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Previous release (v1)
2025-05-17 03:22:41, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_131340 2198 bp mRNA linear VRT 25-FEB-2025
DEFINITION Danio rerio thyroid hormone receptor beta (thrb), mRNA.
ACCESSION NM_131340 XM_687890
VERSION NM_131340.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 2198)
AUTHORS Xu,Y., Zhang,S., Bao,Y., Luan,J., Fu,Z., Sun,M., Zhao,X. and
Feng,X.
TITLE Melatonin protects zebrafish pancreatic development and
physiological rhythms from sodium propionate-induced disturbances
via the hypothalamic-pituitary-thyroid axis
JOURNAL J Sci Food Agric 104 (12), 7454-7463 (2024)
PUBMED 38717324
REFERENCE 2 (bases 1 to 2198)
AUTHORS Fagundes,T., Pannetier,P., Golz,L., Behnstedt,L., Morthorst,J.,
Vergauwen,L., Knapen,D., Holbech,H., Braunbeck,T. and Baumann,L.
TITLE The generation gap in endocrine disruption: Can the integrated fish
endocrine disruptor test (iFEDT) bridge the gap by assessing
intergenerational effects of thyroid hormone system disruption?
JOURNAL Aquat Toxicol 272, 106969 (2024)
PUBMED 38824743
REFERENCE 3 (bases 1 to 2198)
AUTHORS Ai,N., Han,C.R., Zhao,H., Cheng,S.Y. and Ge,W.
TITLE Disruption of Thyroid Hormone Receptor Thrab Leads to Female
Infertility in Zebrafish
JOURNAL Endocrinology 165 (5) (2024)
PUBMED 38527850
REFERENCE 4 (bases 1 to 2198)
AUTHORS Yang,L., Tu,P.H., Zhang,C.X., Xie,R.R., Dong,M., Jing,Y., Chen,X.,
Wei,G. and Song,H.D.
TITLE Influence of two anti-tumor drugs, pazopanib, and axitinib, on the
development and thyroid-axis of zebrafish (Danio rerio)
embryos/larvae
JOURNAL Front Endocrinol (Lausanne) 14, 1204678 (2023)
PUBMED 37600710
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2198)
AUTHORS Harper,M., Hu,Y., Donahue,J., Acosta,B., Dievenich Braes,F.,
Nguyen,S., Zeng,J., Barbaro,J., Lee,H., Bui,H. and McMenamin,S.K.
TITLE Thyroid hormone regulates proximodistal patterning in fin rays
JOURNAL Proc Natl Acad Sci U S A 120 (21), e2219770120 (2023)
PUBMED 37186843
REFERENCE 6 (bases 1 to 2198)
AUTHORS Takayama,S., Hostick,U., Haendel,M., Eisen,J. and Darimont,B.
TITLE An F-domain introduced by alternative splicing regulates activity
of the zebrafish thyroid hormone receptor alpha
JOURNAL Gen Comp Endocrinol 155 (1), 176-189 (2008)
PUBMED 17583703
REFERENCE 7 (bases 1 to 2198)
AUTHORS Walpita,C.N., Van der Geyten,S., Rurangwa,E. and Darras,V.M.
TITLE The effect of 3,5,3'-triiodothyronine supplementation on zebrafish
(Danio rerio) embryonic development and expression of iodothyronine
deiodinases and thyroid hormone receptors
JOURNAL Gen Comp Endocrinol 152 (2-3), 206-214 (2007)
PUBMED 17418841
REFERENCE 8 (bases 1 to 2198)
AUTHORS Krasowski,M.D., Yasuda,K., Hagey,L.R. and Schuetz,E.G.
TITLE Evolutionary selection across the nuclear hormone receptor
superfamily with a focus on the NR1I subfamily (vitamin D, pregnane
X, and constitutive androstane receptors)
JOURNAL Nucl Recept 3, 2 (2005)
PUBMED 16197547
REMARK Publication Status: Online-Only
REFERENCE 9 (bases 1 to 2198)
AUTHORS Liu,Y.W. and Chan,W.K.
