LOCUS       NM_197933               1979 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio protein disulfide isomerase family A, member 6 (pdia6),
            mRNA.
ACCESSION   NM_197933
VERSION     NM_197933.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Zhang Y, Su G, Li M, Li S, Wang Q, Zhu G, Letcher RJ and Liu C.
  TITLE     Chemical and biological transfer: Which one is responsible for the
            maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate
            in zebrafish?
  JOURNAL   Environ Pollut 243 (Pt B), 1376-1382 (2018)
   PUBMED   30273864
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Beaudoin JD, Novoa EM, Vejnar CE, Yartseva V, Takacs CM, Kellis M
            and Giraldez AJ.
  TITLE     Analyses of mRNA structure dynamics identify embryonic gene
            regulatory programs
  JOURNAL   Nat Struct Mol Biol 25 (8), 677-686 (2018)
   PUBMED   30061596
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1979)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1979)
  AUTHORS   Gourronc F, Ahmad N, Nedza N, Eggleston T and Rebagliati M.
  TITLE     Nodal activity around Kupffer's vesicle depends on the T-box
            transcription factors Notail and Spadetail and on Notch signaling
  JOURNAL   Dev Dyn 236 (8), 2131-2146 (2007)
   PUBMED   17654709
REFERENCE   7  (bases 1 to 1979)
  AUTHORS   Hoshijima K, Metherall JE and Grunwald DJ.
  TITLE     A protein disulfide isomerase expressed in the embryonic midline is
            required for left/right asymmetries
  JOURNAL   Genes Dev 16 (19), 2518-2529 (2002)
   PUBMED   12368263
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC044507.1.
            
            On Jan 25, 2004 this sequence version replaced NM_197933.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044507.1, AF387900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="AB"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     gene            1..1979
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="protein disulfide isomerase family A, member 6"
                     /db_xref="GeneID:322160"
                     /db_xref="ZFIN:ZDB-GENE-030131-879"
     exon            1..42
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    9..11
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="upstream in-frame stop codon"
     CDS             27..1349
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase-related protein
                     (provisional)"
                     /codon_start=1
                     /product="protein disulfide-isomerase A6 precursor"
                     /protein_id="NP_922915.2"
                     /db_xref="GeneID:322160"
                     /db_xref="ZFIN:ZDB-GENE-030131-879"
                     /translation="

MRALLGVLACSLTVLSAYGLYTSSDDVVELNPSNFNREVIQSDSLWLVEFYAPWCGHCKSLAPEWKKAATALKGIVKVGAVDADQHNSLGGQYGVRGFPTIKIFGGNKHKPEDYQGGRTNQAIVDAALNALRSLVKDRLGGKTGGSDYSRQSGGGAGNKKDVVELTDDNFDRTVLESDDVWLVEFFAPWCGHCKNLEPEWTAAATEVKEQTKGKVRLAAEDATVHQGLASRFGIRGFPTIKVFRKGEEPEDYQGGRTRSDIVARALELYSDNIPAPELQEVLNEGILKKTCEDYQLCIIAVLPHILDTGASGRNSYLEVMKTMAEKHKKKMWGWLWTEAGAQMELEASLGIGGFGYPAMAAINSRKMKFALLKGSFSETGIHEFLRELSVGRGSTATVGGGALPKINTVQAWDGKDGELPMEDDIDLSDVDLDDLEKDEL"

