LOCUS       NM_131218               2016 bp    mRNA    linear   VRT 24-NOV-2024
DEFINITION  Danio rerio LIM homeobox 5 (lhx5), mRNA.
ACCESSION   NM_131218
VERSION     NM_131218.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Itoh,T., Uehara,M., Yura,S., Wang,J.C., Fujii,Y., Nakanishi,A.,
            Shimizu,T. and Hibi,M.
  TITLE     Foxp and Skor family proteins control differentiation of Purkinje
            cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456494
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Zhang,Q., Zhang,C., Zhang,C. and Peng,G.
  TITLE     Wnt Signaling Regulates Ipsilateral Pathfinding in the Zebrafish
            Forebrain through slit3
  JOURNAL   Neuroscience 449, 9-20 (2020)
   PUBMED   32949671
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Schredelseker,T., Veit,F., Dorsky,R.I. and Driever,W.
  TITLE     Bsx Is Essential for Differentiation of Multiple Neuromodulatory
            Cell Populations in the Secondary Prosencephalon
  JOURNAL   Front Neurosci 14, 525 (2020)
   PUBMED   32581684
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Schredelseker,T. and Driever,W.
  TITLE     Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish
            Embryos
  JOURNAL   Front Neuroanat 14, 3 (2020)
   PUBMED   32116574
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Martik,M.L., Gandhi,S., Uy,B.R., Gillis,J.A., Green,S.A.,
            Simoes-Costa,M. and Bronner,M.E.
  TITLE     Evolution of the new head by gradual acquisition of neural crest
            regulatory circuits
  JOURNAL   Nature 574 (7780), 675-678 (2019)
   PUBMED   31645763
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Tallafuss,A., Wilm,T.P., Crozatier,M., Pfeffer,P., Wassef,M. and
            Bally-Cuif,L.
  TITLE     The zebrafish buttonhead-like factor Bts1 is an early regulator of
            pax2.1 expression during mid-hindbrain development
  JOURNAL   Development 128 (20), 4021-4034 (2001)
   PUBMED   11641225
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Kobayashi,M., Toyama,R., Takeda,H., Dawid,I.B. and Kawakami,K.
  TITLE     Overexpression of the forebrain-specific homeobox gene six3 induces
            rostral forebrain enlargement in zebrafish
  JOURNAL   Development 125 (15), 2973-2982 (1998)
   PUBMED   9655819
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Fisher,S., Amacher,S.L. and Halpern,M.E.
  TITLE     Loss of cerebum function ventralizes the zebrafish embryo
  JOURNAL   Development 124 (7), 1301-1311 (1997)
   PUBMED   9118801
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Sheng,H.Z., Bertuzzi,S., Chiang,C., Shawlot,W., Taira,M., Dawid,I.
            and Westphal,H.
  TITLE     Expression of murine Lhx5 suggests a role in specifying the
            forebrain
  JOURNAL   Dev Dyn 208 (2), 266-277 (1997)
   PUBMED   9022063
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Moens,C.B., Yan,Y.L., Appel,B., Force,A.G. and Kimmel,C.B.
  TITLE     valentino: a zebrafish gene required for normal hindbrain
            segmentation
  JOURNAL   Development 122 (12), 3981-3990 (1996)
   PUBMED   9012518
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L42547.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L42547.1, BC098523.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="21"
                     /map="21"
     gene            1..2016
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="LIM homeobox 5"
                     /db_xref="GeneID:30465"
                     /db_xref="ZFIN:ZDB-GENE-980526-484"
     misc_feature    136..138
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="upstream in-frame stop codon"
     CDS             295..1494
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="homeobox protein LIM-5; LIM homeobox protein 5"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx5"
                     /protein_id="NP_571293.1"
                     /db_xref="GeneID:30465"
                     /db_xref="ZFIN:ZDB-GENE-980526-484"
                     /translation="

