LOCUS       NM_001003611            1695 bp    mRNA    linear   VRT 08-DEC-2024
DEFINITION  Danio rerio methyltransferase 16, N6-methyladenosine (mettl16),
            mRNA.
ACCESSION   NM_001003611
VERSION     NM_001003611.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Han,Y., Sun,K., Yu,S., Qin,Y., Zhang,Z., Luo,J., Hu,H., Dai,L.,
            Cui,M., Jiang,C., Liu,F., Huang,Y., Gao,P., Chen,X., Xin,T.,
            Ren,X., Wu,X., Song,J., Wang,Q., Tang,Z., Chen,J., Zhang,H.,
            Zhang,X., Liu,M. and Luo,D.
  TITLE     A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of
            embryonic hematopoietic stem and progenitor cells
  JOURNAL   EMBO J 43 (10), 1990-2014 (2024)
   PUBMED   38605226
  REMARK    GeneRIF: A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle
            progression of embryonic hematopoietic stem and progenitor cells.
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Lee,Y.R., Khan,K., Armfield-Uhas,K., Srikanth,S., Thompson,N.A.,
            Pardo,M., Yu,L., Norris,J.W., Peng,Y., Gripp,K.W., Aleck,K.A.,
            Li,C., Spence,E., Choi,T.I., Kwon,S.J., Park,H.M., Yu,D., Heo,W.D.,
            Mooney,M.R., Baig,S.M., Wentzensen,I.M., Telegrafi,A., McWalter,K.,
            Moreland,T., Roadhouse,C., Ramsey,K., Lyons,M.J., Skinner,C.,
            Alexov,E., Katsanis,N., Stevenson,R.E., Choudhary,J.S., Adams,D.J.,
            Kim,C.H., Davis,E.E. and Schwartz,C.E.
  TITLE     Mutations in FAM50A suggest that Armfield XLID syndrome is a
            spliceosomopathy
  JOURNAL   Nat Commun 11 (1), 3698 (2020)
   PUBMED   32703943
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078220.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="15"
                     /map="15"
     gene            1..1695
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="methyltransferase 16, N6-methyladenosine"
                     /db_xref="GeneID:445217"
                     /db_xref="ZFIN:ZDB-GENE-040801-130"
     misc_feature    90..92
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="upstream in-frame stop codon"
     CDS             96..1511
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /EC_number="2.1.1.346"
                     /EC_number="2.1.1.348"
                     /note="putative methyltransferase METT10D;
                     methyltransferase-like protein 16; methyltransferase 10
                     domain-containing protein; methyltransferase 10 domain
                     containing; N6-adenosine-methyltransferase METTL16; U6
                     small nuclear RNA (adenine-(43)-N(6))-methyltransferase;
                     methyltransferase like 16; RNA
                     N6-adenosine-methyltransferase mettl16; methyltransferase
                     16, N6-methyladenosin"
                     /codon_start=1
                     /product="RNA N(6)-adenosine-methyltransferase mettl16"
                     /protein_id="NP_001003611.1"
                     /db_xref="GeneID:445217"
                     /db_xref="ZFIN:ZDB-GENE-040801-130"
                     /translation="

MALNKSMHPRNRYKDKPPDFVYLASKYPEFQKHVQTTLTGRVTLNFKDPEAVRALTCTLLKEDFGLTIEIPLERLIPTVPLRLNYIHWVEDLIGGQGNPQRGIDIGTGASCIYPLLGATMNGWFFLATEVDDICFNYAKKNVEQNHLAELIKVVKVPQKTLLMDALKEESIVYDFCMCNPPFFANQLEAKGVNSRNSRRPPPSSINTGGVTEIMAEGGELEFVKRVIHDSLQLKKRLRWYSCMLGKKCSLAPLKDELRKQGVAKVTHTEFCQGRTMRWALAWSFYDDVPVPSPPCKKRKLEKARKPLTFTVLKATVAELQAQTPHSSPTESVSAWLENILTDLKVLHKRVPGGEVELSLFLTAVENTWIHSRQKRREQGRHLRELPRAQEPPSEETSVTEQQQQPDIPPESPANAEALQHFLFKCLVNVKQEEEKDVLVEMHWVEGQNKDLMNQLCTCLKNALFRQVAKPT"

     misc_feature    96..953
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
                     cl17173"
                     /db_xref="CDD:473071"
     misc_feature    144..155
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    order(408..428,480..485,561..569,630..632)
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:100107"
     misc_feature    570..584
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: K-loop. /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    675..713
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    828..842
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    909..929
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    945..1265
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: VCR 1. /evidence=ECO:0000250|UniProtKB:Q86W50"
     misc_feature    1218..1331
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1356..1505
                     /gene="mettl16"
                     /gene_synonym="fi09d09; im:7148386; mett10d; wu:fi09d09;
                     zgc:100981; zgc:158576"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DC64.1);
                     Region: VCR 2. /evidence=ECO:0000250|UniProtKB:Q86W50"
ORIGIN      

ggggggaacgttgaggcaacgtgattcgccaatgacagctgaatgtgctgaacactgagaaactactgaagttttcatctatcgtttcatgaagaatggcgctgaataaatccatgcatccccgaaaccgttacaaggacaaaccaccagactttgtttacctggcctccaaatatcctgaattccagaagcacgtgcagaccacactgaccggcagagttacgctcaactttaaagacccagaggctgtccgggccctcacatgcaccctgctgaaagaggattttggcctaaccatcgagatccccctggaacggctcatccccaccgtcccgctccgcctcaactacatccactgggtggaagacctgatcggggggcagggaaacccgcagaggggcattgacattggtactggagcttcctgtatttacccccttctaggagccacaatgaatggctggttcttcctggccacagaagtggatgacatctgctttaattatgcaaagaaaaacgttgaacaaaaccacctggcagagctcattaaagtggtgaaagtcccccagaagactctcctgatggatgcgctgaaggaagagtccattgtctatgatttctgcatgtgcaatcctccattcttcgccaaccagttagaagcaaagggagtgaactcgaggaactcgcgcagacctccacccagctccatcaacaccgggggcgtcactgagatcatggcagagggtggagagctggagttcgtcaaacgggtcatccatgacagtctgcagctgaagaagaggctcaggtggtacagttgcatgctgggaaagaagtgtagcctggctcctttgaaagatgagctgcggaaacaaggagttgctaaagtaacacacacagagttctgtcaagggcggaccatgcgctgggccctcgcctggagtttctatgatgacgtacctgtaccttctccgccctgtaagaagcgtaagctggagaaggcccgtaaacccctcaccttcaccgtcctgaaggccacagtggcagagctgcaggctcagacgcctcacagcagccctacagagagtgtgtctgcctggctggagaacatcctcactgacctcaaggtccttcataagcgtgttcctggtggagaagtggagctgagcctcttcctgacagctgtggagaacacctggatccacagccggcaaaaaagaagagaacagggccgacatctgcgagagctacccagagcacaggagccaccctcagaagaaacctccgtcacagagcagcagcagcagccggacatcccgccggagtctcctgcaaacgcagaagcactgcagcacttccttttcaagtgcctggtgaacgtaaagcaggaggaggagaaggatgtgctggtggagatgcactgggtggagggccagaataaagacctgatgaaccagctctgtacctgcttaaagaacgctctcttccgacaggtagccaagcccacctgaacagcacacacacacacacacacacacacacactgatcattctgcacataaacaccatccacaatgctggaaaaccgaactgcaagtcaaaagttaatcgttactgcaccaactgatgttttttataagacactgaacaaagttttactatgtttgtaataaaaaaaaaaaaaaaaaaaaaaaa

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