LOCUS       NM_131537               1656 bp    mRNA    linear   VRT 26-JAN-2025
DEFINITION  Danio rerio homeobox B5b (hoxb5b), mRNA.
ACCESSION   NM_131537
VERSION     NM_131537.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1656)
  AUTHORS   Maeno,A., Koita,R., Nakazawa,H., Fujii,R., Yamada,K., Oikawa,S.,
            Tani,T., Ishizaka,M., Satoh,K., Ishizu,A., Sugawara,T., Adachi,U.,
            Kikuchi,M., Iwanami,N., Matsuda,M. and Kawamura,A.
  TITLE     The Hox code responsible for the patterning of the anterior
            vertebrae in zebrafish
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38940461
REFERENCE   2  (bases 1 to 1656)
  AUTHORS   Sundaramoorthi,H., Fallatah,W., Mary,J. and Jagadeeswaran,P.
  TITLE     Discovery of seven hox genes in zebrafish thrombopoiesis
  JOURNAL   Blood Cells Mol Dis 104, 102796 (2024)
   PUBMED   37717409
REFERENCE   3  (bases 1 to 1656)
  AUTHORS   Wang,H., He,J., Han,X., Wu,X., Ye,X., Lv,W. and Zu,Y.
  TITLE     hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated
            Heart Malformation in Bosley-Salih-Alorainy Syndrome
  JOURNAL   Biology (Basel) 12 (7), 899 (2023)
   PUBMED   37508332
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1656)
  AUTHORS   Howard,A.G.A. 4th, Nguyen,A.C., Tworig,J., Ravisankar,P.,
            Singleton,E.W., Li,C., Kotzur,G., Waxman,J.S. and Uribe,R.A.
  TITLE     Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric
            Neuronal Development in Zebrafish
  JOURNAL   Front Cell Dev Biol 9, 803370 (2022)
   PUBMED   35174164
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1656)
  AUTHORS   Yamada,K., Maeno,A., Araki,S., Kikuchi,M., Suzuki,M., Ishizaka,M.,
            Satoh,K., Akama,K., Kawabe,Y., Suzuki,K., Kobayashi,D., Hamano,N.
            and Kawamura,A.
  TITLE     An atlas of seven zebrafish hox cluster mutants provides insights
            into sub/neofunctionalization of vertebrate Hox clusters
  JOURNAL   Development 148 (11) (2021)
   PUBMED   34096572
REFERENCE   6  (bases 1 to 1656)
  AUTHORS   Crow,K.D., Stadler,P.F., Lynch,V.J., Amemiya,C. and Wagner,G.P.
  TITLE     The 'fish-specific' Hox cluster duplication is coincident with the
            origin of teleosts
  JOURNAL   Mol Biol Evol 23 (1), 121-136 (2006)
   PUBMED   16162861
REFERENCE   7  (bases 1 to 1656)
  AUTHORS   Santini,S. and Bernardi,G.
  TITLE     Organization and base composition of tilapia Hox genes:
            implications for the evolution of Hox clusters in fish
  JOURNAL   Gene 346, 51-61 (2005)
   PUBMED   15716008
REFERENCE   8  (bases 1 to 1656)
  AUTHORS   Amores,A., Suzuki,T., Yan,Y.L., Pomeroy,J., Singer,A., Amemiya,C.
            and Postlethwait,J.H.
  TITLE     Developmental roles of pufferfish Hox clusters and genome evolution
            in ray-fin fish
  JOURNAL   Genome Res 14 (1), 1-10 (2004)
   PUBMED   14707165
REFERENCE   9  (bases 1 to 1656)
  AUTHORS   Davidson,A.J., Ernst,P., Wang,Y., Dekens,M.P., Kingsley,P.D.,
            Palis,J., Korsmeyer,S.J., Daley,G.Q. and Zon,L.I.
  TITLE     cdx4 mutants fail to specify blood progenitors and can be rescued
            by multiple hox genes
  JOURNAL   Nature 425 (6955), 300-306 (2003)
   PUBMED   13679919
REFERENCE   10 (bases 1 to 1656)
  AUTHORS   Kudoh,T., Tsang,M., Hukriede,N.A., Chen,X., Dedekian,M.,
            Clarke,C.J., Kiang,A., Schultz,S., Epstein,J.A., Toyama,R. and
            Dawid,I.B.
  TITLE     A gene expression screen in zebrafish embryogenesis
  JOURNAL   Genome Res 11 (12), 1979-1987 (2001)
   PUBMED   11731487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078285.1.
            
