LOCUS       NM_001077626            2583 bp    mRNA    linear   VRT 10-NOV-2024
DEFINITION  Danio rerio cytokine receptor family member b2 (crfb2), mRNA.
ACCESSION   NM_001077626
VERSION     NM_001077626.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Chen,K., Tian,J., Shi,Y., Xie,T., Huang,W., Jia,Z., Zhang,Y.,
            Yuan,G., Yan,H., Wang,J. and Zou,J.
  TITLE     Distinct antiviral activities of IFNphi1 and IFNphi4 in zebrafish
  JOURNAL   Fish Shellfish Immunol 146, 109396 (2024)
   PUBMED   38244820
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Deng,Y.H., Li,B., Chen,S.N., Ren,L., Zhang,B.D., Liu,L.H., Liu,S.
            and Nie,P.
  TITLE     Molecular characterization of nineteen cytokine receptor family B
            (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two
            CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama
            amblycephala
  JOURNAL   Dev Comp Immunol 145, 104725 (2023)
   PUBMED   37146740
REFERENCE   3  (bases 1 to 2583)
  AUTHORS   Liang,H., Li,Y., Li,M., Zhou,W., Chen,J., Zhang,Z., Yang,Y., Ran,C.
            and Zhou,Z.
  TITLE     The effect and underlying mechanism of yeast beta-glucan on
            antiviral resistance of zebrafish against spring viremia of carp
            virus infection
  JOURNAL   Front Immunol 13, 1031962 (2022)
   PUBMED   36405758
  REMARK    Erratum:[Front Immunol. 2024 Feb 19;15:1357392. doi:
            10.3389/fimmu.2024.1357392. PMID: 38440730]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2583)
  AUTHORS   Laghi,V., Rezelj,V., Boucontet,L., Fretaud,M., Da Costa,B.,
            Boudinot,P., Salinas,I., Lutfalla,G., Vignuzzi,M. and Levraud,J.P.
  TITLE     Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive
            SARS-CoV-2 Replication in the Swim Bladder
  JOURNAL   Front Cell Infect Microbiol 12, 790851 (2022)
   PUBMED   35360100
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2583)
  AUTHORS   Chen,S.N., Gan,Z., Hou,J., Yang,Y.C., Huang,L., Huang,B., Wang,S.
            and Nie,P.
  TITLE     Identification and establishment of type IV interferon and the
            characterization of interferon-upsilon including its class II
            cytokine receptors IFN-upsilonR1 and IL-10R2
  JOURNAL   Nat Commun 13 (1), 999 (2022)
   PUBMED   35194032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2583)
  AUTHORS   Aggad,D., Stein,C., Sieger,D., Mazel,M., Boudinot,P., Herbomel,P.,
            Levraud,J.P., Lutfalla,G. and Leptin,M.
  TITLE     In vivo analysis of Ifn-gamma1 and Ifn-gamma2 signaling in
            zebrafish
  JOURNAL   J Immunol 185 (11), 6774-6782 (2010)
   PUBMED   21048110
  REMARK    Erratum:[J Immunol. 2012 Feb 15;188(4):2038]
REFERENCE   7  (bases 1 to 2583)
  AUTHORS   Aggad,D., Mazel,M., Boudinot,P., Mogensen,K.E., Hamming,O.J.,
            Hartmann,R., Kotenko,S., Herbomel,P., Lutfalla,G. and Levraud,J.P.
  TITLE     The two groups of zebrafish virus-induced interferons signal via
            distinct receptors with specific and shared chains
  JOURNAL   J Immunol 183 (6), 3924-3931 (2009)
   PUBMED   19717522
REFERENCE   8  (bases 1 to 2583)
  AUTHORS   Fox,B.A., Sheppard,P.O. and O'Hara,P.J.
