LOCUS       NM_031700               1501 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus claudin 3 (Cldn3), mRNA.
ACCESSION   NM_031700
VERSION     NM_031700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer
            S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE
            and Haseloff RF.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Wang J, Chen J, Tang Z, Li Y, Hu L and Pan J.
  TITLE     The Effects of Copper on Brain Microvascular Endothelial Cells and
            Claudin Via Apoptosis and Oxidative Stress
  JOURNAL   Biol Trace Elem Res 174 (1), 132-141 (2016)
   PUBMED   27038183
  REMARK    GeneRIF: identified four claudin isoforms (1, 3, 5, and 12) and
            showed that their expression levels were regulated as a group by
            copper
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA and
            Rizzolo LJ.
  TITLE     Claudin-3 and claudin-19 partially restore native phenotype to
            ARPE-19 cells via effects on tight junctions and gene expression
  JOURNAL   Exp Eye Res 151, 179-189 (2016)
   PUBMED   27593915
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M and Gunzel D.
  TITLE     Probing the cis-arrangement of prototype tight junction proteins
            claudin-1 and claudin-3
  JOURNAL   Biochem J 468 (3), 449-458 (2015)
   PUBMED   25849148
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Martinez CA, de Campos FG, de Carvalho VR, de Castro Ferreira C,
            Rodrigues MR, Sato DT and Pereira JA.
  TITLE     Claudin-3 and occludin tissue content in the glands of colonic
            mucosa with and without a fecal stream
  JOURNAL   J Mol Histol 46 (2), 183-194 (2015)
   PUBMED   25649016
  REMARK    GeneRIF: Colonic glands without a fecal stream showed a reduction
            in claudin-3 content independent of the time and reduction in
            occludin content after 12 weeks of intestinal exclusion.
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Rahner C, Mitic LL and Anderson JM.
  TITLE     Heterogeneity in expression and subcellular localization of
            claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut
  JOURNAL   Gastroenterology 120 (2), 411-422 (2001)
   PUBMED   11159882
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Furuse M, Sasaki H and Tsukita S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Kubota K, Furuse M, Sasaki H, Sonoda N, Fujita K, Nagafuchi A and
            Tsukita S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Morita K, Furuse M, Fujimoto K and Tsukita S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   10 (bases 1 to 1501)
  AUTHORS   Briehl MM and Miesfeld RL.
  TITLE     Isolation and characterization of transcripts induced by androgen
            withdrawal and apoptotic cell death in the rat ventral prostate
  JOURNAL   Mol Endocrinol 5 (10), 1381-1388 (1991)
   PUBMED   1723140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000227.1 and BC062411.1.
            
            On Nov 23, 2005 this sequence version replaced NM_031700.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC062411.1, M74067.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JACYVU010000227.1  2979376-2979750     c
            376-1501            BC062411.1         1-1126
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1501
                     /gene="Cldn3"
                     /note="claudin 3"
                     /db_xref="GeneID:65130"
                     /db_xref="RGD:68425"
     exon            1..1473
                     /gene="Cldn3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    348..350
                     /gene="Cldn3"
                     /note="upstream in-frame stop codon"
     CDS             441..1100
                     /gene="Cldn3"
                     /note="RVP1; ventral prostate.1 protein"
                     /codon_start=1
                     /product="claudin-3"
                     /protein_id="NP_113888.2"
                     /db_xref="GeneID:65130"
                     /db_xref="RGD:68425"
                     /translation="

MSMGLEITGTSLAVLGWLCTIVCCALPMWRVSAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKMYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDETAKAKITIVAGVLFLLAAVLTLVPVSWSANTIIRDFYNPLVPEAQKREMGTGLYVGWAAAALQLLGGALLCCSCPPREKYAPTKILYSAPRSTGPGTGTGTAYDRKDYV"

     misc_feature    447..941
                     /gene="Cldn3"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
     misc_feature    465..527
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    681..743
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    786..848
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    924..986
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     transmembrane region"
     misc_feature    1029..1031
                     /gene="Cldn3"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site"
     misc_feature    1032..1034
                     /gene="Cldn3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q63400.2); phosphorylation site"
     misc_feature    1092..1097
                     /gene="Cldn3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63400.2);
                     Region: Interactions with TJP1, TJP2 and TJP3.
                     /evidence=ECO:0000250"
ORIGIN      

ccccatccccacccacacgcacacacatatatagttctgcattgaggttggttctagctaattcctttctcccatggtgaagagggttggggagtaccgatcggactggacgggacacacgtcactgtcccctgggccagaagagcgagctccgccctcctcctctgggcaccaagctaagtccaacccaccccatcccagagccaacccagtctcagaaagacgtctccaaagccacaggcaggtgcaggggcagtctccgtgcgagccccgggaaaggagccgttagcgtgctccgtccattgccatccaccggtcgttcccggcgacagacctccgtcaacttttgaaggggagttggttctcaggtccagcggccgcgatccctggtctcccagcctacggagttacccggcggagccggttcaagtccagcagccatgtccatgggcctggagatcaccggcacgtcgctggccgtgctgggctggctgtgcaccatcgtgtgctgcgcccttcccatgtggcgcgtttcggcattcatcggcagcagcatcatcacggcgcagatcacctgggaaggcctgtggatgaactgcgtggtgcagagcaccggccagatgcagtgcaagatgtacgactcgctgctggccctgccgcaggacctccaggccgcccgagctctcatcgtggtgtctatcctactggcagccttcgggctcctcgtggcgctcgtgggggcccagtgtaccaactgcgtacaagatgagacggccaaggccaagatcaccatcgtggcgggagtgcttttcctgttggcggctgtgctcaccttagtgccggtgtcctggtccgccaacaccatcatccgggatttttataacccgctggtacctgaggcccagaagcgagagatgggaactgggttgtacgtgggctgggctgccgccgcgctgcaattgctagggggcgccttgctgtgttgctcctgcccaccacgcgagaagtacgcacccaccaagatcctctattccgcgccgcgatccaccggccctggcaccggtaccggcaccgcctatgaccgtaaggactacgtctgagaggccgggtgcgcgcacaccgcaccatcaccactaccaaccgtcgatgtaccccacccgtccagcgtgcagcctcgcctcagagaccaccccaccttccagatggttacagacgccacgcagtctgcttgctaggctggaagaggacagacagcctggcgtccccttttctccggttgccacctgattacctggcctaggaactgtccaagtcgaatggacaaagacacctcgcccttcccaagtacagggttggggtggccatcgcagctacttgccagccccgcagccagaaggctcatagtgggcagagacaggcaaactataaaaagggccgtttcgtatttttcaataaaagcctttcgtttttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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