LOCUS       NM_131297               1526 bp    mRNA    linear   VRT 12-JAN-2025
DEFINITION  Danio rerio distal-less homeobox 2b (dlx2b), mRNA.
ACCESSION   NM_131297
VERSION     NM_131297.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Benard,E.L., Kucukaylak,I., Hatzold,J., Berendes,K.U.W.,
            Carney,T.J., Beleggia,F. and Hammerschmidt,M.
  TITLE     wnt10a is required for zebrafish median fin fold maintenance and
            adult unpaired fin metamorphosis
  JOURNAL   Dev Dyn 253 (6), 566-592 (2024)
   PUBMED   37870737
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Liao,T., Xu,X., Wu,J., Xie,Y. and Yan,J.
  TITLE     Increased expression levels of DLX5 inhibit the development of the
            nervous system
  JOURNAL   Int J Dev Neurosci 83 (8), 728-739 (2023)
   PUBMED   37767888
  REMARK    GeneRIF: Increased expression levels of DLX5 inhibit the
            development of the nervous system.
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Jackson,A., Lin,S.J., Jones,E.A., Chandler,K.E., Orr,D., Moss,C.,
            Haider,Z., Ryan,G., Holden,S., Harrison,M., Burrows,N., Jones,W.D.,
            Loveless,M., Petree,C., Stewart,H., Low,K., Donnelly,D., Lovell,S.,
            Drosou,K., Varshney,G.K. and Banka,S.
  CONSRTM   Genomics England Research Consortium; Solve-RD consortium
  TITLE     Clinical, genetic, epidemiologic, evolutionary, and functional
            delineation of TSPEAR-related autosomal recessive ectodermal
            dysplasia 14
  JOURNAL   HGG Adv 4 (2), 100186 (2023)
   PUBMED   37009414
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1526)
  AUTHORS   Coltogirone,R.A., Sherfinski,E.I., Dobler,Z.A., Peterson,S.N.,
            Andlinger,A.R., Fadel,L.C., Patrick,R.L. and Bergeron,S.A.
  TITLE     Gsx2, but not Gsx1, is necessary for early forebrain patterning and
            long-term survival in zebrafish
  JOURNAL   Dev Dyn 252 (3), 377-399 (2023)
   PUBMED   36184733
REFERENCE   5  (bases 1 to 1526)
  AUTHORS   Suzuki,T., Hirai,Y., Uehara,T., Ohga,R., Kosaki,K. and Kawahara,A.
  TITLE     Involvement of the zebrafish trrap gene in craniofacial development
  JOURNAL   Sci Rep 11 (1), 24166 (2021)
   PUBMED   34934055
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1526)
  AUTHORS   Borday-Birraux,V., Van der Heyden,C., Debiais-Thibaud,M.,
            Verreijdt,L., Stock,D.W., Huysseune,A. and Sire,J.Y.
  TITLE     Expression of Dlx genes during the development of the zebrafish
            pharyngeal dentition: evolutionary implications
  JOURNAL   Evol Dev 8 (2), 130-141 (2006)
   PUBMED   16509892
REFERENCE   7  (bases 1 to 1526)
  AUTHORS   Whitehead,G.G., Makino,S., Lien,C.L. and Keating,M.T.
  TITLE     fgf20 is essential for initiating zebrafish fin regeneration
  JOURNAL   Science 310 (5756), 1957-1960 (2005)
   PUBMED   16373575
REFERENCE   8  (bases 1 to 1526)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   9  (bases 1 to 1526)
  AUTHORS   Jackman,W.R., Draper,B.W. and Stock,D.W.
  TITLE     Fgf signaling is required for zebrafish tooth development
  JOURNAL   Dev Biol 274 (1), 139-157 (2004)
   PUBMED   15355794
REFERENCE   10 (bases 1 to 1526)
  AUTHORS   Van de Peer,Y., Frickey,T., Taylor,J. and Meyer,A.
  TITLE     Dealing with saturation at the amino acid level: a case study based
            on anciently duplicated zebrafish genes
  JOURNAL   Gene 295 (2), 205-211 (2002)
   PUBMED   12354655
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC134899.1.
            
