LOCUS       XM_030358231            2924 bp    mRNA    linear   VRT 09-JUL-2025
DEFINITION  PREDICTED: Gadus morhua argonaute RISC component 1 (ago1),
            transcript variant X4, mRNA.
ACCESSION   XM_030358231
VERSION     XM_030358231.1
DBLINK      BioProject: PRJNA557709
KEYWORDS    RefSeq.
SOURCE      Gadus morhua (Atlantic cod)
  ORGANISM  Gadus morhua
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Neoteleostei;
            Acanthomorphata; Zeiogadaria; Gadariae; Gadiformes; Gadoidei;
            Gadidae; Gadus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_044053.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_902167405.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/09/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Gadus morhua"
                     /mol_type="mRNA"
                     /db_xref="taxon:8049"
                     /chromosome="6"
     gene            1..2924
                     /gene="ago1"
                     /note="argonaute RISC component 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 30 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:115545258"
     CDS             432..2924
                     /gene="ago1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X3"
                     /protein_id="XP_030214091.1"
                     /db_xref="GeneID:115545258"
                     /translation="

MEPGPSGAVPPVGAFPPPLQQVFQAPRRPGMGTVGKPIKLLANYFEVEIPKMDVFHYEVDIKPDKCPRRVNREVVEYMVQHFKPQLFGDRKPVYDGKKNIYTVLALPIGSEKVDFEVTIPGEGKDRIFKVSIRWLAKVSWRLLQEALVSGRMQVPLDSVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKTLTDSQRVRFTKEIKGGLLSSGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNANFNLDPYIQEFGIKVKDEMAEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSFMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKSERIGKSGNIPAGTTVDTSITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDR"

     misc_feature    537..929
                     /gene="ago1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    957..1109
                     /gene="ago1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    1110..1490
                     /gene="ago1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1284..1286,1329..1331,1371..1373,1383..1385,
                     1437..1439,1458..1460,1464..1466)
                     /gene="ago1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1623..2900
                     /gene="ago1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2034..2036,2046..2048,2082..2093,2100..2102,
                     2124..2126,2133..2135,2145..2147,2157..2159)
                     /gene="ago1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2238..2240,2244..2246,2454..2456,2868..2870)
                     /gene="ago1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ttgaatctttgggaggaggagaagaagcgtgggggtctgggggccttttttgttcggctggagagtcctgtctgagcggccagcaggagcacaacacaccgcatagggactgcatcttcaccaacactctgccactgcgttctccgctgaactgataaccgcccacaggatctatttgaacaccaccaccaggctcggaaacgtactgttactggcccttttggatcctgggtcaacctccaggttttatccgccgttagccagagtttttgctgcgggttctgggggtgtgttggacagcgggcgggcgttcagctgcacgctgcctggagggggctggaagtccgatccgctgccagcctgaagcggccggcgcggtggccgcagaacttggactagtcggcctgtatcctcgcagctaagtggatgggatggagccaggaccgtctggcgctgtgccccccgtgggggccttcccccctcccctgcagcaggtgttccaggcgccgcggagaccaggtatggggacggtggggaagcccatcaagctgctggccaactactttgaggtggagatccccaagatggacgtcttccactacgaggtcgacatcaagccggacaagtgcccccgcagggtcaacagagaggtggttgagtacatggtccaacacttcaagccacagctgtttggtgacaggaagccggtgtacgacgggaagaagaacatctataccgtgcttgcactccctatagggagcgagaaggtggactttgaggtgaccatcccaggcgagggaaaggaccggatcttcaaggtgtcgatccgctggctagccaaggtgtcctggcgtcttctgcaggaggcgctggtcagcgggcgaatgcaggttcccctcgactcagtccaggctctggacgtggccatgcgccacctggcctctatgaggtacaccccggtgggccgttcgttcttctcccccccagaggggtactaccaccccctgggggggggcagggaggtgtggttcggcttccatcagtctgtccgccccgccatgtggaagatgatgctcaacatcgacgtgtctgccaccgccttctacaaagcccagccggttattgagttcatgtgcgaggtcctggacatccgtaacatcgacgagcagcccaagaccctgaccgactctcagagagtccgcttcaccaaggagattaaaggtgggctcctgagcagtggtctgaaggtagaggtgacccactgtgggcagatgaagcggaagtaccgtgtgtgtaacgtcacacgccgcccggccagccaccagacgtttcccctgcagctagagagcggtcagacagtggagtgcacggtggcgcagtacttcaaacagaagtacaacctgcagctgaagtacccccacctgccctgtctgcaggtgggccaggagcagaaacacacctacctgcccctggaggtgtgtaacattgtagcaggccagcgctgcatcaagaagctgactgataaccagacctcgacgatgatcaaggccacggctcgctctgcccccgacagacaggaagagatcagccggctgatgaagaacgccaacttcaacctggacccgtacatccaggagtttgggatcaaggtgaaggacgagatggccgaggtgacgggccgggtgctgcctgcacccatcctgcagtatggaggccggaaccgggccatcgccacacccaaccagggggtgtgggacatgcgggggaagcagttctacaacggcatcgagatcaaggtgtgggcgatcgcctgcttcgccccgcagaaacagtgccgagaggaggtgctcaagaacttcacggaccagctgcgtaagatctccaaggacgctgggatgcccatccagggccagccgtgcttctgtaaatacgcccagggggccgacagcgtggagcccatgttcagacacctgaagaacacctacgccggcctgcagctcatcattgtcatcctgcccgggaagacccccgtctacgcggaggtgaagcgtgtgggagacaccctcctgggcatggccacgcagtgtgtccaggtgaagaacgtggtgaagacgtccccacagacgctgtccaacctctgcctcaagatcaacgtcaagctgggaggaatcaacaacatcctggtccctcaccaacgctcggctgtgttccagcagcctgttatcttcctgggagccgacgtcacccacccccctgctggggacggcaagaagccctccatcactgctgtggtaggcagtatggacgcccacccaagcaggtactgcgccacggtgcgcgtccagaggcccaggcaggagatcatcgaggacctgtccttcatggtgcgagagctcctgatccagttctacaagtccacccgcttcaagcccaccaggatcatcttctaccgggacggggttccagaaggacagctgccccagatcttacactacgagctgctggcgatccgggacgcctgcatcaagctggagaaggactaccagcccggcatcacctacatcgtggtccagaaacgccatcacacccgcctcttctgcgcagacaagtctgaacgaattggaaagagcgggaacattccagcaggaaccaccgtggacaccagcatcacacaccccttcgagttcgacttctacctgtgcagccacgctggaattcagggcaccagtcggccctcccattactacgtcctctgggacgacaaccgcttcacggcggacgagctgcagatcctcacctaccagctgtgccacacgtacgtccgctgcacgcgctccgtgtccatccccgcgccggcctactacgcacgtctggtcgccttccgcgcccgctaccacctggtggacaaggagcacgacaggtga

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