LOCUS       NM_213401               1029 bp    mRNA    linear   VRT 19-OCT-2024
DEFINITION  Danio rerio stathmin-like 4 (stmn4), mRNA.
ACCESSION   NM_213401
VERSION     NM_213401.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Jing,Y., Luo,Y., Li,L., Liu,M. and Liu,J.X.
  TITLE     Deficiency of copper responsive gene stmn4 induces retinal
            developmental defects
  JOURNAL   Cell Biol Toxicol 40 (1), 2 (2024)
   PUBMED   38252267
  REMARK    GeneRIF: Deficiency of copper responsive gene stmn4 induces retinal
            developmental defects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Li,L., Tai,Z., Liu,W., Luo,Y., Wu,Y., Lin,S., Liu,M., Gao,B. and
            Liu,J.X.
  TITLE     Copper overload impairs hematopoietic stem and progenitor cell
            proliferation via prompting HSF1/SP1 aggregation and the
            subsequently downregulating FOXM1-Cytoskeleton axis
  JOURNAL   iScience 26 (4), 106406 (2023)
   PUBMED   37009226
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Lin,M.J. and Lee,S.J.
  TITLE     Stathmin-like 4 is critical for the maintenance of neural
            progenitor cells in dorsal midbrain of zebrafish larvae
  JOURNAL   Sci Rep 6, 36188 (2016)
   PUBMED   27819330
  REMARK    GeneRIF: These results suggest that the Wnt-mediated Stmn4
            homeostasis is crucial for preventing dorsal midbrain from
            premature differentiation via the G2 phase control during the
            neural keel stage.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Cardoso,J.C., Bergqvist,C.A., Felix,R.C. and Larhammar,D.
  TITLE     Corticotropin-releasing hormone family evolution: five ancestral
            genes remain in some lineages
  JOURNAL   J Mol Endocrinol 57 (1), 73-86 (2016)
   PUBMED   27220618
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Li,S., Yin,M., Liu,S., Chen,Y., Yin,Y., Liu,T. and Zhou,J.
  TITLE     Expression of ventral diencephalon-enriched genes in zebrafish
  JOURNAL   Dev Dyn 239 (12), 3368-3379 (2010)
   PUBMED   21061380
  REMARK    GeneRIF: Data revealed that expression of DNA binding inhibitor 3,
            early B cell factor 2, Ebf3, Iroquois related homeobox 1,
            Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein
            7 and stathmin-like 4,were enriched in the diencephalon of
            zebrafish.
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Sundstrom,G., Dreborg,S. and Larhammar,D.
  TITLE     Concomitant duplications of opioid peptide and receptor genes
            before the origin of jawed vertebrates
  JOURNAL   PLoS One 5 (5), e10512 (2010)
   PUBMED   20463905
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059583.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505385, SAMEA3505392
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="wild type"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     gene            1..1029
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /note="stathmin-like 4"
                     /db_xref="GeneID:406710"
                     /db_xref="ZFIN:ZDB-GENE-040426-2732"
     exon            1..35
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     exon            36..91
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    43..45
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /note="upstream in-frame stop codon"
     CDS             79..645
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /codon_start=1
                     /product="stathmin-4"
                     /protein_id="NP_998566.1"
                     /db_xref="GeneID:406710"
                     /db_xref="ZFIN:ZDB-GENE-040426-2732"
                     /translation="

MTLAAYRDKVKELPLVSLLCSCINSNRAENPTYKAEDAVDLNWCVIKEMEVIELNKRTSGQAFEVILKPPSFDVAPELNTSIPQRKDPSLEEIQKKLEAAEERRKFQEAEMLKHLAEKREHEREVIQKAFEENNNFIKNAKEKLEQRMEANKENREALLAAMLERLQEKDKHAEEVRKNKELKEEACR"

     misc_feature    223..624
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /note="Stathmin family; Region: Stathmin; pfam00836"
                     /db_xref="CDD:459956"
     exon            92..187
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     exon            188..393
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     exon            394..585
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     exon            586..683
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1012
                     /gene="stmn4"
                     /gene_synonym="wu:fj44e06; zgc:73243"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gggagatcgggacaacacctcatcaaagagaaaaggacagagtgaagacttcttaacttaacacaattctgcttaaacatgaccttggcagcatatcgagacaaggtgaaggagctccctctagtgtcacttctgtgctcctgcatcaactcaaaccgtgcagaaaaccccacatacaaggccgaggatgcggtggatctcaactggtgtgtgatcaaagagatggaggtcattgagctgaacaagcggacctcgggacaggcttttgaggtgatcctgaaacccccttcctttgatgttgcacccgagcttaacacatccattccccagcgtaaagacccgtcgctggaggagatccaaaagaaactggaagcagccgaggagaggcggaagttccaggaggccgagatgttgaagcatcttgctgagaagagagagcatgagcgagaggtcattcagaaggcctttgaggagaacaacaacttcattaagaatgctaaagaaaagctggagcagaggatggaggccaacaaagagaaccgcgaggctttgcttgctgccatgctggagaggctacaggaaaaggacaaacacgcagaggaggtgaggaagaacaaagagctgaaggaggaggcctgtcggtagaggagcgagcacttcagctgatgaaaaccaagcaaacggtgctgcagaagacgtgaatggtcacttacgtccaagtcctgtctcttcacacacacaagattgaacagatgttgtccgctgcacccactgttatgaacaaacctccagtcagtgctagcattttcagagattgaagcttactgaatctctgcacacttactgtgcttttgttgttattaaatggtcgggctgaacttttaaaagtttaaaagtcttaattataaagtttaataattcatatttctatatattttgtacttctggtagcttttcagttcggtagctgattgtgacatagcctgtttaaaataaagaggaaaagcaagcaaaaaaaaaaaaaaaaaa

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