LOCUS       XM_009862027            6566 bp    mRNA    linear   INV 22-OCT-2018
DEFINITION  PREDICTED: Ciona intestinalis endoribonuclease Dicer
            (LOC100181362), mRNA.
ACCESSION   XM_009862027
VERSION     XM_009862027.3
DBLINK      BioProject: PRJNA187185
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_020176.2) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 22, 2018 this sequence version replaced XM_009862027.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Ciona intestinalis Annotation
                                           Release 104
            Annotation Version          :: 104
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6566
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="11"
     gene            1..6566
                     /gene="LOC100181362"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 33 ESTs, 4 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 72 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:100181362"
     CDS             76..6255
                     /gene="LOC100181362"
                     /codon_start=1
                     /product="endoribonuclease Dicer"
                     /protein_id="XP_009860329.1"
                     /db_xref="GeneID:100181362"
                     /translation="

MLSSGSSQEPGKPSWTSNSQCNSFIPRPYQIELLECAAKQNTIICLNGDFGKCFMYTMFLREVIIKHNGKLNNAPKFAVLLLKEDCMVNEQSELLRSHLDVDIISCTHNMTDSFTDESLQQLCHDHQVLVCTPEVFVKLLSISLYIAQYMDLVIFDDCHLVNIEMHPIRKIMKILDENRYTPMILGLTSSLLNNNITADELNKCIHSMETVMHCKAQTATDLIAVDRHNINPPVENIILSSDENKDGLNSQLLSDIRKILNGALEWLNSCQIVSTTRTKTTEWQLASTENEEEKILTNYNSNTSVIPKTSLDVGILEEEDGTQRLCSVKSPPLSECHEGSKKIVMDKKEKQEEDLDVCTVAIQLINESLMVADVLGPWCVYQLIVVVLKQLQKNLHLINVHLNTEAQNTENGEVTSGKWMWQAVMLQYVQTKFKMVYSICHWYMGDQKAVNLAFVAPKVHRLIQVLKEYKPVVEGEEKQNTSFKYNNRNESDYVSWWQDSDAEDEDADMMEGKKEEKEDENHPSLFINTLCGIVFVEERYVAMMLQRLLRELSKEDKNLKHVSSSHLTPGVEGERRGVDPASMDQSKQEEVLRKFRSHESNLLICTGDLEDCAYMPKCNLIMRFDVPKSYRSYAESKSRARAQTSAYVMLVRETEKSHFMEKLQEYKKIEKVLLGPDWSLNEVYDNNEDDDIEEMIPPYILNRNTQVNMKNAVRIVNRYCNRLPSDPFTHLSPRCEVVEVLNDGDSPMFMCILQLPINSHVREPVQGIVMPTLQLAQQAVAMETCKVLYEAGELDENLMPIGKETVKYAEELDPWKREVSSITGRPGSTKKRQTYNKDSPQILRSCLPQPDINLFIYEIEMKIKNPLLDELNVRRRKLFFPEETSRCFGILTTKPIPQIPGFPIFTRSGEESAKLKFCRGFVQLSAQQIKLVRIFHRYVFSDMLRVDRVPLSFQPEKSTSQLLVVVLNKVGTNKSSTANSSQLNIDWSFMMKTESKRRVIEKMKSDPWYKHKMNEQNKVFVFNRQLYEDGVVVAKYRSCDQPNRFYVAELKDDMTPLSSFPSSEYESFLHYYQLKYGLDIRCLKQPLLDVDHTSSRLNLLTPRHLNQKGKALPMSSLEKKRAKYESLHNRQILVPELCEVHPIPASLWRKAVCLPSVLYRVNQLLIAEELRKNIAFKSGITMEQPPIGNMWQNLHFGWTDNEDSDDDNEKLLEKSPAQRKSQVDEISSENNEVLNENKNVFDENIPKVPNSVENDGECAQHDNLEETNHKQNQHVDFENSTAKSDVYKTTVINHMKENHDEDDYVHVHGSNDVNVHKKNINHDNDSDRIGDTVHHGADDENVHDEKNDVHYHEVNDNHLCDDDIHDSDDYIHNENKDDHCHDNIHNDDDDDDDRFSFSSHDYEAHFDLSDHEDENMKNNVNDSLASIRGCKKKIKDVENPIWISSDVIDDYNKENPVKNLGPGPGLILQALTLSNASDGFNLERLEMLGDSFLKHAVTVYLYCTYPESHEGKLSYMRSKKVSNYNLYRIGKQFGLAGKMTGLIFDPTVNWLPTGFVVGASGQGQDSDEDISDDDVEIGVWTGIPSKKKVVKKTTTSNAVDPPPSLPPSTINDEEEIYEEDEIRMIDGMLGGCIRTLGGSPKGDNGLFGLDIGHALSSHQSMHFTDKAALRRSQLNKQNLEDFVIDTWTPVDASGKPLNNSDPLMLDLHTQHSLADKSIADCVEALLGAYLTTCGHRSAQLLLCHLGLNVLPKVAQAETSKTVDRFGYLTPPTNKMLECRPNQQNKLDQLLVALSGFERKINYTFKNKAYLLQAFTHASYYYNTVTDCYQRLEFLGDAVLDFLITRHLFNDERHHSPGALTDLRSALVNNTIFASLAVHYDFHKYFKSISPELHHIIEDFVMYQQKQEDAQGMDAHLMRDYDRVEIVAPSSLEKDEEEGENEDVEVPKALGDIFESVAGAIYMDSGMDLSSVWKVYSVMMLPLIEKFSACVPRSPVRELLEMEPETAKFSCAEKRYDGKVRVTVEIIGKGRFKGVGRSYRIAKSAAARRALRYLKGPFIY"

