LOCUS       XM_010901059            5480 bp    mRNA    linear   VRT 11-MAY-2020
DEFINITION  PREDICTED: Esox lucius argonaute RISC component 1 (ago1),
            transcript variant X6, mRNA.
ACCESSION   XM_010901059
VERSION     XM_010901059.4
DBLINK      BioProject: PRJNA629749
KEYWORDS    RefSeq.
SOURCE      Esox lucius (northern pike)
  ORGANISM  Esox lucius
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
            Esociformes; Esocidae; Esox.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_047588.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 11, 2020 this sequence version replaced XM_010901059.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Esox lucius Annotation Release 104
            Annotation Version          :: 104
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5480
                     /organism="Esox lucius"
                     /mol_type="mRNA"
                     /isolate="fEsoLuc1"
                     /db_xref="taxon:8010"
                     /chromosome="20"
                     /tissue_type="liver, spleen"
                     /dev_stage="adult"
                     /country="Czech Republic: Jihlava River, Danube basin"
                     /lat_lon="49.218 N 16.717 E"
                     /collection_date="29-Nov-2018"
                     /collected_by="Martin Reichard"
     gene            1..5480
                     /gene="ago1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 4 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 8 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:105028369"
     CDS             441..3050
                     /gene="ago1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X6"
                     /protein_id="XP_010899361.1"
                     /db_xref="GeneID:105028369"
                     /translation="

MEPGPSGAVPMGPFPPPLQQVFQAPRRPGMGTVGKPIKLLANYFEVEIPKMDVFHYEVDIKPDKCPRRVNREVVEYMVQHFKPQLFGDRKPVYDGKKNIYTVLALPIGSEKVDFEVTIPGEGKDRIFKVSIRFLATVSWRLLQETLVSGRLQVPLDSVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKTLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNANFNLDPYIQEFGIKVKDDMAEVTGRVLPAPILQYGGRLLSPTCSTSQNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKSERIGKSGNIPAGTTVDTSITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSSGEGSHVSGQSNGRDPQALAKAVQIHHDTLRTMYFA"

