LOCUS       XM_023758506            2341 bp    mRNA    linear   MAM 26-JAN-2018
DEFINITION  PREDICTED: Myotis lucifugus argonaute 4, RISC catalytic component
            (AGO4), transcript variant X5, mRNA.
ACCESSION   XM_023758506
VERSION     XM_023758506.1
DBLINK      BioProject: PRJNA208947
KEYWORDS    RefSeq.
SOURCE      Myotis lucifugus (little brown bat)
  ORGANISM  Myotis lucifugus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
            Vespertilionidae; Myotis.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_005871179.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Myotis lucifugus Annotation Release
                                           102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Myotis lucifugus"
                     /mol_type="mRNA"
                     /db_xref="taxon:59463"
                     /chromosome="Unknown"
                     /sex="female"
                     /country="USA: Framingham, MA"
     gene            1..2341
                     /gene="AGO4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 6 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:102437202"
     CDS             150..2225
                     /gene="AGO4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform X4"
                     /protein_id="XP_023614274.1"
                     /db_xref="GeneID:102437202"
                     /translation="

MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQMLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEVSQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKAERMFLYALVYHPQLKITTGRMEPNKLPSNLCLDGK"

     misc_feature    159..413
                     /gene="AGO4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    444..596
                     /gene="AGO4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    597..959
                     /gene="AGO4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(753..755,798..800,840..842,852..854,906..908,
                     927..929,933..935)
                     /gene="AGO4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1098..>2123
                     /gene="AGO4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1509..1511,1521..1523,1557..1568,1575..1577,
                     1599..1601,1608..1610,1620..1622,1632..1634)
                     /gene="AGO4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
ORIGIN      

gtcctggccttggaactgttggaaaaccaattcgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcactatgatgtggatattaaaccagaaaaacggcctcgtagagtcaacagggaggtagtagatacaatggtgcggcacttcaagatgcaaatatttggtgatcggcagcctggctatgatggcaaaagaaacatgtacacagcacatccactgccaattggacgggatagggttgatatggaagtgacccttccaggtgagggtaaagaccaaacctttaaagtgtctgttcagtgggtgtccgttgtgagccttcagatgcttttagaagctttagccgggcacttgaatgaagtcccagatgactcagtacaagcacttgatgttattacaagacacctcccctccatgaggtacactccagtgggccgttcctttttctcgcctccggaaggttactaccaccctctgggagggggcagggaggtttggtttggctttcatcagtctgtgagacctgccatgtggaatatgatgctcaatattgatgtatctgcaactgctttctaccgggctcagcctatcattgagttcatgtgtgaggtattggacattcagaatatcaacgaacagaccaaacctctaacagactcccagcgtgtcaagtttaccaaagaaatcagaggtcttaaagttgaggtgactcactgtggacagatgaagcgaaaatatcgagtttgtaatgtaaccagacggccagccagtcatcaaacttttcctttacagctagaaaatggtcaagccatggaatgtactgtagctcaatattttaagcaaaagtatagtctgcagctgaaatatccccatcttccctgtctccaagtgggacaagaacaaaagcatacatacttgccacttgaggtctgtaatatagtggcaggacagcgatgtataaagaaacttacagacaatcagacttccacgatgatcaaagccacagcaagatctgctcctgacagacaggaagaaatcagtagactggtgaagagtaacagcatggtgggtggacctgatccataccttaaagaatttggtattgttgtccacaatgaaatgacagagctcacaggcagggtacttccagcaccaatgctacagtatggaggccggaataaaacagtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtttgggcagttgcttgttttgcgcctcagaaacaatgtagggaagatttactaaagagtttcactgaccagctccgtaaaatctctaaggatgcaggaatgcccatccagggccagccatgtttctgcaagtatgcacaaggtgcagacagcgtggagcctatgtttaaacatctgaaaatgacatatgtgggcctacagctaatagtggtgatcttgcctgggaagacaccagtatatgcggaggtgaaacgtgttggagataccctcctgggtatggccacccagtgtgtccaggtaaaaaatgtagtgaagacctcaccccagaccctttccaacctttgcctgaagataaatgcaaagcttggaggaattaacaacgtgcttgtacctcatcaaaggccatcagtgttccagcagcctgtcatcttcctgggagcagatgtcacccacccccctgcaggggacgggaagaagccttccattgctgctgttgttggcagtatggatggccaccccagccggtactgtgccactgttcgggtgcagacctcccgccaggaggtctcccaggagctcctctatagtcaggaggtgatccaggacctcactaacatggttcgagagctgctgatccagttctacaagtccacacgcttcaaacctacacggatcatctactaccgtggaggggtatccgagggacaaatgaagcaggtagcttggccagaactaatagcaattcgaaaggcatgtattagcttggaagaagattaccggccaggaataacctacattgtggtacagaaaagacatcacacacgactcttctgtgcggataaagcagaaaggatgttcttgtatgcattggtgtatcatcctcagctgaagataaccacagggagaatggagccaaataaactcccatcaaatttgtgcctagatggcaaataaaattcctcacatggaaccctgctgtacagcagaagagaatgaaaattgtccaaatagcaagatttaatttctttccttgtaaatgcatttctaaagttctccctctgcttttctag

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