LOCUS       NM_131149               1470 bp    mRNA    linear   VRT 25-FEB-2025
DEFINITION  Danio rerio tyrosine hydroxylase (th), mRNA.
ACCESSION   NM_131149 XM_682702
VERSION     NM_131149.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Roychaudhury,A., Lee,Y.R., Choi,T.I., Thomas,M.G., Khan,T.N.,
            Yousaf,H., Skinner,C., Maconachie,G., Crosier,M., Horak,H.,
            Constantinescu,C.S., Kim,T.Y., Lee,K.H., Kyung,J.J., Wang,T.,
            Ku,B., Chodirker,B.N., Hammer,M.F., Gottlob,I., Norton,W.H.J.,
            Gerlai,R., Kim,H.G., Graziano,C., Pippucci,T., Iovino,E.,
            Montanari,F., Severi,G., Toro,C., Boerkoel,C.F., Cha,H.S.,
            Choi,C.Y., Kim,S., Yoon,J.H., Gilmore,K., Vora,N.L., Davis,E.E.,
            Chudley,A.E., Schwartz,C.E. and Kim,C.H.
  TITLE     SRPK3 Is Essential for Cognitive and Ocular Development in Humans
            and Zebrafish, Explaining X-Linked Intellectual Disability
  JOURNAL   Ann Neurol 96 (5), 914-931 (2024)
   PUBMED   39073169
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Wang,H., Li,X., Li,J., Yu,F., Li,Q., Qin,M., Gui,L., Qian,Y. and
            Huang,M.
  TITLE     Long-term exposure to ionic liquid [C8mim]Br induces the potential
            risk of anxiety and memory deterioration through disturbing
            neurotransmitter systems
  JOURNAL   Neurotoxicology 104, 66-74 (2024)
   PUBMED   39084264
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Ruan,D.D., Zou,J., Liao,L.S., Ji,M.D., Wang,R.L., Zhang,J.H.,
            Zhang,L., Gao,M.Z., Chen,Q., Yu,H.P., Wei,W., Li,Y.F., Li,H.,
            Lin,F., Luo,J.W. and Lin,X.F.
  TITLE     In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating
            hemiplegia of childhood and rapid-onset dystonia-parkinsonism
  JOURNAL   Front Neurosci 18, 1415576 (2024)
   PUBMED   39145297
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Miyazaki,S., Shimizu,N., Miyahara,H., Teranishi,H., Umeda,R.,
            Yano,S., Shimada,T., Shiraishi,H., Komiya,K., Katoh,A.,
            Yoshimura,A., Hanada,R. and Hanada,T.
  TITLE     DHCR7 links cholesterol synthesis with neuronal development and
            axonal integrity
  JOURNAL   Biochem Biophys Res Commun 712-713, 149932 (2024)
   PUBMED   38626530
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Guo,J., Zou,Z., Dou,X., Zhao,X., Wang,Y., Wei,L., Pi,Y., Wang,Y.,
            He,C. and Guo,S.
  TITLE     Zebrafish Mbd5 binds to RNA m5C and regulates histone
            deubiquitylation and gene expression in development metabolism and
            behavior
  JOURNAL   Nucleic Acids Res 52 (8), 4257-4275 (2024)
   PUBMED   38366571
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Holzschuh,J., Barrallo-Gimeno,A., Ettl,A.K., Durr,K., Knapik,E.W.
            and Driever,W.
  TITLE     Noradrenergic neurons in the zebrafish hindbrain are induced by
            retinoic acid and require tfap2a for expression of the
            neurotransmitter phenotype
  JOURNAL   Development 130 (23), 5741-5754 (2003)
   PUBMED   14534139
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Holzschuh,J., Hauptmann,G. and Driever,W.
  TITLE     Genetic analysis of the roles of Hh, FGF8, and nodal signaling
            during catecholaminergic system development in the zebrafish brain
  JOURNAL   J Neurosci 23 (13), 5507-5519 (2003)
   PUBMED   12843251
REFERENCE   8  (bases 1 to 1470)
  AUTHORS   Parareda,A., Villaescusa,J.C., Sanchez de Toledo,J. and Gallego,S.
  TITLE     New splicing variants for human Tyrosine Hydroxylase gene with
            possible implications for the detection of minimal residual disease
            in patients with neuroblastoma
  JOURNAL   Neurosci Lett 336 (1), 29-32 (2003)
   PUBMED   12493595
  REMARK    GeneRIF: In the analyzed samples we found two novel TH mRNAs, one
            lacking exon 8, and another lacking exons 8+9. These new splicing
            variants are described in a region of TH previously reported to be
            conserved.
REFERENCE   9  (bases 1 to 1470)
  AUTHORS   Rink,E. and Wullimann,M.F.
  TITLE     Development of the catecholaminergic system in the early zebrafish
            brain: an immunohistochemical study
  JOURNAL   Brain Res Dev Brain Res 137 (1), 89-100 (2002)
   PUBMED   12128258
REFERENCE   10 (bases 1 to 1470)
  AUTHORS   Guo,S., Brush,J., Teraoka,H., Goddard,A., Wilson,S.W., Mullins,M.C.
            and Rosenthal,A.
  TITLE     Development of noradrenergic neurons in the zebrafish hindbrain
            requires BMP, FGF8, and the homeodomain protein soulless/Phox2a
  JOURNAL   Neuron 24 (3), 555-566 (1999)
   PUBMED   10595509
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL954320.5.
            
