctggctgggcttttatcgttgattcccgtcgcctggaagacccacgaagtggtgcagaccttctacatgcccaacatgccagccagtcttaaatttgagattggcgattgtctgtatgtaggtttagcttcctctcttttgtccatgcttggtggcggactattgagtgcatcctgttgcgatgacatagatggaaacaggggatccagacggcattatccctatccagagcggaatgccttgcgtgggccgtcccattcaatgacctaccagccagccgctctacattcaaccacaaaccccaacattaccaataagacgcagactcttaatagtcacacaagctccggtacccactccattcaagcccaggattcaaggaaaatgactcggcaaaacactgcggctggctatgatgtcactggctatgtttgaagatttgtgtcggccagtgcagttgagttttacataaagtgattaatacttggattgctgaaaggctcagagaatgtagacgctggtagagcatgaggaagggtgtgtgtgtgtgaaggtctatgaggtgtgtttggcttcttttttgcataattgtcttttttaggagtttcaaaatgaaaacaaaatagcaaaatgatttaatgattgtatggattgaaggtggtttgtaaacacgcaagttaatattttagttgtcgtataagaagaaccgtgtcaattagccttcttaaagggatagttggcccaaaagagaaatttagcagctaatttaccctacctttaggtgtagtttttgttgattttgaaagaaatactgttcgtaaaaaaagcatggttctcgctgattcataaatggcaagtcgagttgcacttttagagtaaaaatatacttataggcaaagcaaaattaatacctgaggtactaaataaataagtagcctgtgctacctgttaatatctgatacagtaatgtctcgtgaagtgaaattatcagtctgtgcagcaaactgaacgttatttataccctagttttggctaaaaattttatttaacgtgctgctgaagaaaaatgtctcccactatattgtcctaaaggtgagtaaattaccggcaagagcgaactatccctttaagaacattttttatattcaaatgcttgttttttatgacatttaaatacattggttttatttgtttctaatagcagtcttcacttttcactgtttctaagcacctatatgcactcggttgagcacttaaggaacatattaaccttgtaaataaaattttgagttgtttactagt

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