     misc_feature    543..935
                     /gene="ago1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    963..1115
                     /gene="ago1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    1116..1478
                     /gene="ago1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1272..1274,1317..1319,1359..1361,1371..1373,
                     1425..1427,1446..1448,1452..1454)
                     /gene="ago1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1611..2918
                     /gene="ago1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2052..2054,2064..2066,2100..2111,2118..2120,
                     2142..2144,2151..2153,2163..2165,2175..2177)
                     /gene="ago1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2256..2258,2262..2264,2472..2474,2886..2888)
                     /gene="ago1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gaatgcgacatcaatcaaaatggaagaaggggttccagaattcgtgtagaggggttggcccttttttgttcggctggagaatcctgcttgaacggggagcaggaacataacagaccgcccagaaagcatcgcgccacggacgatcctacatatcaggccgggcaacgggcgttcaacccaaaggagagtagacagagacacggtacggcactagagccgttcagacgtcggttctggactcataagatagctaggtagctcttgttgttacaactctgggggtactggaaggggtagggggcggaggtctagcgagtacggagaagcctacacgccgagaggagggggctggaagtctgcaacgcttccagcctgaaggggccggcgctgtggccatagaaccctggactgtctagagcccgcgcggctaagtggatgggatggagccgggaccgtctggcgctgtgcccatggggcccttccccccacccctgcagcaggtgttccaggcgccccgccggccaggcatgggcacggtgggcaaaccaatcaagctgctggccaactactttgaggtggagatccccaagatggatgtcttccactacgaggtggacatcaagcccgacaagtgcccccgacgggttaacagggaagtggtggaatacatggtgcaacacttcaagccccagctctttggcgacaggaaaccagtgtatgatggcaagaagaacatctatacggtgctagcacttcctatcggaagtgagaaggtggactttgaggtgaccattcccggggaggggaaggatcgtatcttcaaggtgtctatccgatttctggccacggtgtcatggcgtctgctccaagaaacgctggtcagcgggcgcctgcaggtacccctggactcggtccaggcgctggatgtggccatgcgccacctggcctccatgaggtacactcctgtaggacgatcgtttttctcccctccagaaggctactaccaccctctgggaggggggagggaggtgtggtttgggttccaccagtcggtacgacccgccatgtggaagatgatgctcaacattgacgtgtctgccacggccttttacaaagcccagccagtgatcgagttcatgtgtgaggtcctggacatccgcaacatagacgagcagcccaaaaccctgaccgactcgcagagggtccgcttcaccaaggagatcaaaggtctgaaggtggaggtgactcactgcggtcagatgaagaggaagtaccgggtctgcaacgtgacccggcgtcccgccagccaccagacgtttcccttgcagcttgagagtggccagactgtagaatgtacagtagcccagtacttcaagcagaagtacaatctccagctgaaatacccccacctcccctgccttcaggtgggccaggagcagaagcacacctacctacccctggaggtgtgtaacatcgtagcaggacaacggtgcatcaagaagctgaccgataatcagacgtccactatgatcaaagccacggctcgttctgcaccggacagacaggaggagatcagcagactgatgaagaatgccaactttaacctggacccgtacattcaggagtttgggatcaaggtgaaggatgacatggcggaggtgaccgggagagtgctgcccgcccccatccttcagtacggaggacggcttttgtctcccacctgttctacctcacagaaccgggccatcgcaactcccaaccagggggtgtgggacatgaggggcaaacaattttacaacggcattgagatcaaagtgtgggccatcgcttgcttcgccccccagaagcagtgtcgggaggaggtgctcaagaacttcaccgaccagctgcgtaagatctccaaggatgctgggatgcccatccagggccagccatgtttctgtaaatacgcccagggtgccgacagtgtggagcccatgttcaggcacctgaagaacacctactccggactccagctcatcatcgtcattctgcctggaaagaccccagtctatgcggaggtgaagagggttggagacaccctccttggaatggccactcagtgtgtccaggtgaagaacgttgtgaagacgtccccccaaaccctgtccaacctctgcctgaagatcaacgtcaagctggggggaatcaacaacattctggtgcctcaccaacggtcagcagtgttccagcagcctgtcatcttccttggggctgatgttacacaccccccggctggagacgggaagaagccctccatcactgctgtggtgggcagtatggacgcccaccccagcaggtactgtgccacagtgagggttcagaggcccaggcaggagatcatcgaggacctgtcttacatggtgcgagagctgctgatccagttctacaagtccacccgctttaagcccaccaggatcatcttctacagggacggagtgccagagggtcagctgccacagatcctccactatgagcttttggctatcagggatgcatgcatcaagctggagaaggactaccagcctggcatcacctacattgtggtccagaagcgtcaccatacccgcctcttctgtgccgacaagtcagagagaattgggaagagtgggaacattcctgcagggaccacggtggacaccagcattactcacccatttgagtttgacttctacctgtgcagtcacgcagggatacaggggacaagtcgtccttcgcattactacgttctttgggacgacaatcgtttcaccgctgacgagctgcaaatcctcacctaccagctgtgccacacctacgtgcgctgtacccgctccgtctcaatccccgcgccagcttactacgcccgcctcgtggccttccgtgctcgctaccatctggtggacaaggagcacgacagtagtggggagggcagccatgtctctggccagagcaacggtcgcgacccccaggctctggccaaggccgtgcagattcaccacgacaccctaaggaccatgtacttcgcctgagcaccacaccgccaccatgactgcccttaacacccagcgggcggccctctggtgaggggcttaggagtccacttgatgcctcactcctcagcttctcacaccttcggccaccgcagcaccagaaccatacttcgctcacctgaacgacccaggcagactgcagcgtcctgcactcagttattgttaatattattatttttgtttactttgccatgacagtgctctttttatgttgacttttaaaacaaatgggtattattgcagtgtatgcaaccttccacactgctatggaagtatgcaatatggaaggaaggaaaacgggctttgagacgccctgggacttcagactgccacaatgctgcctcttactggtccgcaccacggacaacagtgttctgtttccgagcctctggtacaactgggggtcacggggggtcccggagggcaacagaaagaacacacacttcttatctttttaaccttttatcatgacctctgttcttatgttgccgttgtgtttttttgttttatttttgccttaaggcacacggcgtgaggtatggtgcattagcacttagcagttagcatgtagacaacaccgccccaccctgcacctaatatgaagtttatctgtacgcgtgaggctagccctcggctcttggtagtagcagaatgaggagggcaggtacaacttatgctacacgtgtgcaggacacgtagtcctcccacatgatacctgtgcaggttggggaggtccctcttgcctagagaattatctaatagagagaggcaaatgtagacgttagatggaccattgcatcgagtgtattaaatatacttgcacctcgtgcacataagccagcattctgaatgagcaaatgggatgccaaccaacagaacaggggcacttacataaacacaatggggggggggttcattcccccacgccacacacacacacacacttagtaacataattcatgttcttacacataaaacctctctaagcttgctgaacctttcgagtaacagtagcaatacaaggtagcagcagaccgacgtgggccagagagcgccatggtgttcgtctctcaccttgggcactcagccttggctgtaccgcctccagcacattctgtcttcacagtccgccgtgttgtcagtggagacgacgtccacacttaacgcaccacgatgtggcgtacacctacacacacacacacactgatactgtcagaacacttagccccgctcccttattttgtacatagctcctcttcctacctaaaggcattgaccacggcaactgggacacaagcgcgctcatgcctcctcaaccgctctgtcgtgctcgtacttaagagagtaccgagccgcctccacacatgtccttgccccattgaaagcccccacataaacacttgcgccctccttctgacacccccatcctctttcctaggcatacccttcatcgttggccactcccctcagcctagtggacaatccccattggtgcgctgtgtgcatggacaacacagatacggggttttctacgaaggttatgggggtttctcccttaatatgtcctgccttcacttctggtcactttctggctttatgatacgcatgcaacattatttttttattattgtgactggatattctgagccaccttatttcagttttcctagtgataggagcttattacgctcacttcttctgcctgtcagtcatagcttcaattgtgtaaatggcgtttctgaaaggctgctttttgtgttctgtattgtagtgagtagtgtcagagtgtatcctcaagggggtgctacctttcccttgttgccctcaaacgcctcaaatcatgtctgttgggttgtagagctcctttttgtcggaagcgatcaacgatagagattcaatgatatgccagattttttttgacacatgttaatgaacttgcgtaatcaaaatgcctttgtacaccattttactgaccccatgtgtccaaggtgatttgtatataacctataatgtattttggctcatcaatgtagcagggcctttgcagttggggttagtctccctcacccaccccctctgttaaaatgtcaggctcgggaagcccagttccactgatccagatacagttcgtaacttaatttactgaagccacaaagcaccttgcaaccggggagagcaacaatatggaattaccctggaaaaagcatcatgatgagaaatccgctccacccagcctcactgactaagcaatataaaagccactgatcaggaacagtccttgtcatagcacttcccaatagattgatgaagggacatggaataatgttattttggctctgtatgatgtaagagtatggggctctgttggggagggctattttttaaagaaaataaatttgttttttatta

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