LOCUS       NM_205740               1721 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio BarH-like homeobox 2 (barhl2), mRNA.
ACCESSION   NM_205740 XM_001336612
VERSION     NM_205740.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Soto,X., Burton,J., Manning,C.S., Minchington,T., Lea,R., Lee,J.,
            Kursawe,J., Rattray,M. and Papalopulu,N.
  TITLE     Sequential and additive expression of miR-9 precursors control
            timing of neurogenesis
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36189829
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Zhang,H., Wang,H., Shen,X., Jia,X., Yu,S., Qiu,X., Wang,Y., Du,J.,
            Yan,J. and He,J.
  TITLE     The landscape of regulatory genes in brain-wide neuronal phenotypes
            of a vertebrate brain
  JOURNAL   Elife 10, e68224 (2021)
   PUBMED   34895465
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Tambalo,M., Mitter,R. and Wilkinson,D.G.
  TITLE     A single cell transcriptome atlas of the developing zebrafish
            hindbrain
  JOURNAL   Development 147 (6) (2020)
   PUBMED   32094115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Farnsworth,D.R., Saunders,L.M. and Miller,A.C.
  TITLE     A single-cell transcriptome atlas for zebrafish development
  JOURNAL   Dev Biol 459 (2), 100-108 (2020)
   PUBMED   31782996
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Hong,S.K., Tsang,M. and Dawid,I.B.
  TITLE     The mych gene is required for neural crest survival during
            zebrafish development
  JOURNAL   PLoS One 3 (4), e2029 (2008)
   PUBMED   18446220
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Gongal,P.A. and Waskiewicz,A.J.
  TITLE     Zebrafish model of holoprosencephaly demonstrates a key role for
            TGIF in regulating retinoic acid metabolism
  JOURNAL   Hum Mol Genet 17 (4), 525-538 (2008)
   PUBMED   17998248
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Scholpp,S., Foucher,I., Staudt,N., Peukert,D., Lumsden,A. and
            Houart,C.
  TITLE     Otx1l, Otx2 and Irx1b establish and position the ZLI in the
            diencephalon
  JOURNAL   Development 134 (17), 3167-3176 (2007)
   PUBMED   17670791
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Staudt,N. and Houart,C.
  TITLE     The prethalamus is established during gastrulation and influences
            diencephalic regionalization
  JOURNAL   PLoS Biol 5 (4), e69 (2007)
   PUBMED   17341136
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Colombo,A., Reig,G., Mione,M. and Concha,M.L.
  TITLE     Zebrafish BarH-like genes define discrete neural domains in the
            early embryo
  JOURNAL   Gene Expr Patterns 6 (4), 347-352 (2006)
   PUBMED   16448861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY145141.1.
            
            On Feb 21, 2008 this sequence version replaced XM_001336612.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY145141.1, BC097030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="6"
                     /map="6"
     gene            1..1721
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /note="BarH-like homeobox 2"
                     /db_xref="GeneID:100001699"
                     /db_xref="ZFIN:ZDB-GENE-050913-153"
     exon            1..955
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    364..366
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /note="upstream in-frame stop codon"
     CDS             400..1494
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /note="barH-class homeodomain transcription factor;
                     BarH-like 2"
                     /codon_start=1
                     /product="barH-like 2 homeobox protein"
                     /protein_id="NP_991303.1"
                     /db_xref="GeneID:100001699"
                     /db_xref="ZFIN:ZDB-GENE-050913-153"
                     /translation="

MEGSSGASFGIDTILSTTNSGTSVLMNGDFRLGDSSRTADFRSQATPSPCSEIDTVGTAPSSPISVTMEHPEPHLVQDSLQHHHHHHHHSQAQSLQLSPQPHLLGQAGCAPRTATSSFLIKDILGDSKPLAACAPYSTSVPSPHHSPKTESGTAPDGIRPKLEQDENRSKLDKRDDIQSDLKCLNGTKEEGDREISSSRDSPPVRSKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGTVDSTTAAAAAAAMYSSMYRTPSTPHPSLQRPLVPRVLIHGLGPGGQPALNPIPNPIPGTPHAR"

     misc_feature    1027..1197
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            956..1181
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1711
                     /gene="barhl2"
                     /gene_synonym="B-H2; wu:fq39g04; zgc:113948"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgtcgaggagttagagcatcccaatctctccacacctcaactttgaaagaaagttcaataaccataacaaaaggacgtggactacacagatccacttgctttccacatttcaccttgaatgtaaccaaagctcggagcgcaggctatatttctctttttttctttgcttaagtgcaaggattttgtttttgttttgttttttgtttgcgcgtacgaaatgtttattttgcactttttcggggcttttttgctgcgctaattgtttagttctggtatttttgtttgttccgtttaagtttttttttttttttttttggttgttgccgttgtcttttcttttttattgtacaggaaagttgttatgaagacgacttgagtgctcatccttttcttatactatggaaggatccagtggggctagtttcggaatagacactattttgtccacaaccaattctggcacctcagtactgatgaacggagattttcgtctcggtgacagtagcagaacagcggatttcaggagccaggcgaccccatcaccatgttcggagatagacactgtgggaacagccccctcatccccgatttcggtcacgatggagcatcccgaaccgcatcttgtccaagacagccttcagcatcaccatcaccatcatcatcacagtcaggctcagagtttgcagctttcacctcagcctcatctgctcggtcaggctggttgtgcccccaggactgccacctcctcctttctaatcaaagacattttgggcgacagtaaaccgcttgcagcgtgcgctccttacagcaccagtgtaccatctccacaccacagccccaaaacagagagcggaaccgccccggacggcatcaggcccaaactagaacaagatgaaaacagaagcaaactggacaaaagagatgatatccagagtgatttgaaatgtttgaacggaacaaaagaagagggcgatcgggaaatttctagttccagagacagtccaccagtccgttctaaaaaacctcgcaaagcgcggacggccttctccgaccatcaacttaaccagctggagcgcagttttgagagacagaaatacctcagtgtacaggaccgaatggacctggcagcagccctaaacctcacagacacacaagtaaagacttggtatcaaaaccgacggacgaaatggaagaggcagacggctgtcggattagaactgctggctgaagctggaaattattcggccttacagagaatgtttccttccccgtatttctatcatccgagtttattaggaaccgtggacagcacgacagcggccgcagccgccgctgccatgtacagcagcatgtaccggactccgtccacaccgcatccgtctctccagagaccgctcgtccccagagtgcttattcacggcctggggcccgggggacaaccggcactaaaccccataccaaacccaattccgggcacaccgcatgctcggtaaaacaagaagacactgagagacaaatgtatcacaagtgatgtgacagactgaactttcacagaagctttttttcctaaaaaaaaaaacaaaacaccgagagacgatttttatcgaagacaaagatgtattatttaatatggaccatttctgacttataggccaaactgaaccagtcgagcctgtgaccgtgacagtaaaaggactgttcattgtcaaaaaaaaaaaaa

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