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Previous release (v1)
2025-04-24 10:32:34, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001365432 2855 bp mRNA linear VRT 19-JAN-2025
DEFINITION Danio rerio MDM2 proto-oncogene (mdm2), transcript variant 1, mRNA.
ACCESSION NM_001365432
VERSION NM_001365432.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 2855)
AUTHORS Flentke,G.R., Wilkie,T.E., Baulch,J., Huang,Y. and Smith,S.M.
TITLE Alcohol exposure suppresses ribosome biogenesis and causes
nucleolar stress in cranial neural crest cells
JOURNAL PLoS One 19 (6), e0304557 (2024)
PUBMED 38941348
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2855)
AUTHORS Prykhozhij,S.V., Ban,K., Brown,Z.L., Kobar,K., Wajnberg,G.,
Fuller,C., Chacko,S., Lacroix,J., Crapoulet,N., Midgen,C.,
Shlien,A., Malkin,D. and Berman,J.N.
TITLE miR-34a is a tumor suppressor in zebrafish and its expression
levels impact metabolism, hematopoiesis and DNA damage
JOURNAL PLoS Genet 20 (5), e1011290 (2024)
PUBMED 38805544
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2855)
AUTHORS Madakashira,B.P., Magnani,E., Ranjan,S. and Sadler,K.C.
TITLE DNA hypomethylation activates Cdk4/6 and Atr to induce DNA
replication and cell cycle arrest to constrain liver outgrowth in
zebrafish
JOURNAL Nucleic Acids Res 52 (6), 3069-3087 (2024)
PUBMED 38321933
REFERENCE 4 (bases 1 to 2855)
AUTHORS Lin,S.J., Vona,B., Lau,T., Huang,K., Zaki,M.S., Aldeen,H.S.,
Karimiani,E.G., Rocca,C., Noureldeen,M.M., Saad,A.K., Petree,C.,
Bartolomaeus,T., Abou Jamra,R., Zifarelli,G., Gotkhindikar,A.,
Wentzensen,I.M., Liao,M., Cork,E.E., Varshney,P., Hashemi,N.,
Mohammadi,M.H., Rad,A., Neira,J., Toosi,M.B., Knopp,C., Kurth,I.,
Challman,T.D., Smith,R., Abdalla,A., Haaf,T., Suri,M., Joshi,M.,
Chung,W.K., Moreno-De-Luca,A., Houlden,H., Maroofian,R. and
Varshney,G.K.
TITLE Evaluating the association of biallelic OGDHL variants with
significant phenotypic heterogeneity
JOURNAL Genome Med 15 (1), 102 (2023)
PUBMED 38031187
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2855)
AUTHORS Sun,K., Han,Y., Li,J., Yu,S., Huang,Y., Zhang,Y., Reilly,J., Tu,J.,
Gao,P., Jia,D., Chen,X., Hu,H., Ren,M., Li,P., Luo,J., Ren,X.,
Zhang,X., Shu,X., Liu,F., Liu,M. and Tang,Z.
TITLE The splicing factor DHX38 enables retinal development through
safeguarding genome integrity
JOURNAL iScience 26 (11), 108103 (2023)
PUBMED 37867960
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2855)
AUTHORS Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
TITLE The zebrafish gene map defines ancestral vertebrate chromosomes
JOURNAL Genome Res 15 (9), 1307-1314 (2005)
PUBMED 16109975
REFERENCE 7 (bases 1 to 2855)
AUTHORS Langenau,D.M., Feng,H., Berghmans,S., Kanki,J.P., Kutok,J.L. and
Look,A.T.
TITLE Cre/lox-regulated transgenic zebrafish model with conditional
myc-induced T cell acute lymphoblastic leukemia
JOURNAL Proc Natl Acad Sci U S A 102 (17), 6068-6073 (2005)
PUBMED 15827121
REFERENCE 8 (bases 1 to 2855)
AUTHORS Berghmans,S., Murphey,R.D., Wienholds,E., Neuberg,D., Kutok,J.L.,
Fletcher,C.D., Morris,J.P., Liu,T.X., Schulte-Merker,S.,
Kanki,J.P., Plasterk,R., Zon,L.I. and Look,A.T.
TITLE tp53 mutant zebrafish develop malignant peripheral nerve sheath
tumors
JOURNAL Proc Natl Acad Sci U S A 102 (2), 407-412 (2005)
PUBMED 15630097
REFERENCE 9 (bases 1 to 2855)
AUTHORS Song,H.D., Sun,X.J., Deng,M., Zhang,G.W., Zhou,Y., Wu,X.Y.,
Sheng,Y., Chen,Y., Ruan,Z., Jiang,C.L., Fan,H.Y., Zon,L.I.,
Kanki,J.P., Liu,T.X., Look,A.T. and Chen,Z.
