LOCUS       NM_131142               1628 bp    mRNA    linear   VRT 20-NOV-2025
DEFINITION  Danio rerio homeobox B1b (hoxb1b), mRNA.
ACCESSION   NM_131142
VERSION     NM_131142.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Moriyama,Y., Mitsui,T. and Heisenberg,C.P.
  TITLE     Hoxb genes determine the timing of cell ingression by regulating
            cell surface fluctuations during zebrafish gastrulation
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40576478
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Alsakran,A.A., Gibson,B., Wong,H.Y., Heaton,C., Boreham,R.,
            Minhas,R., Ball,J. and Kudoh,T.
  TITLE     Ethanol downregulates gastrula gene expression and cell movement,
            causing symptoms of foetal alcohol spectrum disorders
  JOURNAL   Biol Open 14 (6) (2025)
   PUBMED   40331622
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Sundaramoorthi,H., Fallatah,W., Mary,J. and Jagadeeswaran,P.
  TITLE     Discovery of seven hox genes in zebrafish thrombopoiesis
  JOURNAL   Blood Cells Mol Dis 104, 102796 (2024)
   PUBMED   37717409
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Wang,H., He,J., Han,X., Wu,X., Ye,X., Lv,W. and Zu,Y.
  TITLE     hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated
            Heart Malformation in Bosley-Salih-Alorainy Syndrome
  JOURNAL   Biology (Basel) 12 (7), 899 (2023)
   PUBMED   37508332
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Silva,N. and Campinho,M.A.
  TITLE     In a zebrafish biomedical model of human Allan-Herndon-Dudley
            syndrome impaired MTH signaling leads to decreased neural cell
            diversity
  JOURNAL   Front Endocrinol (Lausanne) 14, 1157685 (2023)
   PUBMED   37214246
  REMARK    Erratum:[Front Endocrinol (Lausanne). 2023 May 31;14:1228183. doi:
            10.3389/fendo.2023.1228183. PMID: 37324251]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Vlachakis,N., Ellstrom,D.R. and Sagerstrom,C.G.
  TITLE     A novel pbx family member expressed during early zebrafish
            embryogenesis forms trimeric complexes with Meis3 and Hoxb1b
  JOURNAL   Dev Dyn 217 (1), 109-119 (2000)
   PUBMED   10679934
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   Barth,K.A., Kishimoto,Y., Rohr,K.B., Seydler,C., Schulte-Merker,S.
            and Wilson,S.W.
  TITLE     Bmp activity establishes a gradient of positional information
            throughout the entire neural plate
  JOURNAL   Development 126 (22), 4977-4987 (1999)
   PUBMED   10529416
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Essner,J.J., Johnson,R.G. and Hackett,P.B. Jr.
  TITLE     Overexpression of thyroid hormone receptor alpha 1 during zebrafish
            embryogenesis disrupts hindbrain patterning and implicates retinoic
            acid receptors in the control of hox gene expression
  JOURNAL   Differentiation 65 (1), 1-11 (1999)
   PUBMED   10448709
REFERENCE   9  (bases 1 to 1628)
  AUTHORS   Nikaido,M., Tada,M., Takeda,H., Kuroiwa,A. and Ueno,N.
  TITLE     In vivo analysis using variants of zebrafish BMPR-IA: range of
            action and involvement of BMP in ectoderm patterning
  JOURNAL   Development 126 (1), 181-190 (1999)
   PUBMED   9834197
REFERENCE   10 (bases 1 to 1628)
  AUTHORS   Koshida,S., Shinya,M., Mizuno,T., Kuroiwa,A. and Takeda,H.
  TITLE     Initial anteroposterior pattern of the zebrafish central nervous
            system is determined by differential competence of the epiblast
  JOURNAL   Development 125 (10), 1957-1966 (1998)
   PUBMED   9550728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC133876.1.
            
