LOCUS       NM_001013498            1601 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio engrailed homeobox 1b (en1b), mRNA.
ACCESSION   NM_001013498 XM_696209
VERSION     NM_001013498.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1601)
  AUTHORS   Zhou,J., Yang,Y.J., Gan,R.H., Wang,Y., Li,Z., Zhang,X.J., Gui,J.F.
            and Zhou,L.
  TITLE     Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary
            development in zebrafish
  JOURNAL   Gene Expr Patterns 46, 119286 (2022)
   PUBMED   36341978
REFERENCE   3  (bases 1 to 1601)
  AUTHORS   Labbaf,Z., Petratou,K., Ermlich,L., Backer,W., Tarbashevich,K.,
            Reichman-Fried,M., Luschnig,S., Schulte-Merker,S. and Raz,E.
  TITLE     A robust and tunable system for targeted cell ablation in
            developing embryos
  JOURNAL   Dev Cell 57 (16), 2026-2040 (2022)
   PUBMED   35914525
REFERENCE   4  (bases 1 to 1601)
  AUTHORS   England,S.J., Cerda,G.A., Kowalchuk,A., Sorice,T., Grieb,G. and
            Lewis,K.E.
  TITLE     Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and
            Lateral Line Development
  JOURNAL   Genetics 216 (4), 1153-1185 (2020)
   PUBMED   33077489
REFERENCE   5  (bases 1 to 1601)
  AUTHORS   Wang,G., Muhl,L., Padberg,Y., Dupont,L., Peterson-Maduro,J.,
            Stehling,M., le Noble,F., Colige,A., Betsholtz,C.,
            Schulte-Merker,S. and van Impel,A.
  TITLE     Specific fibroblast subpopulations and neuronal structures provide
            local sources of Vegfc-processing components during zebrafish
            lymphangiogenesis
  JOURNAL   Nat Commun 11 (1), 2724 (2020)
   PUBMED   32483144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1601)
  AUTHORS   Van de Peer,Y., Frickey,T., Taylor,J. and Meyer,A.
  TITLE     Dealing with saturation at the amino acid level: a case study based
            on anciently duplicated zebrafish genes
  JOURNAL   Gene 295 (2), 205-211 (2002)
   PUBMED   12354655
REFERENCE   7  (bases 1 to 1601)
  AUTHORS   Scholpp,S. and Brand,M.
  TITLE     Morpholino-induced knockdown of zebrafish engrailed genes eng2 and
            eng3 reveals redundant and unique functions in midbrain--hindbrain
            boundary development
  JOURNAL   Genesis 30 (3), 129-133 (2001)
   PUBMED   11477690
REFERENCE   8  (bases 1 to 1601)
  AUTHORS   Force,A., Lynch,M., Pickett,F.B., Amores,A., Yan,Y.L. and
            Postlethwait,J.
  TITLE     Preservation of duplicate genes by complementary, degenerative
            mutations
  JOURNAL   Genetics 151 (4), 1531-1545 (1999)
   PUBMED   10101175
  REMARK    Review article
REFERENCE   9  (bases 1 to 1601)
  AUTHORS   Amores,A., Force,A., Yan,Y.L., Joly,L., Amemiya,C., Fritz,A.,
            Ho,R.K., Langeland,J., Prince,V., Wang,Y.L., Westerfield,M.,
            Ekker,M. and Postlethwait,J.H.
  TITLE     Zebrafish hox clusters and vertebrate genome evolution
  JOURNAL   Science 282 (5394), 1711-1714 (1998)
   PUBMED   9831563
REFERENCE   10 (bases 1 to 1601)
  AUTHORS   Hatta,K., Bremiller,R., Westerfield,M. and Kimmel,C.B.
  TITLE     Diversity of expression of engrailed-like antigens in zebrafish
  JOURNAL   Development 112 (3), 821-832 (1991)
   PUBMED   1682127
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091669.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001013498.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091669.1, BC165537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1601              BC091669.1         5-1605
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     gene            1..1601
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /note="engrailed homeobox 1b"
                     /db_xref="GeneID:541371"
                     /db_xref="ZFIN:ZDB-GENE-980526-6"
     exon            1..781
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    184..186
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /note="upstream in-frame stop codon"
     CDS             277..1101
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /note="engrailed 4; engrailed 1b"
                     /codon_start=1
                     /product="homeobox protein engrailed-1b"
                     /protein_id="NP_001013516.1"
                     /db_xref="GeneID:541371"
                     /db_xref="ZFIN:ZDB-GENE-980526-6"
                     /translation="