TITLE Thyroid hormones are important for embryonic to larval transitory
phase in zebrafish
JOURNAL Differentiation 70 (1), 36-45 (2002)
PUBMED 11963654
REMARK GeneRIF: Data suggest that the embryonic to larval transitory phase
is characterized by its dependency on the timely synthesis of
thyroid hormone and the concomitant autoinductive increase in
thyroid hormone receptor beta mRNA levels.
REFERENCE 10 (bases 1 to 2198)
AUTHORS Marchand,O., Safi,R., Escriva,H., Van Rompaey,E., Prunet,P. and
Laudet,V.
TITLE Molecular cloning and characterization of thyroid hormone receptors
in teleost fish
JOURNAL J Mol Endocrinol 26 (1), 51-65 (2001)
PUBMED 11174854
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF109732.1.
On Jul 6, 2005 this sequence version replaced XM_687890.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF109732.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA3505370,
SAMEA3505371 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2198
/organism="Danio rerio"
/mol_type="mRNA"
/db_xref="taxon:7955"
/chromosome="19"
/map="19"
gene 1..2198
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="thyroid hormone receptor beta"
/db_xref="GeneID:30607"
/db_xref="ZFIN:ZDB-GENE-990415-268"
exon 1..147
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 148..192
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 193..255
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 256..307
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 308..372
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
misc_feature 345..347
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="upstream in-frame stop codon"
CDS 366..1526
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="TRbeta1; nuclear receptor subfamily 1 group A
member 2; thyroid hormone receptor beta-1; thyroid hormone
receptor beta 2"
/codon_start=1
/product="thyroid hormone receptor beta"
/protein_id="NP_571415.1"
/db_xref="GeneID:30607"
/db_xref="ZFIN:ZDB-GENE-990415-268"
/translation="
MSEQADKCNSRWKDEAMQNGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLNPTYACKYEGKCVIDKVTRNQCQECRFKKCIAVGMATDLVLDDSKRLAKRKLIEENRERRRREELQKTVWDRPEPTQEEWEMIRVVTEAHMATNAQGNHWKQKRKFLPEDIGSAPIVNAPEGNKVDIEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGVSLSSFNLDDSEVALLQAVILLSSDRPGLTSVERIERCQEEFLLAFEHYINYRKHKVAHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED"
misc_feature 456..716
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="DNA-binding domain of thyroid hormone receptors
(TRs) is composed of two C4-type zinc fingers; Region:
NR_DBD_TR; cd06961"
/db_xref="CDD:143519"
misc_feature order(459..461,468..470,510..512,519..521,573..575,
591..593,621..623,630..632)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:143519"
misc_feature order(489..497,513..518,522..524,528..530,534..539,
546..548,612..617,624..626,633..635,672..680,693..695,
702..707,711..716)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:143519"
misc_feature order(489..491,498..500,663..665,669..674)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:143519"
misc_feature 786..1514
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="The ligand binding domain of thyroid hormone
receptor, a members of a superfamily of nuclear receptors;
Region: NR_LBD_TR; cd06935"
/db_xref="CDD:132733"
misc_feature order(945..947,954..959,963..968,975..977,984..986,
1068..1070,1077..1079,1089..1091,1125..1133,1161..1163,
