LOCUS       NM_001032500            1151 bp    mRNA    linear   INV 26-JAN-2026
DEFINITION  Ciona intestinalis distal-less (dll-b), mRNA.
ACCESSION   NM_001032500
VERSION     NM_001032500.1
KEYWORDS    RefSeq.
SOURCE      Ciona intestinalis (vase tunicate)
  ORGANISM  Ciona intestinalis
            Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
            Cionidae; Ciona.
REFERENCE   1  (bases 1 to 1151)
  AUTHORS   Irvine SQ, Vierra DA, Millette BJ, Blanchette MD and Holbert RE.
  TITLE     Expression of the Distalless-B gene in Ciona is regulated by a
            pan-ectodermal enhancer module
  JOURNAL   Dev. Biol. 353 (2), 432-439 (2011)
   PUBMED   21338600
  REMARK    GeneRIF: cis-regulation of early Dll-B expression is activated by a
            required submodule in the center of a 378bp region upstream of
            Dll-B, termed B1, driving posterior expression, which works in
            combination with redundant submodules
REFERENCE   2  (bases 1 to 1151)
  AUTHORS   Irvine SQ, Cangiano MC, Millette BJ and Gutter ES.
  TITLE     Non-overlapping expression patterns of the clustered Dll-A/B genes
            in the ascidian Ciona intestinalis
  JOURNAL   J. Exp. Zool. B Mol. Dev. Evol. 308 (4), 428-441 (2007)
   PUBMED   17559091
  REMARK    GeneRIF: Contrary to the expectation for clustered gene duplicates,
            expression of Dll-A and Dll-B transcripts do not overlap temporally
            and only partially overlap spatially.
REFERENCE   3  (bases 1 to 1151)
  AUTHORS   Satou Y, Kawashima T, Shoguchi E, Nakayama A and Satoh N.
  TITLE     An integrated database of the ascidian, Ciona intestinalis: towards
            functional genomics
  JOURNAL   Zool. Sci. 22 (8), 837-843 (2005)
   PUBMED   16141696
REFERENCE   4  (bases 1 to 1151)
  AUTHORS   Imai KS, Hino K, Yagi K, Satoh N and Satou Y.
  TITLE     Gene expression profiles of transcription factors and signaling
            molecules in the ascidian embryo: towards a comprehensive
            understanding of gene networks
  JOURNAL   Development 131 (16), 4047-4058 (2004)
   PUBMED   15269171
REFERENCE   5  (bases 1 to 1151)
  AUTHORS   Satou Y and Satoh N.
  TITLE     Genomewide surveys of developmentally relevant genes in Ciona
            intestinalis
  JOURNAL   Dev. Genes Evol. 213 (5-6), 211-212 (2003)
   PUBMED   12736827
REFERENCE   6  (bases 1 to 1151)
  AUTHORS   Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A,
            Hamaguchi M, Awazu S, Yagi K, Sasakura Y, Nakayama A, Ishikawa H,
            Inaba K and Satoh N.
  TITLE     A cDNA resource from the basal chordate Ciona intestinalis
  JOURNAL   Genesis 33 (4), 153-154 (2002)
   PUBMED   12203911
REFERENCE   7  (bases 1 to 1151)
  AUTHORS   Caracciolo A, Di Gregorio A, Aniello F, Di Lauro R and Branno M.
  TITLE     Identification and developmental expression of three Distal-less
            homeobox containing genes in the ascidian Ciona intestinalis
  JOURNAL   Mech. Dev. 99 (1-2), 173-176 (2000)
   PUBMED   11091088
REFERENCE   8  (bases 1 to 1151)
  AUTHORS   Di Gregorio A, Spagnuolo A, Ristoratore F, Pischetola M, Aniello F,
            Branno M, Cariello L and Di Lauro R.
  TITLE     Cloning of ascidian homeobox genes provides evidence for a
            primordial chordate cluster
  JOURNAL   Gene 156 (2), 253-257 (1995)
   PUBMED   7758964
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ278697.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278697.1, BW274116.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Ciona intestinalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:7719"
                     /chromosome="7"
                     /map="7"
     gene            1..1151
                     /gene="dll-b"
                     /gene_synonym="Ci-Dll-B; DLX3"
                     /note="distal-less"
                     /db_xref="GeneID:445682"
     CDS             1..624
                     /gene="dll-b"
                     /gene_synonym="Ci-Dll-B; DLX3"
                     /codon_start=1
                     /product="distal-less"
                     /protein_id="NP_001027672.1"
                     /db_xref="GeneID:445682"
                     /translation="

MGTSTTEQPNTSVNTSKSKKKRNPRTVYSNYQLQELHMYFKKVQYLALPERARLAAALGLTQTQVKVWFQNRRSKIKKLLKSGVVQDLDEIGIQSVIDNQAPDFDGEPPAESVKRARSYDDHVDAESLQWNAPKQHCPSNEGPDIHGRTRNCTLSIITNEPSRKRNPTFSPRSHQPNDELPTLPAVQLFPRNEQQPSFWSQLRSERI"

     misc_feature    64..234
                     /gene="dll-b"
                     /gene_synonym="Ci-Dll-B; DLX3"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="dll-b"
                     /gene_synonym="Ci-Dll-B; DLX3"
ORIGIN      

atgggcacgagcacaacagagcaaccaaatacttcggtcaatacaagcaagtcgaaaaagaaacgcaacccacgtaccgtttactcaaattaccaacttcaggagctgcatatgtattttaagaaagtacaatacctagctttgccggaaagggcaagactagctgctgctttaggacttacacagacacaggttaaagtctggttccaaaaccgacgatccaagattaagaagttgttgaagtctggagttgttcaagatttggacgagattggaattcagtcagtcattgataatcaagctccagattttgatggtgaaccacccgcggagtcagtgaagcgtgcaaggagttacgatgatcacgtggacgctgaatccctgcaatggaacgcaccgaagcaacactgcccgtctaacgaaggacctgatatacacggccggacaaggaactgtacattatccatcattaccaacgaaccatcaaggaagcgaaatccaacgttttccccaagatctcaccaaccaaatgatgaactaccaactctaccagcagtccaactctttccaaggaatgaacagcaaccttccttttggagccaactacgatccgaacgaatatgatcacggtgttatgaagtccaacgcgtatccttctctagcgcccacaagcgacgcaaaccaaaactaccaacagccgccataccgcgctgcagacctcgactgtacagaaggtcaatacggtcaccctaactcaaccgaaacatacatgccaacaacctcgcaccaaatgcaccaaacgcacactgttgacacacccaacacattcaattcgtataaaaacaacttttggtaacttatacaccgttttgcactttatgagttttttttttttgtttttttttttttcagcaccgcacgatcagtatataacatattgtagctaatgagatctcattataaatttatataatctcacgaaaacaaggttggaattcacaatatgctgcacatttatattgtatgttttgtctgtgaaatagcagccaatatatattttgcctttatcggcaacattcactgtttgtcattatcaatcaccaaaccgaataaacgtatttcacttgctcgtgaaaaaaaaaaaaaaaaaa

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