LOCUS       NM_001020780            1958 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio Unc4.1 homeobox (C. elegans) (uncx4.1), mRNA.
ACCESSION   NM_001020780
VERSION     NM_001020780.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Simsek,M.F., Chandel,A.S., Saparov,D., Zinani,O.Q.H., Clason,N. and
            Ozbudak,E.M.
  TITLE     Periodic inhibition of Erk activity drives sequential somite
            segmentation
  JOURNAL   Nature 613 (7942), 153-159 (2023)
   PUBMED   36517597
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Saraswathy,V.M., Zhou,L., McAdow,A.R., Burris,B., Dogra,D.,
            Reischauer,S. and Mokalled,M.H.
  TITLE     Myostatin is a negative regulator of adult neurogenesis after
            spinal cord injury in zebrafish
  JOURNAL   Cell Rep 41 (8), 111705 (2022)
   PUBMED   36417881
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Ban,H., Yokota,D., Otosaka,S., Kikuchi,M., Kinoshita,H., Fujino,Y.,
            Yabe,T., Ovara,H., Izuka,A., Akama,K., Yamasu,K., Takada,S. and
            Kawamura,A.
  TITLE     Transcriptional autoregulation of zebrafish tbx6 is required for
            somite segmentation
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31444219
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Nittoli,V., Fortunato,A.E., Fasano,G., Coppola,U., Gentile,A.,
            Maiella,S., Langellotto,F., Porreca,I., De Paolo,R., Marino,R.,
            Fiengo,M., Donizetti,A., Aniello,F., Kondo,T., Ristoratore,F.,
            Canzoniero,L.M.T., Duboule,D., Wilson,S.W. and Sordino,P.
  TITLE     Characterization of paralogous uncx transcription factor encoding
            genes in zebrafish
  JOURNAL   Gene X 2, 100011 (2019)
   PUBMED   31193955
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Koudijs,M.J., den Broeder,M.J., Groot,E. and van Eeden,F.J.
  TITLE     Genetic analysis of the two zebrafish patched homologues identifies
            novel roles for the hedgehog signaling pathway
  JOURNAL   BMC Dev Biol 8, 15 (2008)
   PUBMED   18284698
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Woolfe,A. and Elgar,G.
  TITLE     Comparative genomics using Fugu reveals insights into regulatory
            subfunctionalization
  JOURNAL   Genome Biol 8 (4), R53 (2007)
   PUBMED   17428329
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Oishi,I., Kawakami,Y., Raya,A., Callol-Massot,C. and Izpisua
            Belmonte,J.C.
  TITLE     Regulation of primary cilia formation and left-right patterning in
            zebrafish by a noncanonical Wnt signaling mediator, duboraya
  JOURNAL   Nat Genet 38 (11), 1316-1322 (2006)
   PUBMED   17013396
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Oates,A.C., Rohde,L.A. and Ho,R.K.
  TITLE     Generation of segment polarity in the paraxial mesoderm of the
            zebrafish through a T-box-dependent inductive event
  JOURNAL   Dev Biol 283 (1), 204-214 (2005)
   PUBMED   15921674
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Kawakami,Y., Raya,A., Raya,R.M., Rodriguez-Esteban,C. and Izpisua
            Belmonte,J.C.
  TITLE     Retinoic acid signalling links left-right asymmetric patterning and
            bilaterally symmetric somitogenesis in the zebrafish embryo
  JOURNAL   Nature 435 (7039), 165-171 (2005)
   PUBMED   15889082
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC116499.1.
            
            On May 21, 2006 this sequence version replaced NM_001020780.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116499.1, AY881012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..1958
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="Unc4.1 homeobox (C. elegans)"
                     /db_xref="GeneID:553947"
                     /db_xref="ZFIN:ZDB-GENE-050714-1"
     exon            1..421
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    52..54
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="upstream in-frame stop codon"
     CDS             160..1572
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="homeobox protein Uncx4.1"
                     /codon_start=1
                     /product="homeobox protein unc-4 homolog"
                     /protein_id="NP_001018616.2"
                     /db_xref="GeneID:553947"
                     /db_xref="ZFIN:ZDB-GENE-050714-1"
                     /translation="

