LOCUS       NM_001032595            1939 bp    mRNA    linear   INV 26-JAN-2026
DEFINITION  Ciona intestinalis LIM homeodomain protein (isl), mRNA.
ACCESSION   NM_001032595
VERSION     NM_001032595.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 1939)
  AUTHORS   Satou,Y., Kawashima,T., Shoguchi,E., Nakayama,A. and Satoh,N.
  TITLE     An integrated database of the ascidian, Ciona intestinalis: towards
            functional genomics
  JOURNAL   Zoolog Sci 22 (8), 837-843 (2005)
   PUBMED   16141696
REFERENCE   2  (bases 1 to 1939)
  AUTHORS   Imai,K.S., Hino,K., Yagi,K., Satoh,N. and Satou,Y.
  TITLE     Gene expression profiles of transcription factors and signaling
            molecules in the ascidian embryo: towards a comprehensive
            understanding of gene networks
  JOURNAL   Development 131 (16), 4047-4058 (2004)
   PUBMED   15269171
REFERENCE   3  (bases 1 to 1939)
  AUTHORS   Satou,Y. and Satoh,N.
  TITLE     Genomewide surveys of developmentally relevant genes in Ciona
            intestinalis
  JOURNAL   Dev Genes Evol 213 (5-6), 211-212 (2003)
   PUBMED   12736827
REFERENCE   4  (bases 1 to 1939)
  AUTHORS   Satou,Y., Yamada,L., Mochizuki,Y., Takatori,N., Kawashima,T.,
            Sasaki,A., Hamaguchi,M., Awazu,S., Yagi,K., Sasakura,Y.,
            Nakayama,A., Ishikawa,H., Inaba,K. and Satoh,N.
  TITLE     A cDNA resource from the basal chordate Ciona intestinalis
  JOURNAL   Genesis 33 (4), 153-154 (2002)
   PUBMED   12203911
REFERENCE   5  (bases 1 to 1939)
  AUTHORS   Giuliano,P., Marino,R., Pinto,M.R. and De Santis,R.
  TITLE     Identification and developmental expression of Ci-isl, a homologue
            of vertebrate islet genes, in the ascidian Ciona intestinalis
  JOURNAL   Mech Dev 78 (1-2), 199-202 (1998)
   PUBMED   9858732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ006220.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ006220.1, AK173986.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="4"
                     /map="4"
     gene            1..1939
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="LIM homeodomain protein"
                     /db_xref="GeneID:445793"
     misc_feature    268..270
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="upstream in-frame stop codon"
     CDS             331..1476
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /function="transcription factor"
                     /note="homeobox transcription factor isl"
                     /codon_start=1
                     /product="LIM homeodomain protein"
                     /protein_id="NP_001027767.1"
                     /db_xref="GeneID:445793"
                     /translation="

MEAACRPRLIATPCRIPLCVGCGSPIHDQYILRVAPNLEWHAGCLKCADCGQYLDETCTCFVRDGKTYCKRDYTRLFGTKCNKCGLCFSKNDFVMRARDKIYHIQCFKCVACSRQLIPGDEFALRDDGLFCKADHEVATSGDMMVHDGHMIPGIPQTPNPQGVISPQMGGERVISHRSGGHSGGQRRSKDAKTTRVRTVLNEKQLHTLRTCYAANCRPDALMKEQLTEMTGLSSRVIRVWFQNKRCKDKKRSIALKQIQEQQAKQQHNNEQGNNVQGLSGMNGVPMVASEPVRNDNSVSVAPVEVRNYQQPAWKALSDFALQSEIEQPAFQQLMNNFSDQGQGSISDSSEISSIPSVSSASMDSTTCSTPHTVESSVPACS"