1170..1172,1176..1178,1197..1199,1443..1445,1464..1466,
1503..1505)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="ligand binding site [chemical binding]; other site"
/db_xref="CDD:132733"
misc_feature order(981..983,990..992,1002..1004,1032..1034,1044..1046,
1053..1055,1497..1502,1509..1511)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="coactivator recognition site [polypeptide binding];
other site"
/db_xref="CDD:132733"
misc_feature order(1182..1184,1317..1319,1407..1409,1416..1421,
1428..1430,1437..1442,1446..1451)
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:132733"
exon 373..423
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 424..524
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 525..672
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 673..878
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 879..1025
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 1026..1284
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
exon 1285..2198
/gene="thrb"
/gene_synonym="fj24f03; NR1A2; thr2; TR-beta; trb; TR[b]1;
wu:fj24f03"
/inference="alignment:Splign:2.1.0"
ORIGIN
cttctttctgtgtcttcgggtccatgttggagttgatctgctctgctgggtcatttcaggccacgtatgtccgatcacaggagcaaacattaaagttacagagatatcaatgaaggacatacacacatgctgtgttgcagcttcgagggtctctcatctgaatgaatgcattgcccatgaagtcagcgatggggcgttgcaagaggggctctggctcttatgacatggtttagaggatgaaaggcaggatgtaaggctctgcttcttcataccactctgggacaacttcaaaatcacaaagcacgagatatcagcgagtctgtggacaacaaaagaatgatggttaaggcctaatatactgcagtatgtcagagcaagcagacaaatgcaactcccgctggaaagatgaggccatgcagaatgggtacataccaagttacctggacaaggatgagctgtgtgttgtttgtggagacaaagcaactggttatcactatcgctgcattacatgtgagggctgcaaaggtttctttcgacgcacaattcagaagaacttaaacccaacatacgcatgcaagtatgaaggaaagtgtgtcattgacaaagttacccgaaaccagtgccaagaatgtcgcttcaagaaatgcatcgctgttggcatggctacagacttggtattggatgacagtaaacgtttagccaagcggaagctgattgaggagaaccgtgaacgccgacggcgtgaggagctgcagaagactgtatgggatcgaccagagcccacacaggaagagtgggagatgatacgggttgtcacagaggcccatatggccacaaatgcccaaggcaaccactggaaacaaaagcgcaaattcctgccagaagacattggatcggcacctattgtcaatgcaccagaggggaacaaagtggacattgaagccttcagtcagtttacaaaaattatcacccccgccatcactcgtgtcgtggattttgccaaaaagctacccatgttctgtgagctgccttgtgaggaccagatcattttgctgaagggttgttgcatggagatcatgtctcttcgagcagcagtgcgttatgaccccgagagcgatactctgacgctaaacggggagatggctgtcacacggggccagctcaagaatgggggtttgggtgttgtctcagatgccatctttgatctgggtgtctcgctgtcctcttttaacttggacgattcagaggtggcgttgttacaagccgtgattctgctttcctctgatcgtccaggtttaacaagcgttgagcggatagagcgttgtcaggaggagtttcttttggcctttgaacattacatcaactaccgtaagcacaaggtggctcacttttggcccaaactgctgatgaaggtgacagacctgcgcatgattggtgcctgccatgccagccgcttcctgcacatgaaggtggaatgtcccacagagctctttccgcccctcttcctggaagtgtttgaagactgatggcaatccaatcaggccaagctgctcccaccaacaccaacctccacaaatcagacctctacagtctccctgttcctggtcatatgtttctagcactactgaacatcatttcattccatagagttaggagtagctctggggcctatttgatgggatccattccttttacaaagcgggtacatttgaatagcataaaaaaataaattctgttactattgttttgttttttcagaaatgtttgatatctggtcatagtgttggataccgctcaacagaaatgtatgaactatgcattcaggtttcatgtcacatcaggcctcagaaataagtcaaatagcgccacactgcaaaggataatagcaatattttgtttcaatttacgtccttattctattggtctataggtctttttaagcttatgttaagctataggttgtttattgttttgttccagaaccctgtaaagcacttacagtacctagaccgaatttcattacatcaataggcgcaaagtaaaatcacaattgtgggctatattattacaatacttttgtcctagacaaaatcactaaatggaaaatgcatttatacttgtaactttaatttgcatagtttaggagcagtaccacaaaaatagatcttagactctttattgtctcaggtttgtcagaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]