LOCUS       NM_131297               1727 bp    mRNA    linear   VRT 21-NOV-2025
DEFINITION  Danio rerio distal-less homeobox 2b (dlx2b), mRNA.
ACCESSION   NM_131297
VERSION     NM_131297.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1727)
  AUTHORS   Chen,Z.Z., Narayanan,S.N., Stagliano,L.M., Huynh,P.Q., Sundaram,S.,
            Mackey,E.J., Miller,C.T. and Square,T.A.
  TITLE     Ectodysplasin overexpression reveals spatiotemporally dynamic tooth
            formation competency in stickleback and zebrafish
  JOURNAL   Development 152 (18) (2025)
   PUBMED   40923183
REFERENCE   2  (bases 1 to 1727)
  AUTHORS   Chen,X., Huang,Y., Yang,X., Lu,H. and Yang,J.
  TITLE     The Molecular Mechanism of Craniofacial Cartilage Deformity Induced
            by High Glucose in Zebrafish
  JOURNAL   Curr Issues Mol Biol 47 (9), 687 (2025)
   PUBMED   41020809
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1727)
  AUTHORS   Benard,E.L., Kucukaylak,I., Hatzold,J., Berendes,K.U.W.,
            Carney,T.J., Beleggia,F. and Hammerschmidt,M.
  TITLE     wnt10a is required for zebrafish median fin fold maintenance and
            adult unpaired fin metamorphosis
  JOURNAL   Dev Dyn 253 (6), 566-592 (2024)
   PUBMED   37870737
REFERENCE   4  (bases 1 to 1727)
  AUTHORS   Liao,T., Xu,X., Wu,J., Xie,Y. and Yan,J.
  TITLE     Increased expression levels of DLX5 inhibit the development of the
            nervous system
  JOURNAL   Int J Dev Neurosci 83 (8), 728-739 (2023)
   PUBMED   37767888
  REMARK    GeneRIF: Increased expression levels of DLX5 inhibit the
            development of the nervous system.
REFERENCE   5  (bases 1 to 1727)
  AUTHORS   Jackson,A., Lin,S.J., Jones,E.A., Chandler,K.E., Orr,D., Moss,C.,
            Haider,Z., Ryan,G., Holden,S., Harrison,M., Burrows,N., Jones,W.D.,
            Loveless,M., Petree,C., Stewart,H., Low,K., Donnelly,D., Lovell,S.,
            Drosou,K., Varshney,G.K. and Banka,S.
  CONSRTM   Genomics England Research Consortium; Solve-RD consortium
  TITLE     Clinical, genetic, epidemiologic, evolutionary, and functional
            delineation of TSPEAR-related autosomal recessive ectodermal
            dysplasia 14
  JOURNAL   HGG Adv 4 (2), 100186 (2023)
   PUBMED   37009414
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1727)
  AUTHORS   Borday-Birraux,V., Van der Heyden,C., Debiais-Thibaud,M.,
            Verreijdt,L., Stock,D.W., Huysseune,A. and Sire,J.Y.
  TITLE     Expression of Dlx genes during the development of the zebrafish
            pharyngeal dentition: evolutionary implications
  JOURNAL   Evol Dev 8 (2), 130-141 (2006)
   PUBMED   16509892
REFERENCE   7  (bases 1 to 1727)
  AUTHORS   Whitehead,G.G., Makino,S., Lien,C.L. and Keating,M.T.
  TITLE     fgf20 is essential for initiating zebrafish fin regeneration
  JOURNAL   Science 310 (5756), 1957-1960 (2005)
   PUBMED   16373575
REFERENCE   8  (bases 1 to 1727)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   9  (bases 1 to 1727)
  AUTHORS   Jackman,W.R., Draper,B.W. and Stock,D.W.
  TITLE     Fgf signaling is required for zebrafish tooth development
  JOURNAL   Dev Biol 274 (1), 139-157 (2004)
   PUBMED   15355794
REFERENCE   10 (bases 1 to 1727)
  AUTHORS   Van de Peer,Y., Frickey,T., Taylor,J. and Meyer,A.
  TITLE     Dealing with saturation at the amino acid level: a case study based
            on anciently duplicated zebrafish genes
  JOURNAL   Gene 295 (2), 205-211 (2002)
   PUBMED   12354655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000001.1.
            