TITLE Hematopoietic gene expression profile in zebrafish kidney marrow
JOURNAL Proc Natl Acad Sci U S A 101 (46), 16240-16245 (2004)
PUBMED 15520368
REFERENCE 10 (bases 1 to 2855)
AUTHORS Piette,J., Neel,H. and Marechal,V.
TITLE Mdm2: keeping p53 under control
JOURNAL Oncogene 15 (9), 1001-1010 (1997)
PUBMED 9285554
REMARK Review article
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL929141.7.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMEA3505370,
SAMEA3505373 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-80 AL929141.7 179897-179976 c
81-152 AL929141.7 179740-179811 c
153-227 AL929141.7 179581-179655 c
228-361 AL929141.7 177991-178124 c
362-411 AL929141.7 177634-177683 c
412-470 AL929141.7 177464-177522 c
471-540 AL929141.7 177239-177308 c
541-698 AL929141.7 174515-174672 c
699-848 AL929141.7 174253-174402 c
849-917 AL929141.7 174074-174142 c
918-950 AL929141.7 173724-173756 c
951-2855 AL929141.7 170970-172874 c
FEATURES Location/Qualifiers
source 1..2855
/organism="Danio rerio"
/mol_type="mRNA"
/strain="Tuebingen"
/db_xref="taxon:7955"
/chromosome="4"
/map="4"
gene 1..2855
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="MDM2 proto-oncogene"
/db_xref="GeneID:30637"
/db_xref="ZFIN:ZDB-GENE-990415-153"
exon 1..80
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 81..152
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
CDS 93..1553
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/EC_number="2.3.2.27"
/note="isoform 1 is encoded by transcript variant 1; E3
ubiquitin-protein ligase Mdm2; double minute 2 protein;
p53-binding protein Mdm2; murine double minute 2 homolog;
transformed 3T3 cell double minute 2 homolog; RING-type E3
ubiquitin transferase Mdm2; etID309863.4; MDM2 oncogene,
E3 ubiquitin protein ligase"
/codon_start=1
/product="E3 ubiquitin-protein ligase Mdm2 isoform 1"
/protein_id="NP_001352361.1"
/db_xref="GeneID:30637"
/db_xref="ZFIN:ZDB-GENE-990415-153"
/translation="
MATESCLSSSQISKVDNEKLVRPKVQLKSLLEDAGADKDVFTMKEVMFYLGKYIMSKELYDKQQQHIVHCGEDPLGAVLGVKSFSVKEPRALFALINRNLVTVKNPESQSTFSEPRSQSEPDRGPGDTDSDSRSSTSQQQRRRRRSSDPESSSAEDESRERRKRHKSDSFSLTFDDSLSWCVIGGLHRERGNSESSDANSNSDVGISRSEGSEESEDSDSDSDNFSVEFEVESINSDAYSENDVDSVPGENEIYEVTIFAEDEDSFDEDTEITEAGFTGTKLTINEDYWKCPKCDQFNPPLPRHCKTCWTVRADWLPETHSNWENLSRNTRTNPEDTSVTTTPNTTFEKKLSKPSSPLPETDDGVDVPDGKCFPSPATTKDELPSSATITDSQTTSSQPSTSSGGGSSQEETPELERFNSLEACLPATCLEPCVICQSRPKNGCIVHGRTGHLMACYTCAKKLKNRNKLCPVCREPIQSVVLTYMS"
misc_feature 144..392
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="p53-binding domain found in E3 ubiquitin-protein
ligase MDM2 and similar proteins; Region: MDM2; cd17672"
/db_xref="CDD:349491"
misc_feature order(231..233,240..245,252..257,270..272,285..287,
348..353,357..359,366..371)
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="p53 binding site [polypeptide binding]; other site"
/db_xref="CDD:349491"
misc_feature 948..1028
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="Zn-finger in Ran binding protein and others;
Region: zf-RanBP; pfam00641"
/db_xref="CDD:395516"
misc_feature 1380..1550
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="Modified RING finger, HC subclass (C2H2C4-type),
found in E3 ubiquitin-protein ligase MDM2 and similar
proteins; Region: mRING-HC-C2H2C4_MDM2; cd16783"
/db_xref="CDD:438438"
misc_feature order(1422..1424,1428..1430,1434..1454,1506..1508,
1527..1529,1533..1538)
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:438438"
exon 153..227
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 228..361
