LOCUS       NM_198814               3741 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio zinc fingers and homeoboxes 2a (zhx2a), mRNA.
ACCESSION   NM_198814
VERSION     NM_198814.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   Vauti F, Vogele V, Deppe I, Hahnenstein ST and Koster RW.
  TITLE     Structural Analysis and Spatiotemporal Expression of Atxn1 Genes in
            Zebrafish Embryos and Larvae
  JOURNAL   Int J Mol Sci 22 (21), 11348 (2021)
   PUBMED   34768779
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Cambier S, Rogeberg M, Georgantzopoulou A, Serchi T, Karlsson C,
            Verhaegen S, Iversen TG, Guignard C, Kruszewski M, Hoffmann L,
            Audinot JN, Ropstad E and Gutleb AC.
  TITLE     Fate and effects of silver nanoparticles on early life-stage
            development of zebrafish (Danio rerio) in comparison to silver
            nitrate
  JOURNAL   Sci Total Environ 610-611, 972-982 (2018)
   PUBMED   28838034
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Diotel N, Rodriguez Viales R, Armant O, Marz M, Ferg M, Rastegar S
            and Strahle U.
  TITLE     Comprehensive expression map of transcription regulators in the
            adult zebrafish telencephalon reveals distinct neurogenic niches
  JOURNAL   J Comp Neurol 523 (8), 1202-1221 (2015)
   PUBMED   25556858
REFERENCE   5  (bases 1 to 3741)
  AUTHORS   Huang HT, Kathrein KL, Barton A, Gitlin Z, Huang YH, Ward TP,
            Hofmann O, Dibiase A, Song A, Tyekucheva S, Hide W, Zhou Y and Zon
            LI.
  TITLE     A network of epigenetic regulators guides developmental
            haematopoiesis in vivo
  JOURNAL   Nat Cell Biol 15 (12), 1516-1525 (2013)
   PUBMED   24240475
REFERENCE   6  (bases 1 to 3741)
  AUTHORS   Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF and
            Ruddle FH.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC141782.1.
            
            On May 28, 2007 this sequence version replaced NM_198814.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..3741
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="zinc fingers and homeoboxes 2a"
                     /db_xref="GeneID:386660"
                     /db_xref="ZFIN:ZDB-GENE-031107-2"
     exon            1..117
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /inference="alignment:Splign:2.1.0"
     exon            118..218
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..2801
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    338..340
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="upstream in-frame stop codon"
     CDS             374..2791
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="zinc fingers and homeoboxes 2"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 2a"
                     /protein_id="NP_942109.2"
                     /db_xref="GeneID:386660"
                     /db_xref="ZFIN:ZDB-GENE-031107-2"
                     /translation="

MASRRKSTTPCMIRPDDLVPADDPEETDSCVDGAEENGSSHVSSSEEWTDRKSSVNSMQETAVLEKPEVKTRPQRKPQGGYECKYCPFSTQNLNEFKDHVDSNHPNVILNPLYLCAVCNFNTRKFDSLTEHNEKCHPGESNFKFKRIKLNSQTILEQTIEGSNCAVIYDPTSPQSGEDFAAFPLSKSTTIKLGKPKADSLRLQDDSPLDKLAQDLPKKQITAVNVNGTVIIPDATLKDGLSHIMPSLQRPPNYNLVPKIAVPLNTSKYNPSLDDNLTLITSFNKFPYPTQAELSWLTAASKHPEEQIKVWFTTQRLKQGISWSPEEVEEARKKMFNGTIQPVQQAFTVLPAQLSQSTKASQPLIQTVPCHVLGQSGLVLAPVANGSTATSASLALSVANQIAQGVKRPHTAPLVAPEIKRPSIIQSVQSTPKSVSPTPSFSSDSEKTPDQIRELTASYAQCQFPDDEEVYRLIETTGLSWGEIKKWFSDQRHGNHKAVQQIKTDLSSKDSQPHKPVATQFPLLERVKGKSSEQMKKLEESFQRTSFPTQAEMEHLVADTRLSKNEIDCWFTERRALRDNLEQALLNSMGSKRLEHHLPMGSLNGFHEQDGRVRDSPLPILASPTCPEAIDSKSLCLLKDMFAQTQWPSPEEYNQLEVQTGLARTEIVRWFKDNRSALKNGTLDWMEQFQSLSSKRPNGQNSSLTSEQAQNVLQRHFQDSKVQRGDGFEKLAEQSKLTNQDIVEWFTSKLGHNMPDISKSKDQHGQANIDGKKWVSLAADIDGKDFDAQKVGRDLEVLSAEHRVTG"

