LOCUS       NM_001098747            1737 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio oxidative stress responsive kinase 1a (oxsr1a), mRNA.
ACCESSION   NM_001098747 XM_691938
VERSION     NM_001098747.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Hou CY, Ma CY, Lin YJ, Huang CL, Wang HD and Yuh CH.
  TITLE     WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis
            towards Developing a Combinatorial Anti-Cancer Strategy
  JOURNAL   Int J Mol Sci 23 (20), 12100 (2022)
   PUBMED   36292952
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Hortle E, Tran VL, Wright K, Fontaine AR, Pinello N, O'Rourke MB,
            Wong JJ, Hansbro PM, Britton WJ and Oehlers SH.
  TITLE     OXSR1 inhibits inflammasome activation by limiting potassium efflux
            during mycobacterial infection
  JOURNAL   Life Sci Alliance 5 (9), e202201476 (2022)
   PUBMED   35545295
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Baran A, Sulukan E, Turkoglu M, Ghosigharehagaji A, Yildirim S,
            Kankaynar M, Bolat I, Kaya M, Topal A and Ceyhun SB.
  TITLE     Is sodium carboxymethyl cellulose (CMC) really completely innocent?
            It may be triggering obesity
  JOURNAL   Int J Biol Macromol 163, 2465-2473 (2020)
   PUBMED   32987073
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Ma D, Tu C, Sheng Q, Yang Y, Kan Z, Guo Y, Shyr Y, Scott IC and Lou
            X.
  TITLE     Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS
            Approach
  JOURNAL   J Proteome Res 17 (3), 1300-1308 (2018)
   PUBMED   29369637
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC142933.1.
            
            On Jun 20, 2007 this sequence version replaced XM_691938.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142933.1, BC124256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476729, SAMEA4476730
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1737
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="oxidative stress responsive kinase 1a"
                     /db_xref="GeneID:568602"
                     /db_xref="ZFIN:ZDB-GENE-070620-25"
     exon            1..218
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="upstream in-frame stop codon"
     CDS             149..1696
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /EC_number="2.7.11.1"
                     /note="oxidative stress responsive 1a"
                     /codon_start=1
                     /product="serine/threonine-protein kinase OSR1a"
                     /protein_id="NP_001092217.1"
                     /db_xref="GeneID:568602"
                     /db_xref="ZFIN:ZDB-GENE-070620-25"
                     /translation="

MSEDPSSQPWSIDKDDYELQEVIGSGATAVVQAAYCKPRKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDFIKYIISKGEHKSGVMDEPSIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDMTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADLWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPCLETGVTDKEMVKKYGKSFRKMISLCLQKDPEKRPTAAELLKHKFFTKAKNTDYLKEKLLERAPTIGERSRKVRRVPGSSGRLHKTEDGEWEWSDDELDVESEEGKAAVAALRSPRVKEEAVPNAEVFPAESSGFLQPAAVGQPEVPHAADDTATISASQAVAGPTTTGQDSAKIPISLVLRLRNTKKELNDIRFEFMPGRDTADGVSQELVSAGLVDGRDLVIVAANLQKIVDDPQTHKNVTFKLASGVDSSEIPDDVKLMGFAQLSIS"

     misc_feature    191..1021
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Oxidative stress response kinase and Ste20-related proline
                     alanine-rich kinase; Region: STKc_OSR1_SPAK; cd06610"
                     /db_xref="CDD:270787"
     misc_feature    order(215..229,239..241,278..280,284..286,374..376,
                     422..433,440..445,452..454,584..586,590..601,605..607,
                     635..640,647..649,704..715,719..721,803..805,830..832)
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="active site"
                     /db_xref="CDD:270787"
     misc_feature    order(215..229,239..241,278..280,284..286,374..376,
                     422..433,440..445,452..454,590..592,596..601,605..607,
                     638..640)
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(224..229,584..586,590..598,647..649,704..715,
                     719..721,803..805,830..832)
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(587..592,662..670,707..748,752..760,770..772,
                     779..784,791..796,803..805,821..823,842..844,851..859,
                     863..868,968..970,974..979,983..985)
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270787"
     misc_feature    order(635..676,695..721)
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270787"
     misc_feature    1412..1585
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /note="Oxidative-stress-responsive kinase 1 C-terminal
                     domain; Region: OSR1_C; pfam12202"
                     /db_xref="CDD:463491"
     exon            219..331
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            332..440
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            441..582
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            583..638
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            639..748
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            749..850
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            851..984
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1033
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1099
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1222
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1261
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1363
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1434
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1487
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1556
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1621
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1722
                     /gene="oxsr1a"
                     /gene_synonym="wu:fb77f12; zgc:165661"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gttggcaaagtttggctgttgagactgagagcggtcggtgagatcagcacaagtacatcgagtataaatacagatcggtcgtttaccagcgctcgccgccgtgtaagcgtgcagtggggcgtccggctgtcgtgatctgaccgcagtcatgtccgaggacccgagctctcaaccttggtccatcgacaaggatgactatgagctacaggaggtgatcgggagtggagccacagctgtggtccaggcagcgtattgcaaacccaggaaggagaaggtggccattaaacgcatcaatcttgagaaatgccagaccagcatggatgagctcctgaaagagatccaggcaatgagccagtgccatcacccaaatattgtgtcttattacacgtcctttgtggtcaaggatgagctttggctggtcatgaagttgctcagtggcggctcagtgcttgattttattaagtacatcatttccaaaggagagcataaatcgggcgtgatggacgagcccagcattgccaccatactaagagaggtgctagaaggtctcgaatatctgcacaaaaatggccagattcacagggatgtgaaggctggaaatattcttttaggagaggacggctcagttcagattgcagactttggtgttagtgcctttttagcgactggtggagacatgactcgaaacaaagtgaggaagacgtttgtaggaactccatgctggatggctcctgaggtcatggagcaggttaggggttatgatttcaaagctgatttatggagctttgggatcacggcgattgagctggcaaccggagctgctccatatcacaaatatcctccgatgaaggttctcatgttaaccctgcagaatgaccctccgtgtttagagactggagttacagacaaagagatggttaaaaagtatggtaaatctttccgaaagatgatctccttgtgcctccagaaggatccagaaaaacggcctacagctgctgaactcttgaaacacaagttcttcacaaaagccaagaacactgattacttgaaagaaaaactgctggagagggcacctacaataggagagagatcaaggaaggtgcggagggttccgggctccagcggtcggctccacaagactgaggacggagagtgggaatggagtgatgatgagctggatgtggagagtgaggaaggaaaggctgcagtggctgctttacggtcaccaagagtaaaggaggaggcggtgccgaatgcggaggtttttccagctgaatcgtctggtttcctgcagccagcagctgtaggtcagcctgaagtgccacacgctgcagatgacacggccacgatatcagcctctcaggctgttgctggaccaactacgacggggcaggactcggctaaaatccctattagcctggtccttagattgaggaatacaaagaaagagctgaacgatatcagatttgagttcatgccagggagagacacagcagatggagtgtctcaggagcttgtgtctgctggactggtggatgggagagatctagtcattgttgcagccaacttacagaaaattgttgatgatccacaaacccacaaaaatgtcactttcaagctggcatcaggagtggacagctctgaaattccagacgatgttaaactcatgggatttgctcagctgagtataagttaaaacctagtattaccagcaaacgtaaaaaaaaaaaaaaaaaa

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