MMVHCAGCERPILDRFLLNVLDRAWHAKCVQCCECNCNLTEKCFSRDGKLYCKIDFFRRFGTKCAGCLQGISPSDLVRRARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKEDYLSASAIKEVNLNSVSSCTDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNSCTKRRGPRTTIKAKQLETLKAAFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRGPRRMRPLGGRLEDPDIMGPGGYSYYGEYQGDYYGPVVNYDFFPHGPPSSQAHSPAESPYLLSSGSGALEGGPVSAHHPSDDQRFTDMISHADTPSPEPGMTGPLHSNPQGEGGFTGSPPFPLANNTSYSGPMSHPGQEMGENTVW"

     misc_feature    307..462
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="The first LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; Region: LIM1_Lhx1_Lhx5; cd09367"
                     /db_xref="CDD:188753"
     misc_feature    order(307..309,316..318,370..372,379..381,388..390,
                     397..399,448..450,457..459)
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188753"
     misc_feature    484..651
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="The second LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; Region: LIM2_Lhx1_Lhx5; cd09375"
                     /db_xref="CDD:188761"
     misc_feature    order(484..486,493..495,550..552,559..561,568..570,
                     577..579,637..639,646..648)
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188761"
     misc_feature    670..>1020
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    700..849
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="propagated from UniProtKB/Swiss-Prot (P52889.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    835..1005
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1195..1491
                     /gene="lhx5"
                     /gene_synonym="lim5"
                     /note="propagated from UniProtKB/Swiss-Prot (P52889.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      

ggcacgagcaggtggatcgaggacaacttggaaaagtcaaaactctgcgctacaagtatatttatgttctgatttgctggatatctggaaaacgacaggtataatgcataacaatcacgtccggagtgtttacactaggcgtggtggggactcattgtcaagacggaacatttgctctgctgttgcctccctctccaagaagccaagacgttgctccgcaccgattcgtgtggccccaatccgaggcgcggtgcccgtttgggaaggtcggctctcggtcccctccagggcggaatgatggtgcactgcgcggggtgtgagaggcccattctggatcggttcctcttaaacgttctggaccgcgcatggcacgccaagtgtgtccaatgctgcgagtgtaactgcaacctgaccgaaaaatgtttctccagggatggaaagctctattgcaaaattgactttttcaggcgttttggtacgaaatgtgcgggctgcttgcagggaatttcgcccagcgatctcgtgcgaagagcgcgcagcaaggtgtttcatctcaactgtttcacgtgcatggtgtgcaacaaacagctgtccacgggcgaggagctctacgtcattgacgaaaacaaatttgtgtgtaaagaggactacctgagcgcgagcgccatcaaagaggtcaatttaaactcagtgtcgtcgtgtacagaccggagtttatcgcctgatcttccggatcaaatccaggacgacacgaaggagacggacaattccacatcttcagataaagacactaacaacaacgaaaacgaggagcaaaactcgtgcacgaaacggcgaggcccgcgcaccaccatcaaggccaaacagctggagactctgaaagccgcgttcgtggccacgccgaaacccacgcgacacatccgcgagcaactcgcgcaggagacaggccttaacatgcgggtgattcaggtgtggtttcaaaaccggcggtctaaagaacgtagaatgaagcagctcagtgctctcggtgctcgacgacatgctttcttcaggggaccacgaagaatgaggcctctcggaggaagactagaggaccccgacataatgggccctggaggatacagctactacggagaataccaaggtgactattacggcccagtggtcaactatgatttcttccctcacggacccccttcctcacaggcacactctccagctgaatccccttatcttctcagctcgggttcaggagccctggagggtggcccggtctctgctcaccacccctcagatgaccaaaggttcacggacatgatatcccatgcagacacccctagtcccgaaccaggcatgactggacctctccattccaatccacagggggaaggtggattcacagggagtccacccttccccctggccaacaataccagttacagcggcccaatgtcccatcctggtcaagagatgggggagaacactgtttggtaggacagagacaataagactctatggacacagaggggattccaacctaaccagtctaccttagtggtctaccaagggagggcttattggctgttcatggaccagaacacaccaacatttggaccataaacctgagagttggactgacatcatgtgctctctcttgcagtttaggttctgctatcaaaggatgtgtattgtcagtggtcaccctggtttgagtgcgttcgcaaaggtttattacgattacatcacaatcaagatgtttgtctgagggatttttctactgctttgacttactcattagcaaccgcatctgatggtcagaagtgagctagtacttaaaggcaaatccattttcatccttctgttggcttcagtttctttcttttccaagacacagaggctcggttggttcaaatgttttcttttctgtcttacaacaggtccatttgtaacatatttggttcattcattaactgacgaattggttcattaaacatttcaatgaacacccagaaaaaa

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