  TITLE     The role of genomic data in the discovery, annotation and
            evolutionary interpretation of the interferon-lambda family
  JOURNAL   PLoS One 4 (3), e4933 (2009)
   PUBMED   19300512
REFERENCE   9  (bases 1 to 2583)
  AUTHORS   Levraud,J.P., Boudinot,P., Colin,I., Benmansour,A., Peyrieras,N.,
            Herbomel,P. and Lutfalla,G.
  TITLE     Identification of the zebrafish IFN receptor: implications for the
            origin of the vertebrate IFN system
  JOURNAL   J Immunol 178 (7), 4385-4394 (2007)
   PUBMED   17371995
REFERENCE   10 (bases 1 to 2583)
  AUTHORS   Stein,C., Caccamo,M., Laird,G. and Leptin,M.
  TITLE     Conservation and divergence of gene families encoding components of
            innate immune response systems in zebrafish
  JOURNAL   Genome Biol 8 (11), R251 (2007)
   PUBMED   18039395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR361551.8.
            
            On Nov 6, 2015 this sequence version replaced NM_001077626.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF014953.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA3505374,
                                           SAMEA3505375 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               CR361551.8         73604-73867         c
            265-397             CR361551.8         72022-72154         c
            398-570             CR361551.8         69799-69971         c
            571-719             CR361551.8         67948-68096         c
            720-855             CR361551.8         62382-62517         c
            856-965             CR361551.8         61872-61981         c
            966-2583            CR361551.8         55101-56718         c
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="9"
                     /map="9"
     gene            1..2583
                     /gene="crfb2"
                     /note="cytokine receptor family member b2"
                     /db_xref="GeneID:777653"
                     /db_xref="ZFIN:ZDB-GENE-070905-2"
     exon            1..264
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    192..194
                     /gene="crfb2"
                     /note="upstream in-frame stop codon"
     CDS             195..1604
                     /gene="crfb2"
                     /codon_start=1
                     /product="cytokine receptor family member b2 precursor"
                     /protein_id="NP_001071094.2"
                     /db_xref="GeneID:777653"
                     /db_xref="ZFIN:ZDB-GENE-070905-2"
                     /translation="

MRFRHCTMSVITSILAFTVLFTLVLCMEIPAPEHLNLSSQYFVHLLSWKMGPGSPDGVHYSVKIKTKSGSMVVVEACENVTSPLLCNLTEAFSDVEEIYYIIVSAALGSHMSPNASYTPFKPIDNTILEPPLVTITVCNQSLCVSLRAPAERLSEIYKSFKLKYRLRVSSEDGTEEGLGNEPLSNLAPGQRYCVTVSIIDRSPPNRPPVCASTPKTANVSDAVISVILCLLMVIFVMCTPRLVVHFFCLKADLPAVLGSYKGINNVIFIPTGEPISALYEEKGRLEKEIEGEAEEELKYEKLVDLYQDFQGSSLAIFPVSSSSCLLMNQSPDKQLCPTSSMNAQNNGLIMYEGSHVHTEPAEPTASPRCEHLAQGTTQLPNLCSVVPLALEKQDSENSTDVNLFSVRLGGFLAEKHKVDPDKTCRTKDELGSYPQSPVETAVMGPTWISDVQSQNSEDEDEYSDYLSQN"

     sig_peptide     195..272
                     /gene="crfb2"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    243..521
                     /gene="crfb2"
                     /note="Tissue factor; Region: Tissue_fac; pfam01108"
