LOCUS       NM_199567               2099 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio TGFB-induced factor homeobox 1 (tgif1), mRNA.
ACCESSION   NM_199567
VERSION     NM_199567.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Al Qaryoute,A., Fallatah,W., Dhinoja,S., Raman,R. and
            Jagadeeswaran,P.
  TITLE     Role of microRNAs and their downstream target transcription factors
            in zebrafish thrombopoiesis
  JOURNAL   Sci Rep 13 (1), 16066 (2023)
   PUBMED   37752184
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Keatinge,M., Tsarouchas,T.M., Munir,T., Porter,N.J., Larraz,J.,
            Gianni,D., Tsai,H.H., Becker,C.G., Lyons,D.A. and Becker,T.
  TITLE     CRISPR gRNA phenotypic screening in zebrafish reveals
            pro-regenerative genes in spinal cord injury
  JOURNAL   PLoS Genet 17 (4), e1009515 (2021)
   PUBMED   33914736
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Newman,M., Hin,N., Pederson,S. and Lardelli,M.
  TITLE     Brain transcriptome analysis of a familial Alzheimer's disease-like
            mutation in the zebrafish presenilin 1 gene implies effects on
            energy production
  JOURNAL   Mol Brain 12 (1), 43 (2019)
   PUBMED   31053140
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Taylor,S.M., Giuffre,E., Moseley,P. and Hitchcock,P.F.
  TITLE     The MicroRNA, miR-18a, Regulates NeuroD and Photoreceptor
            Differentiation in the Retina of Zebrafish
  JOURNAL   Dev Neurobiol 79 (2), 202-219 (2019)
   PUBMED   30615274
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Ranski,A.H., Kramer,A.C., Morgan,G.W., Perez,J.L. and Thummel,R.
  TITLE     Characterization of retinal regeneration in adult zebrafish
            following multiple rounds of phototoxic lesion
  JOURNAL   PeerJ 6, e5646 (2018)
   PUBMED   30258730
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Shi,X., He,B.L., Ma,A.C., Guo,Y., Chi,Y., Man,C.H., Zhang,W.,
            Zhang,Y., Wen,Z., Cheng,T. and Leung,A.Y.
  TITLE     Functions of idh1 and its mutation in the regulation of
            developmental hematopoiesis in zebrafish
  JOURNAL   Blood 125 (19), 2974-2984 (2015)
   PUBMED   25778530
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Lenkowski,J.R., Qin,Z., Sifuentes,C.J., Thummel,R., Soto,C.M.,
            Moens,C.B. and Raymond,P.A.
  TITLE     Retinal regeneration in adult zebrafish requires regulation of
            TGFbeta signaling
  JOURNAL   Glia 61 (10), 1687-1697 (2013)
   PUBMED   23918319
  REMARK    GeneRIF: Tgif1 expression and regulation of TGFbeta signaling are
            implicated in the function of several types of stem cells, but this
            is the first demonstration that this regulatory network is
            necessary for regeneration of neurons.
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Zheng,W., Wang,Z., Collins,J.E., Andrews,R.M., Stemple,D. and
            Gong,Z.
  TITLE     Comparative transcriptome analyses indicate molecular homology of
            zebrafish swimbladder and mammalian lung
  JOURNAL   PLoS One 6 (8), e24019 (2011)
   PUBMED   21887364
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Gongal,P.A. and Waskiewicz,A.J.
  TITLE     Zebrafish model of holoprosencephaly demonstrates a key role for
            TGIF in regulating retinoic acid metabolism
  JOURNAL   Hum Mol Genet 17 (4), 525-538 (2008)
   PUBMED   17998248
  REMARK    GeneRIF: Tgif is necessary for normal initiation of genes that
            control RA synthesis and degradation, resulting in defects in
            RA-dependent central nervous system patterning in Tgif-depleted
            embryos.
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Song,H.D., Sun,X.J., Deng,M., Zhang,G.W., Zhou,Y., Wu,X.Y.,
            Sheng,Y., Chen,Y., Ruan,Z., Jiang,C.L., Fan,H.Y., Zon,L.I.,
            Kanki,J.P., Liu,T.X., Look,A.T. and Chen,Z.
  TITLE     Hematopoietic gene expression profile in zebrafish kidney marrow
  JOURNAL   Proc Natl Acad Sci U S A 101 (46), 16240-16245 (2004)
   PUBMED   15520368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC044510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044510.1, AY391467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476736, SAMEA4476792
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="AB"
                     /db_xref="taxon:7955"
                     /chromosome="24"
                     /map="24"
     gene            1..2099
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="TGFB-induced factor homeobox 1"
                     /db_xref="GeneID:321756"
                     /db_xref="ZFIN:ZDB-GENE-030131-475"
     exon            1..239
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    161..163
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="upstream in-frame stop codon"
     CDS             224..1045
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="TG interacting factor; transforming growth
                     factor-beta-induced factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1"
                     /protein_id="NP_955861.1"
                     /db_xref="GeneID:321756"
                     /db_xref="ZFIN:ZDB-GENE-030131-475"
                     /translation="