MMDSRILEHPHAQFGGSLGSMVGMGFPYHLGHHHVYDISGHQLQSAAAVPFSIDGLLNGSCSGSVANSNPLLGSGCGVNGDSQYKLGDGGDPDKESPGCKRRRTRTNFTGWQLEELEKASNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARRELERLEKKKRKQERKLLKSQNKLLAGELFHTPGSDSDSGVSQSTDSESTPHTGPQHSAHRQQTEHICEQHARHQRASTVNETAEPMDSTRNSGLCPANGITRASTLQKLNPFSVESLLADSSPRRKTILDFSQLPPQRPLVGKGHFLLYPITQPLGFIVPQTAMKQSHDSGNSGHHCSTTDTSTSNQKNVNHLCRDNTGASDELQRETKNSSIQSPSTSSEKCFSESNSPQKESENDSESTVTNSSQKESISANLSEYSDRKSRSSADTNTDGEDVDMD"

     misc_feature    406..465
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q50D79.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    463..633
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    628..714
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q50D79.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    754..1026
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q50D79.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1222..1569
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /note="propagated from UniProtKB/Swiss-Prot (Q50D79.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            422..597
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1887
                     /gene="uncx4.1"
                     /gene_synonym="uncx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aagtaggagagagcgaataagcccgcacgcctgcctcggtctccttattcctaattcgggagcgcaaggcatgtcaacgccgcacgtcccttcacggctgctgcatgcgttctgagggaagagttggagcttgttttggccagacgaacgcgagatgcaatgatggatagccggatcctcgagcatcctcatgcccaatttggaggctctttgggaagcatggttggaatgggtttcccctaccacctcggtcatcatcatgtttacgatatctccggacaccagctacagtcggcggccgctgtacctttttctatagacggattacttaacggatcatgctcggggtctgttgcaaactccaacccattgcttggatctggttgtggtgtaaacggggatagtcaatataaactgggcgatggcggagaccccgacaaggaaagccctggttgtaaaaggaggcgaacacgtacaaattttacgggttggcagctggaggaactagagaaagcctccaacgaaagccattatccggacgtgttcatgcgcgaggcgctcgcgctacgtctagaccttgttgagtcacgtgttcaggtttggtttcaaaaccggcgagccaaatggcgcaaaaaggagaacacgaaaaaagggcccggtcgaccggctcacaactctcaccccactacctgcagcggcgagccaatggacccagaggaaatagcacgacgggagttggagcgtttggagaagaaaaagcgaaaacaggaacgtaaactgctcaagtctcagaacaagctcttagccggtgagctcttccacacgcccggttctgacagcgacagtggagtatcgcaaagcaccgatagcgagtccactccgcacactgggcctcagcatagcgcgcaccggcagcagacagaacatatatgtgagcaacatgcacgccaccaaagagccagtacggtcaatgagacagcggagcccatggactccacacggaactctggcctgtgccccgcaaacggcatcacacgcgcctccacgctccagaaactcaacccatttagtgtggagagtttactagccgactcgagtcccaggagaaaaactatcctggatttttctcagttaccgccgcagcgaccactggtcggtaaaggccatttccttctgtatcccattacccagccgctgggtttcattgtgccacagacagcgatgaaacagagtcatgattcaggaaactcgggtcaccactgttccacgacagacacctcaacctcaaaccagaaaaatgtcaatcacttgtgcagagacaacaccggtgcaagcgacgagctgcagagagaaaccaagaactcttcaatccagtctccaagcacaagctcagagaaatgcttttcagaatctaactcgccacaaaaggagtctgaaaatgactccgagtccactgtcacaaactctagtcagaaagaaagcatctctgctaacctgtctgaatattctgacaggaaaagccgcagttctgctgacacaaatacagatggagaggatgtagacatggactgaaatataaataggccagaagcagtggcgccaagtgacttgtcacaatcccaaagctgataacgacacgtttttttgtatacaagactgtttgaattcactttttctactttccagaaacggatattctttattcaggtgaactgtctgtctgtttcggcttaaaatgtttgttccagttcagtggctctgctcacttgaaggagcaggttagctacacgagcaggacacacgaacaaaacatcctcaaatcgttgtataaatgataaagtatcgaaaatatttatatatgtatcattttgataagtaataataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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