LOCUS       NM_001194972            2586 bp    mRNA    linear   MAM 20-FEB-2022
DEFINITION  Sus scrofa argonaute RISC component 4 (AGO4), mRNA.
ACCESSION   NM_001194972
VERSION     NM_001194972.1
KEYWORDS    RefSeq.
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Zhou X, Guo H, Chen K, Cheng H and Zhou R.
  TITLE     Identification, chromosomal mapping and conserved synteny of
            porcine Argonaute family of genes
  JOURNAL   Genetica 138 (7), 805-812 (2010)
   PUBMED   20454920
  REMARK    GeneRIF: Data show that Ago4- Ago1-Ago3 genes are linked together
            at the p12 of the chromosome 6, while Ago2 is located at the p15 of
            the chromosome 4.
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D,
            Hamasima N and Awata T.
  TITLE     PEDE (Pig EST Data Explorer) has been expanded into Pig Expression
            Data Explorer, including 10 147 porcine full-length cDNA sequences
  JOURNAL   Nucleic Acids Res. 35 (Database issue), D650-D653 (2007)
   PUBMED   17145712
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H,
            Okumura N, Hamasima N and Awata T.
  TITLE     PEDE (Pig EST Data Explorer): construction of a database for ESTs
            derived from porcine full-length cDNA libraries
  JOURNAL   Nucleic Acids Res. 32 (Database issue), D484-D488 (2004)
   PUBMED   14681463
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from GQ329717.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ329717.1, SRR5275321.371397.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103886111, SAMEA103886115
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Sus scrofa"
                     /mol_type="mRNA"
                     /db_xref="taxon:9823"
                     /chromosome="6"
                     /map="6"
     gene            1..2586
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="argonaute RISC component 4"
                     /db_xref="GeneID:100499507"
     CDS             1..2586
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="eukaryotic translation initiation factor 2C, 4;
                     argonaute 4, RISC catalytic component; argonaute RISC
                     catalytic component 4"
                     /codon_start=1
                     /product="protein argonaute-4"
                     /protein_id="NP_001181901.1"
                     /db_xref="GeneID:100499507"
                     /translation="

MEAVGPGPPTSLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVNIEPEKRPRRVNREVVDTMVRHFKIQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVRTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    76..465
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    496..648
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    649..1011
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(805..807,850..852,892..894,904..906,958..960,
                     979..981,985..987)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1150..2457
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1561..1563,1573..1575,1609..1620,1627..1629,
                     1651..1653,1660..1662,1672..1674,1684..1686)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1765..1767,1771..1773,2011..2013,2425..2427)
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /note="active site"
                     /db_xref="CDD:240015"
     exon            1..19
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            20..185
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            186..306
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            307..488
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            489..625
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            626..760
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            761..848
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            849..996
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1116
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1245
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1379
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1564
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1724
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..2040
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2175
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2277
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2477
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2586
                     /gene="AGO4"
                     /gene_synonym="EIF2C4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atggaagcagtgggacccggacctccaactagcctgtttcagccacctcgtcgtcctggccttggaactgtcggaaaaccaattcgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcattatgatgtgaatatcgaaccagaaaaacggcctcgtagagtcaacagggaggtagtagatacaatggtgcggcactttaagatccaaatatttggtgatcggcagcctggctatgatggcaaaagaaatatgtacacagcacatccactgccaattggacgggatagggtcgatatggaagtgacccttccaggcgagggtaaagaccagacctttaaagtgtctgttcagtgggtgtcagttgtgagtcttcagttgcttttagaagctttggccgggcacttgaatgaagtcccagatgactcagttcaagcacttgatgttatcacaagacaccttccctccatgaggtacactccagtgggtcgctcctttttctcacctcctgaaggttattaccatcctctgggaggaggtagagaggtttggtttggctttcatcagtctgtgagacctgccatgtggaatatgatgctcaatattgatgtatctgcaactgctttctacagggctcagcctatcattgagttcatgtgtgaggttttagacattcagaacatcaatgaacagaccaaacctctaacagactcccagcgtgtcaaatttaccaaagaaatcagaggtcttaaagttgaggtgacccactgtggacagatgaaacgcaaatatcgagtttgtaatgtgactagacggccagccagtcatcaaacttttcccttacagctagaaaacggtcaagctatggaatgtacagtagctcaatattttaagcaaaagtatagtctgcagctgaaatacccccatcttccctgtctccaagtaggacaagaacaaaagcatacatacttgccacttgaggtctgtaatattgtggcagggcagcgatgtataaagaagctcacggacaatcagacttccacgatgatcaaagccacagcacgatccgctcctgacagacaggaagaaatcagtagactggtgaagagtaacagcatggtgggtggacctgatccataccttaaagagtttggtattgttgtccacaatgaaatgacagagctcacaggcagggtccttccagcaccaatgctgcagtatggaggccggaataaaacggtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtttgggcagttgcttgttttgcgcctcagaaacaatgtagggaagatttactaaagagtttcactgaccaactccgtaaaatctctaaggatgcaggaatgcccatccagggtcaaccatgtttttgcaagtatgcccaaggtgcagacagcgtggagcccatgtttaaacacctgaaaatgacatatgtgggcctacagctaatagtggttattttgcctggaaagacaccagtatatgcggaggtgaaacgtgttggagatactctcttgggtatggctacacagtgtgtccaggtaaaaaatgtcgtgaggacttcacctcagaccctttctaacctttgcctgaagataaatgcaaagcttggaggaatcaacaatgtgcttgtacctcatcaaaggccttcggtgttccagcagcctgtcatcttcctgggagcagatgtcacgcaccccccagcaggggatggcaagaagccttccatcgccgctgttgttggcagtatggatggccaccccagccggtactgtgctactgttcgggtgcagacctctcgccaggagatctcccaggagctcctctatagtcaggaggtaatccaggacctcactaacatggttcgagagctgctgattcagttctacaaatccacacgcttcaaacccactcggatcatctattaccgtggaggggtatccgagggacagatgaaacaggtagcttggccagaactaatagcaattcgaaaagcatgtattagcttggaagaagattatcggccaggaataacctatattgtggttcagaaaagacatcacacaagactcttctgtgcggataaaacagaaagggtggggaaaagtggcaacgtaccagcaggcactactgtggacagcaccatcacacatccatctgagtttgacttttacctctgtagtcatgcaggaattcagggaaccagccgtccgtcacattaccaggtcttgtgggatgacaactgcttcactgcagatgagctccagttactaacttaccagctgtgtcatacttatgtgcggtgcacacgctcagtctctattccagcccctgcctattatgcccggcttgtagcattcagggcacggtatcatctggtggataaagatcacgacagtgcggaaggcagtcacgtgtcaggacagagcaacggccgagatcctcaggccttggccaaagccgtgcagatccaccatgatacccagcacacgatgtattttgcctga

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