            On Apr 15, 2007 this sequence version replaced NM_131142.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133876.1, EH590761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..1628
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="homeobox B1b"
                     /db_xref="GeneID:30374"
                     /db_xref="ZFIN:ZDB-GENE-980526-290"
     exon            1..963
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    348..350
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="upstream in-frame stop codon"
     CDS             375..1298
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="hox-A1; homeobox protein Hox-A1; homeobox gene A-1;
                     homeo box B1b"
                     /codon_start=1
                     /product="homeobox protein Hox-B1b"
                     /protein_id="NP_571217.2"
                     /db_xref="GeneID:30374"
                     /db_xref="ZFIN:ZDB-GENE-980526-290"
                     /translation="

MNSYLDYTIYNRGSNTYSSKVGCFPVEQEYLPSACASTNSYIPEGRPVGGNTFTSAPHETHGTSYAQIQSQPFHLNVDMGKTGHSNFCKQTRPPHSDYGHQHVLTQADDHMRLQSPGFSVVNMGANIGTYSESNCRPGSVSASHYQSYAYGEPEPHGYGSFSKYQVSPDSDSDSKTNIKQAPTFDWMKVKRNPPKTVKVAEYGIHGQQNIIRTNFTTKQLTELEKEFHFNKYLTRARRVEVAATLELNETQVKIWFQNRRMKQKKREKEGTAPVIKRVTLCSSGQNADHSTSSSPGASPTSDSSTAI"

     misc_feature    849..908
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90423.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    921..938
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90423.3);
                     Region: Antp-type hexapeptide"
     misc_feature    1008..1169
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1167..1295
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90423.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            964..1606
                     /gene="hoxb1b"
                     /gene_synonym="cb249; Hoxa-1; hoxa1; id:ibd5001"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atttatagctcgctaaacaaatacagttgtcctcaccgtcacaggtacacaatagctataaattatctcttgctgtactcgctttaattcacattagacctacatagcgactttatcagattgacgggtggattcgattgatgtgtttgtcatgtaaatacgaatcgtttgatggacacctgcaacgcccagagtgctaccgcaggtcgcacactattggcgcaaaattagtcacatgatctgtcacttaactgatatgagctcagatacaactttgcgtggtttgacatactgcttagaggttgtaggggcactgggaccacacatcagctcatattgaccctgcttaatcaattttgcttggtcagtcaacaatgaattcttacttagattatacgatttataaccgtggttctaacacttatagttcgaaagttgggtgttttcctgtagagcaagaatacttgccaagtgcttgtgcaagtacaaatagttacattcccgagggacggccagtcggaggaaacactttcacatcggcaccgcacgaaactcatggcacatcttacgcacaaattcaatcgcagcccttccacctcaacgtggacatgggtaaaacaggacacagcaatttctgcaagcaaaccagacctcctcattcggactatggacatcaacacgttctcactcaagcagatgaccacatgcgccttcagtcccctggcttttccgtcgtgaatatgggagccaatattggaacttacagtgaatcaaactgcaggcctggctcggtctctgcaagccactatcaatcatatgcatatggagaacccgaaccacacggctatggttcgttcagcaagtatcaggtctcccctgacagtgacagcgactccaagacgaacattaaacaagcgccaacctttgactggatgaaagtcaagaggaatccccctaaaacagttaaagtcgccgaatacggaatccatggccagcagaacataatacgcaccaatttcaccaccaagcagctcacggaacttgagaaggagtttcacttcaacaaatacttgaccagagcgcgcagagtggaggtggccgccacactcgaactgaacgaaacgcaggttaaaatctggtttcagaatcgcagaatgaagcagaagaagcgcgagaaggaaggcacggccccggtgattaaaagagtaaccctttgctcttctggtcaaaacgcagaccactcaactagctcatcgcctggtgcttcgcctacctcggactcttccactgcaatttgatgagtgccagactttcgtttcgttgctggaggactatttaacttattctgtcgtagaaaaaaatattgtttacgtgctatttgtgtttttgtgctgcattagaactactaaatagatgcattaacagggtatatgcttaacgttcaaatgttctttttcttgttgttgtcgtccggtcaattattttgcactacagattcattcctctgttgaaagagtaataaaatgtgaaaaagactgacatgtttatgtatttcgaatatattcggacctgtgacctgataaataaatattttatttttctgaaaaaaaaaaaaaaaaaaaaaaaaa

//