            On Jul 8, 2025 this sequence version replaced NM_131297.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC134899.1, U67843.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA4476751,
                                           SAMEA4476815 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               JBMGRA010000001.1  34587421-34587859   c
            440-444             JBMGRA010000001.1  34587290-34587294   c
            445-624             JBMGRA010000001.1  34579083-34579262   c
            625-1727            JBMGRA010000001.1  34577857-34578959   c
FEATURES             Location/Qualifiers
     source          1..1727
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..1727
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="distal-less homeobox 2b"
                     /db_xref="GeneID:30557"
                     /db_xref="ZFIN:ZDB-GENE-980526-18"
     exon            1..439
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    97..99
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="upstream in-frame stop codon"
     CDS             121..951
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="DLX-5; distal-less homeobox protein 2b; distal-less
                     homeobox gene 5; distal-less homeobox gene 2b"
                     /codon_start=1
                     /product="homeobox protein Dlx2b"
                     /protein_id="NP_571372.1"
                     /db_xref="GeneID:30557"
                     /db_xref="ZFIN:ZDB-GENE-980526-18"
                     /translation="

MTAVLDSLGSDMHTNHITSSSFSTVHKSQDSPTLPVSTVTDSSFFSSSQTGHCAGTAYAQLASYSYHPGTVGNVHYSPKAYDLGYASSYGAYGTYGASSSPTPTEPEKEESEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKLWKNGEIPADQQVASGDSPSSSPPPQAGWDFPPNPTQNDGDTVSEQPTGPPNTTAPSFLTNYSWYSSTNAVTHLQPSTLIQPHHSSAMSTGTIF"

     misc_feature    205..426
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="Homeobox protein distal-less-like N terminal;
                     Region: DLL_N; pfam12413"
                     /db_xref="CDD:463567"
     misc_feature    409..489
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q98876.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    496..666
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    691..834
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q98876.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            440..444
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..624
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1727
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcaaggcaaaacaaactacctctagaagttgtgtgattttgaatcaactattaactgttaggaagtacagcaatatattttagaagtgatcacgttgagtagtctcttcttcctgcgaaatgaccgctgttctggatagccttggctcggatatgcatacaaaccatattacctcgagcagcttcagcaccgttcacaagtcacaggattctccaacactgccggtgtcaacggtgaccgacagcagcttcttcagcagttcacagacaggtcactgtgcagggacagcgtacgcacaactggcatcatattcctatcatcctggcacggtgggtaatgttcattacagccccaaagcgtacgatttaggctatgcttcctcctatggcgcttatggaacgtatggagccagctcttcacccacaccaactgaaccggaaaaagaagagagtgaaccggaggtgcgcatggtgaatggaaagccaaaaaaagtacggaaaccgcgaaccatctactccagttttcagctggcggctctccagcgcagattccagaagacccagtacctcgcgcttccagagcgcgccgaactggcggcgtctttggggctcacgcagacccaggtgaagatatggttccagaacagacgctcaaaattcaaaaagttgtggaaaaatggcgagattcctgcagaccagcaggttgcttccggtgactctccttccagctctccaccgccacaagcaggttgggatttcccaccgaacccaacacagaacgacggggacacagtttcagagcagcccactgggccgccaaacaccactgccccatcgttcttaacaaactactcctggtactcatctacaaatgcggttacacatctacaacccagtaccttaatacaacctcatcacagctctgcaatgagtacagggaccatattctaacagaggactaaaatggccgaatacacctgttgtaggaggatataataggcctattgtcactggacttgtattttaggagaacattaacttcaaaatctattttcaggctgggtttgttaaagatgtttgccgtggaattctttggcgcgactaatgcgctcgagcaacgcacattaaattatttttctatttatttatttgttttcgttttagtccagttgaaaatggtaatcagatacttttaattcacattccaagtacaaacgggtagcctttttgagtgttgtacagaaatgattaggtttagtaataaatctattaaaatgcttgcaatctgcagtaataattaaatgtgcgttttactcagttaaggtttcattatttggttgtcatttaaagtattttatattgccatatgtttgtgctgtaaagcaaatctagatcttactggatcataaaagtcccataaaggatccttttaagctgacatcaacgattttttaataaacacttgaaattatccttcgataatattagatggatacccagtaacatatggactaatttagatttttttttattcagtccgcattaacggtgtagaatctctgtagaatacacatgcagattctctctgttcatatcttcctctaattcctacaatgcataaagtatatattttttatctttagagattatgcaacaactctgctcctttttatccctttgtaaattgtcttggtgaagaggtactatcctgtacctctgggtatgag

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