LOCUS       NM_001079816            1367 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio mix-type homeobox gene 2 (mxtx2), mRNA.
ACCESSION   NM_001079816 NM_131559
VERSION     NM_001079816.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R,
            Pal M, Deshpande O, Dsilva G, Tang Y, Mishra R, Deshpande G,
            Giraldez AJ, Sonawane M, Heisenberg CP and Galande S.
  TITLE     Satb2 acts as a gatekeeper for major developmental transitions
            during early vertebrate embryogenesis
  JOURNAL   Nat Commun 12 (1), 6094 (2021)
   PUBMED   34667153
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Zhang C, Lu T, Zhang Y, Li J, Tarique I, Wen F, Chen A, Wang J,
            Zhang Z, Zhang Y, Shi DL and Shao M.
  TITLE     Rapid generation of maternal mutants via oocyte transgenic
            expression of CRISPR-Cas9 and sgRNAs in zebrafish
  JOURNAL   Sci Adv 7 (32) (2021)
   PUBMED   34362733
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1367)
  AUTHORS   Vong YH, Sivashanmugam L, Leech R, Zaucker A, Jones A and Sampath
            K.
  TITLE     The RNA-binding protein Igf2bp3 is critical for embryonic and
            germline development in zebrafish
  JOURNAL   PLoS Genet 17 (7), e1009667 (2021)
   PUBMED   34214072
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1367)
  AUTHORS   Hilbert L, Sato Y, Kuznetsova K, Bianucci T, Kimura H, Julicher F,
            Honigmann A, Zaburdaev V and Vastenhouw NL.
  TITLE     Transcription organizes euchromatin via microphase separation
  JOURNAL   Nat Commun 12 (1), 1360 (2021)
   PUBMED   33649325
  REMARK    Erratum:[Nat Commun. 2021 Jul 6;12(1):4240. PMID: 34230494]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1367)
  AUTHORS   He M, Zhang R, Jiao S, Zhang F, Ye D, Wang H and Sun Y.
  TITLE     Nanog safeguards early embryogenesis against global activation of
            maternal beta-catenin activity by interfering with TCF factors
  JOURNAL   PLoS Biol 18 (7), e3000561 (2020)
   PUBMED   32702011
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1367)
  AUTHORS   Xu C, Fan ZP, Muller P, Fogley R, DiBiase A, Trompouki E,
            Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley
            GQ, Schier AF, Young RA and Zon LI.
  TITLE     Nanog-like regulates endoderm formation through the Mxtx2-Nodal
            pathway
  JOURNAL   Dev Cell 22 (3), 625-638 (2012)
   PUBMED   22421047
  REMARK    GeneRIF: This study identified a Nanog-like-Mxtx2-Nodal pathway and
            establishes a role for Nanog-like in regulating the formation of
            the extraembryonic tissue required for endoderm induction.
REFERENCE   7  (bases 1 to 1367)
  AUTHORS   Du S, Draper BW, Mione M, Moens CB and Bruce A.
  TITLE     Differential regulation of epiboly initiation and progression by
            zebrafish Eomesodermin A
  JOURNAL   Dev Biol 362 (1), 11-23 (2012)
   PUBMED   22142964
REFERENCE   8  (bases 1 to 1367)
  AUTHORS   Hong SK, Jang MK, Brown JL, McBride AA and Feldman B.
  TITLE     Embryonic mesoderm and endoderm induction requires the actions of
            non-embryonic Nodal-related ligands and Mxtx2
  JOURNAL   Development 138 (4), 787-795 (2011)
   PUBMED   21266414
  REMARK    GeneRIF: show that Mxtx2 directly activates expression of ndr2 via
            binding to its first intron and is required for ndr2 expression in
            the yolk syncytial layer
REFERENCE   9  (bases 1 to 1367)
  AUTHORS   Wilkins SJ, Yoong S, Verkade H, Mizoguchi T, Plowman SJ, Hancock
            JF, Kikuchi Y, Heath JK and Perkins AC.
  TITLE     Mtx2 directs zebrafish morphogenetic movements during epiboly by
            regulating microfilament formation
  JOURNAL   Dev Biol 314 (1), 12-22 (2008)
   PUBMED   18154948
REFERENCE   10 (bases 1 to 1367)
  AUTHORS   Bruce AE, Howley C, Dixon Fox M and Ho RK.
  TITLE     T-box gene eomesodermin and the homeobox-containing Mix/Bix gene
            mtx2 regulate epiboly movements in the zebrafish
  JOURNAL   Dev Dyn 233 (1), 105-114 (2005)
   PUBMED   15765511
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC115163.1.
            
