LOCUS       NM_001032796             952 bp    mRNA    linear   INV 30-AUG-2020
DEFINITION  Ciona intestinalis diencephalon/mesencephalon homeobox protein
            1-like (LOC100178876), mRNA.
ACCESSION   NM_001032796 XM_002119104
VERSION     NM_001032796.2
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Takahashi T.
  TITLE     The evolutionary origins of vertebrate midbrain and MHB: insights
            from mouse, amphioxus and ascidian Dmbx homeobox genes
  JOURNAL   Brain Res. Bull. 66 (4-6), 510-517 (2005)
   PUBMED   16144640
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Takahashi T and Holland PW.
  TITLE     Amphioxus and ascidian Dmbx homeobox genes give clues to the
            vertebrate origins of midbrain development
  JOURNAL   Development 131 (14), 3285-3294 (2004)
   PUBMED   15201221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EAAA01000420.1.
            
            On or before Jan 19, 2019 this sequence version replaced
            XM_002119104.3, NM_001032796.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY588476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028081, SAMD00028084
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               EAAA01000420.1     19523-19700
            179-351             EAAA01000420.1     20062-20234
            352-430             EAAA01000420.1     21419-21497
            431-509             EAAA01000420.1     21826-21904
            510-613             EAAA01000420.1     22126-22229
            614-678             EAAA01000420.1     22673-22737
            679-760             EAAA01000420.1     23001-23082
            761-952             EAAA01000420.1     23464-23655
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="1"
                     /map="1"
     gene            1..952
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /note="diencephalon/mesencephalon homeobox protein 1-like"
                     /db_xref="GeneID:100178876"
     exon            1..178
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..777
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /codon_start=1
                     /product="Dmbx protein"
                     /protein_id="NP_001027968.2"
                     /db_xref="GeneID:100178876"
                     /translation="

MNYYDAIRAMSVFNALQQHYPNTQHPYNGYNSNGQIAGSLADLILKGGTFPRKHRRSRTAFTAMQLDALERTFKDGQYPDVETRESLAICTNLAEARIQVWFKNRRAKYRKQQRMLKTQECVPVTDSNETSNKADSLNNESATTSMRVKTERTSDCDETKDGGFPEKDTKPKIEKNPFSLPPPLVAGPFIQPNIHGMLDLSIRGSNYQLPTTSPYPPLATRMLQVPFQPWNLQFSNQSKK"

     misc_feature    217..393
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(217..231,235..237,286..288,304..306,343..345,
                     349..354,361..366,370..378,382..387)
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(223..225,232..234,352..354,361..366,373..375)
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            179..351
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..430
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..509
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..613
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..678
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..760
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..952
                     /gene="LOC100178876"
                     /gene_synonym="dmbx; DMBX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gatttttgcaatttattaagattagacaaagttccactgcttctatacgtcataatgaattattatgacgcaattcgtgcaatgtcagtgttcaacgcattacaacaacattacccaaacacccaacacccttataacggctacaatagtaacgggcaaattgctggatctctggcagatttaatactcaaaggcgggactttcccccgcaaacaccgacgcagcagaacagccttcactgccatgcaacttgacgcgttggaaagaacgttcaaagatgggcagtacccggacgtagaaacgcgagaaagtttggcaatctgtacaaatttagctgaagccaggatacaggtttggtttaaaaaccgaagagcaaaatatcgaaaacaacagagaatgttgaaaacgcaggagtgtgttcccgttacagattcgaacgaaacatccaacaaagctgattctttaaacaatgaatcagcgacaacatctatgagagtgaaaacagaaagaacaagtgattgtgacgaaacaaaggacggtggtttcccagaaaaagatacgaaaccaaaaattgaaaagaatccgttcagtttgcccccacctctagttgctggtccattcattcaaccaaatattcatggaatgttggatctgagcatcaggggatcaaactaccagttgccgacaacctccccctaccctccccttgccacaagaatgctacaagttcctttccaaccttggaatcttcaatttagcaatcaatccaagaaatgatgatgtaatcgttatatctgtgatgtcataatacatgagctggcactcaccccatcatggctgttttatcgataatttattgcacataacttttattcgtgtcgatttaatgcgctgcacactgtctatctgtaaaatagaaatataataaattcttcattttaaaaatcaaaaa

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