LOCUS       NM_214736               1228 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio calmodulin 2b, (phosphorylase kinase, delta) (calm2b),
            mRNA.
ACCESSION   NM_214736
VERSION     NM_214736.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Shim H, Kim JH, Kim CY, Hwang S, Kim H, Yang S, Lee JE and Lee I.
  TITLE     Function-driven discovery of disease genes in zebrafish using an
            integrated genomics big data resource
  JOURNAL   Nucleic Acids Res 44 (20), 9611-9623 (2016)
   PUBMED   27903883
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Hu P, Liu M, Liu Y, Wang J, Zhang D, Niu H, Jiang S, Wang J, Zhang
            D, Han B, Xu Q and Chen L.
  TITLE     Transcriptome comparison reveals a genetic network regulating the
            lower temperature limit in fish
  JOURNAL   Sci Rep 6, 28952 (2016)
   PUBMED   27356472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Bugel SM, Wehmas LC, La Du JK and Tanguay RL.
  TITLE     Phenotype anchoring in zebrafish reveals a potential role for
            matrix metalloproteinases (MMPs) in tamoxifen's effects on skin
            epithelium
  JOURNAL   Toxicol Appl Pharmacol 296, 31-41 (2016)
   PUBMED   26908177
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   Covacu R, Philip H, Jaronen M, Almeida J, Kenison JE, Darko S, Chao
            CC, Yaari G, Louzoun Y, Carmel L, Douek DC, Efroni S and Quintana
            FJ.
  TITLE     System-wide Analysis of the T Cell Response
  JOURNAL   Cell Rep 14 (11), 2733-2744 (2016)
   PUBMED   26972015
REFERENCE   5  (bases 1 to 1228)
  AUTHORS   Wu M, Wu D, Wang C, Guo Z, Li B and Zuo Z.
  TITLE     Hexabromocyclododecane exposure induces cardiac hypertrophy and
            arrhythmia by inhibiting miR-1 expression via up-regulation of the
            homeobox gene Nkx2.5
  JOURNAL   J Hazard Mater 302, 304-313 (2016)
   PUBMED   26476318
REFERENCE   6  (bases 1 to 1228)
  AUTHORS   Maugars G and Dufour S.
  TITLE     Demonstration of the Coexistence of Duplicated LH Receptors in
            Teleosts, and Their Origin in Ancestral Actinopterygians
  JOURNAL   PLoS One 10 (8), e0135184 (2015)
   PUBMED   26271038
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1228)
  AUTHORS   Wang Z, Du J, Lam SH, Mathavan S, Matsudaira P and Gong Z.
  TITLE     Morphological and molecular evidence for functional organization
            along the rostrocaudal axis of the adult zebrafish intestine
  JOURNAL   BMC Genomics 11, 392 (2010)
   PUBMED   20565988
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1228)
  AUTHORS   Sato Y, Hashiguchi Y and Nishida M.
  TITLE     Temporal pattern of loss/persistence of duplicate genes involved in
            signal transduction and metabolic pathways after teleost-specific
            genome duplication
  JOURNAL   BMC Evol Biol 9, 127 (2009)
   PUBMED   19500364
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1228)
  AUTHORS   Friedberg F and Taliaferro L.
  TITLE     Calmodulin genes in zebrafish (revisited)
  JOURNAL   Mol Biol Rep 32 (1), 55-60 (2005)
   PUBMED   15865211
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054600.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054600.1, EH453656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..1228
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /note="calmodulin 2b, (phosphorylase kinase, delta)"
                     /db_xref="GeneID:192322"
                     /db_xref="ZFIN:ZDB-GENE-020415-2"
     exon            1..43
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    2..4
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /note="upstream in-frame stop codon"
     CDS             41..490
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /EC_number="2.7.11.19"
                     /note="CaM alpha 2; calmodulin 2, beta (phosphorylase
                     kinase, delta); CALMx5; calmodulin 2 (phosphorylase
                     kinase, delta)"
                     /codon_start=1
                     /product="calmodulin 2b, (phosphorylase kinase, delta)"
                     /protein_id="NP_999901.1"
                     /db_xref="GeneID:192322"
                     /db_xref="ZFIN:ZDB-GENE-020415-2"
                     /translation="

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"

     misc_feature    41..487
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /note="calmodulin; Provisional; Region: PTZ00184"
                     /db_xref="CDD:185504"
     exon            44..74
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
     exon            75..218
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
     exon            219..325
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
     exon            326..461
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
     exon            462..1137
                     /gene="calm2b"
                     /gene_synonym="calm2; cb169; zgc:64036"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtaacggagaaggagggagacagacggagatcaagcaaaaatggccgatcaactcacagaagagcaaatagctgagttcaaagaggcgttttcgctatttgacaaagatggagatgggacaatcaccacgaaagaactgggtactgtcatgcgctccctgggccagaaccctacagaagcggagctgcaggatatgattaatgaggtggacgcagacgggaatggaacaatagattttcccgagttcttgacgatgatggcaagaaaaatgaaagataccgacagtgaggaggagatcagagaagctttccgtgtctttgataaggacggcaatggctacattagtgcggctgaactgcgtcatgtaatgacaaacttgggggagaaattaacagacgaggaggtggacgaaatgattagggaagcagacattgatggagacggtcaggtcaattatgaagaatttgtacagatgatgacagcaaagtgaaagccttgtacagaatttcttgtataaaataatttgccttttcttgtttttaatttctgtaaaatgtttcattttaatttcccccctcatcctctcctgctgtccaaaggatctgcatgtatactataagatttgagtgctcatgccttcccccaactcttagccattgtaaacggtctattcgaaggagcaattctgggaccaggtgataacatttaggcacagatagatactgactacgcacagacatcttcttccccttctgttgctctgtctgcctgcccacctgacgatcgatgacatcaagggtccagctgactgacagtgtggcgtcatttcaacagttttggcatgattcttttttccactcttttggttttatgtggaggtgcaactctgcatggacaatggactgagttgaaaaagaaatgggaaacgtcctcagcattgcactattgcaacatcattcaactaacgggtttatcgccagatatattcattcactctaatctttttgtatttgttctgttcttactatgctttttaattagtcacttttcttttgtaactgcttaaggcacagccatgcctcagaatccattccaagttgtatatttgttttccaataaaattaacaatttacccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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