            On Aug 31, 2012 this sequence version replaced NM_131537.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078285.1, EH578801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1656              BC078285.1         5-1660
FEATURES             Location/Qualifiers
     source          1..1656
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..1656
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="homeobox B5b"
                     /db_xref="GeneID:58052"
                     /db_xref="ZFIN:ZDB-GENE-000823-6"
     exon            1..680
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    86..88
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="upstream in-frame stop codon"
     CDS             98..928
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="etID309875.12; homeobox gene A-5; homeobox gene
                     zf54; homeobox protein Zf-54; homeo box B5b"
                     /codon_start=1
                     /product="homeobox protein Hox-B5b"
                     /protein_id="NP_571612.2"
                     /db_xref="GeneID:58052"
                     /db_xref="ZFIN:ZDB-GENE-000823-6"
                     /translation="

MSSYFLNSFSGRYPNGSDYQLLNYGTNGAMNASYRDSTSMHSGSFGYNYNGIDLSVNRPNNGHFGAVGDNSRAFQNPSQETRYRQSSCSLSSPDPLSCATSDTLELKGSSPPSDQSTPTGNSRLTNSNNLTSSNSTHFADTDETNVSSETEEGAQTTTTSRTQKQESVATSTTTPNDGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQN"

     misc_feature    284..643
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="propagated from UniProtKB/Swiss-Prot (P09013.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    644..661
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="propagated from UniProtKB/Swiss-Prot (P09013.2);
                     Region: Antp-type hexapeptide"
     misc_feature    701..871
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            681..1626
                     /gene="hoxb5b"
                     /gene_synonym="hoxa5; hoxb5-like; hoxzf54; id:ibd2566;
                     z-2; ZF-54; ZF54; zgc:101134"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

acagtgcattgctataattcattattacatcataaattgtgcggcgctggattttaacgaccaagatctacaaatcaagacattttaaaacatccaaatgagctcttattttctaaactcgttctcagggcgctatccgaatgggtctgactatcagttactaaattatggtactaacggcgctatgaacgcttcttacagggactccaccagcatgcattccgggtctttcggttacaactacaatggaatagacctcagtgtaaaccgtcccaacaatggccatttcggggcagttggagataattctcgcgctttccaaaatccgagtcaggagacccggtacagacagtcgagctgctctctctcgtctccagatcctctgtcttgtgccaccagcgatactctggaattgaagggttcctctcctccatctgatcagagcacaccaaccggcaacagcagacttaccaacagcaacaatcttaccagcagcaatagcacacattttgcggacacagatgaaaccaatgtctcgtccgagaccgaggaaggagcacagaccaccaccaccagtcgtacgcagaagcaagaatctgtggcgacctcgactacaacacctaacgacggtcaaactccacagatattcccctggatgaggaagctgcacattagccatgatatgactggacctgatggaaaacgggctcgaacagcttacactcgctaccagacgctcgagctggagaaagagttccatttcaatagatatctgacgcgcaggaggagaatagagatagctcacgctctctgcctctcagagaggcaaatcaaaatctggttccaaaatcgcaggatgaaatggaagaaggacaataaactgaaaagtatgagtctcgctacagcggggagcgcgtttcaaaattgatcaaatcacatcacatcaattggaaaattcgactactgttacagcgctgcaccttcagcttgttctcacctgacgacgtgtgattctcccgtgcaactcaaaattgtcagctgttgaatgttatcatatgctaaactagttacaattgccataaaatgagtgtgaatgtcaagtgtgtcaagtttatacattcgtggaggaaagcatgttccatgtgagctattcgtgcaacgtattagatctacaaaaattatgtacagtacaactcgcactacctaactatcttaagtgatagtgtaaaaagagaatcttttgttgtatccttgaacttgtattgaaacgtcatgtattattcaagcaacatgctatattcttgttatgtgctgggcttttttgatttctcgtctgatacctgcatcgcgaggaaatgaatcttttcgcacttacatttgtgtacttaggctgcagcacaaaattactttgggctcgtaagatgtcctatgaagaatgtctttatacagtagtgaccaatatgttatttgtagtgcacaacgtgagttatggacgttctgtgttaaaagttggataaaaaatgttttgtcatcgacacgttattggtatctctgccattttttgtatttgtgtctaaaatgaaaacgagttcatccaaaaagaataataaagttttctttctgccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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