     sig_peptide     27..83
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    102..410
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="PDIa family, P5 subfamily; composed of eukaryotic
                     proteins similar to human P5, a PDI-related protein with a
                     domain structure of aa'b (where a and a' are redox active
                     TRX domains and b is a redox inactive TRX-like domain).
                     Like PDI, P5 is located in the...; Region: PDI_a_P5;
                     cd03001"
                     /db_xref="CDD:239299"
     misc_feature    order(189..191,198..200,378..380)
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239299"
     misc_feature    507..824
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="PDIa family, P5 subfamily; composed of eukaryotic
                     proteins similar to human P5, a PDI-related protein with a
                     domain structure of aa'b (where a and a' are redox active
                     TRX domains and b is a redox inactive TRX-like domain).
                     Like PDI, P5 is located in the...; Region: PDI_a_P5;
                     cd03001"
                     /db_xref="CDD:239299"
     misc_feature    order(594..596,603..605,792..794)
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239299"
     misc_feature    849..1238
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /note="P5 family, C-terminal redox inactive TRX-like
                     domain; P5 is a protein disulfide isomerase (PDI)-related
                     protein with a domain structure of aa'b (where a and a'
                     are redox active TRX domains and b is a redox inactive
                     TRX-like domain). Like PDI, P5 is...; Region: P5_C;
                     cd02983"
                     /db_xref="CDD:239281"
     exon            43..187
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            188..245
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            246..372
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            373..479
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            480..610
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            611..725
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            726..866
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            867..951
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1024
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1183
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1280
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1962
                     /gene="pdia6"
                     /gene_synonym="pdi-p5; pdip5; wu:fb51h08; wu:fc09e09"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acattgaataagcacaaagaacaaccatgcgagcgctcctgggtgtgttggcgtgttctctgactgtactgtctgcttacggtctctacacctctagtgatgatgtggttgaactcaacccatccaactttaacagagaagtcattcagagtgacagtctctggctggtcgagttttatgctccctggtgtggtcactgcaagagtttggctcccgaatggaagaaagcagccacagctttaaagggcattgtgaaggtgggcgctgtggatgccgatcaacacaactctctgggaggccagtatggagtccgaggctttccgactatcaagatctttggaggcaacaagcacaagccagaggattaccaaggtggccgtacaaatcaagccattgtagatgcagctctgaatgctcttcgttctctggttaaagacagacttggtggaaagacaggaggctcagactacagcagacagagtggaggtggtgcgggcaataagaaggatgtggtggagctgacggatgataactttgaccgaaccgtgctggagagcgatgatgtctggctggtggagttcttcgccccctggtgtggacactgcaaaaatcttgagccggaatggacagcagccgccacagaagtcaaagagcagacaaaggggaaagtgagactggctgctgaggacgccactgttcaccagggcttggcaagccgctttgggattcgaggattcccgactatcaaggtctttcgtaaaggagaggagcctgaggactatcagggtggacgaacccgatctgacattgttgctcgtgcattggagctgtactctgataacatcccggctcctgagctgcaagaggttttgaatgaaggcattttaaagaagacttgtgaggattatcagctgtgtatcatagctgtgctgccacacattctagatacaggcgcatctggaagaaactcttacctggaggtgatgaagacgatggcagagaaacataagaagaagatgtggggttggttgtggactgaagcaggggcgcagatggagctggaagcctctctggggattggtggatttggctatcctgccatggcagccattaactctcgtaaaatgaagttcgctctgctcaaaggctcattcagtgaaacgggcatccatgaattcctcagggaactttctgttggccgtggctccactgctacggttggaggcggagccttgccaaagatcaacaccgtccaggcttgggatggaaaagatggagagttgccgatggaggatgacattgacctgagtgatgtggatctggatgatctggagaaggatgagttatgagtctggtctaaactactctatacccgaacactgcccatgtcttctctcctgtggatgaggggatgaatgggacacgagtttccttaagacttctgtaaaattacaaataaagcataccgttgtgcagctttttaaaaaaaaacctttgtccctgttagtttaaacatgagcctctttcagtgtgcacatcatgatgccttcacgtttccatttagtgactggccagatcagacaatgaagcagaatctcttttgcagtaagcagatgtttctctctcacacacgcacacaggctctttctgatttctgtttcgtcgaccagattaaatgttttactaatgagatcagccagtggttatttatcttttttttctgtcatttctgcagctcctttcactggagttgtttcacctttcctccctctgatgtgactttttttttggttatttgtttgttttttaaattgttactgaaatgaatgtcagccagcttgtatcccagtttgcccatgtgttagatttgggtgtaatgtgggcgtcgtgtagttctttcatacagtttgttctgaaagacaaaatgtttttgttatgaaaataaaacaaaaataagtgtccgaaaaaaaaaaaaaaaa

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