LOCUS       NM_001076672            2336 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio PTK6 protein tyrosine kinase 6b (ptk6b), mRNA.
ACCESSION   NM_001076672
VERSION     NM_001076672.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Yang Y, Li B, Zhang X, Zhao Q and Lou X.
  TITLE     The zinc finger protein Zfpm1 modulates ventricular trabeculation
            through Neuregulin-ErbB signalling
  JOURNAL   Dev. Biol. 446 (2), 142-150 (2019)
   PUBMED   30611731
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC124500.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC124500.1, BC165387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..2336
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="PTK6 protein tyrosine kinase 6b"
                     /db_xref="GeneID:767734"
                     /db_xref="ZFIN:ZDB-GENE-060929-1150"
     exon            1..444
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    17..19
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="upstream in-frame stop codon"
     CDS             47..1582
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="protein-tyrosine kinase 6b"
                     /protein_id="NP_001070140.1"
                     /db_xref="GeneID:767734"
                     /db_xref="ZFIN:ZDB-GENE-060929-1150"
                     /translation="

MGECCRKTCPCLKTIWDKIYGPPQAEGENSVKVDGDFTNKGFDKNETERRYSKPKIKPPLPPSANNNAAIYMALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYNYLARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQTGDQFYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVPPPSTDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILKNNDALVLREFQLEVQIMKRLRHKHLISLFAVCTSSSPFYIITELIEKGDLLHFLRNPEGRSLQMESLIDMAAQVADGMAYLEANNSIHRDLAARNVLVGDGYVCKIADFGLARIIKEPVYLSDDKKIPYKWTAPEAIGHGTYSSKSDVWSFGILLYEIVTHGGIPYPGVNTGEVYDLITKENYRMPSPPKCPQAIYNIMRACWRIESVDRPNFKVLKDELDNYQGQYSSVGN"

     misc_feature    254..424
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="Src homology 3 domain of Brk (Breast tumor kinase)
                     Protein Tyrosine Kinase (PTK), also called PTK6; Region:
                     SH3_Brk; cd11847"
                     /db_xref="CDD:212781"
     misc_feature    order(269..271,275..277,284..286,296..298,344..352,
                     398..400,404..406,410..415)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212781"
     misc_feature    440..694
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="Src homology 2 domains; Region: SH2; smart00252"
                     /db_xref="CDD:214585"
     misc_feature    order(467..469,527..529,590..592,596..598)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198173"
     misc_feature    order(593..595,671..673)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198173"
     misc_feature    767..1552
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Src-related kinase lacking C-terminal regulatory tyrosine
                     and N-terminal myristylation sites (Srm) and Breast tumor
                     kinase (Brk); Region: PTKc_Srm_Brk; cd05148"
                     /db_xref="CDD:133248"
     misc_feature    order(806..808,812..820,830..832,866..868,872..874,
                     1007..1018,1028..1030,1151..1153,1163..1168,1172..1174,
                     1205..1207,1253..1267,1292..1294,1394..1396)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="active site"
                     /db_xref="CDD:133248"
     misc_feature    order(806..808,815..817,830..832,866..868,872..874,
                     1007..1018,1028..1030,1151..1153,1157..1159,1166..1168,
                     1172..1174,1205..1207)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133248"
     misc_feature    order(848..850,854..856,953..955,962..964,968..970,
                     1010..1012,1088..1090,1100..1102,1184..1186,1544..1546)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="SH3/SH2 domain interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:133248"
     misc_feature    order(1118..1120,1127..1132,1316..1318,1505..1513,
                     1517..1519,1523..1528,1535..1537,1547..1549)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="CSK binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:133248"
     misc_feature    order(1151..1153,1163..1165,1253..1267,1292..1294,
                     1394..1396)
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:133248"
     misc_feature    1202..1273
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133248"
     exon            445..566
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            567..727
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            728..890
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1049
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1231
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1385
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2310
                     /gene="ptk6b"
                     /gene_synonym="zgc:153964"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcgctcatatgggaataatccgcgagagcaggtgctttttacctcatgggggaatgttgtaggaaaacttgcccatgtctcaagacaatatgggacaaaatatacggaccaccacaagcggagggggaaaatagcgtgaaagttgacggtgactttacgaacaagggcttcgacaagaatgagactgaacgccgttattcgaagccgaagatcaagccgcctttaccaccgagtgcaaacaacaatgctgctatttacatggcactgtgggacttcaaggcgcgcaacgaccaggagttgtcctttaaagctggagataagttcgagattaccgaccgttccggtgactggtggactgccaataaaaaggacatattcggccgtgtgaccaccggttttgttccttacaattatctggctcgagattccgtagagtctcaaccgtggttttttggaaagatgaatcgtgttggagcagtgagccacctcatgtctgatgaaaataattatggatcttttcttgtgcgggtcagtgagagtgacgacatgggctacgtactgtcagtgaggacaaaggaaaatgcaaagcacttcaagatctttcagactggtgatcagttctacgtggatgcgttgtttaagttcagcagtatagtagaagtgattgaacattatcaaagtcacccactctccattggggacctactgagtgagccttgcattcggataaagccggagaatgtgccacctccctcaacggatgaatgggagctgcctaaagaggaatttcagctggagaatcagcttggcagtggtcactttgctgatgtgtacagtggcaaatggaaaaatcactctaaagtggccataaaaatcctcaagaacaacgatgctcttgtgctgagggagtttcagttggaggtgcagatcatgaagcgtttacgtcacaagcacctgatttctctctttgctgtgtgcacttcctcctcaccgttttacatcatcaccgaactaatagaaaagggcgacttgcttcatttcctcagaaatccagagggaagatcattgcagatggagtctctgattgacatggcagctcaagtggcagatgggatggcatatttagaggcaaataacagtattcatagggacctcgctgccagaaatgtgcttgtaggagatggatatgtctgcaaaattgctgattttggcctagctcgaatcattaaggagccagtttatttaagcgatgacaagaaaataccatataaatggacagcacctgaggccattggtcatggcacttactccagtaaatctgatgtctggtcctttgggattctcctttatgagattgttactcatggaggaataccttatccaggtgtcaacactggtgaggtgtatgatctcataacgaaggaaaactacagaatgccttcaccacccaagtgtccacaagccatttacaacatcatgcgagcttgctggagaatagagtcagtggacagacccaactttaaggttttgaaggatgagctggacaactatcaaggccaatatagcagtgtgggaaattaacacagacagataacaacatcctgttggctgaaacttttctaaaagacagatccatcatataatcatcttcaatgaattaaatggactggcaattagtccaccgtatcagttttcagaaaatgaggatgcgcacttgaagcactttttggaagctcttagggaataatttattggggttttgggcaatatactgttttattttataatgaacaatgttaaagagtagattgtactgatttgaagaccacgaaataaatgtttaaatctgtaattaacagtttagtcaatcagatcagttctggggcatcaaaaggtttgtaaaaatgtctgattatatactgtacagatacacaaccctatacaaaccaacacaatatgaatgatagttgtatataaacatggtattatcatagtgaacatgaagctaaattaatatttcaaagaatatataaaatgataaatgatatgtatatttatgatgatttttgtattttaaatattgagtaatttgtaaactgtaatagtgcactgcattgttgatttttgcaatttacccaagctaattcttcagtgcagtcataattaccagacttttaagaaagaaagtgcatgcaagattagacaaaaattatgttattcatacttttaacttttattccaaatagacacaatcctagtgtacatgacctctaaagtttatgaccttttataataaaaaattaactgataaaaaaaaaaaaaaaaaaaaaaaaaa

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