MKTKKGVLAMSGSETEDEDSLDVPLDLSSNGGVSGKRKRRGNLPKESVQILRDWLYQHRYNAYPSEQEKALLSKQTHLSTLQVCNWFINARRRLLPEMLRKDGKDPNQFTISRRGSKGGEMLSDNSQSPKHGLLANGEDRNSYEPGSPHPTSNTPTSNGYPKKALSPKTPPSPGPVLPRPSVICHTTITTATQGINTTTRLGVEGATELPLTDAASLFGCRGEGNVSPQSGLFNTPPPTPPDLTQDFSGFQLLVDVALKRAAEMELQAKKLLA"

     misc_feature    order(332..346,350..352,410..412,428..430,467..469,
                     473..478,485..490,494..502)
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(338..340,347..349,476..478,485..490,497..499)
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    386..502
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            240..469
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /inference="alignment:Splign:2.1.0"
     exon            470..2084
                     /gene="tgif1"
                     /gene_synonym="fa06h05; fb33g11; Tgif; wu:fa06h05;
                     wu:fb33g11; zgc:55852"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atcaaacacagtgaatgagacgcgcagcctgtcccaggtacccgacaatgtgttgcgtctccgacaaatgaaaaacgcgctccgcggcgattcctcgacaaaaaaagagaaatatttgcgctcgatacttcgtaacaatctggaataatacagttgtgagtgattaaagcgaggaagaatcgacctccttgttgccaacgtgaaaaggggaattttgacggacatgaagaccaaaaagggtgttttggcgatgtcaggaagcgagacggaggatgaggacagtttggatgtgcctcttgacctctcttcgaatggaggagtgtcagggaagaggaagaggagaggaaacttgcccaaagagtcggtacaaatactccgggactggctctaccaacacagatacaatgcctatccatcagagcaggaaaaagccctgctgtccaagcagacccatctatccacactacaggtttgcaactggtttataaatgcgcggcgacgactccttcctgagatgctccggaaagatggcaaggaccccaaccagttcaccatctcgcggcggggcagcaagggtggcgaaatgctcagtgacaactcccagtcaccgaaacacggtctgctcgccaacggagaagaccgcaacagctacgagcctggctcacctcacccgaccagcaacacacccacttccaacggttaccccaaaaaggccctgtcccctaaaacacctccctcgcccggacctgtcttacccagaccctccgtcatctgccacaccactatcaccacagccacgcaaggcatcaacacaacaacgcgcctcggcgtcgagggagccacagagctgccactcacagatgcggccagcctattcgggtgtcgaggggagggtaacgtcagccctcagagcggcctgttcaacacccctccgcccaccccacccgacctcacccaggacttcagcggtttccagctgctggttgacgtagcgctgaagagggctgccgaaatggagctgcaggccaaaaagctcctcgcctgaagaaaaaaaaaaacggatggaggaattaaagagcttcatcgatgtttgtttttcgcccccccccccaaatgtgaactccactgggagttcataaaaaacttgactgagcaacaaagcaaactagcatggcctgatcatttctatttttggtaaatcaaattgatgaggattcctttatgtaaagcatttcaaggtgccttggcagttcttttttttgtattccatttatatgtaaataaatatgtatcttcattttgtacacaggggaccaaaatcaaacacagtaatacgacttccttctttacgagaagacgagcttttctcccattcctcatgagtctttctttctcgttttcagagattcggctctatgattgtcaatttatgcctcgtttttagagaacacgtctgatattctgcctcgttttcttttgcacaatatggcaggtcatctcagtatcttatcaactctagctttctctccaacagactctaatcactactgcaccaggtcattctgtgtctcatagatgttcagttcttttgtattttctttgttgttgtaaagtttcagatgctgttagtacgtttgttttcttcattactctcgagggatattcagatgtagcagaactatagtctgagatttcctctgaatactcagtgtagaaacggccagtgaatgtgcccacatacttccctccccacccctacacacacatacatacacgcaaacaaatacacaccttggacaagtgagctggaagaataaaacactacatgaatcgtattaagtttttttgttttgtttcttttttgctgtttattacgttgagaccactttcagaggataaaatgaaaagaatggttttatgtcaccaaatatgttgatttcaaggttttgggacctaagaccagtgcatttacagtagccaatgtgacatgatgcccaatgatgtgacttctcctccttactgtgcaatgtatgtggcaaataggggtcacacggtgtttaaataaagttttgttttctacaaaaaaaaaaaaaaaaaaa

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