            On Apr 1, 2007 this sequence version replaced NM_131297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC134899.1, U67843.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA4476751,
                                           SAMEA4476782 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..1526
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="distal-less homeobox 2b"
                     /db_xref="GeneID:30557"
                     /db_xref="ZFIN:ZDB-GENE-980526-18"
     exon            1..439
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    97..99
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="upstream in-frame stop codon"
     CDS             121..951
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="DLX-5; distal-less homeobox protein 2b; distal-less
                     homeobox gene 5; distal-less homeobox gene 2b"
                     /codon_start=1
                     /product="homeobox protein Dlx2b"
                     /protein_id="NP_571372.1"
                     /db_xref="GeneID:30557"
                     /db_xref="ZFIN:ZDB-GENE-980526-18"
                     /translation="

MTAVLDSLGSDMHTNHITSSSFSTVHKSQDSPTLPVSTVTDSSFFSSSQTGHCAGTAYAQLASYSYHPGTVGNVHYSPKAYDLGYASSYGAYGTYGASSSPTPTEPEKEESEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKLWKNGEIPADQQVASGDSPSSSPPPQAGWDFPPNPTQNDGDTVSEQPTGPPNTTAPSFLTNYSWYSSTNAVTHLQPSTLIQPHHSSAMSTGTIF"

     misc_feature    205..426
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="Homeobox protein distal-less-like N terminal;
                     Region: DLL_N; pfam12413"
                     /db_xref="CDD:463567"
     misc_feature    409..489
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q98876.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    496..666
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    691..834
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q98876.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            440..624
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1503
                     /gene="dlx2b"
                     /gene_synonym="dlx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctcaaggcaaaacaaactacctctagaagttgtgtgattttgaatcaactattaactgttaggaagtacagcaatatattttagaagtgatcacgttgagtagtctcttcttcctgcgaaatgaccgctgttctggatagccttggctcggatatgcatacaaaccatattacctcgagcagcttcagcaccgttcacaagtcacaggattctccaacactgccggtgtcaacggtgaccgacagcagcttcttcagcagttcacagacaggtcactgtgcagggacagcgtacgcacaactggcatcatattcctatcatcctggcacggtgggtaatgttcattacagccccaaagcgtacgatttaggctatgcttcctcctatggcgcttatggaacgtatggagccagctcttcacccacaccaactgaaccggaaaaagaagagagtgaaccggaggtgcgcatggtgaatggaaagccaaaaaaagtacggaaaccgcgaaccatctactccagttttcagctggcggctctccagcgcagattccagaagacccagtacctcgcgcttccagagcgcgccgaactggcggcgtctttggggctcacgcagacccaggtgaagatatggttccagaacagacgctcaaaattcaaaaagttgtggaaaaatggcgagattcctgcagaccagcaggttgcttccggtgactctccttccagctctccaccgccacaagcaggttgggatttcccaccgaacccaacacagaacgacggggacacagtttcagagcagcccactgggccgccaaacaccactgccccatcgttcttaacaaactattcctggtactcatctacaaatgcggttacacatctacaacccagtaccttaatacaacctcatcacagctctgcaatgagtacagggaccatattctaacagaggactaaaatggccgaatacacctgttgtaagaggatataataggcctattgtcactggacttgtattttaggagaacattaacttcaaaatctattttcaggctgggtttgttaaagatgtttgccgtggaattctttggcgcgactaatgcgctcgagcaacgcacattaaattatttttctatttatttatttgttttcgttttagtccagttgaaaatggtaatcagatacttttaattcacattccaagtacaaacgggtagcctttttgagtgttgtacagaaatgattaggtttagtaataaatctattaaaatgcttgcaatctgcagtaataattaaatgtgcgttttactcagttaaggtttcattatttggttgtcatttaaagtattttatactgccatatgtttgtgctgtaaagcaaatctagatcttactggatcataaaagtcccataaaggatccttttaagctgacatcaacgattttttaataaacacttgaaattatccttcgataatattagatggatacccagtaaaaaaaaaaaaaaaaaaaaaaaaa

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