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 362..411
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 412..470
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 471..540
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 541..698
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 699..848
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 849..917
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 918..950
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
exon 951..2855
/gene="mdm2"
/gene_synonym="sb:eu923; zgc:109834"
/inference="alignment:Splign:2.1.0"
ORIGIN
cccagagctcaagcactttatgtacagatagtaaagtatatgttttagcaagaatactcaatttacctctttttgcacagataactaccaaaatggcaacagagagttgtttaagcagttctcagatcagcaaggttgacaacgagaaactggtaagaccaaaggtgcaattgaaaagcctgttagaggatgcaggtgcagataaagatgttttcaccatgaaggaggttatgttttatttagggaaatatatcatgagcaaggagttatatgacaagcagcagcaacacatagttcactgtggagaggatcctctcggtgctgttcttggagtgaaaagtttttcagttaaagagccgcgtgccctctttgcattgatcaacagaaaccttgtcacagtgaaaaatccagaatcacagtctaccttctctgaacccaggagtcaaagtgaaccagatcgaggacccggggatacagattcagactctcgctcatctacctcacaacagcagcgcaggaggaggagaagcagtgatcctgagagttcttcagctgaagacgagtctagagaacgcaggaagaggcataagtcggacagcttttccctgacatttgatgacagcctgtcttggtgcgtgattggtggcctgcaccgggagagggggaacagcgagtcttcggatgcaaacagcaactcggatgtaggtatatctcgcagtgagggcagtgaggagagcgaagactcagactctgattctgataactttagtgtggagtttgaggtggagtccatcaactctgatgcttacagtgagaatgatgtggattctgtcccaggagagaacgagatatatgaagtcacaatcttcgcagaagacgaagactcttttgatgaagatactgagataaccgaggcaggattcacagggaccaaactaactattaatgaggactactggaagtgtcccaaatgtgaccagttcaaccctcctcttcctcgacactgcaaaacctgctggaccgtccgagctgattggcttccagaaacacactccaactgggaaaacctttcaagaaatactcgaaccaaccccgaagacaccagcgtcaccacaactcccaacacaaccttcgaaaagaaactctccaaaccctcaagccctctcccagaaacagatgatggagtggacgtacccgacggcaagtgctttccatctcctgccactaccaaagatgagcttccctcctctgctaccattactgactctcagaccacatcatcacagccctccacttcctccggcgggggcagcagtcaggaagagacccccgagctggagcgcttcaacagtctggaggcctgccttcccgctacgtgcctagaaccctgcgtcatctgtcagagtcgccccaagaacggctgcattgttcacggaaggactgggcaccttatggcgtgctacacatgtgccaaaaaattaaaaaaccggaacaagttgtgtccggtgtgccgagagcccattcagtcagtggtgttgacttacatgagctgaggcactgaaatatacctcctcctgtccttaaatgaagtttgggagttgccttgtggttgtattagatataaacgtttgttttcaaattcaatatttgtaatgattcaatatttttttcttattgaatacctaattttatttatgactcgtcgatttcactcacacgttttgtaataaattcacacacttatattttaaggattgtgttagaattgaaacaaaagcttgtgaggtgctgtattgattaaatagtctaatagaaatgtttgtaatttaatttatgtacatgcagatgtagaggtttttgagttgtttgctgcactgaaaaagagttccccgagctcatttaaaaatgttcttatgatatttcggctgcgaagactgtcttattttctttcagaaagacataataaatgattattttgaggttcttctgcttttacagatgagatcaaatctgctttttctgtcctctgctttgaatgattttctgatggcttgtatgtaggttagatgactggtggcagtagggggagttgtttttgttgggggaaatacacagcggtcacccagagagagcttcagttactagggaccctcttttcactctaatatcaagaaacatgttctgacttgtttctctctaatggcaacctagtacaaacactggccttttcaaatatctttttcacaaaaggtgtttttttttttcagatgaaattgtcagcatctatgacagttgtgttatgcaattatcattacaccacctatttaactgctaatttaattttagcaaacaagaaaaaaaaaacacttattggaagatttgatttttatttatttttaaaaataaactttttttttgtaataaactggttttgtagtgtttgcagcagcatggcaaatgaatctgagtctataagttcacctttttatttgtcagatggtgcacaaatgaagtgcgattagaacatgattgctggaatcagatgttttcatacacgaggtatgtatgcactttcctgcacttacatatgtatttgcacagtatgacagactgcaaacgaatgaacactttgtaaacaaattcacagatgttttaaaaggattaaatgcattcaagcttcagaaaatggcatcaatagcacaagtctgatctcttaaatgctatttatacgactatatacctctactttcatattgcaatggcatgtcctatagccatgtatttttatgtatttcttttttgtctcaaatgttatccaagtatttgaagaatatcaaataaatgcatttgttgac
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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