            On Mar 2, 2008 this sequence version replaced XM_682702.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC163630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL954320.5         23783-23866
            85-288              AL954320.5         25124-25327
            289-463             AL954320.5         28278-28452
            464-552             AL954320.5         31706-31794
            553-620             AL954320.5         31944-32011
            621-671             AL954320.5         32526-32576
            672-817             AL954320.5         32664-32809
            818-953             AL954320.5         34266-34401
            954-1023            AL954320.5         37799-37868
            1024-1080           AL954320.5         38283-38339
            1081-1176           AL954320.5         38413-38508
            1177-1310           AL954320.5         40421-40554
            1311-1470           AL954320.5         42783-42942
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="25"
                     /map="25"
     gene            1..1470
                     /gene="th"
                     /note="tyrosine hydroxylase"
                     /db_xref="GeneID:30384"
                     /db_xref="ZFIN:ZDB-GENE-990621-5"
     CDS             1..1470
                     /gene="th"
                     /EC_number="1.14.16.2"
                     /note="th1"
                     /codon_start=1
                     /product="tyrosine 3-monooxygenase"
                     /protein_id="NP_571224.1"
                     /db_xref="GeneID:30384"
                     /db_xref="ZFIN:ZDB-GENE-990621-5"
                     /translation="

MPNSSSSTSSTKSIRRAASELERSDSITSQKFVGRRQSLIEDARKEREAAAAAAEAAGLSEQIVFEESDGKALISLFFTLRCSKSPALSRTLKVFETFEAKIHHLETRPSRKPKDGLEDLEYYVQCEVHLSDVSTLVSSLKRSAEDVKTTKEVKFHWFPRKIAELDKCHHLVTKYDPDLDQDHPGFTDPVYRKRRKMIGDIAFKYRHGEPIPRVDYTEEEIGTWREVYSTLRDLYTTHACSEHLEAFRLLEKHCGYSPDNIPQLEDVSCFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCVHELLGHVPILSDRTFAQFSQSIGLASLGASDEDIEKLSTMYWFTVEFGLCKQGGVIKAYGAGLLSSYGELVHSLSDEPERREFDPDIVAVQPYQDQTYQPVYFVSESFVDATEKLRTYVTRIKRPFSVRFDPYTDSIEVLDNPLKIQKGLETIKDELKILTDALNVLA"

     misc_feature    106..1467
                     /gene="th"
                     /note="tyrosine 3-monooxygenase, tetrameric; Region:
                     Tyr_3_monoox; TIGR01269"
                     /db_xref="CDD:130336"
     exon            1..84
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            85..288
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            289..463
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            464..552
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            553..620
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            621..671
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            672..817
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            818..953
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1023
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1080
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1176
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1310
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1470
                     /gene="th"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgccgaattcaagcagctccacatcttccacaaagagcatccggagagctgcgtctgaactcgagcgctcagattctattacgtctcagaagtttgttgggaggcggcagagtttgatcgaggatgcgcgtaaggagcgcgaggcggcggccgcggcggcggaggctgcaggactgagcgagcagatcgtgtttgaggagagcgatggaaaagcattgatcagcctcttcttcactctcaggtgctctaaaagccctgcgctgtcccgcaccttgaaggttttcgagacatttgaggccaaaatccaccatcttgaaaccagacccagccgaaaaccaaaggatggcttggaggacctagaatattatgttcagtgtgaagtgcacctgtcggatgttagcacgctggtcagctctttgaagagaagtgcagaggatgtcaaaaccacaaaggaggtcaaatttcattggtttcccagaaaaatagctgagcttgataaatgccatcatcttgtcaccaaatatgatccggatctggatcaggatcacccaggatttactgaccctgtttacagaaaacgacggaagatgatcggagacattgccttcaaatacagacatggagaaccaattcctagagtggactatacagaggaagaaatcggaacatggcgggaggtctactccaccctccgagatctgtacacgacccacgcctgcagtgaacatttagaggctttccggttactggagaaacattgcggctacagcccagataacatccctcagctggaggatgtgtcctgcttcttaaaagaacgcacaggatttcagttgaggccagtggcaggtttgctctcagcacgcgattttttggccagcctggcttttcgtgtgttccagtgcacacagtacatacggcacgcttcctcccccatgcactcccctgaaccggattgcgtccatgaactcctcggccatgtaccgatattgtctgatcgaacatttgcacagttttctcagagtattggtttggcatctcttggagcttctgatgaagatattgagaagctatcgacaatgtactggttcactgtggagtttggactgtgtaaacagggaggggtgattaaagcgtatggagcaggactgctgtcatcctatggagagctggtgcattctctttcagatgagccagagagacgagaatttgacccagatattgttgctgttcagccataccaagaccagacttaccaacctgtctattttgtgtcagaaagctttgtggacgctactgagaaactaagaacatatgtgacccgcatcaagcgaccgttttctgtgcggttcgatccgtacacggacagcatagaagtgctggacaacccactgaagatccagaaaggcctggagaccataaaagatgaactgaagattctcacagatgccctgaatgtgttggcttaa

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