LOCUS       NM_066360               5883 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Death-promoting deoxyribonuclease (dcr-1),
            mRNA.
ACCESSION   NM_066360
VERSION     NM_066360.4
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 5883)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 5883)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 5883)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 5883)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003281).
            
            On Sep 4, 2019 this sequence version replaced NM_066360.3.
FEATURES             Location/Qualifiers
     source          1..5883
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="III"
     gene            1..5883
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /db_xref="GeneID:176138"
                     /db_xref="WormBase:WBGene00000939"
     CDS             8..5740
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /standard_name="K12H4.8"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Death-promoting deoxyribonuclease"
                     /protein_id="NP_498761.2"
                     /db_xref="EnsemblGenomes-Gn:WBGene00000939"
                     /db_xref="EnsemblGenomes-Tr:K12H4.8"
                     /db_xref="GeneID:176138"
                     /db_xref="WormBase:WBGene00000939"
                     /translation="

MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPIEDDSDRFEEFDVDSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNEIERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV"

     misc_feature    38..646
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(38..49,56..58,107..130,251..253,443..445,548..550)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(215..220,287..292,368..370,374..379,386..388,
                     461..466,470..472)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    749..1036
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(764..769,776..778,782..787,965..970,977..982,
                     989..991,998..1003,1010..1012)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1076..1522
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1181..1189,1391..1393,1448..1450,1454..1456)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1403..1405,1409..1411,1484..1486,1490..1492)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    1718..1999
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:427264"
     misc_feature    2513..2875
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(2696..2698,2735..2737,2753..2755,2765..2767,
                     2819..2821,2843..2845,2849..2851)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4190..4567
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4244..4249,4256..4261,4268..4270,4277..4282,
                     4289..4294,4298..4306,4334..4336,4760..4762,4787..4789)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(4244..4246,4253..4255,4265..4267,4730..4732,
                     4739..4741)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(4253..4255,4730..4732,4739..4741)
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    4922..5707
                     /gene="dcr-1"
                     /locus_tag="CELE_K12H4.8"
                     /note="dsRNA-specific ribonuclease [Transcription];
                     Region: Rnc; COG0571"
                     /db_xref="CDD:223644"
ORIGIN      

