LOCUS       NM_001030133            1574 bp    mRNA    linear   VRT 29-JAN-2023
DEFINITION  Danio rerio basic helix-loop-helix family, member e23 (bhlhe23),
            mRNA.
ACCESSION   NM_001030133 XM_683169
VERSION     NM_001030133.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Liu Y, Kossack ME, McFaul ME, Christensen LN, Siebert S, Wyatt SR,
            Kamei CN, Horst S, Arroyo N, Drummond IA, Juliano CE and Draper BW.
  TITLE     Single-cell transcriptome reveals insights into the development and
            function of the zebrafish ovary
  JOURNAL   Elife 11, e76014 (2022)
   PUBMED   35588359
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Guo R, Ge K, Wang Y, Lu M, Li F, Tian L, Gan L and Sheng D.
  TITLE     LIM Homeobox 4 (lhx4) regulates retinal neural differentiation and
            visual function in zebrafish
  JOURNAL   Sci Rep 11 (1), 1977 (2021)
   PUBMED   33479361
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Diotel N, Rodriguez Viales R, Armant O, Marz M, Ferg M, Rastegar S
            and Strahle U.
  TITLE     Comprehensive expression map of transcription regulators in the
            adult zebrafish telencephalon reveals distinct neurogenic niches
  JOURNAL   J Comp Neurol 523 (8), 1202-1221 (2015)
   PUBMED   25556858
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Wang Y, Chen K, Yao Q, Zheng X and Yang Z.
  TITLE     Phylogenetic analysis of zebrafish basic helix-loop-helix
            transcription factors
  JOURNAL   J Mol Evol 68 (6), 629-640 (2009)
   PUBMED   19449054
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Vitorino M, Jusuf PR, Maurus D, Kimura Y, Higashijima S and Harris
            WA.
  TITLE     Vsx2 in the zebrafish retina: restricted lineages through
            derepression
  JOURNAL   Neural Dev 4, 14 (2009)
   PUBMED   19344499
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC096864.1.
            
            On Aug 6, 2005 this sequence version replaced XM_683169.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096864.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..1574
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="basic helix-loop-helix family, member e23"
                     /db_xref="GeneID:559796"
                     /db_xref="ZFIN:ZDB-GENE-050913-22"
     exon            1..1559
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    114..116
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="upstream in-frame stop codon"
     CDS             231..914
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="basic helix-loop-helix domain containing, class B,
                     4; Beta3b"
                     /codon_start=1
                     /product="class E basic helix-loop-helix protein 23"
                     /protein_id="NP_001025304.1"
                     /db_xref="GeneID:559796"
                     /db_xref="ZFIN:ZDB-GENE-050913-22"
                     /translation="

MNVGDENLLKSISNDTLLDLTQRYGQSAFGFGAGHGAGSPGRFSLTPAADFLSGQTGKSNESGGEQTSDEDDGFDNLESRKRGAGFDEEKHPGSLTKKSKEQRSLRLSINARERRRMHDLNDALDGLRSVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQGQTITSPIPTALAPFGQAAVYPFSSTALATCAEKCNSFSGTPSNLFKHCNDKP"

     misc_feature    528..767
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="basic helix-loop-helix (bHLH) domain found in Class
                     E basic helix-loop-helix protein 23 (bHLHe23) and similar
                     proteins; Region: bHLH_TS_bHLHe23_bHLHb4; cd18953"
                     /db_xref="CDD:381523"
     misc_feature    order(546..548,558..560,564..572,576..578,591..593,
                     651..662)
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:381523"
     misc_feature    order(585..590,597..602,606..611,663..665,672..674,
                     684..686,690..695,705..707,711..716)
                     /gene="bhlhe23"
                     /gene_synonym="bhlhb4; zgc:111964"
                     /note="putative dimer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:381523"
ORIGIN      

gtctaaagtgcacgcaacatcactgtctgcgcggaggagcggaacacgagtgctcgacgtgataggggaagaaagatctctatcaaaaagtgtcttcattttcaacagccctttgaaggacacccacgaaacagaagacggggaagcgcgagcaagctttcaggagcgcgcgcgccaaagttttccatccggtccgtttttttgttttcattttatttattttctccaaaatgaatgtcggcgacgagaacttgctgaaatcgatcagcaacgacaccttgctggacctgacgcagcgctacggacagtccgccttcggtttcggcgctggccatggtgctggaagtcctggccgcttctcgctcacacctgccgcggatttcctctccggtcaaactggaaagtcgaacgaaagtggcggtgagcagaccagcgacgaagacgacggcttcgacaacctcgagtcccgtaagcgaggcgcgggcttcgacgaagagaagcacccgggctctctcaccaagaagtccaaggagcagagatctctccggctgagcatcaacgcgcgcgagcggagacgcatgcacgacctcaatgacgcgctggacggtctgagatctgtgattccttacgcgcacagcccgtccgtgagaaaactctctaaaattgcaactttgcttcttgcaaaaaactacatcctaatgcaggcgcaggcgctggaggagatgcgccggttggtggcttatcttaaccaaggacagactataacttcgccgattcccaccgcgctcgcgcctttcggacaagcggccgtgtatccgttttcgagcacagcactggccacctgcgcggagaaatgcaactcgttctccggcaccccgtccaacctgttcaaacactgcaacgataagccttgacttccactcgctgaactcttcccgcttccttatgttggtcgaactgttttgttgggactgggcttataggtctgactcaaaactcctgctttgtgtcaaaataagtgcgatgtgtcatccaaatttattagataatgtgaaataaataatcaagagacacggaattactgaaacaagcttataaacccctcaaatttaaagcctttcttccttttcccaaatgaaggatttaaaagattatttgtgtgaaaacaaacaaacaaaagaaattgcttattattgctcacagtttgcgaaggatttcttttttaagtcaaagctttcggtttcatcggtattggtcaactatgcaatttacaattgcccacaataaacaatagtttcttttttttttaagttagtctgaaatgaatatacggatgatatactccatcagtgttttagggaaaaacgtaacatcctcagatgcttggcctataaatcgtttatttatttatttattattttttgttattgcacagttcacttgattgtattgtacaactgtgaagaactacttgatcaaaggattttgaccttgttgcgacatgcgtttcatactgtatattgtttatatgtctttataattaaaacatatatctatgaaaaaaaaaaaaaaaa

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