                     /db_xref="CDD:460067"
     misc_feature    570..836
                     /gene="crfb2"
                     /note="Interferon-alpha/beta receptor, fibronectin type
                     III; Region: Interfer-bind; cl46366"
                     /db_xref="CDD:480706"
     exon            265..397
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..570
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..719
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..855
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..965
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..2583
                     /gene="crfb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ataaacaccaaatgaaaccgaaagctgtggaagtcttttacgttggcaagcgtgtttatatacataatttcaacggaaagtatggactgatatttataaagaactaggctatatggaaaagtggaacctatggaaaataaatcactggatgtctcaatgagggcagataaaacacgacttctggagtcacctaaatgcgattccgacattgcacaatgtctgtgattacaagtatacttgcattcactgttctgtttaccctagtgctatgcatggaaatacctgccccggaacatctaaacctgtcgtcccaatattttgtccacttgttgtcttggaaaatggggccaggctctcctgatggtgtccactactccgtcaaaataaaaacaaaaagtgggagtatggtggtggtggaggcctgtgaaaatgtgacatcccctctactgtgtaatcttacagaagccttttctgatgtggaggaaatctattacattattgtttctgccgctctaggcagccatatgtcaccgaatgcgtcctataccccattcaaacccattgataacactattttagagccaccgctggtgacaatcacagtctgtaatcaatcactgtgtgtaagtctcagagcacctgctgagaggctctctgaaatttacaagtcattcaagttgaagtatagactgagggtcagcagtgaagatggaacagaggaagggttggggaatgaaccccttagcaacctggcccctggccaaaggtactgtgtgactgtcagtatcattgatcgaagcccacccaacagaccaccagtatgtgcctcaacccctaaaacagcaaatgtttcagatgcagttatctctgtcattctttgtctcctgatggtgatattcgtgatgtgcactccgagacttgttgttcacttcttttgtctaaaagcagatcttccagcagttctgggctcgtataagggtataaacaatgttatttttatccctactggtgaacccatcagtgccctctatgaggagaaaggcagactggaaaaagagattgagggagaggcagaggaggaactgaaatatgaaaaacttgtggacctgtatcaggattttcagggttcctctctcgctatttttccagtgtcatctagttcttgtttgcttatgaatcaaagtccagataaacagctgtgccccacctcttccatgaatgctcagaataatggtttgattatgtacgaaggcagtcatgtccatactgagccagctgaaccaacagcctctcctaggtgtgaacaccttgctcaaggaacaactcaacttccgaacttatgttctgttgtcccccttgctttggaaaagcaggacagtgaaaacagtacagatgtaaacctgttttctgtgaggctaggaggatttttagcagagaaacacaaagttgatcctgataaaacctgcaggactaaagatgagctgggatcatatcctcagagcccagtagaaactgctgtaatgggacctacctggatttctgatgtacagtcccaaaactctgaagatgaggatgaatattcagattatttaagtcaaaattaatttgttggaggaaatatatattttactaatgttacttagtcacatgagaatataaaagcagctttatatgcattttttatactgtatttgactttttttttatatgcattaaattctaatggtggtctaacataattattcataataactgtattgctcatatttgtctgaacaagtatgagatagtgttccaagtatcactagcaagtcagaacaagagtattttaaaaatggctgcttacattcatttcattttttattaacattttctgtatatgcttaaatggtttattctttttgttccttacaaggaaaatgtatgtgttggctagacatttgaaccttttatcttgaaatgtgtctgtgcaacaaacattcttttgttactgaagatatacagttgaagtcagaattattcgccccctttgctttttttttctttttcaaatatttcccaaatgatgtttaatagagcaaggaaatttttacagtatgtctgacaatattttttcttctggagaaagtcttatttagtttatttttgcatgaataaaagcagtttttaactttttaaaaataattttaaggtcaaaattattagcccctttaagctatttttttgatagtctagaaaacaaaccattgctatacaataactcgcctaattaccctgacctgcttagttaacctaattaacctagctaagcctttaaatgtcactttaagctgtatagaagtgtcttgaaaaatatctagtaaaatattatttactgtcatcatggcaaagataaaataaatcagttattagaaatacattattaaaactattatgattagaaatgtgttaaaaatactctctgttaaacagaaattggggaaaaaataaacagggtgctaataattcaggggggctaataattctgacttcaactgtataacaaattcaccattaaatcagaataaatgtatactttttgaa

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