accaataatggtcagggtaagagctgatttacaatgttttaaccccagggactaccaggtggaacttttggataaagcgacaaaaaagaacacaatcgtccaactaggcactggttcaggaaaaactttcattgcagttctactgctgaaagaatatggagttcaattgtttgcaccattggatcagggtggaaaacgagcgttttttgttgtagagaaagtaaacctcgttgaacaacaagctatccacatcgaagttcacacaagtttcaaagttggtcaggtccacggacagacaagtagtggtttatgggacagcaaagaacaatgtgatcagttcatgaagaggcaccatgttgttgtgatcacagctcaatgccttcttgatttgattcgacatgcgtacttgaaaattgaagacatgtgtgttctgatctttgacgaatgtcatcatgctctcggttctcaacatccatacagaagcatcatggtcgattataagttattgaaaaaggacaaacccgtcccacgtgtattaggactcacagccagtcttatcaaagcgaaagttgcgccggaaaaactaatggaacagttaaaaaagttggaatctgcgatggacagtgttatagagacagctagtgatttagtctcgctctcgaaatacggtgcgaaaccctatgaagttgtgatcatctgcaaagactttgaaattgggtgcctgggtattccgaatttcgacacagttatagaaatatttgatgaaactgtagcctttgtgaacaccacaacagaatttcatccagatctagatttggatcctcgtagaccgattaaagattctctcaagacgacgcgagctgtttttcgtcaactgggaccttgggcggcatggcgaacggctcaagtttgggagaaagagttgggaaaaattataaaatctcaagtgctaccggataagacgttgcggtttttgaatatggcaaaaacatctatgattacgattaaaagattgttggaaccggagatgaagaaaatcaaaagtattgaagctctccgtccatatgttcctcaacgtgtcatacgtcttttcgaaatcctagaaactttcaaccccgaatttcaaaaagaacgaatgaagttagaaaaagcagaacatttatcagccattatttttgtcgatcaacggtacattgcatattcgttacttcttatgatgcgtcatattaaatcatgggagcctaagttcaagtttgtgaacccggattacgtcgttggagccagcggacgaaatttggcgagttcggatagtcaaggattacataaacgacaaactgaagttcttcgccgtttccatcgaaatgaaatcaattgtcttatcgctacatcagtgcttgaagaaggtgtagatgttaaacaatgtaatcttgtgattaaatttgatcgaccacttgacatgagatcatacgttcagtcaaagggaagagctcggcgagctggatcaagatatgttatcactgttgaggagaaagatactgcggcgtgtgatagtgatttgaaagatttccagcaaatagaaaaaattcttcttagccgccatcgtacagtcaacaatcctattgaagatgattcggatagatttgaagaatttgatgttgattctcaaatggaaccatatgttgttgaaaaaactggtgcaacattgaaaatgtcaactgctatcgcattaattaatagatattgttcgaagcttccttccgatatcttcactcgtcttgttccacacaatcaaatcattccaattgaagagaatggagtgaccaaatactgtgcagagcttcttcttccaattaactcaccgatcaaacatgcaattgtgctcaaaaatccaatgccaaataagaagactgcacagatggcagttgcacttgaagcatgtcgacaattacatttagaaggagaactcgatgataatttacttccaaaaggaagagagtcgattgccaaattattagaacatattgatgaggagccggatgagtatgcacctggaattgctgctaaagttggatcatcaaaacgaaagcaattatatgacaaaaagattgctcgtgctctcaatgaatccttcgtggaagcagataaggaatgtttcatctatgcattcgaattggaacgtttccgggaagccgaacttacgttgaacccgaaaagacgaaagtttgaagatccatttaattatgaatattgcttcggatttctgagcgcaaaagagataccaaagatcccaccattcccagtgtttcttcgacaaggaaatatgaaagtccgattgattgtcgcaccgaaaaagactaccgtaaccgctgctcagcttcaagagattcaactgttccataattatttgttcacacaagttcttcaaatgtgtaaaacgggaaatttggaattcgatggaacatcaaatgcaccattgaacacgttgattgttccacttaacaagcgaaaagatgatatgtcctacacaatcaacatgaaatatgtatcggaagtagttgcaaacatggaaaatatgccacgtattccaaaagatgaagttcgtcgtcaatacaaattcaacgctgaagattataaggatgcgatcgtaatgccgtggtatcgaaatctggaacagcctgtattctactatgttgctgaaattctaccagaatggaggccgtcgtcgaaattcccggatacgcacttcgaaacgtttaacgagtatttcatcaagaaatataaattagagatttatgatcagaatcaaagtttattggatgtagatttcacatctactcgtcttaaccttcttcaacctcgaattcaaaatcaaccacgtcgttcaagaactgtgagtaactcctcaacgtcaaatattcctcaagcatctgcttctgattcaaaagagtcgaatacttccgttccacactcttcacaacgtcagatccttgtaccggaattgatggacattcatcctatctctgcgactctttggaatgttatagcagccctgccaagtattttctatcgtgttaatcagttattgttgactgatgaacttcgagaaacaattttggtgaaagcttttggaaaagagaaaactaaactggatgataatgttgaatggaattctctggcatatgcaaccgaatatgaagagaaacaaacgataatcgttaagaaaattcaacaattgagagatttaaatcaaaaatcgattgaagatcaagaaagagagacgagagaaaatgataagattgacgatggtgaggagttattcaatattggagtttgggatccagaagaggcagtcagaattggtgtagaaattagttcaagagatgatagaatggacggtgaagatcaggatactgtaggactaacacaaggacttcatgatgggaatatatccgatgaagacgatgaactgccgtttgtaatgcatgattacacagccaggctcacttctaacagaaatggaattggtgcatggtcaggatctgagtctattgttccaagcggatggggagattgggatggacctgaaccagataatagtcccatgcctttccaaattctcggtggaccaggtggtttgaatgtgcaggcactgatggctgatgtcggaagagtttttgatccatctactgcttcgtcttccctttctcaaactgtacaagaatcgacagtttcacctccaaaacaattgacaaaagaagaagaacagtttaagaaacttcaaaatgacttgctgaaacaagcaaaagagcgacttgaagctctagaaatgtcagaagatatggagaaaccgcgaagattggaggatactgtgaatttagaagattatggagatgatcaagaaaatcaagaggatgagaatacaccaacaaatttcccgaaaaccatagatgaagaaattgaagagttgtcaattggagcccggaaaaaacaagaaatagacgacaatgcagctaaaactgatgtactcgaaagggaaaactgtgaagttttgccagttgctataaatgaaaagtctcgttcattctcttttgaaaaagaaagtaaagcaataaatggacgacttataagacaacgatcagaggaatacgtgtcacatattgattcagatattggattaggagtatctccatgtcttttgttaactgctcttactacttccaatgctgcagatggaatgtcattagagagattcgaaacaatcggagactctttcttgaagtttgctactaccgattatctctatcacacgttgcttgatcaacatgaaggaaaattgtcgtttgcacgtagtaaagaagtttcaaattgcaatttgtatcgactgggcaagaaattgggaatacctcaattgattgttgcaaataaattcgatgctcacgattcttggctgccaccatgctatattccaacttgcgacttcaaagctcctaacactgatgatgcagaagagaaagataatgaaattgaacgaattttggatggacaagtgattgaagagaaacctgaaaataaaactggatgggacattggtggtgatgtctcgaaaagcactaccgatggaatagagactattacattcccaaagcaagcccgtgttggtaatgatgatatctctccacttccttacaacttgctcacccaacagcatatttcggataaatcaatcgctgacgcagtcgaagctttgatcggagtacatttgctgacgttgggacctaatccaacgctgaaggtgatgaattggatgggactgaaagtaattcaaaaagatcagaagagtgacgtaccttcacctcttctacgattcattgacactccgaccaatccgaatgcttctctaaatttcttgaacaatttgtggcagcaattccagtttacacaattggaagagaaaattggatatcgcttcaaggaacgtgcttatcttgttcaagctttcacacatgcttcgtacatcaataatcgtgtcacaggatgctatcaaagattagaattcctcggagacgctgttctcgactatatgatcaccagatatttgtttgaagattctcgtcaatacagtccgggtgttctcactgatttacgatcagctctcgtcaataatacaattttcgcgtcgttagcagtgaaattcgagtttcaaaagcacttcatcgctatgtgcccagggctttatcacatgattgagaaatttgttaagctgtgctcggagcgcaatttcgatactaatttcaatgctgagatgtatatggtgactactgaggaagaaatagatgaaggccaagaagaggatattgaagttccaaaagcgatgggtgacatatttgaatcagtagctggcgccatttatctcgactctggacgtaatttggataccacttggcaagtgattttccacatgatgcgcgggactattgaattgtgctgtgcgaacccaccaagatcaccgattcgagagcttatggagttcgagcagagcaaagttcgattcagtaaaatggaacgaattctcgagagtggaaaagttcgagttacagtcgaggttgttaataacatgagattcactggaatgggaaggaactatcgaatcgcgaaagctactgctgcgaaaagagctttgaaatacctccatcaaattgagcagcaaagaagacaaagcccatcattaacaactgtttaaattacctcttcactttctgtgatatgctaagtattaagctatgtgtttctaggatctattgatctgattttcctaattctccaatttttactcgtttctattgaatttcatatgtattctgaaaatatacagttttacttgtt

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