            On Dec 20, 2007 this sequence version replaced NM_131559.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115163.1, BC162217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476805, SAMEA4476813
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..1367
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /note="mix-type homeobox gene 2"
                     /db_xref="GeneID:58078"
                     /db_xref="ZFIN:ZDB-GENE-000710-6"
     exon            1..97
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..960
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /codon_start=1
                     /product="mix-type homeobox gene 2"
                     /protein_id="NP_001073284.1"
                     /db_xref="GeneID:58078"
                     /db_xref="ZFIN:ZDB-GENE-000710-6"
                     /translation="

MKDMWTDCIAQDGNSQASKIAGRRKRTSFTKEHLELLKMAFNVDPYPGISVRESLSQATGLPESRIQVWFQNKRARTLKNRAIQSSPQLDNKSPLPSPFLPPHMASVGVSAQQRGIQESPFNIQMSQTSPQHFTFPPSDYSTPVVKPRQTRLMGTSSCSPSDLQATPDSWSYAGSTQISPESWDVAAENFGNSYKDESPFFLYPPPPYPYGSTRVGCPSSMESLSTSPASSDSAFWDMGLENCSPSVPYTSCGSPWDRLTEEQPVAPLPDLSSQCLEDVLGEMEPAWWSFNGQMDL"

     misc_feature    136..297
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            98..270
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /inference="alignment:Splign:2.1.0"
     exon            271..1323
                     /gene="mxtx2"
                     /gene_synonym="mtx2; zgc:136526"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atcagtagcacaaggagcagcgacaagcttgacttacttattttctgcaagagagctgcaaaatactcaatgaaagacatgtggactgactgcattgctcaagatggaaactcacaggccagtaagattgcaggccgcaggaagagaaccagcttcaccaaagaacacttggaacttctcaaaatggcttttaatgtggacccttatcctggcattagtgtcagagaaagtctatctcaagccactggcctgccagaatcacgtattcaggtatggttccagaacaagagagccagaaccctaaagaacagagccattcagagctccccacagctggacaacaaatctcctcttcctagccctttcttacctcctcacatggcttctgtgggagtcagcgctcaacagagaggcattcaggagtcacccttcaacatccagatgtctcaaacatctccacagcactttacctttcctccaagcgactacagcacacctgttgtaaagcctcgacaaaccagactgatgggaaccagctcttgttctccatctgatctgcaagcaacaccagacagctggagctatgctggaagcacacagatctctcctgagtcatgggatgtagcagcagagaattttgggaattcctacaaggatgagagtccattttttctctatccaccacctccttacccttatggaagcaccagagttggatgccctagtagcatggagtcactttcaacatctcctgcgtcttctgattctgcattttgggacatgggattggagaactgctctccatctgtgccttacaccagctgtggcagcccatgggacaggctcacagaggagcagccagtggcccctcttccagatctgtcctctcagtgtctggaggatgtgctcggggaaatggagccagcctggtggagcttcaatggccagatggatctttagcaatcttgcaaacatccataacctacagagacaaacagtgttttagtattgatggggtgcatttttatttttgaattgtattatatgggacgagtggtattgtgcaagtgcaggttacaaagcaatatcacatatgcatattgaacttttatttaatggactttatttatttatattataccaaaatgtagattgtaatgagtagcctatggttgcactagcttatttattctttatgctctttttttaaggtattttggtgcagttggggtatttattactacatttaatgcagttcacacagcctatactgtcactttgtaaattattgtatatttatttgaaataaaatgctaaaatgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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