LOCUS       NM_001032511            2665 bp    mRNA    linear   INV 26-JAN-2026
DEFINITION  Ciona intestinalis Prx1 protein (prx1), mRNA.
ACCESSION   NM_001032511
VERSION     NM_001032511.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Oonuma K and Kusakabe TG.
  TITLE     Spatio-temporal regulation of Rx and mitotic patterns shape the
            eye-cup of the photoreceptor cells in Ciona
  JOURNAL   Dev. Biol. 445 (2), 245-255 (2019)
   PUBMED   30502325
  REMARK    GeneRIF: The expression of Rx commences in non-photoreceptor
            a-lineage cells on the right side of the anterior sensory vesicle
            at the early tailbud stage. At the mid tailbud stage, Rx begins to
            be expressed in the A-lineage photoreceptor cell progenitors
            located on the right side of the posterior sensory vesicle. Thus,
            Rx is specifically but not exclusively expressed in the
            photoreceptor-lineage cells in the ascidian embryo.
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Yoshida K and Saiga H.
  TITLE     Repression of Rx gene on the left side of the sensory vesicle by
            Nodal signaling is crucial for right-sided formation of the ocellus
            photoreceptor in the development of Ciona intestinalis
  JOURNAL   Dev. Biol. 354 (1), 144-150 (2011)
   PUBMED   21402066
  REMARK    GeneRIF: Data show that Ci-Rx, which is essential for the ocellus
            differentiation, is negatively regulated by the Nodal signaling on
            the left side of the sensory vesicle.
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   D'Aniello S, D'Aniello E, Locascio A, Memoli A, Corrado M, Russo
            MT, Aniello F, Fucci L, Brown ER and Branno M.
  TITLE     The ascidian homolog of the vertebrate homeobox gene Rx is
            essential for ocellus development and function
  JOURNAL   Differentiation 74 (5), 222-234 (2006)
   PUBMED   16759288
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Imai KS, Hino K, Yagi K, Satoh N and Satou Y.
  TITLE     Gene expression profiles of transcription factors and signaling
            molecules in the ascidian embryo: towards a comprehensive
            understanding of gene networks
  JOURNAL   Development 131 (16), 4047-4058 (2004)
   PUBMED   15269171
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Satou Y and Satoh N.
  TITLE     Genomewide surveys of developmentally relevant genes in Ciona
            intestinalis
  JOURNAL   Dev. Genes Evol. 213 (5-6), 211-212 (2003)
   PUBMED   12736827
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ299416.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ299416.1, AB210672.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="12"
                     /map="12"
     gene            1..2665
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /note="Prx1 protein"
                     /db_xref="GeneID:445693"
     exon            1..1575
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..2510
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /function="transcription factor"
                     /note="homeobox transcription factor, Rx"
                     /codon_start=1
                     /product="Prx1 protein"
                     /protein_id="NP_001027683.1"
                     /db_xref="GeneID:445693"
                     /translation="

MSTDTSKGEEFAENAKTPGTNLNSTIESRPNEDIKTKQENISKLPVQMSDQENRPVPKSVRSPEDMPSFPNYGSLEYFPPPIKEALRSYLEKMYSSVYTAQDETSIPSGLSHDVAPHPRYGLNGMPGHAGYGVGLPFDLSHYYPPILRSGDRQQFGAHGLDFHHFARNNPDEKVTKSVSKSVKQETPEDVPKFDAPASPTRIVGATTPSEEMGQSSIITPIASEPTEHPTRSTSHNYVSTDTVSPFTLAASQGSLHAFKEDSYLPFAFSMEKKNKDFELPPTKSPEKPKEQIKTATKRPSQDVIGNDSKKIAKEVLLFSPPKHASVSPPKSLSALPQRPLENDLLMAMMMSQQSQLPSTATNDASAIMAQLYSTCSEVAKDNYFNWMLPSAMLMLQQKRAAMRPSTPEEKYLDNGPSADDDDEELLLDPQHPKDGIYNEEVNNIIGNLKKDSAGNKNPGQGTNHSSMLKSEFFGSSFDSHPALESFRSDADAQKRTEDMLEAYRKSFAEQRPEQQEKGIWGEETNRSYRQPSNEDQSVSPPSISPTQCSDSDLKKKLRRNRTTFTTFQLHELERAFERSHYPDVYSREELAGKINLPEVRVQVWFQNRRAKWRRQEKIESGNHEREIRNYNQATALSATVSTKPNNVQRNNPSHQLDQLIASQSSPARHLLPTPSSSFGHTLAASSQASSAFSIPFLSGMLTGGRDPVSSLDSSKTTSPSSAAKLSSDMALYSRYASQMGALQQFSTPPFHLPLHLLGASQARDFPRPNTANEKESNQSNPDRSPSEKSFKRETAEEFRFSPKFTETTDKSSSFESAVNKTLYLMS"

     misc_feature    1542..1967
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    1701..1871
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            1576..1653
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1835
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1938
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2649
                     /gene="prx1"
                     /gene_synonym="Ci-Rx; Rax"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaaaaattagacgggtattttccttgaagatgagtacagacacatctaagggtgaagagtttgccgaaaatgcgaaaacgcctggcacaaatttaaattcaacaatagaaagtagaccaaacgaagatatcaaaacaaaacaagaaaacatttcaaaattaccagttcaaatgagcgaccaggaaaatagacctgttccaaaatcagtaagaagtcctgaagatatgcctagttttcctaactacggttcgctagagtattttccgcccccaataaaagaagccttgagaagttacttagaaaaaatgtactcgtctgtatatactgcacaagacgagacatctattccttcggggctatcccacgacgtagcacctcacccacgttacggcctaaatggcatgccaggccatgcgggttacggcgttggtttaccgtttgatctgtcgcattattaccctcctattctacgaagtggtgatcgtcaacaatttggggcgcacggcttggatttccaccattttgcaagaaacaatcccgacgaaaaagttacaaaaagtgtttctaagtctgttaaacaagaaacacccgaagatgtgcctaaatttgatgctccggcttcaccaacacggatagtgggagcaacgacaccatctgaagaaatggggcaatcgtcgattataactcccattgcttctgaacctacagaacatccgactagatctacaagccacaactatgtaagcactgatactgtgtcaccattcacactcgcagcaagccaaggaagtctacatgctttcaaagaagattcttatctcccatttgcgttttcaatggagaagaaaaacaaagattttgaattgccaccaacaaagtcgcccgagaaaccaaaggaacaaataaaaactgcaactaaacgaccatctcaagacgtgattggaaacgacagtaagaaaatagcaaaagaggtgctactgttttcgccgccaaagcatgcgagtgtaagtccccctaaatcactcagtgctttgccacaaagacctttagaaaacgacttgctcatggcaatgatgatgagtcaacaaagccaactcccgtccacggctaccaacgatgcgtctgcaatcatggctcaattgtactctacatgttccgaggttgcgaaagacaattacttcaattggatgctgccttccgcaatgctgatgctacagcagaaaagagcagcaatgagaccgagtactccggaagaaaaatatcttgataacggtcctagtgcggatgacgacgacgaagagttactgcttgatccgcaacatccaaaagatggcatctacaatgaagaagtcaacaacattatcggcaatcttaaaaaagactccgcgggtaacaaaaatccagggcaagggacgaatcattcatctatgttgaaaagtgagttcttcggaagctctttcgactcccatccggcacttgaaagcttccgatctgatgcggatgcacagaagaggacggaagacatgttggaagcttaccgtaaaagttttgcggaacagcgaccagaacagcaagaaaagggaatttggggtgaggaaaccaaccgttcatatcgccaaccctcgaacgaagatcaaagcgtttcgcctccgagcatttcaccaactcaatgttctgactctgacctgaagaaaaaacttcgtcgcaaccgcacaacgtttaccacgttccaactacatgagttggagcgagcgtttgaacgatctcactacccggatgtttacagcagagaagagttggcaggaaaaattaatctaccagaagttcgggttcaggtttggtttcaaaaccggcgggcaaaatggcgacgtcaagaaaagattgaatctggaaaccatgaacgggaaataaggaattataaccaagccacagcattaagtgcgactgtatctactaagcccaacaacgttcaacgcaataatccttcacaccaactcgatcagcttatcgcaagtcaatcatctccagcgcgccacctactgccgacaccttcttctagtttcggccacacattggcagcatcgagccaagcgtcgagtgcgttttcaattccatttttatccggaatgctaacgggcggacgggatccagtttcgtcattagattctagtaaaacgacttctccatcctcggccgctaaattatccagcgacatggctctgtacagtaggtatgcaagccaaatgggggcgctacagcagttttctactcccccttttcatttgcccttgcaccttctgggggctagtcaggctagggactttcctcgacccaatacggcaaatgaaaaagagagcaaccaatcgaatccagaccgtagtccgtccgaaaaatccttcaaaagagaaacagctgaagaatttcgattctctccgaagtttaccgaaacaaccgataaaagttccagttttgagtcagcagtaaacaaaaccctgtatttaatgtcgtagtttgttgtcgctttttctttatcgggcatttaattatcattgtgtgatacgcagtattaacttcgtgcttatatagttatgttgtgccgatgccatcgcattgtgagttatcgtgtaaaatacaatagttcatttgtaaaaaaaaaaaaaaaaaa

//