     misc_feature    385..549
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="The first LIM domain of Isl, a member of LHX
                     protein family; Region: LIM1_Isl; cd09366"
                     /db_xref="CDD:188752"
     misc_feature    order(385..387,394..396,451..453,460..462,469..471,
                     478..480,535..537,544..546)
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188752"
     misc_feature    571..735
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="The second LIM domain of Isl, a member of LHX
                     protein family; Region: LIM2_Isl; cd09374"
                     /db_xref="CDD:188760"
     misc_feature    order(571..573,580..582,637..639,646..648,655..657,
                     664..666,721..723,730..732)
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188760"
     misc_feature    907..1077
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(913..924,928..930,979..981,997..999,1036..1038,
                     1042..1047,1054..1059,1063..1071,1075..1080)
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(916..918,925..927,1045..1047,1054..1059,1066..1068)
                     /gene="isl"
                     /gene_synonym="Ci-isl"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
ORIGIN      

aattcggcacgaggttagagagaatcggagaaaaagtttcgagagaagctttagataaattgattctgtcgcattcgagtattacaacttgtgtctgtgacgtgagcgagtgaggacaatttactgtgacgtcataatagccagcaatataggggtggaaggtgaataccccgctctacaagcggagaatttcgaaatttcaaacctggatcccggatactcgccgccgttgcgacgactcaaggtcggggtcgttcacaagttttatgaacgaatctttcgccattttcggtcaggacgagaaactgggagcaaagatggcggaccctcatggaggctgcgtgtcggcctcgcttaattgcgaccccttgccgcatacctctatgcgtaggatgtggctcccctatacacgaccaatacatactacgtgtcgctcccaaccttgaatggcatgctggttgcttaaaatgcgctgattgtggtcaatacttggacgagacgtgcacgtgttttgtaagggatgggaaaacgtattgtaaacgggattacacaaggttattcggaacaaaatgcaacaagtgtggtctctgcttcagtaaaaacgactttgtaatgcgagccagagacaagatatatcacatacaatgtttcaagtgtgtggcttgtagcaggcagttaataccaggggacgaattcgctctaagagacgacggtttgttctgcaaagctgaccatgaagttgcaacatccggggacatgatggttcacgacggccacatgattccgggaattccccaaaccccgaaccctcaaggggtcatcagccctcaaatggggggcgagagggtgatcagccatcggtcgggtgggcacagtggggggcaaaggcgaagcaaagatgcgaagacgacgcgagttaggacagtgctcaacgagaaacaactccacacgcttagaacttgttacgcggccaactgtcgacctgacgctctaatgaaagaacaactcacagaaatgactggactatcttcgcgtgtaataagggtttggttccaaaacaaaagatgcaaagacaagaaacgttccatagctttgaaacaaatccaggagcagcaagcgaagcaacagcataataacgaacagggtaataacgtccagggtttatcagggatgaacggagtccccatggttgcatcagaacctgtaagaaacgacaactcagttagtgtagctcctgttgaagtgaggaactaccagcaaccagcttggaaagcactcagcgactttgctcttcaaagcgaaatagaacaaccggccttccaacaactgatgaacaacttttccgatcaaggtcaaggctcgatatccgattcgtccgaaatcagtagcattccttcagtttcctcagccagcatggattcgaccacatgttccaccccgcacacagttgaatcatctgtaccggcgtgtagctaacacgacaaacaattacaaacattcatcatacgtttgtgtagattcgtagtttttgttagacccgcaatattgtcccattactgcaaaatgcaaccaaagaagaaaatgttcttctggcaactaacttatataagctgcttaaaacttaagcaggcaaattgtttccttcccggatcttacacacaagccataggcagtgttgccgagtatttaacgcagtgttgccgattgttccaatttttgtgttcccaagtaatataaaccacgtcattatgacgtcacaaaaatgacgtagttccacgtcacaatcaaaccaacaagcacaatcaacaaaagacaaatctcgttatttttagatacggtgcgtagtatgcatgtcgtcttatattttgtctcattgtggtcgcaatttacaaaataaaatcagagagagagtatacacgaaaaaatacaaaaaaaaaaa

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