     misc_feature    145..738
                     /gene="LOC100181362"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; Region: DEAD-like_helicase_N; cl28899"
                     /db_xref="CDD:452890"
     misc_feature    order(217..237,541..543)
                     /gene="LOC100181362"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:350670"
     misc_feature    <1114..1413
                     /gene="LOC100181362"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    1657..2028
                     /gene="LOC100181362"
                     /note="C-terminal helicase domain of the DEAD-like
                     helicases; Region: DEAD-like_helicase_C; cl38915"
                     /db_xref="CDD:365791"
     misc_feature    1990..1992
                     /gene="LOC100181362"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350171"
     misc_feature    2209..2487
                     /gene="LOC100181362"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:427264"
     misc_feature    3013..3399
                     /gene="LOC100181362"
                     /note="PAZ domain, named PAZ after the proteins Piwi
                     Argonaut and Zwille. PAZ is found in two families of
                     proteins that are essential components of RNA-mediated
                     gene-silencing pathways, including RNA interference, the
                     piwi and Dicer families. PAZ functions as a...; Region:
                     PAZ; cl00301"
                     /db_xref="CDD:444818"
     misc_feature    order(3211..3213,3277..3279,3289..3291,3343..3345,
                     3367..3369,3373..3375)
                     /gene="LOC100181362"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239207"
     misc_feature    4471..>4692
                     /gene="LOC100181362"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(4522..4527,4534..4539,4546..4548,4555..4560,
                     4567..4572,4576..4584,4612..4614)
                     /gene="LOC100181362"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5500..6036
                     /gene="LOC100181362"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5560..5565,5572..5577,5584..5586,5593..5598,
                     5605..5610,5614..5622,5650..5652,5956..5958,5989..5991)
                     /gene="LOC100181362"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5560..5562,5569..5571,5581..5583,5926..5928,
                     5935..5937)
                     /gene="LOC100181362"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5569..5571,5926..5928,5935..5937)
                     /gene="LOC100181362"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    6049..6237
                     /gene="LOC100181362"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(6049..6054,6058..6063,6070..6075,6082..6087,
                     6097..6099,6112..6120,6124..6126,6130..6132,6181..6192,
                     6199..6201)
                     /gene="LOC100181362"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
ORIGIN      