MDEQKDQNSRDSTESESVSLSPNIPSPPILPHQAAQQAHRTTNFFIDNILRPDFGCKKDPGSRDRAQTSGRENVNPMVIRPSHNSSLCQDSNCSSDSTSSSSSSSPSSKQSSVKHFEGNGSTAARNGENTPSIMMVNANGGTPPAKESQPLLWPAWVYCTRYSDRPSSGPRTRKLKKKKSEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQSLAQELNLNESQIKIWFQNKRAKIKKASGYKNGLALQLMAQGLYNHSTTTVQDEKEDSE"

     misc_feature    832..999
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1000..1092
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /note="Engrailed homeobox C-terminal signature domain;
                     Region: Engrail_1_C_sig; pfam10525"
                     /db_xref="CDD:431338"
     exon            782..1577
                     /gene="en1b"
                     /gene_synonym="eng1b; eng4; wu:fc84e11; zgc:113499"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaaagagtttgttaagcgcgagcagtcacacggggcagcgagtcagggactgcggagcatcgcgcgatgtattgtctgacatgaataacgggtgtgttttgacacttgaaacgccttgatcgcggaaagcattccgatgctatgacagtcgcttcttttaaggtatttcgtatacctttaatttaacactatagactgcattcttgtttgttgttatccggatactgttcattgcaacaagtggaattttggtgtgcagaccacgatccagctgtcatggacgagcaaaaggatcaaaatagtcgtgattcgactgagtctgagagcgtctcgctctcacccaatataccatctcctccgattttacctcaccaggctgcgcagcaagcccacagaaccacgaactttttcatcgacaatattttaaggccagatttcggctgcaagaaagatcctgggagtagggatcgggcgcaaacgtcgggtagggagaatgttaacccaatggtaataaggccgtcgcataatagcagtctttgccaggattcaaactgcagtagtgacagcacttcttcgtcctcgtcgtcttcgccatcctcaaagcagtcctcggtaaagcatttcgaaggaaatggatctaccgcagcaaggaacggggagaatacgccgtcgataatgatggtgaacgccaacgggggaactccgccagctaaagaatcacagcctttactatggcctgcgtgggtgtactgcaccaggtactcggacagaccttcatctggcccaaggacacgaaaattgaaaaagaagaaaagcgaaaaggaagacaagcgaccgagaactgctttcacggctgaacagctgcagagacttaaagccgagtttcaggcgaatcggtacattacggagcagcgaagacagtctctggcccaggaactcaacctcaatgagtcgcaaataaaaatctggttccagaataagagggccaaaatcaaaaaggcttctggctataagaacggccttgctcttcagctcatggctcaaggactctacaaccattccacaaccacagttcaagacgaaaaagaagatagcgaataaaaatggcccggctcctgtgttttaagaaggtcatggacgctgaccccgacagaagtgatttttcatattttttatgaatcaaatgaaaaggaagtgtcttcgaattctgcgaaacgaagatgcgatatttaaacaaatttctgtttatcaaacactatatggacatgcatctaaatacgaacactatgaaaatttatatatagccaaaactgtaagatgtgtatatttaattccaggtaaggggatgtctatattgctccttacttgctgaatatttctaacgtttcttctcctttcccaatgtggttgctcaccgttccagtaggcctaagtgtcaggcttgttagtttttgtgatagccctgtctcttaaatcccttatctcacagttcttcaaatgcgtgactgaaccaacgcttcaagccaaagattttaatatgttcagattatgttgtctgaaataaaaaggtagaatgttaaaaaaaaaaaaaaaaaaaaaaa

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