LOCUS       NM_001030269            1322 bp    mRNA    linear   VRT 04-JAN-2026
DEFINITION  Danio rerio muscle segment homeobox 2a (msx2a), mRNA.
ACCESSION   NM_001030269 NM_131274 XM_690624
VERSION     NM_001030269.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Zhu,J., Wang,H.T., Chen,Y.R., Yan,L.Y., Han,Y.Y., Liu,L.Y., Cao,Y.,
            Liu,Z.Z. and Xu,H.A.
  TITLE     The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar
            Development in Zebrafish
  JOURNAL   Neurosci Bull 36 (9), 1023-1034 (2020)
   PUBMED   32812127
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Seifinejad,A., Li,S., Mikhail,C., Vassalli,A., Pradervand,S.,
            Arribat,Y., Pezeshgi Modarres,H., Allen,B., John,R.M., Amati,F. and
            Tafti,M.
  TITLE     Molecular codes and in vitro generation of hypocretin and melanin
            concentrating hormone neurons
  JOURNAL   Proc Natl Acad Sci U S A 116 (34), 17061-17070 (2019)
   PUBMED   31375626
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Murciano,C., Cazorla-Vazquez,S., Gutierrez,J., Hijano,J.A.,
            Ruiz-Sanchez,J., Mesa-Almagro,L., Martin-Reyes,F., Fernandez,T.D.
            and Mari-Beffa,M.
  TITLE     Widening control of fin inter-rays in zebrafish and inferences
            about actinopterygian fins
  JOURNAL   J Anat 232 (5), 783-805 (2018)
   PUBMED   29441573
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Garcia-Valtanen,P., Ortega-Villaizan Mdel,M., Martinez-Lopez,A.,
            Medina-Gali,R., Perez,L., Mackenzie,S., Figueras,A., Coll,J.M. and
            Estepa,A.
  TITLE     Autophagy-inducing peptides from mammalian VSV and fish VHSV
            rhabdoviral G glycoproteins (G) as models for the development of
            new therapeutic molecules
  JOURNAL   Autophagy 10 (9), 1666-1680 (2014)
   PUBMED   25046110
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Varshney,G.K., Lu,J., Gildea,D.E., Huang,H., Pei,W., Yang,Z.,
            Huang,S.C., Schoenfeld,D., Pho,N.H., Casero,D., Hirase,T.,
            Mosbrook-Davis,D., Zhang,S., Jao,L.E., Zhang,B., Woods,I.G.,
            Zimmerman,S., Schier,A.F., Wolfsberg,T.G., Pellegrini,M.,
            Burgess,S.M. and Lin,S.
  TITLE     A large-scale zebrafish gene knockout resource for the genome-wide
            study of gene function
  JOURNAL   Genome Res 23 (4), 727-735 (2013)
   PUBMED   23382537
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Postlethwait,J.H., Yan,Y.L., Gates,M.A., Horne,S., Amores,A.,
            Brownlie,A., Donovan,A., Egan,E.S., Force,A., Gong,Z., Goutel,C.,
            Fritz,A., Kelsh,R., Knapik,E., Liao,E., Paw,B., Ransom,D.,
            Singer,A., Thomson,M., Abduljabbar,T.S., Yelick,P., Beier,D.,
            Joly,J.S., Larhammar,D., Rosa,F., Westerfield,M., Zon,L.I.,
            Johnson,S.L. and Talbot,W.S.
  TITLE     Vertebrate genome evolution and the zebrafish gene map
  JOURNAL   Nat Genet 18 (4), 345-349 (1998)
   PUBMED   9537416
  REMARK    Erratum:[Nat Genet 1998 Jul;19(3):303]
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Ekker,M., Akimenko,M.A., Allende,M.L., Smith,R., Drouin,G.,
            Langille,R.M., Weinberg,E.S. and Westerfield,M.
  TITLE     Relationships among msx gene structure and function in zebrafish
            and other vertebrates
  JOURNAL   Mol Biol Evol 14 (10), 1008-1022 (1997)
   PUBMED   9335141
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Fritz,A., Rozowski,M., Walker,C. and Westerfield,M.
  TITLE     Identification of selected gamma-ray induced deficiencies in
            zebrafish using multiplex polymerase chain reaction
  JOURNAL   Genetics 144 (4), 1735-1745 (1996)
   PUBMED   8978059
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Akimenko,M.A., Johnson,S.L., Westerfield,M. and Ekker,M.
  TITLE     Differential induction of four msx homeobox genes during fin
            development and regeneration in zebrafish
  JOURNAL   Development 121 (2), 347-357 (1995)
   PUBMED   7768177
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Holland,P.W.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC095602.1.
            