tcttggcttaacaaaacttttatttaatacagcaacttggtacatttttctgttaactcttaatgtaaattagtcatgttgtcttctggtagctcccaagaacctgggaaaccttcctggacaagcaattctcaatgtaattcgtttattccacggccataccagattgaattgctagaatgtgcggccaagcaaaacaccattatttgcttgaatggagactttggaaagtgtttcatgtacaccatgtttttaagggaggtcatcataaaacataatgggaaattaaacaatgctccgaaatttgctgtcctgcttttaaaagaagattgtatggtgaatgagcagtcagaacttttacgaagtcatttagacgttgatataatatcatgtacgcacaatatgaccgattcttttactgatgaatctttacaacaactctgccatgaccaccaagtgttagtttgcactccagaagtctttgtaaagttgctcagcattagcctatacatagctcagtacatggacttagttatatttgatgattgccatttggtgaacattgaaatgcacccgatacggaaaataatgaagatattagatgaaaataggtacacacccatgatacttggtttaacgtcatcgcttctaaataacaacattactgcagatgaattaaacaaatgcattcatagcatggaaactgtaatgcactgcaaggcccaaactgcaacagatctaatcgctgtagatcgccacaatataaatccacctgttgaaaacattatattaagctcagatgaaaacaaagatggtttaaattctcagctactttctgacattaggaaaatattaaatggagcattggaatggctaaattcttgtcagatagtctccacaacaagaacaaaaacaacagaatggcaattagcatctacagaaaacgaagaggaaaaaattttgactaattacaactcgaacacaagtgttattccaaaaacgtccttggatgttggaatattggaggaagaggatggaactcaaagattatgttcggtaaaaagtcctcctttatcggagtgccatgaaggatccaaaaaaattgtaatggataagaaagaaaagcaagaagaagatttggatgtttgtacagttgcaatacaacttataaatgaaagtttgatggtagctgatgtactaggaccttggtgtgtgtatcaattgattgtagtcgttttaaagcagttgcaaaaaaatttgcatttgatcaacgttcatctaaatactgaagctcaaaacacagaaaatggtgaagtgacatctggaaagtggatgtggcaagctgtgatgttgcaatatgtgcaaactaaattcaagatggtgtacagcatatgtcactggtacatgggagatcagaaagctgtcaatttagcttttgttgcacccaaagtacatcgcttaattcaagtattgaaggaatacaaaccagtggttgagggagaagaaaaacaaaatacttcgttcaaatataataaccgaaatgagtcggattatgtgtcatggtggcaagactctgacgcagaagacgaagatgccgatatgatggagggaaagaaggaagagaaagaagatgagaatcatccgtctctcttcatcaatactttgtgtgggattgtctttgtagaagaaagatatgtcgcaatgatgttacaacgattgctgcgggaactttcaaaggaagacaagaatttaaaacacgtttcttcctcccatcttactcctggagtggagggtgagagaagaggagttgatcctgcatccatggatcagagcaaacaggaagaggtcctccggaagtttaggagccatgagagcaacctgctcatctgtacaggagatttggaggattgcgcttacatgccaaagtgcaacctcatcatgcgcttcgatgttccgaaaagttatcgaagttacgctgaatcaaaaagccgagccagagcccaaacatcagcctatgttatgttggttagagaaacggaaaaatcacattttatggaaaaacttcaggaatacaagaaaattgaaaaggtgttactgggtccagactggtccttaaacgaggtgtatgataataatgaggatgatgacattgaagagatgatccctccttatatacttaataggaatacacaagttaatatgaagaatgctgtgcgaattgttaataggtattgcaaccgcttgccaagcgacccgtttactcacctcagtcccaggtgtgaggtggtagaggttctcaatgatggggattcacccatgttcatgtgcattctgcagttgccaatcaactcccatgttagagaacctgtgcagggaattgtcatgccaactctccaacttgcccaacaagcagtagccatggaaacatgcaaggttctttatgaagctggagaattagatgaaaacttgatgcccattggcaaagagacggtaaaatatgccgaggaattagatccatggaaacgtgaagttagttccatcactgggagacctggatcaactaaaaaacgacaaacttataataaagattctcctcagatcctgaggtcctgtcttccacaacctgatatcaatctcttcatctacgagattgagatgaagatcaaaaatcctcttcttgacgaacttaacgttagaagaagaaaactttttttcccagaagaaacttctcgttgttttgggatcctgacaacaaaaccaatacctcaaattcctgggtttccaatcttcacaaggtcaggggaagaaagtgccaagttgaaattttgtcgagggtttgtccaactttctgctcaacaaatcaaacttgttcgaatatttcatcgttatgttttctctgacatgttgagagtagatcgagttcctttatctttccaacctgagaaatctacaagccagttgctggtagttgtgctgaacaaggtgggaacaaataagtcttcaacagcaaacagcagccaactcaacatagactggagttttatgatgaagactgaaagtaaacgtcgagttattgaaaaaatgaaatctgatccgtggtataaacataaaatgaacgaacaaaataaagtttttgtttttaatcgacaactatacgaagatggggtggtagtggccaagtacagaagctgtgatcagcctaacaggttttacgttgccgagttaaaagatgacatgacacctttgagtagtttcccatcttcagaatacgagagtttcctacattattatcaacttaaatatgggcttgacattcgttgtcttaaacaacctttacttgatgtggaccatacttcatcaaggttaaaccttctgacccctcgacatttaaaccagaaaggaaaagctctgcccatgtcctcacttgagaaaaagcgagcaaagtacgaaagtttgcacaacagacagattttagtcccagagttatgtgaagtacatcctatacctgcttcactgtggaggaaagctgtttgtctgccttctgttctgtacagagtgaaccaacttctaatagctgaggaacttcgtaaaaatattgctttcaaatctggaattacaatggaacaaccacctataggtaacatgtggcagaatcttcactttggttggacagacaatgaagacagcgacgacgacaatgaaaaattgttagaaaaaagtccagctcaacggaaatctcaggttgacgaaatttcaagtgaaaacaatgaagttttgaatgaaaataaaaacgtttttgatgaaaatattccaaaagttccaaattctgtagaaaatgatggagaatgcgcacaacatgacaacttagaagaaaccaatcataaacaaaatcaacatgttgattttgagaattcaactgccaaaagtgatgtttataaaaccactgtgataaatcatatgaaggagaatcatgatgaagatgattatgttcatgttcatggaagtaacgatgttaatgttcataaaaagaatatcaatcatgataatgattctgatcgtattggtgatactgttcatcatggtgctgatgatgaaaatgttcatgatgaaaagaatgatgttcactatcatgaagttaatgataatcacctttgtgatgatgatattcacgatagtgatgattacattcacaatgaaaataaagatgatcattgccatgataatattcacaatgatgatgatgatgatgatgaccggttttctttctcatctcatgattacgaagcccattttgacttatctgatcacgaagatgaaaacatgaaaaacaatgtgaacgattctctcgcatcaattagaggttgtaaaaagaagataaaagatgttgaaaacccaatctggatatcttctgatgtaattgacgattataataaagagaatccggtcaagaaccttgggccgggacctggacttattttgcaggctcttactttatcaaacgctagcgatggttttaatttggaaagacttgaaatgttgggagattcttttctcaaacatgctgttactgtgtatttgtattgcacttatccagagtcccatgaaggcaagctttcttacatgagaagcaaaaaggtttccaattacaacttatatagaatcggcaaacagtttgggcttgctgggaaaatgacgggacttatatttgacccaacagtaaactggttaccaactggttttgtggttggtgcatcgggccaggggcaagattcggacgaagatatttctgatgatgatgtcgaaataggtgtttggactggaattccaagcaaaaagaaagtggtgaaaaaaacaacaacttctaacgcagttgatccccctccctcacttccaccatccacgatcaatgatgaggaggagatttacgaggaagatgagatccggatgatagatgggatgttggggggttgcatccggactttgggagggtcacccaagggagacaacggacttttcggattagatattggacacgcattatcaagtcatcaatccatgcatttcaccgataaagctgcgcttagaagaagccaacttaataaacaaaatttggaagattttgtgatagatacatggacacctgtggatgcgtcaggaaagccactaaacaacagcgaccctctaatgcttgaccttcacactcaacattcgttggccgataaatcaatcgcagattgtgttgaagcattactcggcgcttatttaacgacgtgtggtcatcgttctgcccaacttctgctgtgtcacctcggtttaaatgttcttcctaaagtagcacaagcagagacgagcaaaacagttgacagatttggatacctcacgcccccaactaataaaatgttagaatgtcggccaaaccagcaaaataaacttgaccagttgcttgtggctctgagtggttttgaaagaaagataaattacacgttcaagaataaagcttacctacttcaagcattcactcatgcctcgtattactacaacactgtaacggattgctaccaacgtcttgaatttttgggcgacgcagttcttgatttcctgatcacgcgtcatctttttaacgacgagcgacatcattcaccgggtgctcttacagatctgagatccgctctcgtcaataacacaatctttgcctcacttgccgtacattatgatttccataaatatttcaagtccatctcaccagagcttcaccacatcattgaagacttcgtgatgtatcagcaaaagcaggaagatgctcaaggaatggatgctcacctgatgcgggattatgatcgtgttgagatcgttgctccatcatcactggagaaagatgaagaagaaggagagaatgaagacgtggaggtccccaaagcccttggagatatatttgaatcggtagcaggtgcaatatacatggacagtggaatggacttaagttctgtatggaaagtttattctgttatgatgttacctcttattgaaaagttcagcgcatgtgttccaagatcaccagttcgagagttattagaaatggaaccagaaaccgcaaaattcagttgtgccgagaaacgttatgatgggaaggtcagggtgactgtggaaattattggtaaaggtcgtttcaagggggtgggtagaagttatcgaattgctaaatccgctgcagccagaagagctttaagatatttaaaaggaccattcatttattaaatacttttgtgatggaatttataaaattatttttcaatcaatttttatccctgctattactgtatatttggttgatagtatttttctatttaaattttttctaaaatgctacacaatgcagtaatgtatacaaaacagtgattttagcgactaaaagtaatcaccatttgatttggtcacaaaatacagttgctgtttcttagtgcaaatttaagcctagtgggtctttatttagcataaaataaatcttgtggttttgtgtcatctatttaagccaaatattttggtccttgttaaaaaatattaaaaaa

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