LOCUS       NM_199988               1743 bp    mRNA    linear   VRT 05-OCT-2024
DEFINITION  Danio rerio septin 5a (septin5a), mRNA.
ACCESSION   NM_199988
VERSION     NM_199988.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Campbell,P.D., Lee,I., Thyme,S. and Granato,M.
  TITLE     Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental
            locus regulate neural stem and progenitor cell proliferation
  JOURNAL   Mol Psychiatry 28 (9), 3769-3781 (2023)
   PUBMED   37794116
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Torraca,V., Bielecka,M.K., Gomes,M.C., Brokatzky,D.,
            Busch-Nentwich,E.M. and Mostowy,S.
  TITLE     Zebrafish null mutants of Sept6 and Sept15 are viable but more
            susceptible to Shigella infection
  JOURNAL   Cytoskeleton (Hoboken) 80 (7-8), 266-274 (2023)
   PUBMED   36855298
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   van Leeuwen,L.M., Evans,R.J., Jim,K.K., Verboom,T., Fang,X.,
            Bojarczuk,A., Malicki,J., Johnston,S.A. and van der Sar,A.M.
  TITLE     A transgenic zebrafish model for the in vivo study of the blood and
            choroid plexus brain barriers using claudin 5
  JOURNAL   Biol Open 7 (2) (2018)
   PUBMED   29437557
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Helmprobst,F., Lillesaar,C. and Stigloher,C.
  TITLE     Expression of sept3, sept5a and sept5b in the Developing and Adult
            Nervous System of the Zebrafish (Danio rerio)
  JOURNAL   Front Neuroanat 11, 6 (2017)
   PUBMED   28261064
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Guna,A., Butcher,N.J. and Bassett,A.S.
  TITLE     Comparative mapping of the 22q11.2 deletion region and the
            potential of simple model organisms
  JOURNAL   J Neurodev Disord 7 (1), 18 (2015)
   PUBMED   26137170
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Groh,K.J., Schonenberger,R., Eggen,R.I., Segner,H. and Suter,M.J.
  TITLE     Analysis of protein expression in zebrafish during gonad
            differentiation by targeted proteomics
  JOURNAL   Gen Comp Endocrinol 193, 210-220 (2013)
   PUBMED   23968773
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Cao,L., Ding,X., Yu,W., Yang,X., Shen,S. and Yu,L.
  TITLE     Phylogenetic and evolutionary analysis of the septin protein family
            in metazoan
  JOURNAL   FEBS Lett 581 (28), 5526-5532 (2007)
   PUBMED   17967425
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Pan,F., Malmberg,R.L. and Momany,M.
  TITLE     Analysis of septins across kingdoms reveals orthology and new
            motifs
  JOURNAL   BMC Evol Biol 7, 103 (2007)
   PUBMED   17601340
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC059564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059564.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505372,
                                           SAMEA3505378 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="wild type"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     gene            1..1743
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="septin 5a"
                     /db_xref="GeneID:335925"
                     /db_xref="ZFIN:ZDB-GENE-030131-7868"
     exon            1..99
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1166
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /EC_number="3.1.5.1"
                     /note="septin 5"
                     /codon_start=1
                     /product="septin 5a"
                     /protein_id="NP_956282.1"
                     /db_xref="GeneID:335925"
                     /db_xref="ZFIN:ZDB-GENE-030131-7868"
                     /translation="

MTTNIRYKSRSMKSEDSEDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYKDRKLLNAEERINQTVEITKHTVDIEEKGVKLKLTIVDTPGFGDAVNNNECWRPITDYIDQQFEQYFRDESGLNRKNILDNRVHCCLYFIPPFGHGLRPVDVEFMKALHEKVNIIPLISKADCLTPTEVKKLKDRVRDEIERFGIKVYQFPECDSDEEEEFKQMDKELKECTPFAVIGSNTVVEARGQRVRGRLYPWGIVEVENQSHCDFVKLRNMLIRSHMHDLKDVTCDVHYENYRAHCIQEMTSKLAQDNRTDSPLPILPLPTPDVETEKLIKMKDEELKRMQEMLEKMQQQMHEKDQ"

     misc_feature    174..992
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="Region: Septin; pfam00735"
                     /db_xref="CDD:395596"
     misc_feature    201..224
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="G1 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    order(207..227,372..374,381..383,615..620,624..626,
                     792..797)
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206649"
     misc_feature    297..323
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206649"
     misc_feature    303..305
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="G2 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    372..383
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="G3 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    order(378..485,486..515)
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206649"
     misc_feature    615..626
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="G4 box; other site"
                     /db_xref="CDD:206649"
     misc_feature    792..800
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /note="G5 box; other site"
                     /db_xref="CDD:206649"
     exon            100..110
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            111..201
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            202..288
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            289..412
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            413..547
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            548..665
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            666..767
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            768..864
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1000
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1103
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1720
                     /gene="septin5a"
                     /gene_synonym="fj37h04; sept5; sept5a; wu:fj37h04;
                     zgc:73218"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgggaccgagcgagagacgcagacggagccgccgagcagcacagcagagcctaaacatgacgaccaacatccgatacaagagcaggtcgatgaaatccgaggacagtgaggacaagcagtatgtcggctttgccacgcttcctaaccaggtccacagaaagtcagtgaagaagggctttgacttcactctgatggtggcaggggaatctggactgggcaagtctacactagtcaacagtctgtttctcacagacctctataaagacagaaaactgctcaatgcagaagagcgcattaatcagacggttgagatcaccaaacacacagtggacatcgaggagaaaggagtgaagctcaaactcactattgtggacacgccggggtttggagacgctgtcaataataatgaatgttggaggcccatcacagactacattgaccagcagtttgagcagtacttcagagatgagagcggactgaacagaaagaacattttggacaacagagttcactgctgtttgtacttcatcccaccatttggacacggtttgcggccggtggatgtggagttcatgaaggctttacatgagaaagtcaacatcattcctctgatctccaaagcagactgtctgacccccactgaggtcaaaaagctcaaggacagggtacgagacgagattgagcgtttcgggattaaagtctatcagtttcctgagtgtgactctgatgaagaagaggagttcaaacagatggacaaagagctgaaggagtgtactccgtttgctgtcataggcagtaatacagtggtggaggccagaggtcaaagggttagaggtcgtctttacccctggggtattgtggaagtggagaatcagtctcactgtgactttgtgaagctgaggaacatgttgattcgctctcatatgcacgacctgaaagatgtgacatgtgacgtacattatgaaaactacagagctcactgcatccaggagatgaccagtaaacttgcacaggataaccgcacagacagtccattacccatcctgcctctgccaacaccagatgtagagacagagaaactcatcaagatgaaggatgaagagctgaagagaatgcaggagatgctggaaaagatgcaacaacagatgcacgagaaagaccagtgatacacacactacagcctcacagcacccttcagatgtgaatgcatttaaatgatactgtacaactgtcatatctacagctctgctcatcagctcggtgcttctgtctgctggatcaaatatggcgtcatgtgattcatcatgtggtaaatactgaggaacgtacataaaccagtaacttaagttaacttctaaagggatctaatttataattatgtttttttttattatttgcttagccagatgaatgtgtgtgagagtgttttctgaagcagtgcagagtttattcatgtgcgtttgagagagactgatgccttttgctatgaatttgttggcgttttattttttgcagtgaatgtgagaatacagttatgttttcaataaacatactcggtcctgacggatggtttttgcttgttttataacagtaatcatcagaataagatatattattattatcagtgttaatggcctttaataatttaataatttatattattatgtcagttgttctgtaaatcttgaagttaagcttgctaataaatgtgaataatgtaaaaaaaaaaaaaaaaaaaaaaaa

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