            On or before May 22, 2007 this sequence version replaced
            NM_131274.1, XM_690624.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095602.1, BC165506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="14"
                     /map="14"
     gene            1..1322
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /note="muscle segment homeobox 2a"
                     /db_xref="GeneID:573620"
                     /db_xref="ZFIN:ZDB-GENE-980526-322"
     exon            1..362
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    8..10
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /note="upstream in-frame stop codon"
     CDS             44..817
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /note="etID309845.14; muscle segment homeobox A"
                     /codon_start=1
                     /product="homeobox protein MSH-A"
                     /protein_id="NP_001025440.1"
                     /db_xref="GeneID:573620"
                     /db_xref="ZFIN:ZDB-GENE-980526-322"
                     /translation="

MVLTQNVGIFSGMISANHKSKVSSDEDDDDHGSRSVRTQSLPFSVDALMSTKERSESTSRGSIHMTRIINQDDRSIYSDSVDFTKRCESAKEDSSWINKPRLSTSPRSQSPTICPLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELERFKMASKPILHPGLTLPFPLCTQPQTAALVCGQSFPFSRHMLPFAPIGIYSTPMGYSMCHLSKDGYSVEPV"

     misc_feature    410..580
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            363..1299
                     /gene="msx2a"
                     /gene_synonym="msh-A; mshA; msxa; zgc:111929"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgtagctaaaagttaagggagagcgagcgcgtttacaggttaatggttcttactcaaaacgtcggtattttctccgggatgatttctgctaatcataaaagtaaagtgtcctccgatgaagatgatgatgaccacggctcacggtcagtgcggacgcaaagcctcccgttcagcgtcgatgccctgatgtcgactaaagaaaggagcgagtcaacttcacggggatcaattcatatgacacgcatcataaatcaagatgatcgatcaatatattcagattcggtggatttcaccaaacgatgtgaatctgctaaagaggactcctcatggatcaataagccaagattgtcaacatcaccacgctcacagagtcccacaatatgtcctctccgaaagcacaagacaaaccgcaaaccccggacacctttcaccactgctcagctcttggccctcgagcggaagttccgtcagaagcaatacttgtcaattgctgaacgtgctgagttttccagctctctcagcttgactgagacacaggtgaagatctggttccagaaccgaagagcgaaagccaaacgactgcaagaagcagaactagaaaggttcaaaatggccagcaaacccatcttacatcctggccttactctaccgtttccactctgtacacaacctcagactgcagctctagtttgtggacagtctttcccttttagcagacatatgctgccttttgcacctattggaatatactccacaccgatgggttacagtatgtgtcatctctccaaagacggctactctgtggaaccagtctagaggagcttttcgtaactattcgtttatctgctggacatattgacatttttatatttgacacaccaaacatggggtatcatacattttttatatatattttggatttcattttttttttttttacatccaactttactttggaagctaccaaggactaatgacatactttgaggtttactgatcttaaagtgtcacagaatgtaataccattctgccattttgctttgaaatattaatcttagtgggattttgagtcacactactaaaaataacttagaaaattagttattttaccaaatatgtttctagaataaagcatagctgtgtaaggattccaaactcaagtgtgtttctaaaaagcaaatgtaacattttatattttacacttgatttgatttacataatttgcaccaagattgttttgtatcctaattggatattttaatgaaagaactataaatattaaaccttttatgctcagaaaaaaaaaaaaaaaaaaaaaaaa

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