     misc_feature    698..853
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="Zinc-fingers and homeoboxes C2H2 finger domain;
                     Region: zf_C2H2_ZHX; pfam18387"
                     /db_xref="CDD:465737"
     misc_feature    1169..1327
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(1172..1177,1181..1183,1232..1234,1250..1252,
                     1289..1291,1295..1300,1307..1312,1316..1324,1328..1333)
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1178..1180,1298..1300,1307..1312,1319..1321)
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1712..1846
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    1961..2098
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    2273..2410
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     exon            2802..3719
                     /gene="zhx2a"
                     /gene_synonym="ZHX1; zhx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cggcagaatcattacaatcgcacgcttctgtcggctgtacacgtggaaaagtaagcaattttggaccctagctggcaataacatcacatccctgcgttttccgttggaggtgggcaggggaggagcagttgggtgaaagaaagggggccgaggagaaaaacgtgcctcaaaagaccttagagatcctgtactctgaaggtggaggtcgtcattgacagactgcgtggtctgggatgaagtctcatgaagtcttacattggagctgacgttcacagtcagcgaaatcatcctttaccgatcctccagcagacaaagacttgcccattacccattaacatagtcccacttcactgcactgttttactccctgaacatggctagtcgaagaaagtctacaacaccctgcatgatccgaccagatgacttggtgcctgcagatgacccagaagaaactgattcttgtgttgatggtgcagaagagaatggatcttcacatgtatcttctagtgaggaatggacggataggaagagttctgtgaactctatgcaggaaacagcagtgctggagaaacctgaagtaaaaacacgtccacagcgaaaaccccagggaggttacgaatgcaaatactgtcccttttccacacaaaacctcaacgagtttaaagatcacgttgactccaaccaccccaatgttatactcaacccactgtatttgtgtgcggtatgcaatttcaacacaagaaagtttgattctttgacagaacacaatgagaagtgccatcctggggagagcaacttcaagtttaagagaatcaaactgaacagtcagaccattctggaacagacaatcgaaggttcaaactgtgcagtcatttatgatccaaccagccctcagtcaggagaggactttgctgcctttcctctgagcaaatccactactattaagctaggtaagcctaaagcagacagtttacggttgcaagatgacagtccattggacaaacttgctcaagatctgccgaaaaagcaaattactgcagtgaatgtgaatgggactgtaatcatcccagatgcaacacttaaggatgggctttctcatataatgccgtctctgcaacggccacccaactacaacttagtaccaaaaattgctgtccccttgaacacttcaaagtacaacccctcactggatgataacttgaccctcatcacctctttcaacaagtttccataccctacccaagcagagctctcttggctcactgcagcctccaaacatcctgaagaacaaattaaagtgtggttcactacccaacggctaaaacaaggtatcagttggtctcctgaggaggttgaggaagctcgaaaaaagatgttcaatggaacgattcagcctgttcaacaggcattcactgtcttgcctgcacagttatctcagtccactaaagcttcacagccccttatccaaaccgtcccttgccatgttcttggacaatctggtctagtgctggcacctgttgccaatggctcaactgcaaccagtgcttctcttgcactatcagttgcaaatcaaatagcacagggtgtcaagaggccccacacagcaccacttgttgccccagagataaagaggccttcgataatccagtccgttcagagtactcccaagtctgtttctccgacaccaagcttttcttcagatagtgagaaaacccctgatcagatcagagagctgaccgccagctatgctcagtgccagtttcctgatgacgaagaagtgtatcgtctcatcgagacaactggcctctcctggggagagatcaaaaaatggttcagtgatcagcgccatggaaaccataaggcagtgcagcagattaaaacagacctctcttcgaaggacagccaaccgcataagcctgtcgccacacaatttccactactagagagagtcaaaggcaaatcctctgagcaaatgaaaaagttagaggagagtttccaaaggactagctttccgacccaggctgagatggagcaccttgtggcagataccaggctctccaaaaatgaaatcgactgctggtttacggagcggcgtgcactacgagacaacctagagcaagccttgcttaactcaatgggctcaaaaaggctggagcatcaccttcctatggggtcattgaatggattccatgagcaggacggcagagtcagggactcaccgcttccgattcttgcatccccaacgtgtccagaggccatagatagcaagtctctctgccttcttaaagacatgtttgcacaaacccagtggccatcaccagaagagtacaaccaactagaagttcaaacagggttagcacgtacagaaattgtccgctggtttaaggacaacagatctgctctgaagaacggaaccttagattggatggagcaatttcaaagtcttagcagcaagagacccaatggacaaaacagttcactgacctcagagcaggctcagaatgtcctacaaaggcactttcaagattcaaaggtacaaaggggggatggttttgagaagcttgcagagcagtcaaaactaaccaaccaggacatagtggaatggtttactagtaagctgggccacaacatgcctgatatcagcaagagtaaggaccaacatggacaggcaaacatagatggcaagaagtgggtttccttggcagctgacattgatggtaaagactttgatgcacagaaggtgggccgagaccttgaagtgctgtcggcagagcacagagtgactggatgaagttataaagaaggaaaaaggctgctatgactgatctagacgggcctgatgattaaggaatgacctcggtcatcgtatatggaaccaatgatctcatatttggactctgagattattagatgtgagatggactaggagcatctgtgaaacactgtccagagagtgaccatggagtgccaaagtttgactgctatgttgttagaattatgtttattttataaaagggcccttgtacatatttttttctgtacttcaacagatttgtaaaattttttgaagatgagacttttgttacgtttataataggagtcctaagacatttcccttgacccttataacggaatgttcaatcattattgtgagaggacacaaaaccaacccacctgctggtgaagctggtaaaaaaacacaatgtggtccatgatggcacttaatatttcaagtggacacatacaagcggtgcttcagtaaaaaccatctcattccagaaaacgaggtgatattatggacttttctttttttttttttttttggaccatgaacacattgcctgcactctcatactgtaccttatcgccaaggggacagagccacatggtggacataatcataatgaactgaaatcagtacaatacagtgatgcacagcacatgtttatttgtagttctaggctaatgtttggcaatattacagtaactgcaaaattatccttatcatgttggcttttcctggtatccaaggcgtagttccattttcactactcagctgtgaactgctttcagctcgcttaagtgtatttctttttcctgcagctgctttagtgtcatgttcagacatgtatcaggaatactgtactgctaccaagaatcctgcttgctctttataagaaccagtctgctgtaatttaataaaacacaactgattgaaaaaaaaaaaaaaaaaaaaaaaaa

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